X0306 4 2022-10-27 0 0001850838 Omega Therapeutics, Inc. OMGA 0001824252 Zeng Ling C/O OMEGA THERAPEUTICS, INC. 20 ACORN PARK DRIVE CAMBRIDGE MA 02140 0 1 0 0 See Remarks Option (Right to Buy) 5.27 2022-10-27 4 A 0 55000 0.00 A 2032-10-26 Common Stock 55000 55000 D The options vest and become exercisable as to 25% of the underlying shares on October 27, 2023 and as to 6.25% of the underlying shares upon the Reporting Person's completion of each three full months of continued service to the Issuer thereafter, such that the option will be fully vested and exercisable on October 27, 2026. Chief Legal and Administrative Officer /s/ Barbara Chan as Attorney-in-Fact for Ling Zeng 2022-10-28