X0306 4 2022-05-31 0 0001850838 Omega Therapeutics, Inc. OMGA 0001746541 Reed Joshua C/O OMEGA THERAPEUTICS, INC. 20 ACORN PARK DRIVE CAMBRIDGE MA 02140 0 1 0 0 Chief Financial Officer Option (Right to Buy) 2.27 2022-05-31 4 A 0 320000 0.00 A 2032-05-30 Common Stock 320000 320000 D The options vest and become exercisable with respect to 25% of the underlying shares on May 23, 2023 and in equal quarterly installments thereafter such that the option will become fully vested and exercisable on May 23, 2026, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Barbara Chan as Attorney-in-Fact for Joshua Reed 2022-06-02