X0306 4 2021-07-29 0 0001850838 Omega Therapeutics, Inc. OMGA 0001204876 BERRY DAVID A C/O OMEGA THERAPEUTICS, INC. 20 ACORN PARK DRIVE CAMBRIDGE MA 02140 1 0 0 0 Stock Option (Right to Buy) 17.00 2021-07-29 4 A 0 19852 0.00 A 2031-07-28 Common Stock 19852 19852 D The options vest and become exercisable as to 100% of the underlying shares on the earlier of (i) July 29, 2022 or (ii) the date of the Issuer's next annual meeting of stockholders held after July 29, 2021, subject to the Reporting Person's continued service to the Issuer through such vesting date. /s/ Barbara Chan as Attorney-in-fact for David A. Berry, M.D., Ph.D. 2021-07-30