Stock based compensation (Tables)

3 Months Ended

Mar. 31, 2023

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of reserved shares of common stock

	Shares
Options and RSUs issued and outstanding	10,915,052
Shares available for future stock option and RSU grants	4,863,670
Shares available for employee stock purchase plan	1,114,126
Total	16,892,848

Schedule of common stock available under 2021 Incentive Plan

	Shares
Balance, December 31, 2022	5,786,358
Shares reserved for issuance	2,954,788
Options granted	(3,770,399)
RSU’s granted	(546,795)
Options and RSUs forfeited / cancelled	439,718
Balance March 31, 2023	4,863,670

Schedule of stock option activity

		Weighted Average
				Remaining		Aggregate
				Contractual		Intrinsic
				Term		Value
	Shares	Exercise Price		(years)		(in thousands)
Outstanding January 1, 2023	7,489,678	$	7.77	7.84	$	8,991
Granted	3,770,399		4.66	—		—
Exercised	(452,102)		0.99	—		—
Forfeited	(437,573)		10.39	—		—
Outstanding, March 31, 2023	10,370,402	$	5.28	4.55	$	3,952
Exercisable at March 31, 2023	3,145,362	$	6.45	6.93	$	3,262

Schedule of weighted-average assumptions

	March 31, 2022		December 31, 2022
Expected dividend rate	—		—
Expected option term (years)	6.08		6.09
Expected volatility	79.15	%	69.73	%
Risk-free interest rate	3.65	%	1.08	%

Schedule of stock-based compensation expense and by award type

	Three Months Ended		Three Months Ended
	March 31,		March 31,
	2023		2022
Research and development	$	2,112	$	1,309
General and administrative		1,685		1,071
Total stock-based compensation	$	3,797	$	2,380

Stock-based compensation expense by award type included within the condensed consolidated statements of operations is as follows:

	Three Months Ended		Three Months Ended
	March 31,		March 31,
	2023		2022
Stock options	$	3,546	$	2,108
Restricted stock units		97		—
Restricted stock awards		93		272
Employee stock purchase plan		61		—
Total stock-based compensation	$	3,797	$	2,380

Restricted stock units

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of restricted stock activity

		Weighted Average
	Shares	Grant Date Fair Value
Total Unvested December 31, 2022	—	$	—
Granted	546,795		4.64
Forfeited	(2,145)		4.64
Total Unvested March 31, 2023	544,650	$	4.64

Restricted stock

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of restricted stock activity

		Weighted Average
	Shares	Grant Date Fair Value
Total Unvested December 31, 2022	193,031	$	8.41
Granted	—		—
Forfeited	(47,689)		—
Vested	(95,877)		2.50
Total Unvested March 31, 2023	49,465	$	7.27