SCHEDULE 13G/A 0000919574-24-006933 0001534261 XXXXXXXX LIVE 1 Common Stock, $0.0001 par value per share 03/31/2025 0001850119 Century Therapeutics, Inc. 15673T100 25 North 38th Street, 11th Floor Philadelphia PA 19104 Rule 13d-1(b) Casdin Capital, LLC DE 0.00 3212316.00 0.00 3212316.00 3212316.00 N 3.7 IA Eli Casdin X1 0.00 3212316.00 0.00 3212316.00 3212316.00 N 3.7 HC IN Century Therapeutics, Inc. 25 North 38th Street, 11th Floor, Philadelphia, Pennsylvania 19104 Casdin Capital, LLC Eli Casdin Casdin Capital, LLC 1350 Avenue of the Americas, Suite 2600 New York, New York 10019 Eli Casdin 1350 Avenue of the Americas, Suite 2600 New York, New York 10019 Casdin Capital, LLC - Delaware Eli Casdin - United States N IA HC Casdin Capital, LLC - 3,212,316 Eli Casdin - 3,212,316 Casdin Capital, LLC - 3.7% Eli Casdin - 3.7% Casdin Capital, LLC - 0 Eli Casdin - 0 Casdin Capital, LLC - 3,212,316 Eli Casdin - 3,212,316 Casdin Capital, LLC - 0 Eli Casdin - 0 Casdin Capital, LLC - 3,212,316 Eli Casdin - 3,212,316 N Y N All of the securities reported in this Schedule 13G are directly owned by advisory clients of Casdin Capital, LLC. None of those advisory clients may be deemed to beneficially own more than 5% of the Common Stock, $0.01 par value. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit A - Joint Filing Agreement Casdin Capital, LLC /s/ Eli Casdin 05/15/2025 Eli Casdin /s/ Eli Casdin 05/15/2025 * Each Reporting Person disclaims beneficial ownership of the reported securities except to the extent of his, her or its pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. To the extent that "ownership of 5 percent or less of a class" was indicated in Item 5, such response only applies to the Reporting Person(s) that indicated elsewhere herein that it beneficially owns five percent (5%) or less of the class.