<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13D" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13D/A</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: CAISSE DE DEPOT ET PLACEMENT DU QUEBEC -->
          <cik>0000898286</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>9</amendmentNo>
      <securitiesClassTitle>Common Stock, par value $0.001 per share</securitiesClassTitle>
      <dateOfEvent>09/30/2025</dateOfEvent>
      <previouslyFiledFlag>false</previouslyFiledFlag>
      <issuerInfo>
        <issuerCIK>0001849089</issuerCIK>
        <issuerCUSIP>000000000</issuerCUSIP>
        <issuerName>Lafayette Square USA, Inc.</issuerName>
        <address>
          <com:street1>175 SW 7th St</com:street1>
          <com:street2>Unit 2307</com:street2>
          <com:city>Miami</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33130-2992</com:zipCode>
        </address>
      </issuerInfo>
      <authorizedPersons>
        <notificationInfo>
          <personName>Soulef Hadjoudj</personName>
          <personPhoneNum>(514) 847-5998</personPhoneNum>
          <personAddress>
            <com:street1>Caisse de depot et placement du Quebec</com:street1>
            <com:street2>1000, place Jean-Paul-Riopelle</com:street2>
            <com:city>Montreal</com:city>
            <com:stateOrCountry>A8</com:stateOrCountry>
            <com:zipCode>H2Z 2B3</com:zipCode>
          </personAddress>
        </notificationInfo>
      </authorizedPersons>
    </coverPageHeader>
    <reportingPersons>
      <reportingPersonInfo>
        <reportingPersonCIK>0000898286</reportingPersonCIK>
        <reportingPersonNoCIK>N</reportingPersonNoCIK>
        <reportingPersonName>Caisse de depot et placement du Quebec</reportingPersonName>
        <memberOfGroup>b</memberOfGroup>
        <fundType>OO</fundType>
        <legalProceedings>N</legalProceedings>
        <citizenshipOrOrganization>A8</citizenshipOrOrganization>
        <soleVotingPower>6114196.07</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>6114196.07</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
        <aggregateAmountOwned>6114196.07</aggregateAmountOwned>
        <isAggregateExcludeShares>N</isAggregateExcludeShares>
        <percentOfClass>23.3</percentOfClass>
        <typeOfReportingPerson>OO</typeOfReportingPerson>
      </reportingPersonInfo>
    </reportingPersons>
    <items1To7>
      <item1>
        <securityTitle>Common Stock, par value $0.001 per share</securityTitle>
        <issuerName>Lafayette Square USA, Inc.</issuerName>
        <issuerPrincipalAddress>
          <com:street1>175 SW 7th St</com:street1>
          <com:street2>Unit 2307</com:street2>
          <com:city>Miami</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33130-2992</com:zipCode>
        </issuerPrincipalAddress>
        <commentText>This amendment No. 9 ("Amendment No. 9") to Schedule 13D relates to the Schedule 13D filed on June 24, 2022 , as amended by Amendment No. 1, dated September 14, 2022, Amendment No. 2, dated December 22, 2022, Amendment No. 3, dated January 27, 2023, Amendment No. 4, dated March 29, 2023, Amendment No. 5, dated June 29, 2023, Amendment No. 6 dated December 15, 2023, Amendment No. 7, dated May 2, 2024, and Amendment No. 8 dated September 30, 2024 (the "Schedule 13D") by Caisse de depot et placement du Quebec (the "Reporting Person") relating to the Common Stock, par value $0.001 per share (the "Common Stock") issued by Lafayette Square USA, Inc. (formerly, Lafayette Square Empire BDC, Inc.), a Delaware corporation (the "Issuer"). The principal executive offices of the Issuer are located at 175 SW Seventh St., Unit 2307, Miami, Florida, 33130.</commentText>
      </item1>
      <item2>
        <convictionDescription>Item 2 of the Schedule 13D is hereby amended and supplemented by adding the following information:

"The citizenship of the natural persons who are officers, directors or controlling persons of the Reporting Person is set forth in Annex A hereto."</convictionDescription>
      </item2>
      <item3>
        <fundsSource>Item 3 of the Schedule 13D is hereby amended and supplemented by adding the following information:

"On September 30, 2025, the Reporting Person purchased 399,733.51 shares of Common Stock from the Issuer, at a purchase price of $15.01 per share, for an aggregate purchase price of $6,000,000, following the delivery by the Issuer to the Reporting Person of a drawdown notice pursuant to the Subscription Agreement. The source of funds used by the Reporting Person was funds on deposit at the Reporting Person."</fundsSource>
      </item3>
      <item5>
        <percentageOfClassSecurities>Item 5(a) and (b) is amended and restated as follows:

As a result of the transactions described above, the Reporting Person is the direct beneficial owner of 6,114,196.07 shares of Common Stock, which represents approximately 23.3% of the Issuer's outstanding Common Stock, based on 26,192,798.89 shares of Common Stock outstanding as of September 30, 2025.</percentageOfClassSecurities>
        <transactionDesc>Item 5(c) is amended and restated as follows:

The transactions by the Reporting Persons in the shares of Common Stock during the past sixty days are set forth in Annex B. Except as otherwise disclosed therein, the Reporting Persons have not effected any transaction in the shares of Common Stock in the last 60 days.</transactionDesc>
        <listOfShareholders>Item 5(d) is amended and restated as follows:

No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of the shares of Common Stock beneficially owned by the Reporting Person.</listOfShareholders>
        <date5PercentOwnership>Item 5(e) is amended and restated as follows:

Not applicable.</date5PercentOwnership>
      </item5>
    </items1To7>
    <signatureInfo>
      <signaturePerson>
        <signatureReportingPerson>Caisse de depot et placement du Quebec</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Soulef Hadjoudj</signature>
          <title>Soulef Hadjoudj/Authorized Signatory</title>
          <date>10/02/2025</date>
        </signatureDetails>
      </signaturePerson>
    </signatureInfo>
  </formData>

</edgarSubmission>
