144 0001762176 XXXXXXXX LIVE 0001847903 Centessa Pharmaceuticals plc 001-40445 3RD FLOOR 1 ASHLEY ROAD ALTRINCHAM, CHESHIRE X0 WA14 2DT 44 7391 789784 Anderson Karen M. Officer ADR UBS Financial Services Inc.

1000 Harbor Blvd 3rd Floor Weehawken NJ 07086

120029 3103949.94 134447836 03/13/2026 Nasdaq ADR 03/13/2026 Exercise of Stock Options Issuer N 109398 03/13/2026 CASH ADR 02/01/2026 Vested RSUs Issuer N 10631 02/01/2026 NA Y The transactions reported herein were effected pursuant to a Rule 10b5-1 trading plan. 03/13/2026 11/12/2025 /s/ UBS Financial Services Inc, as attorney-in-fact for Karen Anderson