144 0001861926 XXXXXXXX LIVE 0001847903 Centessa Pharmaceuticals 001-40445 1 Federal Street 38th Floor Boston MA 02110 6174685770 Saurabh Saha Previous Officer Class A Common Stock UBS Financial Services Inc

1000 Harbor Blvd 3rd Floor Weehawken NJ 07086

2500000 60750000 131947836 01/02/2026 NASDAQ Class A Common Stock 01/02/2025 Stock Option Exercise Issuer N 2500000 01/02/2026 Cash Y The proceeds from the proposed sale of these securities may be allocated to fund the exercise and hold of stock options, including related withholding taxes. This will enable the filer to acquire and retain direct ownership of the underlying shares, thereby preserving continued economic exposure to the issuer. 01/02/2026 /s/Mijo Suric, for UBS Financial Services Inc, as attorney-in-fact for Saurabh Saha