<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001861926</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001847903</issuerCik>
      <issuerName>Centessa Pharmaceuticals plc</issuerName>
      <secFileNumber>001-40445</secFileNumber>
      <issuerAddress>
        <com:street1>3RD FLOOR</com:street1>
        <com:street2>1 ASHLEY ROAD</com:street2>
        <com:city>ALTRINCHAM, CHESHIRE</com:city>
        <com:stateOrCountry>X0</com:stateOrCountry>
        <com:zipCode>WA14 2DT</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>44 7391 789784</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SAHA SAURABH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>CEO</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services, Inc</name>
        <address>
          <com:street1>1000 Harbor Blvd</com:street1>
          <com:street2>3rd Floor</com:street2>
          <com:city>Weehawken</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07086</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>55000</noOfUnitsSold>
      <aggregateMarketValue>707575.00</aggregateMarketValue>
      <noOfUnitsOutstanding>133618774</noOfUnitsOutstanding>
      <approxSaleDate>06/20/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/20/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>55000</amountOfSecuritiesAcquired>
      <paymentDate>06/20/2025</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Saurabh Saha</name>
        <address>
          <com:street1>3RD FLOOR</com:street1>
          <com:street2>1 ASHLEY ROAD</com:street2>
          <com:city>ALTRINCHAM, CHESHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>WA14 2D</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/20/2025</saleDate>
      <amountOfSecuritiesSold>55000</amountOfSecuritiesSold>
      <grossProceeds>918060.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Saurabh Saha</name>
        <address>
          <com:street1>3RD FLOOR</com:street1>
          <com:street2>1 ASHLEY ROAD</com:street2>
          <com:city>ALTRINCHAM, CHESHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>WA14 2DT</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>04/21/2025</saleDate>
      <amountOfSecuritiesSold>14656</amountOfSecuritiesSold>
      <grossProceeds>180100.26</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Saurabh Saha</name>
        <address>
          <com:street1>3RD FLOOR</com:street1>
          <com:street2>1 ASHLEY ROAD</com:street2>
          <com:city>ALTRINCHAM, CHESHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>WA14 2D</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>04/22/2025</saleDate>
      <amountOfSecuritiesSold>40344</amountOfSecuritiesSold>
      <grossProceeds>501475.92</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Saurabh Saha</name>
        <address>
          <com:street1>3RD FLOOR</com:street1>
          <com:street2>1 ASHLEY ROAD</com:street2>
          <com:city>ALTRINCHAM, CHESHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>WA14 2DT</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/20/2025</saleDate>
      <amountOfSecuritiesSold>55000</amountOfSecuritiesSold>
      <grossProceeds>699110.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The transactions reported herein were effected pursuant to a Rule 10b5-1 trading plan.</remarks>
    <noticeSignature>
      <noticeDate>06/20/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>05/16/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for Saurabh Saha</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
