Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Income Statement [Abstract]
License and other revenue	$ 0	$ 0	$ 15,000	$ 0
Operating expenses:
Research and development	42,741	32,815	76,184	55,467
General and administrative	11,912	11,165	24,246	24,603
Loss from operations	(54,653)	(43,980)	(85,430)	(80,070)
Interest and investment income	4,380	3,240	12,270	5,831
Interest expense	(2,884)	(2,525)	(5,761)	(5,054)
Other non-operating income (expense), net	3,592	154	4,618	(1,383)
Loss before income taxes	(49,565)	(43,111)	(74,303)	(80,676)
Income tax expense	778	705	2,175	1,186
Net loss	(50,343)	(43,816)	(76,478)	(81,862)
Other comprehensive (loss) income:
Foreign currency translation adjustment	(479)	(61)	164	(86)
Unrealized (loss) gain on available for sale marketable securities, net of reclassification adjustment and tax	(5)	33	(2,786)	188
Other comprehensive (loss) income	(484)	(28)	(2,622)	102
Total comprehensive loss	$ (50,827)	$ (43,844)	$ (79,100)	$ (81,760)
Net loss per ordinary share - basic (in dollars per share)	$ (0.38)	$ (0.40)	$ (0.57)	$ (0.78)
Net loss per ordinary share - diluted (in dollars per share)	$ (0.38)	$ (0.40)	$ (0.57)	$ (0.78)
Weighted average ordinary shares outstanding - basic (in shares)	133,677,405	109,489,184	133,354,373	104,688,452
Weighted average ordinary shares outstanding - diluted (in shares)	133,677,405	109,489,184	133,354,373	104,688,452