X0306 4 2022-06-30 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001861844 GOYAL ARJUN C/O CENTESSA PHARMACEUTICALS PLC 3RD FLOOR, 1 ASHLEY RD, ALTRINCHAM CHESHIRE X0 WA14 2DT UNITED KINGDOM 1 0 0 0 Share Option (right to buy) 4.87 2022-06-30 4 A 0 48000 0.00 A 2032-06-30 Ordinary Shares 48000 48000 D The shares subject to such option will vest in full on the earlier of (i) the first anniversary of the grant date or (ii) the Issuer's next annual meeting of shareholders, subject to continued service as a director through the applicable vesting date. The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. /s/ Marella Thorell, attorney-in-fact 2022-07-05