X0306 4 2022-02-01 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001861871 CHAO DAVID M C/O CENTESSA PHARMACEUTICALS PLC 3RD FL., 1 ASHLEY RD, ALTRINCHAM CHESHIRE X0 WA14 2DT UNITED KINGDOM 0 1 0 0 Chief Administrative Officer Share Option (right to buy) 9.53 2022-02-01 4 A 0 230000 0.00 A 2032-02-01 Ordinary Shares 230000 230000 D 14,373 shares subject to such option shall vest and become exercisable on May 1,2022 and the remaining 215,627 shares subject to such option shall vest and become exercisable in 45 substantially equal installments on each monthly anniversary thereafter. The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. /s/ Marella Thorell, attorney-in-fact 2022-02-03