X0306 4 2022-02-01 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001654274 Templeman Thomas C/O CENTESSA PHARMACEUTICALS PLC 3RD FL., 1 ASHLEY RD, ALTRINCHAM CHESHIRE X0 WA14 2DT UNITED KINGDOM 0 1 0 0 Chief Technology Officer Share Option (right to buy) 9.53 2022-02-01 4 A 0 140000 0.00 A 2032-02-01 Ordinary Shares 140000 140000 D 11,664 shares subject to such option shall vest and become exercisable on June 1,2022 and the remaining 128,336 shares subject to such option shall vest and become exercisable in 44 substantially equal installments on each monthly anniversary thereafter. The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. /s/ Marella Thorell, attorney-in-fact 2022-02-03