X0306 4 2021-06-02 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001400975 Weinhoff Gregory M C/O CENTESSA PHARMACEUTICALS PLC 3RD FL., 1 ASHLEY RD, ALTRINCHAM CHESHIRE X0 WA14 2DT UNITED KINGDOM 0 1 0 0 Chief Financial Officer Ordinary Shares 2021-06-02 4 P 0 10000 20.00 A 10000 D Share Option (right to buy) 5.84 2021-03-04 4 A 0 958981 0.00 A 2031-03-04 Ordinary Shares 958981 958981 D Share Option (right to buy) 5.84 2021-04-08 5 G 0 E 319660 0.00 D 2031-03-04 Ordinary Shares 319660 639321 D Share Option (right to buy) 5.84 2021-04-08 5 G 0 E 319660 0.00 A 2031-03-04 Ordinary Shares 319660 319660 I See footnote The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. Pursuant to maximum allowed participation in the Directed Share Program. On May 20, 2021, the Issuer effected a share capital reorganization, which had the effect of a one for two reverse share split of the Issuer's share capital ("Share Split"). This amount has been adjusted to give effect to the Share Split. This transaction occurred prior to the effectiveness of the Issuer's registration under Section 12 of the Securities Exchange Act of 1934 and is being reported on Form 4 solely for purposes of compliance with Rule 16a-2(a) under the Securities Exchange Act of 1934, as amended. The securities covered by such transaction were previously included on the Reporting Person's Form 3. 25% of the shares subject to such option shall vest and become exercisable on March 1, 2022 and the remaining 75% of the shares subject to such option shall vest and become exercisable in 36 monthly installments on the first day of each month thereafter. Represented A Ordinary Shares that were redesignated as Ordinary Shares immediately prior to the closing of the initial public offering. The Reporting Person transferred and assigned this option for no consideration to the Gregory Weinhoff 2017 Trust, a spousal lifetime access trust ("SLAT"). Held by the SLAT, of which the Reporting Person's spouse and another immediate family member are trustees. The beneficiaries of the trust are the Reporting Person's spouse and children. The Reporting Person disclaims beneficial ownership of the securities held by the SLAT. /s/ Marella Thorell, attorney-in-fact 2021-06-04