X0306 4 2021-06-02 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001715579 Medicxi Ventures Management (Jersey) Ltd C/O INTERTRUST FUND SERVICES (JERSEY) LIMITED 44 ESPLANADE ST. HELIER Y9 JE4 9WG JERSEY 0 0 1 0 0001690310 Medicxi Growth I LP C/O INTERTRUST FUND SERVICES (JERSEY) LIMITED 44 ESPLANADE ST. HELIER Y9 JE4 9WG JERSEY 0 0 1 0 0001715578 Medicxi Growth Co-Invest I LP C/O INTERTRUST FUND SERVICES (JERSEY) LIMITED 44 ESPLANADE ST. HELIER Y9 JE4 9WG JERSEY 0 0 1 0 0001715600 Medicxi Growth I GP Ltd C/O INTERTRUST FUND SERVICES (JERSEY) LIMITED 44 ESPLANADE ST. HELIER Y9 JE4 9WG JERSEY 0 0 1 0 Ordinary Shares 2021-06-02 4 C 0 1886990 A 3155532 I See footnote Ordinary Shares 2021-06-02 4 C 0 44828 A 74964 I See footnote Ordinary Shares 2021-06-02 4 P 0 586077 20.00 A 3741609 I See footnote Ordinary Shares 2021-06-02 4 P 0 13923 20.00 A 88887 I See footnote Ordinary Shares 4398519 I See footnote Ordinary Shares 55677 I See footnote Ordinary Shares 9403092 I See footnote Ordinary Shares 236108 I See footnote Series A Preferred Shares 2021-06-02 4 C 0 1886990 0.00 D Ordinary Shares 1886990 0 I See footnote Series A Preferred Shares 2021-06-02 4 C 0 44828 0.00 D Ordinary Shares 44828 0 I See footnote The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. Immediately prior to the closing of the initial public offering, the Series A Preferred Shares automatically converted on a one-to-one basis into Ordinary Shares without payment or further consideration. The Series A Preferred Shares had no expiration date. Held by Medicxi Growth I LP, a Jersey limited partnership ("Medicxi Growth I"). Medicxi Growth I GP Limited, a Jersey limited liability company ("MGI GP"), is the sole managing general partner of Medicxi Growth I, and Medicxi Ventures Management (Jersey) Limited, a Jersey limited liability company ("Medicxi Manager") is the sole manager of Medicxi Growth I. The Reporting Person is a member of the board of directors of Medicxi Manager. The Reporting Person disclaims Section 16 beneficial ownership of the securities held by Medicxi Growth I, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed to be an admission that he has beneficial ownership of such shares for Section 16 or any other purpose. Held by Medicxi Growth Co-Invest I LP, a Jersey limited partnership ("Medicxi Growth Co-Invest I"). MGI GP is the sole managing general partner of Medicxi Growth Co-Invest I, and Medicxi Manager is the sole manager of Medicxi Growth Co-Invest I. The Reporting Person is a member of the board of directors of Medicxi Manager. The Reporting Person disclaims Section 16 beneficial ownership of the securities held by Medicxi Growth Co-Invest I, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed to be an admission that he has beneficial ownership of such shares for Section 16 or any other purpose. Held by Medicxi Ventures I LP, a Jersey limited partnership ("Medicxi Ventures I"). Medicxi Ventures I GP Limited, a Jersey limited liability company ("MVI GP"), is the sole managing general partner of Medicxi Ventures I, and Medicxi Manager is the sole manager of Medicxi Ventures I. The Reporting Person is a member of the board of directors of Medicxi Manager. The Reporting Person disclaims Section 16 beneficial ownership of the securities held by Medicxi Ventures I, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed to be an admission that he has beneficial ownership of such shares for Section 16 or any other purpose. Held by Medicxi Co-Invest I LP, a Jersey limited partnership ("Medicxi Co-Invest I"). MVI GP is the sole managing general partner of Medicxi Co-Invest I, and Medicxi Manager is the sole manager of Medicxi Co-Invest I. The Reporting Person is a member of the board of directors of Medicxi Manager. The Reporting Person disclaims Section 16 beneficial ownership of the securities held by Medicxi Co-Invest I, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed to be an admission that he has beneficial ownership of such shares for Section 16 or any other purpose. Held by Medicxi Secondary I LP, a Jersey limited partnership ("Medicxi Secondary I"). Medicxi Secondary I GP Limited, a Jersey limited liability company ("MSI GP"), is the sole managing general partner of Medicxi Secondary I, and Medicxi Manager is the sole manager of Medicxi Secondary I. The Reporting Person is a member of the board of directors of Medicxi Manager. The Reporting Person disclaims Section 16 beneficial ownership of the securities held by Medicxi Secondary I, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed to be an admission that he has beneficial ownership of such shares for Section 16 or any other purpose. Held by Medicxi Secondary Co-Invest I LP, a Jersey limited partnership ("Medicxi Secondary Co-Invest I"). MSI GP is the sole managing general partner of Medicxi Secondary Co-Invest I, and Medicxi Manager is the sole manager of and Medicxi Secondary Co-Invest I. The Reporting Person is a member of the board of directors of Medicxi Manager. The Reporting Person disclaims Section 16 beneficial ownership of the securities held by Medicxi Secondary Co-Invest I, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed to be an admission that he has beneficial ownership of such shares for Section 16 or any other purpose. Medicxi Ventures (UK) LLP and Medicxi Ventures (Jersey) Limited act as sub-advisers to Index Ventures Life VI (Jersey) Limited, which acts as the adviser to Index Ventures Life VI (Jersey) LP, and as such, Index Ventures Life VI and Yucca (Jersey) SLP, each of which hold Ordinary Shares as of the date hereof, and the Medicxi Funds may be deemed to be members of a "group" as defined in Rule 13d-5 of the Securities Exchange Act of 1934, as amended. Medicxi Ventures Management (Jersey) Limited, By: /s/ Andrew Jeanne, Its: Director 2021-06-04 Medicxi Growth I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Andrew Jeanne, Its: Director 2021-06-04 Medicxi Growth Co-Invest I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Andrew Jeanne, Its: Director 2021-06-04 Medicxi Growth I GP Limited, By: /s/ Andrew Jeanne, Its: Director 2021-06-04