X0206 3/A 2021-05-27 2021-05-27 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001591199 INDEX VENTURES LIFE VI (JERSEY) L.P. C/O INTERTRUST FUND SERVICES (JERSEY) LIMITED 44 ESPLANADE ST. HELIER Y9 JE4 9WG JERSEY 0 0 1 0 0001591294 Yucca (Jersey) SLP C/O EFG FUND ADMINISTRATION 5TH FLOOR, 44 ESPLANADE ST. HELIER Y9 JE1 3FG JERSEY 0 0 1 0 0001865139 Index Venture Life Associates VI Ltd C/O INTERTRUST FUND SERVICES (JERSEY) LIMITED 44 ESPLANADE ST. HELIER Y9 JE4 9WG JERSEY 0 0 1 0 Ordinary Shares 9812368 D Ordinary Shares 149421 D Represents A Ordinary Shares that will be redesignated as Ordinary Shares immediately prior to the closing of the initial public offering ("IPO"). Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. Held by Index Ventures Life VI (Jersey) LP, a Jersey limited partnership ("Index Ventures Life VI"). Index Venture Life Associates VI Limited, a Jersey limited liability company ("Index Venture Life VI GP"), is the managing general partner of Index Ventures Life VI. The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Index Ventures Life VI, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose. Held by Yucca (Jersey) SLP, a Jersey separate limited partnership ("Yucca"). Yucca administers the Index Ventures Life VI co-investment vehicle that is contractually required to mirror the investment in the shares by Index Ventures Life VI. The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Yucca, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose. Medicxi Ventures (UK) LLP and Medicxi Ventures (Jersey) Limited act as sub-advisers to Index Ventures Life VI (Jersey) Limited, which acts as the adviser to Index Ventures Life VI, and as such, certain funds affiliated with Medicxi, which hold Ordinary Shares and/or Series A Preferred Shares as of the date hereof, and Index Ventures Life VI and Yucca (Jersey) SLP, may be deemed to be members of a "group" as defined in Rule 13d-5 of the Securities Exchange Act of 1934, as amended. This amendment to Form 3 is being filed to include Index Venture Life VI GP as a Reporting Person. Index Ventures Life VI (Jersey) LP, By: Index Venture Life Associates VI Limited, By: /s/ David Middleton, Its: Director 2021-06-03 Yucca (Jersey) SLP, By Intertrust Employee Benefit Services Limited, as authorized signatory of Yucca (Jersey) SLP in its capacity as Administrator of the Index Co-Investment Scheme, By: /s/ David Middleton and /s/ Samuel Dustow, Authorized Signatories 2021-06-03 Index Venture Life Associates VI Limited, By: /s/ David Middleton, Its: Director 2021-06-03