The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109   7,530,345 354,703 SH   SOLE   354,703 0 0
3M CO COM 88579Y101   6,425,120 44,241 SH   SOLE   44,241 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100   655,703 70,430 SH   SOLE   70,430 0 0
ABBOTT LABORATORIES COM 002824100   1,592,001 15,506 SH   SOLE   15,506 0 0
ABBVIE INC COM 00287Y109   10,574,581 48,621 SH   SOLE   48,621 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206   2,275,786 507,988 SH   SOLE   507,988 0 0
ACHIEVE LIFE SCIENCE INC COM 004468500   3,482,465 1,184,512 SH   SOLE   1,184,512 0 0
ADOBE INC COM 00724F101   550,819 2,266 SH   SOLE   2,266 0 0
AGNC INVT CORP COM 00123Q104   1,037,955 103,485 SH   SOLE   103,485 0 0
ALIGN TECHNOLOGY INC COM 016255101   18,325,353 106,897 SH   SOLE   106,897 0 0
ALIGNMENT HEALTHCARE INC COM 01625V104   3,401,224 193,032 SH   SOLE   193,032 0 0
AMERICAN EXPRESS CO COM 025816109   255,898 846 SH   SOLE   846 0 0
AMGEN INC COM 031162100   5,574,711 15,844 SH   SOLE   15,844 0 0
ANNALY CAPITAL MANAGEMENT IN COM NEW 035710839   1,044,873 49,403 SH   SOLE   49,403 0 0
APPLIED MATLS INC COM 038222105   333,245 975 SH   SOLE   975 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104   972,258 234,279 SH   SOLE   234,279 0 0
ARMOUR RESIDENTIAL REIT INC COM SHS 042315705   899,052 53,900 SH   SOLE   53,900 0 0
ARTIVA BIOTHERAPEUTICS INC COM 04317A107   149,601 23,230 SH   SOLE   23,230 0 0
ASTRAZENECA PLC ORD G0593M107   5,091,826 25,818 SH   SOLE   25,818 0 0
AUTODESK INC COM 052769106   263,819 1,102 SH   SOLE   1,102 0 0
BENITEC BIOPHARMA INC COM NEW 08205P209   5,987,877 562,242 SH   SOLE   562,242 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702   1,256,462 2,622 SH   SOLE   2,622 0 0
BIOHAVEN LTD COM G1110E107   7,600,464 898,400 SH   SOLE   898,400 0 0
BIT DIGITAL INC SHS G1144A105   30,710 23,443 SH   SOLE   23,443 0 0
BLACKROCK INC COM 09290D101   205,806 214 SH   SOLE   214 0 0
BOOKING HOLDINGS INC COM 09857L108   227,357 54 SH   SOLE   54 0 0
BOSTON SCIENTIFIC CORP COM 101137107   710,581 11,324 SH   SOLE   11,324 0 0
CADENCE DESIGN SYSTEM INC COM 127387108   384,016 1,382 SH   SOLE   1,382 0 0
CATERPILLAR INC COM 149123101   406,656 574 SH   SOLE   574 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   2,188,490 68,994 SH   SOLE   68,994 0 0
CHIMERA INVT CORP COM SHS 16934Q802   640,364 51,025 SH   SOLE   51,025 0 0
CIENA CORP COM NEW 171779309   225,562 581 SH   SOLE   581 0 0
CISCO SYS INC COM 17275R102   1,540,860 19,859 SH   SOLE   19,859 0 0
CLOUDFLARE INC CL A COM 18915M107   323,128 1,566 SH   SOLE   1,566 0 0
COCA COLA CO COM 191216100   306,786 4,034 SH   SOLE   4,034 0 0
COHERUS ONCOLOGY INC COM 19249H103   427,807 253,140 SH   SOLE   253,140 0 0
COMCAST CORP NEW CL A 20030N101   524,283 18,691 SH   SOLE   18,691 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   879,558 159,052 SH   SOLE   159,052 0 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101   134,864 51,475 SH   SOLE   51,475 0 0
COOPER COS INC COM 216648501   710,853 9,942 SH   SOLE   9,942 0 0
CORCEPT THERAPEUTICS INC COM 218352102   1,522,227 37,763 SH   SOLE   37,763 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   296,140 20,242 SH   SOLE   20,242 0 0
CVS HEALTH CORP COM 126650100   3,879,214 54,013 SH   SOLE   54,013 0 0
CYPHERPUNK TECHNOLOGIES INC COM NEW 52187K200   16,797 21,139 SH   SOLE   21,139 0 0
DANAHER CORP DEL COM 235851102   6,124,838 32,304 SH   SOLE   32,304 0 0
DATADOG INC CL A COM 23804L103   201,511 1,707 SH   SOLE   1,707 0 0
DELCATH SYS INC COM NEW 24661P807   2,423,249 261,126 SH   SOLE   261,126 0 0
DELL TECHNOLOGIES INC CL C 24703L202   504,371 3,073 SH   SOLE   3,073 0 0
DYNEX CAP INC COM 26817Q886   1,040,948 81,579 SH   SOLE   81,579 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108   1,127,366 14,078 SH   SOLE   14,078 0 0
ELECTRONIC ARTS INC COM 285512109   254,430 1,248 SH   SOLE   1,248 0 0
ELI LILLY & CO COM 532457108   15,362,918 16,703 SH   SOLE   16,703 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   3,009,851 53,009 SH   SOLE   53,009 0 0
EXXON MOBIL CORP COM 30231G102   826,414 4,871 SH   SOLE   4,871 0 0
EYEPOINT INC COM NEW 30233G209   4,203,970 326,142 SH   SOLE   326,142 0 0
FLUOR CORP COM 343412102   254,289 5,451 SH   SOLE   5,451 0 0
FORTINET INC COM 34959E109   300,403 3,676 SH   SOLE   3,676 0 0
FULCRUM THERAPEUTICS INC COM 359616109   889,674 115,994 SH   SOLE   115,994 0 0
GE AEROSPACE COM NEW 369604301   473,045 1,667 SH   SOLE   1,667 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107   2,794,527 39,260 SH   SOLE   39,260 0 0
GE VERNOVA INC COM 36828A101   313,371 359 SH   SOLE   359 0 0
GILEAD SCIENCES INC COM 375558103   8,549,653 61,345 SH   SOLE   61,345 0 0
GUARDANT HEALTH INC COM 40131M109   1,923,236 20,821 SH   SOLE   20,821 0 0
HOME DEPOT INC COM 437076102   337,770 1,027 SH   SOLE   1,027 0 0
HONEYWELL INTL INC COM 438516106   232,133 1,027 SH   SOLE   1,027 0 0
IMMUNIC INC COM 4525EP101   487,215 438,932 SH   SOLE   438,932 0 0
INSMED INC COM PAR $.01 457669307   1,763,236 10,783 SH   SOLE   10,783 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101   1,161,048 4,790 SH   SOLE   4,790 0 0
INTUIT COM 461202103   612,250 1,416 SH   SOLE   1,416 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   4,963,479 10,767 SH   SOLE   10,767 0 0
INVENTIVA SA ADS 46124U107   1,264,973 227,923 SH   SOLE   227,923 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108   40,179 11,447 SH   SOLE   11,447 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101   29,946,000 775,000 SH Call SOLE   775,000 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101   26,894,000 700,000 SH   SOLE   700,000 0 0
ISHARES TR CORE S&P500 ETF 464287200   713,479,074 1,092,266 SH   SOLE   1,092,266 0 0
ISHARES TR CORE US AGGBD ET 464287226   407,013,552 4,100,066 SH   SOLE   4,100,066 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   9,779,556 51,730 SH   SOLE   51,730 0 0
JOHNSON & JOHNSON COM 478160104   8,096,097 33,121 SH   SOLE   33,121 0 0
KALARIS THERAPEUTICS INC COM 482929106   504,448 87,426 SH   SOLE   87,426 0 0
KYVERNA THERAPEUTICS INC COM 501976104   1,493,905 173,106 SH   SOLE   173,106 0 0
LAM RESEARCH CORP COM NEW 512807306   326,045 1,526 SH   SOLE   1,526 0 0
LEONABIO INC COM 04746L203   1,534,588 149,279 SH   SOLE   149,279 0 0
MASTERCARD INCORPORATED CL A 57636Q104   762,481 1,526 SH   SOLE   1,526 0 0
MERCK & CO INC COM 58933Y105   787,178 6,544 SH   SOLE   6,544 0 0
MFA FINL INC COM 55272X607   2,002,220 209,000 SH   SOLE   209,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   1,792,622 1,506,405 SH   SOLE   1,506,405 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   330,009 2,505 SH   SOLE   2,505 0 0
NOVO-NORDISK A S ADR 670100205   12,030,370 327,357 SH   SOLE   327,357 0 0
OCULAR THERAPEUTIX INC COM 67576A100   762,300 90,000 SH   SOLE   90,000 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102   1,772,676 66,667 SH   SOLE   66,667 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   932,395 219,387 SH   SOLE   219,387 0 0
OVID THERAPEUTICS INC COM 690469101   290,405 130,813 SH   SOLE   130,813 0 0
OXFORD LANE CAP CORP COM 691543847   978,000 100,000 SH   SOLE   100,000 0 0
PACIRA BIOSCIENCES INC COM 695127100   1,415,958 62,653 SH   SOLE   62,653 0 0
PALANTIR TECHNOLOGIES INC CL A 69608A108   1,712,061 11,704 SH   SOLE   11,704 0 0
PALISADE BIO INC COM 696389402   612,500 350,000 SH   SOLE   350,000 0 0
PALO ALTO NETWORKS INC COM 697435105   635,989 3,967 SH   SOLE   3,967 0 0
PEPSICO INC COM 713448108   202,653 1,305 SH   SOLE   1,305 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   2,915,108 262,386 SH   SOLE   262,386 0 0
PHILIP MORRIS INTL INC COM 718172109   235,940 1,427 SH   SOLE   1,427 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207   30,892,901 1,272,360 SH   SOLE   1,272,360 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103   9,190,338 1,770,778 SH   SOLE   1,770,778 0 0
QUALCOMM INC COM 747525103   717,820 5,574 SH   SOLE   5,574 0 0
REGENERON PHARMACEUTICALS COM 75886F107   8,421,776 10,900 SH   SOLE   10,900 0 0
RITHM CAPITAL CORP COM NEW 64828T201   3,190,902 336,593 SH   SOLE   336,593 0 0
ROCKWELL AUTOMATION INC COM 773903109   203,844 568 SH   SOLE   568 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202   717,091 187,230 SH   SOLE   187,230 0 0
SEAGATE TECHNOLOGY HLDNGS PL ORD SHS G7997R103   385,884 985 SH   SOLE   985 0 0
SERVICENOW INC COM 81762P102   566,766 5,421 SH   SOLE   5,421 0 0
SIMPLIFY EXCHANGE TRADED FUN ANCORATO TARGET 82889N343   2,832,500 125,000 SH   SOLE   125,000 0 0
SIMPLIFY EXCHANGE TRADED FUN TARGET 15 DISTRI 82889N350   14,711,005 624,406 SH   SOLE   624,406 0 0
SIMPLIFY EXCHANGE TRADED FUN MULTI QIS ALTERN 82889N533   45,792,310 3,777,620 SH   SOLE   3,777,620 0 0
SIMPLIFY EXCHANGE TRADED FUN TREASURY OPT INC 82889N640   39,958,500 1,700,000 SH   SOLE   1,700,000 0 0
SIMPLIFY EXCHANGE TRADED FUN SHORT TERM TREA 82889N657   116,655,570 5,528,700 SH   SOLE   5,528,700 0 0
SIMPLIFY EXCHANGE TRADED FUN NATL MUNI BD ETF 82889N442   37,530,496 1,553,376 SH   SOLE   1,553,376 0 0
SIMPLIFY EXCHANGE TRADED FUN PIPER SANDLER US 82889N327   2,612,596 91,464 SH   SOLE   91,464 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND E 82889N723   42,920,734 2,109,127 SH   SOLE   2,109,127 0 0
SIMPLIFY EXCHANGE TRADED FUN NEXT INTANGIBLE 82889N475   24,416,890 822,303 SH   SOLE   822,303 0 0
SIMPLIFY EXCHANGE TRADED FUN MANAGED FUTURES 82889N699   4,574,734 151,381 SH   SOLE   151,381 0 0
SIMPLIFY EXCHANGE TRADED FUN GOVERNMENT MONEY 82889N269   4,606,639,826 46,038,775 SH   SOLE   46,038,775 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQT PLS UPSID 82889N301   72,225,994 1,634,812 SH   SOLE   1,634,812 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQUITY PLUS M 82889N228   2,678,240 100,000 SH   SOLE   100,000 0 0
SNOWFLAKE INC COM SHS 833445109   260,617 1,728 SH   SOLE   1,728 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102   520,793 1,074 SH   SOLE   1,074 0 0
STRYKER CORPORATION COM 863667101   561,889 1,710 SH   SOLE   1,710 0 0
TESLA INC COM 88160R101   4,124,194 11,094 SH   SOLE   11,094 0 0
TG THERAPEUTICS INC COM 88322Q108   533,148 16,049 SH   SOLE   16,049 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   8,557,046 17,409 SH   SOLE   17,409 0 0
TREVI THERAPEUTICS INC COM 89532M101   780,365 65,412 SH   SOLE   65,412 0 0
UBER TECHNOLOGIES INC COM 90353T100   236,722 3,291 SH   SOLE   3,291 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   20,310,158 34,251 SH   SOLE   34,251 0 0
UNITEDHEALTH GROUP INC COM 91324P102   784,982 2,901 SH   SOLE   2,901 0 0
UPSTREAM BIO INC COM 91678A107   700,137 77,793 SH   SOLE   77,793 0 0
VANECK BITCOIN ETF SH BEN INT 92189K105   4,007,333 209,151 SH   SOLE   209,151 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   3,543,741 7,936 SH   SOLE   7,936 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   1,099,878 56,231 SH   SOLE   56,231 0 0
VOR BIOPHARMA INC COM NEW 929033207   954,618 53,510 SH   SOLE   53,510 0 0
WALMART INC COM 931142103   1,766,889 14,217 SH   SOLE   14,217 0 0
WARBY PARKER INC CL A COM 93403J106   6,127,809 290,831 SH   SOLE   290,831 0 0
WESTERN DIGITAL CORP COM 958102105   414,661 1,533 SH   SOLE   1,533 0 0
XCF GLOBAL INC COM CL A 98400U103   69,027 188,857 SH   SOLE   188,857 0 0
ZEVRA THERAPEUTICS INC COM NEW 488445206   937,872 100,630 SH   SOLE   100,630 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   299,742 3,315 SH   SOLE   3,315 0 0