The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100   410,935 4,243 SH   SOLE   4,243 0 0
ABBVIE INC COM 00287Y109   2,552,205 17,122 SH   SOLE   17,122 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   117,000 150,000 SH   SOLE   150,000 0 0
ADVANCED MICRO DEVICES INC COM 007903107   428,142 4,164 SH   SOLE   4,164 0 0
AGF INVTS TR US MARKET NETRL 00110G408   1,282,797 64,592 SH   SOLE   64,592 0 0
AGNC INVT CORP COM 00123Q104   623,040 66,000 SH   SOLE   66,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108   3,023,521 59,777 SH   SOLE   59,777 0 0
ALLOGENE THERAPEUTICS INC COM 019770106   776,650 245,000 SH   SOLE   245,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102   768,600 60,000 SH Put SOLE   60,000 0 0
AMGEN INC COM 031162100   3,638,742 13,539 SH   SOLE   13,539 0 0
ANNALY CAPITAL MANAGEMENT IN COM NEW 035710839   605,682 32,200 SH   SOLE   32,200 0 0
ANNEXON INC COM 03589W102   1,162,524 492,595 SH   SOLE   492,595 0 0
APPLIED THERAPEUTICS INC COM 03828A101   6,019,587 2,417,505 SH   SOLE   2,417,505 0 0
ARGENX SE SPONSORED ADR 04016X101   1,493,572 3,038 SH   SOLE   3,038 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210   212,506 361 SH   SOLE   361 0 0
ATAI LIFE SCIENCES NV SHS N0731H103   180,600 140,000 SH   SOLE   140,000 0 0
ATHIRA PHARMA INC COM 04746L104   3,015,440 1,492,792 SH   SOLE   1,492,792 0 0
ATRICURE INC COM 04963C209   504,532 11,519 SH   SOLE   11,519 0 0
AUTONATION INC COM 05329W102   1,514,000 10,000 SH Put SOLE   10,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   797,500 125,000 SH   SOLE   125,000 0 0
BECTON DICKINSON & CO COM 075887109   1,472,328 5,695 SH   SOLE   5,695 0 0
BIO-TECHNE CORP COM 09073M104   311,488 4,576 SH   SOLE   4,576 0 0
BOSTON SCIENTIFIC CORP COM 101137107   3,226,925 61,116 SH   SOLE   61,116 0 0
CAESARS ENTERTAINMENT INC NE COM 12769G100   695,250 15,000 SH Put SOLE   15,000 0 0
CARNIVAL CORP COMMON STOCK 143658300   445,900 32,500 SH Put SOLE   32,500 0 0
CARVANA CO CL A 146869102   621,304 14,800 SH Put SOLE   14,800 0 0
CENTRAL & EASTERN EUROPE FD COM 153436100   335,030 38,957 SH   SOLE   38,957 0 0
COOPER COS INC COM NEW 216648402   238,826 751 SH   SOLE   751 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   3,420,100 115,000 SH   SOLE   115,000 0 0
CYBIN INC COM 23256X100   265,700 500,000 SH   SOLE   500,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   2,147,471 175,018 SH   SOLE   175,018 0 0
DELTA AIR LINES INC DEL COM NEW 247361702   925,000 25,000 SH Put SOLE   25,000 0 0
DEXCOM INC COM 252131107   216,549 2,321 SH   SOLE   2,321 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105   823,500 2,700,000 SH   SOLE   2,700,000 0 0
ELI LILLY & CO COM 532457108   2,639,994 4,915 SH   SOLE   4,915 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   624,808 12,733 SH   SOLE   12,733 0 0
EXACT SCIENCES CORP COM 30063P105   657,300 9,635 SH   SOLE   9,635 0 0
FULCRUM THERAPEUTICS INC COM 359616109   2,533,104 570,519 SH   SOLE   570,519 0 0
GENERAC HLDGS INC COM 368736104   762,720 7,000 SH Call SOLE   7,000 0 0
GILEAD SCIENCES INC COM 375558103   1,346,972 17,974 SH   SOLE   17,974 0 0
HERON THERAPEUTICS INC COM 427746102   444,538 431,590 SH   SOLE   431,590 0 0
HUMANA INC COM 444859102   873,303 1,795 SH   SOLE   1,795 0 0
IDEXX LABS INC COM 45168D104   616,988 1,411 SH   SOLE   1,411 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   2,169,084 7,421 SH   SOLE   7,421 0 0
IQVIA HLDGS INC COM 46266C105   385,630 1,960 SH   SOLE   1,960 0 0
ISHARES GOLD TR ISHARES NEW 464285204   1,897,438 54,228 SH   SOLE   54,228 0 0
ISHARES INC CORE MSCI EMKT 46434G103   3,867,116 81,259 SH   SOLE   81,259 0 0
ISHARES TR BLACKROCK ULTRA 46434V878   2,107,547 41,833 SH   SOLE   41,833 0 0
ISHARES TR 20 YR TR BD ETF 464287432   4,425,631 49,900 SH   SOLE   49,900 0 0
ISHARES TR MSCI EMG MKT ETF 464287234   14,701,830 387,400 SH Put SOLE   387,400 0 0
ISHARES TR IBOXX HI YD ETF 464288513   1,105,800 15,000 SH Call SOLE   15,000 0 0
ISHARES TR 20 YR TR BD ETF 464287432   4,425,631 49,900 SH Call SOLE   49,900 0 0
ISHARES TR 0-5YR INVT GR CP 46434V100   2,091,190 43,571 SH   SOLE   43,571 0 0
ISHARES TR IBONDS DEC24 ETF 46434VBG4   2,112,981 85,442 PRN   SOLE   85,442 0 0
ISHARES TR RUSSELL 2000 ETF 464287655   23,347,354 132,100 SH Put SOLE   132,100 0 0
ISHARES TR IBOXX HI YD ETF 464288513   4,933,564 66,923 SH   SOLE   66,923 0 0
ISHARES TR IBOXX INV CP ETF 464287242   38,825,853 380,571 SH   SOLE   380,571 0 0
ISHARES TR CORE S&P500 ETF 464287200   278,397,322 648,295 SH   SOLE   648,295 0 0
ISHARES TR CORE MSCI EAFE 46432F842   15,337,050 238,338 SH   SOLE   238,338 0 0
ISHARES TR IBONDS DEC23 ETF 46434VAX8   2,109,622 83,187 PRN   SOLE   83,187 0 0
ISHARES TR MBS ETF 464288588   6,868,414 77,347 SH   SOLE   77,347 0 0
ISHARES TR CORE US AGGBD ET 464287226   6,479,356 68,900 SH   SOLE   68,900 0 0
ISHARES TR MSCI EAFE ETF 464287465   81,973,448 1,189,400 SH Put SOLE   1,189,400 0 0
JOHNSON & JOHNSON COM 478160104   2,517,699 16,165 SH   SOLE   16,165 0 0
KAYNE ANDERSON ENERGY INFRST COM 486606106   1,236,548 147,033 SH   SOLE   147,033 0 0
KURA ONCOLOGY INC COM 50127T109   729,600 80,000 SH   SOLE   80,000 0 0
KYMERA THERAPEUTICS INC COM 501575104   424,158 30,515 SH   SOLE   30,515 0 0
LEMONADE INC COM 52567D107   191,474 16,478 SH   SOLE   16,478 0 0
LIVANOVA PLC SHS G5509L101   227,437 4,301 SH   SOLE   4,301 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   2,087,496 14,294 SH   SOLE   14,294 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200   1,207,500 150,000 SH   SOLE   150,000 0 0
MEDTRONIC PLC SHS G5960L103   2,308,956 29,466 SH   SOLE   29,466 0 0
MERCK & CO INC COM 58933Y105   1,934,122 18,787 SH   SOLE   18,787 0 0
MICROSOFT CORP COM 594918104   315,750 1,000 SH   SOLE   1,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   2,212,000 70,000 SH   SOLE   70,000 0 0
NVIDIA CORPORATION COM 67066G104   13,354,193 30,700 SH Put SOLE   30,700 0 0
NVIDIA CORPORATION COM 67066G104   426,290 980 SH   SOLE   980 0 0
OAKTREE SPECIALTY LENDING CO COM 67401P405   3,775,619 187,655 SH   SOLE   187,655 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   2,467,386 237,935 SH   SOLE   237,935 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304   4,309,100 82,000 SH   SOLE   82,000 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207   22,122,443 1,372,360 SH   SOLE   1,372,360 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103   1,592,931 283,945 SH   SOLE   283,945 0 0
QUANTERIX CORP COM 74766Q101   643,707 23,718 SH   SOLE   23,718 0 0
QUIDELORTHO CORP COM 219798105   282,957 3,874 SH   SOLE   3,874 0 0
REGENERON PHARMACEUTICALS COM 75886F107   3,540,374 4,302 SH   SOLE   4,302 0 0
REPLIMUNE GROUP INC COM 76029N106   2,566,500 150,000 SH   SOLE   150,000 0 0
REVVITY INC COM 714046109   265,126 2,395 SH   SOLE   2,395 0 0
SAGE THERAPEUTICS INC COM 78667J108   2,470,217 120,030 SH   SOLE   120,030 0 0
SANOFI SPONSORED ADR 80105N105   3,183,963 59,358 SH   SOLE   59,358 0 0
SARATOGA INVT CORP COM NEW 80349A208   1,246,450 48,500 SH   SOLE   48,500 0 0
SERES THERAPEUTICS INC COM 81750R102   1,310,490 550,626 SH   SOLE   550,626 0 0
SIMPLIFY EXCHANGE TRADED FUN HIGH YIELD PLUS 82889N830   5,905,656 273,410 SH   SOLE   273,410 0 0
SIMPLIFY EXCHANGE TRADED FUN MANAGED FUTURES 82889N699   5,140,114 186,574 SH   SOLE   186,574 0 0
SIMPLIFY EXCHANGE TRADED FUN SHORT TERM TREA 82889N657   9,941,109 455,179 SH   SOLE   455,179 0 0
SIMPLIFY EXCHANGE TRADED FUN INTMD TERM TRSRY 82889N798   1,742,744 137,116 SH   SOLE   137,116 0 0
SIMPLIFY EXCHANGE TRADED FUN SIMPLIFY INTERST 82889N855   4,035,298 42,250 SH   SOLE   42,250 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND E 82889N723   58,377,096 2,736,854 SH   SOLE   2,736,854 0 0
SIMPLIFY EXCHANGE TRADED FUN COMMODITIES STRA 82889N566   2,242,223 88,056 SH   SOLE   88,056 0 0
SIMPLIFY EXCHANGE TRADED FUN MARKET NEUTRAL 82889N541   1,663,659 67,056 SH   SOLE   67,056 0 0
SIMPLIFY EXCHANGE TRADED FUN ENHANCED INM ETF 82889N632   409,798 16,471 SH   SOLE   16,471 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   112,982,964 264,300 SH Put SOLE   264,300 0 0
SPDR SER TR BLOOMBERG INVT 78468R200   284,682 9,267 SH   SOLE   9,267 0 0
SPDR SER TR PORTFOLIO SHORT 78464A474   2,092,862 71,380 SH   SOLE   71,380 0 0
STOKE THERAPEUTICS INC COM 86150R107   405,761 102,985 SH   SOLE   102,985 0 0
STRYKER CORPORATION COM 863667101   1,211,679 4,434 SH   SOLE   4,434 0 0
SUTRO BIOPHARMA INC COM 869367102   416,400 120,000 SH   SOLE   120,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   183,896 12,665 SH   SOLE   12,665 0 0
TELESAT CORP CL A & CL B SHS 879512309   3,729,168 260,781 SH   SOLE   260,781 0 0
TESLA INC COM 88160R101   474,918 1,898 SH   SOLE   1,898 0 0
TESLA INC COM 88160R101   9,608,448 38,400 SH Call SOLE   38,400 0 0
THE CIGNA GROUP COM 125523100   2,605,239 9,107 SH   SOLE   9,107 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   868,082 1,715 SH   SOLE   1,715 0 0
TSCAN THERAPEUTICS INC COM 89854M101   2,680,105 1,046,916 SH   SOLE   1,046,916 0 0
UNITEDHEALTH GROUP INC COM 91324P102   2,412,549 4,785 SH   SOLE   4,785 0 0
VANGUARD BD INDEX FDS SHORT TRM BOND 921937827   2,078,349 27,712 SH   SOLE   27,712 0 0
VANGUARD SCOTTSDALE FDS MTG-BKD SECS ETF 92206C771   4,848,848 111,100 SH   SOLE   111,100 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   2,581,970 7,425 SH   SOLE   7,425 0 0
WESTERN ASSET EMERGING MKTS COM 95766A101   1,373,650 165,500 SH   SOLE   165,500 0 0
WESTERN DIGITAL CORP. COM 958102105   752,895 16,500 SH Put SOLE   16,500 0 0
X4 PHARMACEUTICALS INC COM 98420X103   436,000 400,000 SH   SOLE   400,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   1,703,387 15,179 SH   SOLE   15,179 0 0
ZOETIS INC CL A 98978V103   248,269 1,427 SH   SOLE   1,427 0 0