X0306 4 2021-03-01 0 0001720893 BioXcel Therapeutics, Inc. BTAI 0001845487 Bray June C/O BIOXCEL THERAPEUTICS, INC. 555 LONG WHARF DRIVE NEW HAVEN CT 06511 1 0 0 0 Stock Option (Right to Buy) 55.71 2021-03-01 4 A 0 4167 0 A 2021-03-01 Common Stock 4167 4167 D The option vests and becomes exercisable on the earlier of the earlier of the first anniversary of March 1, 2021 or the day immediately prior to the start of the next BioXcel Therapeutics, Inc. annual meeting of stockholders, subject to the Reporting Person's continued service through the vesting date. /s/ Richard Steinhart, as Attorney-in-Fact for June Bray 2021-03-03