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Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Cash flows from operating activities:      
Net Income (Loss) $ (95,496) $ (188,917) $ (142,181)
Adjustments to reconcile net loss to net cash used in operating activities:      
Acquired in-process research and development assets 55,000 3,000 0
Share-based compensation expense 48,263 39,341 27,242
Depreciation expense 92 36 63
Accretion of discounts on short-term investments, net (6,389) (10,078) (2,030)
Amortization of intangible assets 1,470 0 0
Amortization of operating right-of-use asset 467 347 468
Gain from sale of priority review voucher (108,000) 0 0
Changes in operating assets and liabilities:      
Accounts receivable, net (13,876) 0 0
Inventory (3,243) 0 0
Prepaid expenses and other current assets (4,556) (3,322) (546)
Deposits and other long-term assets 93 255 (300)
Accounts payable 686 2,316 (1,484)
Accrued expenses and other current liabilities 42,101 10,574 9,241
Deferred revenue 4,787 0 0
Operating lease liability (273) (405) (347)
Other long-term liability 761 0 0
Net cash used in operating activities (78,113) (146,853) (109,874)
Cash flows from investing activities:      
Cash paid for purchase of short-term investments (658,616) (443,838) (394,206)
Proceeds from maturity of short-term investment 314,482 575,440 139,158
Proceeds from sale of short-term investments 79,409 0 0
Cash paid for acquired intangible assets (17,100) 0 0
Proceeds from sale of priority review voucher 108,000 0 0
Cash paid for acquired in-process research and development assets (55,000) (3,000) 0
Cash paid for purchase of property and equipment (2,169) (224) (26)
Net cash (used in) provided by investing activities (230,994) 128,378 (255,074)
Cash flows from financing activities:      
Proceeds from issuance of common stock in connection with private placement, net of placement agent fees and offering costs 178,177 0 0
Proceeds from issuance of prefunded warrants to purchase common stock in connection with private placement, net of issuance costs 20,941 0 0
Proceeds from issuance of common stock, net 0 161,409 161,610
Proceeds from issuance of common stock upon stock option exercises 2,267 1,338 3,649
Proceeds from issuance of common stock upon Employee Stock Purchase Plan purchase 1,906 1,250 642
Cash provided by financing activities 203,291 163,997 165,901
Net (decrease) increase in cash and cash equivalents (105,816) 145,522 (199,047)
Cash and cash equivalents, beginning of period 230,784 85,262 284,309
Cash and cash equivalents, end of period 124,968 230,784 85,262
Supplemental disclosure of cash flow information:      
Income taxes paid 1,898 0 0
Supplemental disclosures of noncash activities:      
Cash not yet paid for license agreement milestone payment 20,000    
Right-of-use asset obtained in exchange for new operating lease liabilities $ 2,554 $ 0 $ 940