Commitments and Contingencies - Additional Information (Detail)	1 Months Ended	12 Months Ended
	Apr. 30, 2022 USD ($) ft²	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Lessee Lease Description [Line Items]
Weighted-average remaining lease term		1 year 10 months 24 days
Weighted-average discount rate		9.00%
Amortization of operating right-of-use assets		$ 468,000	$ 179,000	$ 139,000
Research And Development Agreements
Lessee Lease Description [Line Items]
Termination and cancellation charges payable		0	0
Viracta License Agreement [Member]
Lessee Lease Description [Line Items]
Royalty fee payable		0	0
Indemnification Agreement
Lessee Lease Description [Line Items]
Termination and cancellation charges payable		0	0
Central America
Lessee Lease Description [Line Items]
Operating lease term	31 months
Area of land | ft²	12,000
Security deposit	$ 40,000
Operating lease payments	$ 1,100,000
Lease For Corporate Office Facility | Central America
Lessee Lease Description [Line Items]
Tenant improvement allowances receivable		$ 10,000
Lessee operating lease renewal lease term		3 years
Amortization of operating right-of-use assets		$ 500,000	200,000	100,000
Operating lease payments		$ 400,000	$ 200,000	$ 200,000