X0306 4 2022-02-12 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001845310 Schott Robert J. C/O SANGAMO THERAPEUTICS, INC. 7000 MARINA BLVD. BRISBANE CA 94005 0 1 0 0 SVP, Head of Development Common Stock 2022-02-12 4 F 0 5463 5.76 D 34537 D Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on February 12, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding, using the Issuer's closing stock price on February 11, 2022 of $5.76/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). Includes 7,869 shares resulting from the February 12, 2022 vesting of the Reporting Person's February 12, 2021 RSU grant and 26,668 shares subject to such RSU grant that will vest in two remaining annual installments of 13,332 shares and 13,336 shares on February 12, 2023 and 2024, respectively. The vesting of all such RSUs is subject to the Reporting Person's continuous service as defined in the Issuer's 2018 EIP through such dates and subject to acceleration as defined in the 2018 EIP. Robert J. Schott, by /s/ Ron A. Metzger, Attorney-in-Fact 2022-02-24