X0306 4 2021-02-12 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001845310 Schott Robert J. 7000 MARINA BLVD BRISBANE CA 94005 0 1 0 0 SVP, Head of Development Common Stock 2021-02-12 4 A 0 40000 0.00 A 40000 D Stock Option (Right to Buy) 13.68 2021-02-12 4 A 0 80000 0.00 A 2031-02-11 Common Stock 80000 80000 D Includes 40,000 shares of common stock issuable upon settlement of restricted stock units ("RSUs") granted to the Reporting Person on February 12, 2021. The RSUs will vest with respect to 1/3rd of the shares in three equal annual installments over the three-year period measured from the date of grant, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP, as amended")), through such dates and subject to acceleration as defined in the 2018 EIP, as amended. One-quarter (1/4) of the option shares vest and become exercisable upon completion of one (1) year of Continuous Service, as defined in the 2018 EIP, as amended, by the Reporting Person measured from the February 12, 2021 grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, subject to the Reporting Person's Continuous Service as defined in the 2018 EIP, as amended, through each such vesting date, and subject to acceleration as provided in the 2018 EIP, as amended. Remarks: /s/ Matthew Colvin, Attorney-in-Fact for Robert J. Schott 2021-02-16