X0306 4 2022-01-04 0 0001098972 AGENUS INC AGEN 0001845281 O'Day Steven J C/O AGENUS INC. 3 FORBES ROAD LEXINGTON MA 02421 0 1 0 0 Chief Medical Officer Common Stock 2022-01-04 4 M 0 100000 A 100000 D Common Stock 2022-01-06 4 S 0 38679 3.0597 D 61321 D Restricted Stock Units 2022-01-04 4 M 0 100000 0.00 D Common Stock 100000 0 D Restricted stock units convert into common stock on a one-for-one basis. Represents sales of shares, as a consequence of the vesting of restricted stock units, to cover Federal, state and local tax withholding requirements related to the vesting. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $3.055 to $3.065. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. On January 4, 2021, the reporting person was granted 100,000 restricted stock units that fully vested on January 4, 2022. /s/ Steven J. O'Day 2022-01-06