X0101 EFFECT 33 LIVE 2021-05-28 13:00:00

N-1A

0001843263 Tactical Investment Series Trust 333-252544 S000071477 TFA Multi-Strategy Growth Fund C000226693 TFA Multi-Strategy Growth Fund Class I S000071477 TFA Multi-Strategy Growth Fund C000226694 TFA Multi-Strategy Growth Fund Class A S000071478 TFA Multidimensional Tactical Fund C000226695 TFA Multidimensional Tactical Fund Class A S000071478 TFA Multidimensional Tactical Fund C000226696 TFA Multidimensional Tactical Fund Class I S000071479 TFA Quantitative Fund C000226697 TFA Quantitative Fund Class I S000071479 TFA Quantitative Fund C000226698 TFA Quantitative Fund Class A S000071480 Tactical Conservative Allocation Fund C000226699 Tactical Conservative Allocation Fund Class I S000071480 Tactical Conservative Allocation Fund C000226700 Tactical Conservative Allocation Fund Class A S000071481 Tactical Growth Allocation Fund C000226701 Tactical Growth Allocation Fund Class I S000071481 Tactical Growth Allocation Fund C000226702 Tactical Growth Allocation Fund Class A S000071482 Tactical Moderate Allocation Fund C000226703 Tactical Moderate Allocation Fund Class A S000071482 Tactical Moderate Allocation Fund C000226704 Tactical Moderate Allocation Fund Class I