X0101 24F-2NT LIVE 0001843263 XXXXXXXX false false N-1A Tactical Investment Series Trust 11726 Seven Gables Road Cincinnati OH X1 45249 TFA AlphaGen Growth Fund S000071477 TFA AlphaGen Growth Fund Class I C000226693 TFA Multidimensional Tactical Fund S000071478 TFA Multidimensional Tactical Fund Class I C000226696 TFA Quantitative Fund S000071479 TFA Quantitative Fund Class I C000226697 TFA Tactical Income Fund S000071480 TFA Tactical Income Fund Class I C000226699 TFA Tactical Income Fund Class A C000226700 Tactical Growth Allocation Fund S000071481 Tactical Growth Allocation Fund Class I C000226701 Tactical Growth Allocation Fund Class A C000226702 Tactical Moderate Allocation Fund S000071482 Tactical Moderate Allocation Fund Class A C000226703 Tactical Moderate Allocation Fund Class I C000226704 811-23631 333-252544 12/31/2021 246705753.00 211289388.00 0.00 211289388.00 35416365.00 0.00 0.0000927 3283.10 0.00 0.00 0.00 3283.10 /s/ Brian A. Curley Brian A. Curley, Treasurer, Tactical Investment Series Trust 03/23/2022