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Share-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Assumptions Used to Determine Fair Value of Share-Based Awards
The weighted average assumptions used in the Black-Scholes option pricing model to determine the fair value of stock option awards granted to employees during 2021 and 2020 were as follows:
20212020
Expected stock price volatility97.06%97.86%
Risk free interest rate1.07%0.51%
Expected term (in years)5.785.44
Expected dividend yield——
Schedule of Share-Based Award Activity
The following table summarizes the stock option activity for the periods presented:
Number of
Shares
Weighted
Average
Exercise Price Per
Share
Weighted
Average
Remaining
Contractual Term
(years)
Outstanding at January 1, 202010,414 $20.67 8.2
   Granted
14,416 $15.79 
Outstanding at December 31, 202024,830 $17.84 8.4
   Granted
481,861 $5.05 
Outstanding at December 31, 2021506,691 $5.68 9.3
Vested and exercisable at December 31, 2021130,059 $7.30 9.0
Vested and expected to vest at December 31, 2021506,691 $5.68 9.3
Schedule of RSU Share-Based Payment Award Activity
The following table summarizes activity related to RSU share-based payment awards:
Number of
RSUs
Weighted
Average Grant
Date Fair value
Unvested balance at January 1, 2020— 
    Granted177 $    13.55
    Vested(132)$    13.55
Unvested balance at December 31, 202045 $    13.55
   Granted50,096 $1.74 
   Vested(20,915)$1.77 
   Cancelled(29,226)$1.74 
Unvested balance at December 31, 2021—