SCHEDULE 13G/A 0001493152-24-001397 0001595855 XXXXXXXX LIVE 1 Common Stock, par value $0.001 per share 12/31/2024 0001842952 Context Therapeutics Inc. 21077P108 James Silverman, One Boston Place, 26th Floor, Boston, MA 02108 Rule 13d-1(c) Opaleye Management Inc. MA 0.00 0.00 0.00 0.00 0.00 N 0.00 CO Context Therapeutics Inc. 2001 Market Street, Suite 3915, Unit #15 Philadelphia, Pennsylvania 19103 This statement is filed by the entities and persons listed below, who are collectively referred to herein as "Reporting Persons" with respect to the shares of common stock of the Company: This Statement on Schedule 13G (this "Statement") is filed by Opaleye, LP ("Opaleye"); Opaleye GP LLC, the general partner of Opaleye, L.P. ("Opaleye GP"); and James Silverman, the manager of Opaleye GP LLC. One Boston Place, 26th Floor, Boston, MA 02108 Opaleye, L.P. is a Delaware limited partnership. Opaleye GP LLC is a Delaware limited liability company. Mr. Silverman is a United States citizen. Y 0 0.00% 0 0 0 0 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Opaleye Management Inc. /s/ James Silverman 02/13/2025