The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Agilent Technologies Inc Common Stock 00846U101 BBG000C2V3D6 213,411 1,535 SH   SOLE   1,535 0 0
Apple Inc Common Stock 037833100 BBG000B9XRY4 34,604,187 179,734 SH   SOLE   179,734 0 0
AbbVie Inc Common Stock 00287Y109 BBG0025Y4RY4 1,079,986 6,969 SH   SOLE   6,969 0 0
Airbnb Inc Common Stock 009066101 BBG001Y2XS07 592,754 4,354 SH   SOLE   4,354 0 0
Abbott Laboratories Common Stock 002824100 BBG000B9ZXB4 453,378 4,119 SH   SOLE   4,119 0 0
ACADIA Pharmaceuticals Inc Common Stock 004225108 BBG000BHG9K0 716,780 22,893 SH   SOLE   22,893 0 0
Arcellx Inc Common Stock 03940C100 BBG00QHJM4S9 333,666 6,012 SH   SOLE   6,012 0 0
Accenture PLC Common Stock G1151C101 BBG000D9D830 1,886,843 5,377 SH   SOLE   5,377 0 0
Adobe Inc Common Stock 00724F101 BBG000BB5006 4,913,597 8,236 SH   DFND   8,236 0 0
Analog Devices Inc Common Stock 032654105 BBG000BB6G37 1,677,038 8,446 SH   SOLE   8,446 0 0
ADMA Biologics Inc Common Stock 000899104 BBG002NCK5M5 131,351 29,060 SH   SOLE   29,060 0 0
Automatic Data Processing Inc Common Stock 053015103 BBG000JG0547 954,245 4,096 SH   SOLE   4,096 0 0
Autodesk Inc Common Stock 052769106 BBG000BM7HL0 887,241 3,644 SH   SOLE   3,644 0 0
American Electric Power Co Inc Common Stock 025537101 BBG000BB9KF2 424,456 5,226 SH   SOLE   5,226 0 0
Akero Therapeutics Inc Common Stock 00973Y108 BBG00L9211Y8 564,416 24,172 SH   SOLE   24,172 0 0
Alector Inc Common Stock 014442107 BBG00N0PL198 81,332 10,192 SH   SOLE   10,192 0 0
Align Technology Inc Common Stock 016255101 BBG000BRNLL2 209,336 764 SH   SOLE   764 0 0
Alkermes PLC Common Stock G01767105 BBG000C9F2F9 515,215 18,573 SH   SOLE   18,573 0 0
Alnylam Pharmaceuticals Inc Common Stock 02043Q107 BBG000BFGNJ5 639,309 3,340 SH   SOLE   3,340 0 0
Applied Materials Inc Common Stock 038222105 BBG000BBPFB9 2,302,528 14,207 SH   SOLE   14,207 0 0
Advanced Micro Devices Inc Common Stock 007903107 BBG000BBQCY0 45,556,913 309,049 SH   DFND   309,049 0 0
Amgen Inc Common Stock 031162100 BBG000BBS2Y0 2,203,641 7,651 SH   SOLE   7,651 0 0
Amazon.com Inc Common Stock 023135106 BBG000BVPV84 7,489,122 49,290 SH   DFND   49,290 0 0
Arista Networks Inc Common Stock 040413106 BBG000N2HDY5 501,872 2,131 SH   SOLE   2,131 0 0
ANSYS Inc Common Stock 03662Q105 BBG000GXZ4W7 540,328 1,489 SH   SOLE   1,489 0 0
Amphenol Corp Common Stock 032095101 BBG000B9YJ35 500,607 5,050 SH   SOLE   5,050 0 0
Apellis Pharmaceuticals Inc Common Stock 03753U106 BBG007KGRPY4 458,348 7,657 SH   SOLE   7,657 0 0
Ardelyx Inc Common Stock 039697107 BBG001WH4DQ3 456,227 73,585 SH   SOLE   73,585 0 0
Arrowhead Pharmaceuticals Inc Common Stock 04280A100 BBG000BRVKH0 597,649 19,531 SH   SOLE   19,531 0 0
ASML Holding NV NY Reg Shrs N07059210 BBG000K6MRN4 27,108,333 35,814 SH   DFND   35,814 0 0
Autohome Inc ADR 05278C107 BBG005JYTDQ5 12,223,357 435,615 SH   DFND   435,615 0 0
Broadcom Inc Common Stock 11135F101 BBG00KHY5S69 9,428,964 8,447 SH   SOLE   8,447 0 0
Anavex Life Sciences Corp Common Stock 032797300 BBG000C9K8K4 115,332 12,388 SH   SOLE   12,388 0 0
AstraZeneca PLC ADR 046353108 BBG000BZ0DK8 337,558 5,012 SH   SOLE   5,012 0 0
Boeing Co/The Common Stock 097023105 BBG000BCSST7 200,187 768 SH   SOLE   768 0 0
Alibaba Group Holding Ltd ADR 01609W102 BBG006G2JVL2 347,865 4,488 SH   SOLE   4,488 0 0
Bank of America Corp Common Stock 060505104 BBG000BCTLF6 367,407 10,912 SH   SOLE   10,912 0 0
Bridgebio Pharma Inc Common Stock 10806X102 BBG00P9KDZK6 596,225 14,769 SH   SOLE   14,769 0 0
BioCryst Pharmaceuticals Inc Common Stock 09058V103 BBG000BLYWX6 307,389 51,317 SH   SOLE   51,317 0 0
Becton Dickinson & Co Common Stock 075887109 BBG000BCZYD3 247,244 1,014 SH   SOLE   1,014 0 0
Beam Therapeutics Inc Common Stock 07373V105 BBG00KXC8646 494,696 18,174 SH   SOLE   18,174 0 0
KE Holdings Inc ADR 482497104 BBG00W9L9LX1 81,760,160 5,043,810 SH   DFND   5,043,810 0 0
Biohaven Ltd Common Stock G1110E107 BBG017BXV3Q9 621,798 14,528 SH   SOLE   14,528 0 0
Baidu Inc ADR 056752108 BBG000QXWHD1 545,194 4,578 SH   SOLE   4,578 0 0
Biogen Inc Common Stock 09062X103 BBG000C17X76 1,049,312 4,055 SH   SOLE   4,055 0 0
Booking Holdings Inc Common Stock 09857L108 BBG000BLBVN4 1,234,433 348 SH   SOLE   348 0 0
Baker Hughes Co Common Stock 05722G100 BBG00GBVBK51 342,449 10,019 SH   SOLE   10,019 0 0
Bluebird Bio Inc Common Stock 09609G100 BBG000QGWY50 96,675 70,054 SH   SOLE   70,054 0 0
BioMarin Pharmaceutical Inc Common Stock 09061G101 BBG000CZWZ05 498,299 5,168 SH   SOLE   5,168 0 0
Bristol-Myers Squibb Co Common Stock 110122108 BBG000DQLV23 288,311 5,619 SH   SOLE   5,619 0 0
Blueprint Medicines Corp Common Stock 09627Y109 BBG001MC8YF7 598,914 6,493 SH   SOLE   6,493 0 0
Berkshire Hathaway Inc Common Stock 084670702 BBG000DWG505 982,242 2,754 SH   SOLE   2,754 0 0
Boston Scientific Corp Common Stock 101137107 BBG000C0LW92 266,331 4,607 SH   SOLE   4,607 0 0
Kanzhun Ltd ADR 48553T106 BBG01163M5L4 40,241,346 2,422,718 SH   DFND   2,422,718 0 0
Cabaletta Bio Inc Common Stock 12674W109 BBG00MJ3BKW2 255,125 11,239 SH   SOLE   11,239 0 0
Camtek Ltd/Israel Common Stock M20791105 BBG000BJ4M84 598,541 8,627 SH   SOLE   8,627 0 0
Caterpillar Inc Common Stock 149123101 BBG000BF0K17 204,012 690 SH   SOLE   690 0 0
Coca-Cola Europacific Partners Common Stock G25839104 BBG00B6BFWH9 262,422 3,932 SH   SOLE   3,932 0 0
Carnival Corp Common Stock 143658300 BBG000BF6LY3 501,285 27,038 SH   SOLE   27,038 0 0
Avid Bioservices Inc Common Stock 05368M106 BBG000JDWKY3 132,268 20,349 SH   SOLE   20,349 0 0
CareDx Inc Common Stock 14167L103 BBG006JS5785 121,980 10,165 SH   SOLE   10,165 0 0
Cadence Design Systems Inc Common Stock 127387108 BBG000C13CD9 1,258,894 4,622 SH   SOLE   4,622 0 0
CDW Corp/DE Common Stock 12514G108 BBG001P63B80 514,198 2,262 SH   SOLE   2,262 0 0
Constellation Energy Corp Common Stock 21037T109 BBG014KFRNP7 372,762 3,189 SH   SOLE   3,189 0 0
Cerevel Therapeutics Holdings Common Stock 15678U128 BBG00VCYVLH4 322,198 7,599 SH   SOLE   7,599 0 0
Charter Communications Inc Common Stock 16119P108 BBG000VPGNR2 547,650 1,409 SH   SOLE   1,409 0 0
Cigna Group/The Common Stock 125523100 BBG00KXRCDP0 285,376 953 SH   SOLE   953 0 0
Celldex Therapeutics Inc Common Stock 15117B202 BBG000FW8LZ9 315,257 7,949 SH   SOLE   7,949 0 0
Comcast Corp Common Stock 20030N101 BBG000BFT2L4 1,794,079 40,914 SH   SOLE   40,914 0 0
Centene Corp Common Stock 15135B101 BBG000BDXCJ5 200,367 2,700 SH   SOLE   2,700 0 0
Cogent Biosciences Inc Common Stock 19240Q201 BBG007DHZQR7 90,617 15,411 SH   SOLE   15,411 0 0
ConocoPhillips Common Stock 20825C104 BBG000BQQH30 217,631 1,875 SH   SOLE   1,875 0 0
Costco Wholesale Corp Common Stock 22160K105 BBG000F6H8W8 2,976,301 4,509 SH   SOLE   4,509 0 0
Copart Inc Common Stock 217204106 BBG000BM9RH1 465,206 9,494 SH   SOLE   9,494 0 0
Catalyst Pharmaceuticals Inc Common Stock 14888U101 BBG000GZDC67 317,928 18,913 SH   SOLE   18,913 0 0
Caribou Biosciences Inc Common Stock 142038108 BBG008G28LJ5 116,611 20,351 SH   SOLE   20,351 0 0
Salesforce Inc Common Stock 79466L302 BBG000BN2DC2 2,193,535 8,336 SH   SOLE   8,336 0 0
Crinetics Pharmaceuticals Inc Common Stock 22663K107 BBG00BC59224 464,995 13,069 SH   SOLE   13,069 0 0
CRISPR Therapeutics AG Common Stock H17182108 BBG00DBBGRX1 592,196 9,460 SH   SOLE   9,460 0 0
Crowdstrike Holdings Inc Common Stock 22788C105 BBG00BLYKS03 500,172 1,959 SH   SOLE   1,959 0 0
Cisco Systems Inc Common Stock 17275R102 BBG000C3J3C9 3,519,779 69,671 SH   SOLE   69,671 0 0
CoStar Group Inc Common Stock 22160N109 BBG000D7JKW9 355,415 4,067 SH   SOLE   4,067 0 0
CSX Corp Common Stock 126408103 BBG000BGJRC8 682,132 19,675 SH   SOLE   19,675 0 0
Cintas Corp Common Stock 172908105 BBG000H3YXF8 602,660 1,000 SH   SOLE   1,000 0 0
Cognizant Technology Solutions Common Stock 192446102 BBG000BBDV81 643,213 8,516 SH   SOLE   8,516 0 0
CVS Health Corp Common Stock 126650100 BBG000BGRY34 288,836 3,658 SH   SOLE   3,658 0 0
Chevron Corp Common Stock 166764100 BBG000K4ND22 414,963 2,782 SH   SOLE   2,782 0 0
Cytokinetics Inc Common Stock 23282W605 BBG000F0R4N9 1,175,957 14,085 SH   SOLE   14,085 0 0
DoorDash Inc Common Stock 25809K105 BBG005D7QCJ3 315,558 3,191 SH   SOLE   3,191 0 0
Day One Biopharmaceuticals Inc Common Stock 23954D109 BBG00V1KSN04 184,223 12,618 SH   SOLE   12,618 0 0
Datadog Inc Common Stock 23804L103 BBG003NJHZT9 680,820 5,609 SH   SOLE   5,609 0 0
Deckers Outdoor Corp Common Stock 243537107 BBG000BKXYX5 1,717,196 2,569 SH   DFND   2,569 0 0
Danaher Corp Common Stock 235851102 BBG000BH3JF8 1,390,354 6,010 SH   DFND   6,010 0 0
Walt Disney Co/The Common Stock 254687106 BBG000BH4R78 260,577 2,886 SH   SOLE   2,886 0 0
Dollar Tree Inc Common Stock 256746108 BBG000BSC0K9 306,544 2,158 SH   SOLE   2,158 0 0
Denali Therapeutics Inc Common Stock 24823R105 BBG008P7F869 371,043 17,290 SH   SOLE   17,290 0 0
Daqo New Energy Corp ADR 23703Q203 BBG000Q5T9W3 1,349,551 50,735 SH   SOLE   50,735 0 0
Dynavax Technologies Corp Common Stock 268158201 BBG000BFX694 405,644 29,016 SH   SOLE   29,016 0 0
Dexcom Inc Common Stock 252131107 BBG000QTF8K1 631,990 5,093 SH   SOLE   5,093 0 0
Electronic Arts Inc Common Stock 285512109 BBG000BP0KQ8 362,136 2,647 SH   SOLE   2,647 0 0
Editas Medicine Inc Common Stock 28106W103 BBG005MX5GZ2 193,827 19,134 SH   SOLE   19,134 0 0
New Oriental Education & Techn ADR 647581206 BBG000PTRRM5 1,113,929 15,201 SH   DFND   15,201 0 0
Estee Lauder Cos Inc/The Common Stock 518439104 BBG000FKJRC5 997,718 6,822 SH   SOLE   6,822 0 0
Elevance Health Inc Common Stock 036752103 BBG000BCG930 292,367 620 SH   SOLE   620 0 0
89bio Inc Common Stock 282559103 BBG00QKDZ8J5 272,135 24,363 SH   SOLE   24,363 0 0
Edwards Lifesciences Corp Common Stock 28176E108 BBG000BRXP69 223,641 2,933 SH   SOLE   2,933 0 0
Exact Sciences Corp Common Stock 30063P105 BBG000CWL0F5 549,006 7,421 SH   SOLE   7,421 0 0
Exelon Corp Common Stock 30161N101 BBG000J6XT05 355,877 9,913 SH   SOLE   9,913 0 0
Exelixis Inc Common Stock 30161Q104 BBG000BQ4WF8 523,750 21,832 SH   SOLE   21,832 0 0
Diamondback Energy Inc Common Stock 25278X109 BBG002PHSYX9 276,508 1,783 SH   SOLE   1,783 0 0
Fastenal Co Common Stock 311900104 BBG000BJ8YN7 368,541 5,690 SH   SOLE   5,690 0 0
Fair Isaac Corp Common Stock 303250104 BBG000DW76Y6 245,606 211 SH   SOLE   211 0 0
Amicus Therapeutics Inc Common Stock 03152W109 BBG000PLF6N0 603,756 42,548 SH   SOLE   42,548 0 0
Fortinet Inc Common Stock 34959E109 BBG000BCMBG4 699,375 11,949 SH   SOLE   11,949 0 0
Futu Holdings Ltd ADR 36118L106 BBG00MYXW4R8 1,034,911 18,944 SH   SOLE   18,944 0 0
VanEck Gold Miners ETF/USA ETP 92189F106 BBG000PLNQN7 1,828,753 58,973 SH   SOLE   58,973 0 0
GE HealthCare Technologies Inc Common Stock 36266G107 BBG01BFR8YV1 506,910 6,556 SH   SOLE   6,556 0 0
Geron Corp Common Stock 374163103 BBG000GX1891 189,126 89,633 SH   SOLE   89,633 0 0
GLOBALFOUNDRIES Inc Common Stock G39387108 BBG000C2L5G9 285,668 4,714 SH   SOLE   4,714 0 0
Gilead Sciences Inc Common Stock 375558103 BBG000CKGBP2 1,645,718 20,315 SH   SOLE   20,315 0 0
SPDR Gold Shares ETP 78463V107 BBG000CRF6Q8 1,933,302 10,113 SH   SOLE   10,113 0 0
SPDR Gold MiniShares Trust ETP 98149E303 BBG00L8YYP89 3,499,441 85,540 SH   SOLE   85,540 0 0
Alphabet Inc Common Stock 02079K107 BBG009S3NB30 4,050,469 28,741 SH   SOLE   28,741 0 0
Alphabet Inc Common Stock 02079K305 BBG009S39JX6 4,836,068 34,620 SH   DFND   34,620 0 0
Structure Therapeutics Inc ADR 86366E106 BBG01CBVHLW1 1,165,288 28,589 SH   SOLE   28,589 0 0
Halozyme Therapeutics Inc Common Stock 40637H109 BBG000CZ8W54 444,370 12,023 SH   SOLE   12,023 0 0
HCA Healthcare Inc Common Stock 40412C101 BBG000QW7VC1 228,454 844 SH   SOLE   844 0 0
Home Depot Inc/The Common Stock 437076102 BBG000BKZB36 546,509 1,577 SH   SOLE   1,577 0 0
Honeywell International Inc Common Stock 438516106 BBG000H556T9 1,376,536 6,564 SH   SOLE   6,564 0 0
Hewlett Packard Enterprise Co Common Stock 42824C109 BBG0078W3NQ3 185,337 10,915 SH   SOLE   10,915 0 0
HP Inc Common Stock 40434L105 BBG000KHWT55 218,062 7,247 SH   SOLE   7,247 0 0
Hesai Group ADR 428050108 BBG01CCYDD47 1,522,844 170,914 SH   SOLE   170,914 0 0
H World Group Ltd ADR 44332N106 BBG000QFPM65 6,071,868 181,575 SH   SOLE   181,575 0 0
Humana Inc Common Stock 444859102 BBG000BLKK03 213,797 467 SH   SOLE   467 0 0
iShares Gold Trust ETP 464285204 BBG000QLKDR4 3,456,419 88,558 SH   SOLE   88,558 0 0
International Business Machine Common Stock 459200101 BBG000BLNNH6 1,250,994 7,649 SH   SOLE   7,649 0 0
ImmunityBio Inc Common Stock 45256X103 BBG007T9DYW9 198,260 39,494 SH   SOLE   39,494 0 0
IDEXX Laboratories Inc Common Stock 45168D104 BBG000BLRT07 701,583 1,264 SH   DFND   1,264 0 0
Ideaya Biosciences Inc Common Stock 45166A102 BBG00CTZ4D83 369,498 10,385 SH   SOLE   10,385 0 0
Illumina Inc Common Stock 452327109 BBG000DSMS70 402,682 2,892 SH   SOLE   2,892 0 0
ImmunoGen Inc Common Stock 45253H101 BBG000C2JTB5 487,535 16,443 SH   SOLE   16,443 0 0
Immunovant Inc Common Stock 45258J102 BBG00P5MC0Q8 516,345 12,256 SH   SOLE   12,256 0 0
Inhibrx Inc Common Stock 45720L107 BBG00P80N9T9 209,456 5,512 SH   SOLE   5,512 0 0
Incyte Corp Common Stock 45337C102 BBG000BNPSQ9 735,396 11,712 SH   SOLE   11,712 0 0
Insmed Inc Common Stock 457669307 BBG000BWM5P3 532,346 17,178 SH   SOLE   17,178 0 0
Intel Corp Common Stock 458140100 BBG000C0G1D1 3,898,696 77,586 SH   SOLE   77,586 0 0
Intuit Inc Common Stock 461202103 BBG000BH5DV1 3,012,645 4,820 SH   SOLE   4,820 0 0
Ionis Pharmaceuticals Inc Common Stock 462222100 BBG000JH6683 499,070 9,865 SH   SOLE   9,865 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 BBG000FTLBV7 542,580 66,738 SH   SOLE   66,738 0 0
iQIYI Inc ADR 46267X108 BBG00K6DZBD3 16,154,288 3,310,305 SH   DFND   3,310,305 0 0
IQVIA Holdings Inc Common Stock 46266C105 BBG00333FYS2 214,258 926 SH   SOLE   926 0 0
Ironwood Pharmaceuticals Inc Common Stock 46333X108 BBG000GBZ3J2 431,139 37,687 SH   SOLE   37,687 0 0
Intuitive Surgical Inc Common Stock 46120E602 BBG000BJPDZ1 1,339,994 3,972 SH   SOLE   3,972 0 0
Gartner Inc Common Stock 366651107 BBG000BB65D0 395,623 877 SH   DFND   877 0 0
iShares Core S&P 500 ETF ETP 464287200 BBG000BVZ4F5 5,781,711 12,105 SH   SOLE   12,105 0 0
Johnson & Johnson Common Stock 478160104 BBG000BMHYD1 746,082 4,760 SH   SOLE   4,760 0 0
JPMorgan Chase & Co Common Stock 46625H100 BBG000DMBXR2 777,187 4,569 SH   SOLE   4,569 0 0
Keurig Dr Pepper Inc Common Stock 49271V100 BBG000TJM7F0 446,288 13,394 SH   SOLE   13,394 0 0
Keysight Technologies Inc Common Stock 49338L103 BBG0059FN811 234,021 1,471 SH   SOLE   1,471 0 0
Kraft Heinz Co/The Common Stock 500754106 BBG005CPNTQ2 430,188 11,633 SH   SOLE   11,633 0 0
KLA Corp Common Stock 482480100 BBG000BMTFR4 21,688,303 37,310 SH   SOLE   37,310 0 0
Coca-Cola Co/The Common Stock 191216100 BBG000BMX289 426,417 7,236 SH   DFND   7,236 0 0
Karuna Therapeutics Inc Common Stock 48576A100 BBG00NN875G0 740,000 2,338 SH   SOLE   2,338 0 0
Krystal Biotech Inc Common Stock 501147102 BBG00HDGRHH7 557,650 4,495 SH   SOLE   4,495 0 0
Legend Biotech Corp ADR 52490G102 BBG00TTGH5W4 3,844,682 63,897 SH   SOLE   63,897 0 0
Linde PLC Common Stock G54950103 BBG01FND0CC1 314,604 766 SH   SOLE   766 0 0
Eli Lilly & Co Common Stock 532457108 BBG000BNBDC2 881,375 1,512 SH   SOLE   1,512 0 0
iShares iBoxx $ Investment Gr ETP 464287242 BBG000BBV9N3 874,214 7,900 SH   SOLE   7,900 0 0
Lam Research Corp Common Stock 512807108 BBG000BNFLM9 1,752,936 2,238 SH   SOLE   2,238 0 0
Lufax Holding Ltd ADR 54975P201 BBG00XS6QZN2 4,121,969 1,342,661 SH   DFND   1,342,661 0 0
Lululemon Athletica Inc Common Stock 550021109 BBG000R8ZVD1 3,117,335 6,097 SH   DFND   6,097 0 0
Las Vegas Sands Corp Common Stock 517834107 BBG000JWD753 263,027 5,345 SH   SOLE   5,345 0 0
Mastercard Inc Common Stock 57636Q104 BBG000F1ZSQ2 640,192 1,501 SH   DFND   1,501 0 0
Marriott International Inc/MD Common Stock 571903202 BBG000BGD7W6 3,282,524 14,556 SH   DFND   14,556 0 0
McDonald's Corp Common Stock 580135101 BBG000BNSZP1 338,911 1,143 SH   SOLE   1,143 0 0
Microchip Technology Inc Common Stock 595017104 BBG000BHCP19 831,820 9,224 SH   SOLE   9,224 0 0
McKesson Corp Common Stock 58155Q103 BBG000DYGNW7 229,638 496 SH   SOLE   496 0 0
MongoDB Inc Common Stock 60937P106 BBG0022FDRY8 1,116,161 2,730 SH   DFND   2,730 0 0
Madrigal Pharmaceuticals Inc Common Stock 558868105 BBG000QS6NV8 533,562 2,306 SH   SOLE   2,306 0 0
Mondelez International Inc Common Stock 609207105 BBG000D4LWF6 981,426 13,550 SH   SOLE   13,550 0 0
Medtronic PLC Common Stock G5960L103 BBG000BNWG87 297,968 3,617 SH   SOLE   3,617 0 0
MercadoLibre Inc Common Stock 58733R102 BBG000GQPB11 732,338 466 SH   DFND   466 0 0
Meta Platforms Inc Common Stock 30303M102 BBG000MM2P62 5,442,843 15,377 SH   DFND   15,377 0 0
Mirum Pharmaceuticals Inc Common Stock 604749101 BBG00MH7T2M7 206,670 7,001 SH   SOLE   7,001 0 0
MannKind Corp Common Stock 56400P706 BBG000PPL3G9 158,780 43,621 SH   SOLE   43,621 0 0
Monster Beverage Corp Common Stock 61174X109 BBG008NVB1C0 573,796 9,960 SH   SOLE   9,960 0 0
Morphic Holding Inc Common Stock 61775R105 BBG00PBD6W06 314,445 10,888 SH   SOLE   10,888 0 0
Monolithic Power Systems Inc Common Stock 609839105 BBG000C30L48 251,050 398 SH   SOLE   398 0 0
Merck & Co Inc Common Stock 58933Y105 BBG000BPD168 587,400 5,388 SH   SOLE   5,388 0 0
Moderna Inc Common Stock 60770K107 BBG003PHHZT1 1,223,036 12,298 SH   SOLE   12,298 0 0
Mirati Therapeutics Inc Common Stock 60468T105 BBG004TPGBP5 499,551 8,503 SH   SOLE   8,503 0 0
Marvell Technology Inc Common Stock 573874104 BBG00ZXBJ153 447,862 7,426 SH   SOLE   7,426 0 0
Microsoft Corp Common Stock 594918104 BBG000BPH459 58,416,310 155,346 SH   SOLE   155,346 0 0
Motorola Solutions Inc Common Stock 620076307 BBG000BP8Z50 438,952 1,402 SH   SOLE   1,402 0 0
Mettler-Toledo International I Common Stock 592688105 BBG000BZCKH3 202,564 167 SH   SOLE   167 0 0
Micron Technology Inc Common Stock 595112103 BBG000C5Z1S3 3,138,037 36,771 SH   DFND   36,771 0 0
Neurocrine Biosciences Inc Common Stock 64125C109 BBG000GJS7C1 539,689 4,096 SH   SOLE   4,096 0 0
Netflix Inc Common Stock 64110L106 BBG000CL9VN6 2,170,511 4,458 SH   SOLE   4,458 0 0
NIO Inc ADR 62914V106 BBG00LPXZB46 11,602,326 1,279,198 SH   SOLE   1,279,198 0 0
NIKE Inc Common Stock 654106103 BBG000C5HS04 1,089,174 10,032 SH   DFND   10,032 0 0
ServiceNow Inc Common Stock 81762P102 BBG000M1R011 2,399,946 3,397 SH   DFND   3,397 0 0
NetEase Inc ADR 64110W102 BBG000BX72V8 1,058,763 11,365 SH   SOLE   11,365 0 0
Intellia Therapeutics Inc Common Stock 45826J105 BBG007KC7PB0 504,640 16,551 SH   SOLE   16,551 0 0
Natera Inc Common Stock 632307104 BBG001J1BQ86 517,406 8,260 SH   SOLE   8,260 0 0
Nuvalent Inc Common Stock 670703107 BBG00Z1SLMK5 500,265 6,798 SH   SOLE   6,798 0 0
Novavax Inc Common Stock 670002401 BBG000NVSBL7 415,478 86,558 SH   SOLE   86,558 0 0
NVIDIA Corp Common Stock 67066G104 BBG000BBJQV0 15,179,483 30,652 SH   DFND   30,652 0 0
NXP Semiconductors NV Common Stock N6596X109 BBG000BND699 1,009,903 4,397 SH   SOLE   4,397 0 0
Old Dominion Freight Line Inc Common Stock 679580100 BBG000CHSS88 429,244 1,059 SH   SOLE   1,059 0 0
ON Semiconductor Corp Common Stock 682189105 BBG000DV7MX4 611,105 7,316 SH   SOLE   7,316 0 0
Oracle Corp Common Stock 68389X105 BBG000BQLTW7 1,442,493 13,682 SH   SOLE   13,682 0 0
O'Reilly Automotive Inc Common Stock 67103H107 BBG000BGYWY6 559,597 589 SH   SOLE   589 0 0
Palo Alto Networks Inc Common Stock 697435105 BBG0014GJCT9 1,568,172 5,318 SH   SOLE   5,318 0 0
Paychex Inc Common Stock 704326107 BBG000BQSQ38 422,602 3,548 SH   SOLE   3,548 0 0
PACCAR Inc Common Stock 693718108 BBG000BQVTF5 512,077 5,244 SH   SOLE   5,244 0 0
Vaxcyte Inc Common Stock 92243G108 BBG009PHHPL8 532,293 8,476 SH   SOLE   8,476 0 0
PDD Holdings Inc ADR 722304102 BBG00LBLDDR2 670,383,642 4,581,940 SH   DFND   4,581,940 0 0
PepsiCo Inc Common Stock 713448108 BBG000DH7JK6 2,439,921 14,366 SH   DFND   14,366 0 0
Pfizer Inc Common Stock 717081103 BBG000BR2B91 400,814 13,922 SH   SOLE   13,922 0 0
Procter & Gamble Co/The Common Stock 742718109 BBG000BR2TH3 544,396 3,715 SH   SOLE   3,715 0 0
Philip Morris International In Common Stock 718172109 BBG000J2XL74 230,214 2,447 SH   SOLE   2,447 0 0
Pool Corp Common Stock 73278L105 BBG000BCVG28 361,630 907 SH   DFND   907 0 0
Prothena Corp PLC Common Stock G72800108 BBG003PDKJF7 403,229 11,096 SH   SOLE   11,096 0 0
PTC Therapeutics Inc Common Stock 69366J200 BBG000QT15P7 501,261 18,188 SH   SOLE   18,188 0 0
Protagonist Therapeutics Inc Common Stock 74366E102 BBG002B63KM7 205,384 8,957 SH   SOLE   8,957 0 0
PayPal Holdings Inc Common Stock 70450Y103 BBG0077VNXV6 659,236 10,735 SH   SOLE   10,735 0 0
QUALCOMM Inc Common Stock 747525103 BBG000CGC1X8 3,699,202 25,577 SH   SOLE   25,577 0 0
Qifu Technology Inc ADR 88557W101 BBG00MDY4KL0 14,566,850 920,787 SH   DFND   920,787 0 0
Invesco QQQ Trust Series 1 ETP 46090E103 BBG000BSWKH7 1,548,395 3,781 SH   SOLE   3,781 0 0
uniQure NV Common Stock N90064101 BBG005SSJYH3 133,281 19,687 SH   SOLE   19,687 0 0
Ultragenyx Pharmaceutical Inc Common Stock 90400D108 BBG001RWPDW6 567,671 11,871 SH   SOLE   11,871 0 0
Rocket Pharmaceuticals Inc Common Stock 77313F106 BBG000WG3567 335,574 11,197 SH   SOLE   11,197 0 0
Royal Caribbean Cruises Ltd Common Stock V7780T103 BBG000BB5792 993,318 7,671 SH   SOLE   7,671 0 0
Arcus Biosciences Inc Common Stock 03969F109 BBG00DQD26W3 257,869 13,501 SH   SOLE   13,501 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 BBG000C734W3 1,590,583 1,811 SH   SOLE   1,811 0 0
Replimune Group Inc Common Stock 76029N106 BBG00L8Z22R1 208,550 24,739 SH   SOLE   24,739 0 0
iShares MSCI Global Gold Miner ETP 46434G855 BBG002GKR6T9 3,651,703 148,564 SH   SOLE   148,564 0 0
Relay Therapeutics Inc Common Stock 75943R102 BBG00DSS08K9 192,521 17,486 SH   SOLE   17,486 0 0
RLX Technology Inc ADR 74969N103 BBG00YR17764 705,178 352,589 SH   SOLE   352,589 0 0
Avidity Biosciences Inc Common Stock 05370A108 BBG00FQ7LXW1 94,808 10,476 SH   SOLE   10,476 0 0
Roivant Sciences Ltd Common Stock G76279101 BBG007STW2B8 548,698 48,860 SH   SOLE   48,860 0 0
Roper Technologies Inc Common Stock 776696106 BBG000F1ZSN5 992,755 1,821 SH   SOLE   1,821 0 0
Ross Stores Inc Common Stock 778296103 BBG000BSBZH7 469,696 3,394 SH   SOLE   3,394 0 0
REVOLUTION Medicines Inc Common Stock 76155X100 BBG00829F4P8 560,178 19,532 SH   SOLE   19,532 0 0
Recursion Pharmaceuticals Inc Common Stock 75629V104 BBG00PQ4XJ45 533,367 54,094 SH   SOLE   54,094 0 0
Rhythm Pharmaceuticals Inc Common Stock 76243J105 BBG007DLZ601 300,322 6,533 SH   SOLE   6,533 0 0
Sage Therapeutics Inc Common Stock 78667J108 BBG0025X16Y5 357,165 16,482 SH   SOLE   16,482 0 0
Sana Biotechnology Inc Common Stock 799566104 BBG00N5BMH61 95,313 23,361 SH   SOLE   23,361 0 0
Starbucks Corp Common Stock 855244109 BBG000CTQBF3 1,087,409 11,326 SH   SOLE   11,326 0 0
Scilex Holding Co Common Stock 80880W106 BBG00YJTT4L8 64,119 31,431 SH   SOLE   31,431 0 0
Sea Ltd ADR 81141R100 BBG00HTBWMG5 26,730,000 660,000 SH   SOLE   660,000 0 0
Sirius XM Holdings Inc Common Stock 82968B103 BBG000BT0093 180,734 33,041 SH   SOLE   33,041 0 0
Syndax Pharmaceuticals Inc Common Stock 87164F105 BBG000R33JY1 466,344 21,580 SH   SOLE   21,580 0 0
Synopsys Inc Common Stock 871607107 BBG000BSFRF3 1,330,527 2,584 SH   SOLE   2,584 0 0
Splunk Inc Common Stock 848637104 BBG001C7TST4 220,907 1,450 SH   SOLE   1,450 0 0
SPDR S&P 500 ETF Trust ETP 78462F103 BBG000BDTBL9 4,090,993 8,607 SH   SOLE   8,607 0 0
Sarepta Therapeutics Inc Common Stock 803607100 BBG000BCJ161 532,197 5,519 SH   SOLE   5,519 0 0
STAAR Surgical Co Common Stock 852312305 BBG000C4QB95 4,128,958 132,296 SH   SOLE   132,296 0 0
SpringWorks Therapeutics Inc Common Stock 85205L107 BBG00Q011TW9 282,948 7,752 SH   SOLE   7,752 0 0
Stryker Corp Common Stock 863667101 BBG000DN7P92 286,583 957 SH   SOLE   957 0 0
TAL Education Group ADR 874080104 BBG0016XJ8S0 38,555,323 3,052,678 SH   DFND   3,052,678 0 0
Atlassian Corp Common Stock 049468101 BBG01BGWHFR5 317,305 1,334 SH   SOLE   1,334 0 0
TE Connectivity Ltd Common Stock H84989104 BBG000RGM5P1 368,391 2,622 SH   SOLE   2,622 0 0
TG Therapeutics Inc Common Stock 88322Q108 BBG000FVZQY1 521,845 30,553 SH   SOLE   30,553 0 0
Tencent Music Entertainment Gr ADR 88034P109 BBG00LDC5RK5 38,528,111 4,276,150 SH   DFND   4,276,150 0 0
Thermo Fisher Scientific Inc Common Stock 883556102 BBG000BVDLH9 1,472,942 2,775 SH   DFND   2,775 0 0
T-Mobile US Inc Common Stock 872590104 BBG000NDV1D4 1,706,072 10,641 SH   SOLE   10,641 0 0
Tesla Inc Common Stock 88160R101 BBG000N9MNX3 7,081,680 28,500 SH   DFND   28,500 0 0
Taiwan Semiconductor Manufactu ADR 874039100 BBG000BD8ZK0 57,958,264 557,291 SH   DFND   557,291 0 0
Trade Desk Inc/The Common Stock 88339J105 BBG00629NGT2 276,398 3,841 SH   SOLE   3,841 0 0
Take-Two Interactive Software Common Stock 874054109 BBG000BS1YV5 270,074 1,678 SH   SOLE   1,678 0 0
Travere Therapeutics Inc Common Stock 89422G107 BBG000P9D6W9 205,961 22,910 SH   SOLE   22,910 0 0
Twist Bioscience Corp Common Stock 90184D100 BBG006KDCHJ4 452,751 12,283 SH   SOLE   12,283 0 0
Texas Instruments Inc Common Stock 882508104 BBG000BVV7G1 2,664,290 15,630 SH   SOLE   15,630 0 0
Unity Software Inc Common Stock 91332U101 BBG0056JW5G6 376,638 9,211 SH   SOLE   9,211 0 0
UnitedHealth Group Inc Common Stock 91324P102 BBG000CH5208 981,867 1,865 SH   DFND   1,865 0 0
Union Pacific Corp Common Stock 907818108 BBG000BW3299 202,145 823 SH   SOLE   823 0 0
United Therapeutics Corp Common Stock 91307C102 BBG000BV4XJ1 437,141 1,988 SH   SOLE   1,988 0 0
Visa Inc Common Stock 92826C839 BBG000PSKYX7 741,737 2,849 SH   DFND   2,849 0 0
Vericel Corp Common Stock 92346J108 BBG000BDCM24 202,372 5,683 SH   SOLE   5,683 0 0
Veracyte Inc Common Stock 92337F107 BBG001J2M542 235,623 8,565 SH   SOLE   8,565 0 0
Verve Therapeutics Inc Common Stock 92539P101 BBG00P33TCZ8 228,309 16,378 SH   SOLE   16,378 0 0
Vipshop Holdings Ltd ADR 92763W103 BBG002NLDLV8 39,700,455 2,235,386 SH   DFND   2,235,386 0 0
Vir Biotechnology Inc Common Stock 92764N102 BBG00H2QQ8T5 215,536 21,425 SH   SOLE   21,425 0 0
Viking Therapeutics Inc Common Stock 92686J106 BBG006LGV869 413,049 22,195 SH   SOLE   22,195 0 0
Vanguard S&P 500 ETF ETP 922908363 BBG0015VYNT4 1,529,237 3,501 SH   SOLE   3,501 0 0
Viridian Therapeutics Inc Common Stock 92790C104 BBG002H242Z5 236,858 10,875 SH   SOLE   10,875 0 0
Verisk Analytics Inc Common Stock 92345Y106 BBG000BCZL41 344,914 1,444 SH   SOLE   1,444 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100 BBG000C1S2X2 1,770,378 4,351 SH   SOLE   4,351 0 0
Viatris Inc Common Stock 92556V106 BBG00Y4RQNH4 179,366 16,562 SH   SOLE   16,562 0 0
Verizon Communications Inc Common Stock 92343V104 BBG000HS77T5 249,838 6,627 SH   SOLE   6,627 0 0
Weibo Corp ADR 948596101 BBG0065XPGX9 3,385,039 309,136 SH   DFND   309,136 0 0
Walgreens Boots Alliance Inc Common Stock 931427108 BBG000BWLMJ4 223,214 8,549 SH   SOLE   8,549 0 0
Warner Bros Discovery Inc Common Stock 934423104 BBG011386VF4 272,927 23,983 SH   SOLE   23,983 0 0
Workday Inc Common Stock 98138H101 BBG000VC0T95 989,399 3,584 SH   SOLE   3,584 0 0
Wells Fargo & Co Common Stock 949746101 BBG000BWQFY7 282,080 5,731 SH   SOLE   5,731 0 0
Walmart Inc Common Stock 931142103 BBG000BWXBC2 356,604 2,262 SH   SOLE   2,262 0 0
Xcel Energy Inc Common Stock 98389B100 BBG000BCTQ65 340,134 5,494 SH   SOLE   5,494 0 0
Exxon Mobil Corp Common Stock 30231G102 BBG000GZQ728 633,673 6,338 SH   SOLE   6,338 0 0
Full Truck Alliance Co Ltd ADR 35969L108 BBG01186DLS3 38,192,457 5,448,282 SH   SOLE   5,448,282 0 0
Yum China Holdings Inc Common Stock 98850P109 BBG00B8N0HG1 5,515,900 130,000 SH   SOLE   130,000 0 0
JOYY Inc ADR 46591M109 BBG003H0XV18 5,075,367 127,843 SH   DFND   127,843 0 0
Zentalis Pharmaceuticals Inc Common Stock 98943L107 BBG00R2K8TF5 293,001 19,340 SH   SOLE   19,340 0 0
Zscaler Inc Common Stock 98980G102 BBG003338H34 282,932 1,277 SH   SOLE   1,277 0 0
ZTO Express Cayman Inc ADR 98980A105 BBG00DY7QWH1 7,949,761 373,579 SH   SOLE   373,579 0 0
Zoetis Inc Common Stock 98978V103 BBG0039320N9 276,910 1,403 SH   SOLE   1,403 0 0