The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Apple Inc Common Stock 037833100   31,739 244,279 SH   SOLE   244,279 0 0
AbbVie Inc Common Stock 00287Y109   1,079 6,674 SH   SOLE   6,674 0 0
Airbnb Inc Common Stock 009066101   323 3,783 SH   SOLE   3,783 0 0
Abbott Laboratories Common Stock 002824100   479 4,364 SH   SOLE   4,364 0 0
ACADIA Pharmaceuticals Inc Common Stock 004225108   464 29,170 SH   SOLE   29,170 0 0
Accenture PLC Common Stock G1151C101   1,682 6,303 SH   SOLE   6,303 0 0
Adobe Inc Common Stock 00724F101   3,052 9,070 SH   SOLE   9,070 0 0
Analog Devices Inc Common Stock 032654105   1,639 9,990 SH   SOLE   9,990 0 0
ADMA Biologics Inc Common Stock 000899104   161 41,376 SH   SOLE   41,376 0 0
Automatic Data Processing Inc Common Stock 053015103   1,932 8,088 SH   SOLE   8,088 0 0
Autodesk Inc Common Stock 052769106   792 4,236 SH   SOLE   4,236 0 0
American Electric Power Co Inc Common Stock 025537101   557 5,870 SH   SOLE   5,870 0 0
Agenus Inc Common Stock 00847G705   220 91,708 SH   SOLE   91,708 0 0
Agios Pharmaceuticals Inc Common Stock 00847X104   312 11,096 SH   SOLE   11,096 0 0
Akero Therapeutics Inc Common Stock 00973Y108   526 9,604 SH   SOLE   9,604 0 0
Alector Inc Common Stock 014442107   101 10,891 SH   SOLE   10,891 0 0
Align Technology Inc Common Stock 016255101   306 1,453 SH   SOLE   1,453 0 0
Alkermes PLC Common Stock G01767105   447 17,116 SH   SOLE   17,116 0 0
Allakos Inc Common Stock 01671P100   141 16,749 SH   SOLE   16,749 0 0
Allogene Therapeutics Inc Common Stock 019770106   249 39,645 SH   SOLE   39,645 0 0
Alnylam Pharmaceuticals Inc Common Stock 02043Q107   434 1,828 SH   SOLE   1,828 0 0
Altimmune Inc Common Stock 02155H200   515 31,286 SH   SOLE   31,286 0 0
Applied Materials Inc Common Stock 038222105   1,635 16,790 SH   SOLE   16,790 0 0
Advanced Micro Devices Inc Common Stock 007903107   20,596 317,987 SH   SOLE   317,987 0 0
Amgen Inc Common Stock 031162100   2,101 7,999 SH   SOLE   7,999 0 0
Amazon.com Inc Common Stock 023135106   7,718 91,882 SH   SOLE   91,882 0 0
Arista Networks Inc Common Stock 040413106   302 2,490 SH   SOLE   2,490 0 0
ANSYS Inc Common Stock 03662Q105   411 1,702 SH   SOLE   1,702 0 0
Amphenol Corp Common Stock 032095101   456 5,993 SH   SOLE   5,993 0 0
Apellis Pharmaceuticals Inc Common Stock 03753U106   445 8,604 SH   SOLE   8,604 0 0
Arcutis Biotherapeutics Inc Common Stock 03969K108   235 15,880 SH   SOLE   15,880 0 0
Arrowhead Pharmaceuticals Inc Common Stock 04280A100   567 13,978 SH   SOLE   13,978 0 0
ASML Holding NV NY Reg Shrs N07059210   22,713 41,569 SH   SOLE   41,569 0 0
Autohome Inc ADR 05278C107   11,790 385,308 SH   SOLE   385,308 0 0
Atara Biotherapeutics Inc Common Stock 046513107   86 26,352 SH   SOLE   26,352 0 0
Activision Blizzard Inc Common Stock 00507V109   676 8,836 SH   SOLE   8,836 0 0
Broadcom Inc Common Stock 11135F101   4,418 7,901 SH   SOLE   7,901 0 0
Anavex Life Sciences Corp Common Stock 032797300   226 24,362 SH   SOLE   24,362 0 0
AstraZeneca PLC ADR 046353108   394 5,804 SH   SOLE   5,804 0 0
Boeing Co/The Common Stock 097023105   205 1,074 SH   SOLE   1,074 0 0
Bank of America Corp Common Stock 060505104   448 13,513 SH   SOLE   13,513 0 0
Bridgebio Pharma Inc Common Stock 10806X102   258 33,826 SH   SOLE   33,826 0 0
BioCryst Pharmaceuticals Inc Common Stock 09058V103   462 40,255 SH   SOLE   40,255 0 0
Becton Dickinson and Co Common Stock 075887109   251 986 SH   SOLE   986 0 0
Beam Therapeutics Inc Common Stock 07373V105   392 10,035 SH   SOLE   10,035 0 0
KE Holdings Inc ADR 482497104   42,190 3,022,243 SH   DFND   3,022,243 0 0
Biohaven Ltd Common Stock G1110E107   256 18,474 SH   SOLE   18,474 0 0
Biogen Inc Common Stock 09062X103   972 3,511 SH   SOLE   3,511 0 0
Booking Holdings Inc Common Stock 09857L108   899 446 SH   SOLE   446 0 0
Baker Hughes Co Common Stock 05722G100   338 11,451 SH   SOLE   11,451 0 0
BlackRock Inc Common Stock 09247X101   206 290 SH   SOLE   290 0 0
Bluebird Bio Inc Common Stock 09609G100   391 56,432 SH   SOLE   56,432 0 0
BioMarin Pharmaceutical Inc Common Stock 09061G101   428 4,131 SH   SOLE   4,131 0 0
Bristol-Myers Squibb Co Common Stock 110122108   393 5,465 SH   SOLE   5,465 0 0
United States Brent Oil Fund L ETP 91167Q100   1,752 61,965 SH   SOLE   61,965 0 0
Blueprint Medicines Corp Common Stock 09627Y109   391 8,928 SH   SOLE   8,928 0 0
Berkshire Hathaway Inc Common Stock 084670702   1,077 3,488 SH   SOLE   3,488 0 0
Boston Scientific Corp Common Stock 101137107   235 5,070 SH   SOLE   5,070 0 0
Kanzhun Ltd ADR 48553T106   38,550 1,892,483 SH   DFND   1,892,483 0 0
Caterpillar Inc Common Stock 149123101   243 1,016 SH   SOLE   1,016 0 0
Carnival Corp Common Stock 143658300   577 71,564 SH   SOLE   71,564 0 0
Avid Bioservices Inc Common Stock 05368M106   230 16,728 SH   SOLE   16,728 0 0
CareDx Inc Common Stock 14167L103   290 25,455 SH   SOLE   25,455 0 0
Cadence Design Systems Inc Common Stock 127387108   863 5,372 SH   SOLE   5,372 0 0
CDW Corp/DE Common Stock 12514G108   242 1,357 SH   SOLE   1,357 0 0
Constellation Energy Corp Common Stock 21037T109   324 3,755 SH   SOLE   3,755 0 0
Cerevel Therapeutics Holdings Common Stock 15678U128   395 12,509 SH   SOLE   12,509 0 0
Coherus Biosciences Inc Common Stock 19249H103   195 24,587 SH   SOLE   24,587 0 0
Charter Communications Inc Common Stock 16119P108   572 1,687 SH   SOLE   1,687 0 0
Cigna Corp Common Stock 125523100   301 909 SH   SOLE   909 0 0
Celldex Therapeutics Inc Common Stock 15117B202   335 7,511 SH   SOLE   7,511 0 0
Comcast Corp Common Stock 20030N101   1,725 49,331 SH   SOLE   49,331 0 0
Cogent Biosciences Inc Common Stock 19240Q201   196 16,975 SH   SOLE   16,975 0 0
ConocoPhillips Common Stock 20825C104   285 2,413 SH   SOLE   2,413 0 0
Costco Wholesale Corp Common Stock 22160K105   2,309 5,057 SH   SOLE   5,057 0 0
Copart Inc Common Stock 217204106   327 5,373 SH   SOLE   5,373 0 0
Catalyst Pharmaceuticals Inc Common Stock 14888U101   480 25,814 SH   SOLE   25,814 0 0
Caribou Biosciences Inc Common Stock 142038108   70 11,090 SH   SOLE   11,090 0 0
Salesforce Inc Common Stock 79466L302   1,327 10,007 SH   SOLE   10,007 0 0
CRISPR Therapeutics AG Common Stock H17182108   351 8,628 SH   SOLE   8,628 0 0
Crowdstrike Holdings Inc Common Stock 22788C105   218 2,074 SH   SOLE   2,074 0 0
Cisco Systems Inc Common Stock 17275R102   3,817 80,124 SH   SOLE   80,124 0 0
CoStar Group Inc Common Stock 22160N109   359 4,643 SH   SOLE   4,643 0 0
CSX Corp Common Stock 126408103   745 24,042 SH   SOLE   24,042 0 0
Cintas Corp Common Stock 172908105   513 1,137 SH   SOLE   1,137 0 0
CTI BioPharma Corp Common Stock 12648L601   463 77,101 SH   SOLE   77,101 0 0
Cognizant Technology Solutions Common Stock 192446102   575 10,049 SH   SOLE   10,049 0 0
CVS Health Corp Common Stock 126650100   334 3,579 SH   SOLE   3,579 0 0
Chevron Corp Common Stock 166764100   618 3,445 SH   SOLE   3,445 0 0
Cytokinetics Inc Common Stock 23282W605   541 11,806 SH   SOLE   11,806 0 0
Day One Biopharmaceuticals Inc Common Stock 23954D109   232 10,764 SH   SOLE   10,764 0 0
Invesco DB Oil Fund ETP 46140H403   1,748 114,924 SH   SOLE   114,924 0 0
Deciphera Pharmaceuticals Inc Common Stock 24344T101   217 13,239 SH   SOLE   13,239 0 0
Datadog Inc Common Stock 23804L103   204 2,775 SH   SOLE   2,775 0 0
Deere & Co Common Stock 244199105   229 535 SH   SOLE   535 0 0
Danaher Corp Common Stock 235851102   442 1,666 SH   SOLE   1,666 0 0
Walt Disney Co/The Common Stock 254687106   307 3,529 SH   SOLE   3,529 0 0
Dollar Tree Inc Common Stock 256746108   356 2,518 SH   SOLE   2,518 0 0
Denali Therapeutics Inc Common Stock 24823R105   413 14,861 SH   SOLE   14,861 0 0
Design Therapeutics Inc Common Stock 25056L103   128 12,523 SH   SOLE   12,523 0 0
Dynavax Technologies Corp Common Stock 268158201   361 33,893 SH   SOLE   33,893 0 0
Dexcom Inc Common Stock 252131107   604 5,338 SH   SOLE   5,338 0 0
Electronic Arts Inc Common Stock 285512109   384 3,143 SH   SOLE   3,143 0 0
eBay Inc Common Stock 278642103   259 6,236 SH   SOLE   6,236 0 0
Emergent BioSolutions Inc Common Stock 29089Q105   257 21,766 SH   SOLE   21,766 0 0
Editas Medicine Inc Common Stock 28106W103   358 40,380 SH   SOLE   40,380 0 0
Estee Lauder Cos Inc/The Common Stock 518439104   2,235 9,007 SH   SOLE   9,007 0 0
Elevance Health Inc Common Stock 036752103   342 666 SH   SOLE   666 0 0
Enphase Energy Inc Common Stock 29355A107   702 2,651 SH   SOLE   2,651 0 0
Enanta Pharmaceuticals Inc Common Stock 29251M106   203 4,369 SH   SOLE   4,369 0 0
EQRx Inc Common Stock 26886C107   158 64,425 SH   SOLE   64,425 0 0
Erasca Inc Common Stock 29479A108   64 14,832 SH   SOLE   14,832 0 0
Exact Sciences Corp Common Stock 30063P105   469 9,481 SH   SOLE   9,481 0 0
Exelon Corp Common Stock 30161N101   492 11,387 SH   SOLE   11,387 0 0
Exelixis Inc Common Stock 30161Q104   430 26,803 SH   SOLE   26,803 0 0
Diamondback Energy Inc Common Stock 25278X109   274 2,005 SH   SOLE   2,005 0 0
Fastenal Co Common Stock 311900104   312 6,583 SH   SOLE   6,583 0 0
Fate Therapeutics Inc Common Stock 31189P102   226 22,356 SH   SOLE   22,356 0 0
FibroGen Inc Common Stock 31572Q808   218 13,609 SH   SOLE   13,609 0 0
Fidelity National Information Common Stock 31620M106   403 5,938 SH   SOLE   5,938 0 0
Fiserv Inc Common Stock 337738108   1,252 12,389 SH   SOLE   12,389 0 0
Amicus Therapeutics Inc Common Stock 03152W109   442 36,161 SH   SOLE   36,161 0 0
Fortinet Inc Common Stock 34959E109   682 13,943 SH   SOLE   13,943 0 0
VanEck Gold Miners ETF/USA ETP 92189F106   2,724 95,032 SH   SOLE   95,032 0 0
Geron Corp Common Stock 374163103   161 66,662 SH   SOLE   66,662 0 0
GLOBALFOUNDRIES Inc Common Stock G39387108   279 5,178 SH   SOLE   5,178 0 0
Gilead Sciences Inc Common Stock 375558103   1,747 20,347 SH   SOLE   20,347 0 0
SPDR Gold Shares ETP 78463V107   1,918 11,305 SH   SOLE   11,305 0 0
SPDR Gold MiniShares Trust ETP 98149E303   3,664 101,236 SH   SOLE   101,236 0 0
Corning Inc Common Stock 219350105   244 7,638 SH   SOLE   7,638 0 0
Alphabet Inc Common Stock 02079K107   7,526 84,815 SH   SOLE   84,815 0 0
Alphabet Inc Common Stock 02079K305   4,953 56,140 SH   SOLE   56,140 0 0
Gossamer Bio Inc Common Stock 38341P102   315 145,237 SH   SOLE   145,237 0 0
Global Payments Inc Common Stock 37940X102   269 2,707 SH   SOLE   2,707 0 0
Grab Holdings Ltd Common Stock G4124C109   33,327 10,350,000 SH   SOLE   10,350,000 0 0
Goldman Sachs Group Inc/The Common Stock 38141G104   226 657 SH   SOLE   657 0 0
Halozyme Therapeutics Inc Common Stock 40637H109   423 7,427 SH   SOLE   7,427 0 0
HCA Healthcare Inc Common Stock 40412C101   207 862 SH   SOLE   862 0 0
Home Depot Inc/The Common Stock 437076102   624 1,977 SH   SOLE   1,977 0 0
Honeywell International Inc Common Stock 438516106   1,646 7,683 SH   SOLE   7,683 0 0
Hewlett Packard Enterprise Co Common Stock 42824C109   208 13,052 SH   SOLE   13,052 0 0
HP Inc Common Stock 40434L105   238 8,859 SH   SOLE   8,859 0 0
Humana Inc Common Stock 444859102   230 450 SH   SOLE   450 0 0
Horizon Therapeutics Plc Common Stock G46188101   495 4,346 SH   SOLE   4,346 0 0
iShares Gold Trust ETP 464285204   3,661 105,848 SH   SOLE   105,848 0 0
IBM Common Stock 459200101   1,273 9,034 SH   SOLE   9,034 0 0
ImmunityBio Inc Common Stock 45256X103   125 24,706 SH   SOLE   24,706 0 0
Intercept Pharmaceuticals Inc Common Stock 45845P108   172 13,932 SH   SOLE   13,932 0 0
IDEXX Laboratories Inc Common Stock 45168D104   491 1,203 SH   SOLE   1,203 0 0
Illumina Inc Common Stock 452327109   471 2,328 SH   SOLE   2,328 0 0
I-Mab ADR 44975P103   263 62,962 SH   SOLE   62,962 0 0
ImmunoGen Inc Common Stock 45253H101   356 71,705 SH   SOLE   71,705 0 0
Immunovant Inc Common Stock 45258J102   209 11,799 SH   SOLE   11,799 0 0
Inhibrx Inc Common Stock 45720L107   254 10,315 SH   SOLE   10,315 0 0
Incyte Corp Common Stock 45337C102   546 6,802 SH   SOLE   6,802 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201   212 135,683 SH   SOLE   135,683 0 0
Insmed Inc Common Stock 457669307   457 22,897 SH   SOLE   22,897 0 0
Intel Corp Common Stock 458140100   2,130 80,597 SH   SOLE   80,597 0 0
Intuit Inc Common Stock 461202103   2,136 5,487 SH   SOLE   5,487 0 0
Ionis Pharmaceuticals Inc Common Stock 462222100   426 11,272 SH   SOLE   11,272 0 0
Iovance Biotherapeutics Inc Common Stock 462260100   389 60,952 SH   SOLE   60,952 0 0
iQIYI Inc ADR 46267X108   12,004 2,265,003 SH   DFND   2,265,003 0 0
Ironwood Pharmaceuticals Inc Common Stock 46333X108   442 35,685 SH   SOLE   35,685 0 0
IVERIC bio Inc Common Stock 46583P102   447 20,879 SH   SOLE   20,879 0 0
Intuitive Surgical Inc Common Stock 46120E602   1,178 4,440 SH   SOLE   4,440 0 0
Gartner Inc Common Stock 366651107   267 794 SH   SOLE   794 0 0
JD.com Inc ADR 47215P106   259 4,615 SH   SOLE   4,615 0 0
Johnson & Johnson Common Stock 478160104   1,001 5,665 SH   SOLE   5,665 0 0
JPMorgan Chase & Co Common Stock 46625H100   762 5,679 SH   SOLE   5,679 0 0
Chinook Therapeutics Inc Common Stock 16961L106   239 9,117 SH   SOLE   9,117 0 0
Keurig Dr Pepper Inc Common Stock 49271V100   539 15,125 SH   SOLE   15,125 0 0
Keysight Technologies Inc Common Stock 49338L103   308 1,798 SH   SOLE   1,798 0 0
Kraft Heinz Co/The Common Stock 500754106   537 13,203 SH   SOLE   13,203 0 0
KLA Corp Common Stock 482480100   1,044 2,770 SH   SOLE   2,770 0 0
Coca-Cola Co/The Common Stock 191216100   479 7,535 SH   SOLE   7,535 0 0
Karyopharm Therapeutics Inc Common Stock 48576U106   124 36,504 SH   SOLE   36,504 0 0
Karuna Therapeutics Inc Common Stock 48576A100   421 2,143 SH   SOLE   2,143 0 0
Krystal Biotech Inc Common Stock 501147102   256 3,228 SH   SOLE   3,228 0 0
Kura Oncology Inc Common Stock 50127T109   213 17,173 SH   SOLE   17,173 0 0
Kymera Therapeutics Inc Common Stock 501575104   282 11,292 SH   SOLE   11,292 0 0
Kezar Life Sciences Inc Common Stock 49372L100   129 18,273 SH   SOLE   18,273 0 0
Lucid Group Inc Common Stock 549498103   109 15,963 SH   SOLE   15,963 0 0
Linde PLC Common Stock G5494J103   313 959 SH   SOLE   959 0 0
Eli Lilly & Co Common Stock 532457108   667 1,823 SH   SOLE   1,823 0 0
Lockheed Martin Corp Common Stock 539830109   221 454 SH   SOLE   454 0 0
Lowe's Cos Inc Common Stock 548661107   239 1,202 SH   SOLE   1,202 0 0
Lam Research Corp Common Stock 512807108   1,119 2,662 SH   SOLE   2,662 0 0
Lufax Holding Ltd ADR 54975P102   9,932 5,119,132 SH   DFND   5,119,132 0 0
Lululemon Athletica Inc Common Stock 550021109   2,394 7,472 SH   SOLE   7,472 0 0
Las Vegas Sands Corp Common Stock 517834107   361 7,516 SH   SOLE   7,516 0 0
Lyell Immunopharma Inc Common Stock 55083R104   105 30,177 SH   SOLE   30,177 0 0
Mastercard Inc Common Stock 57636Q104   2,953 8,493 SH   SOLE   8,493 0 0
Marriott International Inc/MD Common Stock 571903202   1,226 8,237 SH   SOLE   8,237 0 0
McDonald's Corp Common Stock 580135101   373 1,415 SH   SOLE   1,415 0 0
Microchip Technology Inc Common Stock 595017104   755 10,751 SH   SOLE   10,751 0 0
McKesson Corp Common Stock 58155Q103   211 563 SH   SOLE   563 0 0
Seres Therapeutics Inc Common Stock 81750R102   93 16,667 SH   SOLE   16,667 0 0
Madrigal Pharmaceuticals Inc Common Stock 558868105   1,606 5,532 SH   SOLE   5,532 0 0
Mondelez International Inc Common Stock 609207105   1,040 15,608 SH   SOLE   15,608 0 0
Medtronic PLC Common Stock G5960L103   305 3,918 SH   SOLE   3,918 0 0
MercadoLibre Inc Common Stock 58733R102   405 478 SH   SOLE   478 0 0
Meta Platforms Inc Common Stock 30303M102   3,094 25,714 SH   SOLE   25,714 0 0
MannKind Corp Common Stock 56400P706   354 67,201 SH   SOLE   67,201 0 0
Monster Beverage Corp Common Stock 61174X109   579 5,703 SH   SOLE   5,703 0 0
Merck & Co Inc Common Stock 58933Y105   654 5,893 SH   SOLE   5,893 0 0
Moderna Inc Common Stock 60770K107   1,307 7,278 SH   SOLE   7,278 0 0
Mersana Therapeutics Inc Common Stock 59045L106   128 21,844 SH   SOLE   21,844 0 0
Mirati Therapeutics Inc Common Stock 60468T105   456 10,055 SH   SOLE   10,055 0 0
Marvell Technology Inc Common Stock 573874104   300 8,099 SH   SOLE   8,099 0 0
Morgan Stanley Common Stock 617446448   219 2,575 SH   SOLE   2,575 0 0
Microsoft Corp Common Stock 594918104   30,925 128,951 SH   SOLE   128,951 0 0
Motorola Solutions Inc Common Stock 620076307   433 1,682 SH   SOLE   1,682 0 0
Micron Technology Inc Common Stock 595112103   1,235 24,714 SH   SOLE   24,714 0 0
Myriad Genetics Inc Common Stock 62855J104   157 10,822 SH   SOLE   10,822 0 0
Myovant Sciences Ltd Common Stock G637AM102   391 14,510 SH   SOLE   14,510 0 0
Neurocrine Biosciences Inc Common Stock 64125C109   431 3,606 SH   SOLE   3,606 0 0
Norwegian Cruise Line Holdings Common Stock G66721104   130 10,598 SH   SOLE   10,598 0 0
NextEra Energy Inc Common Stock 65339F101   322 3,847 SH   SOLE   3,847 0 0
Netflix Inc Common Stock 64110L106   1,499 5,084 SH   SOLE   5,084 0 0
NIKE Inc Common Stock 654106103   2,349 20,073 SH   SOLE   20,073 0 0
ServiceNow Inc Common Stock 81762P102   784 2,020 SH   SOLE   2,020 0 0
Intellia Therapeutics Inc Common Stock 45826J105   387 11,103 SH   SOLE   11,103 0 0
Natera Inc Common Stock 632307104   445 11,083 SH   SOLE   11,083 0 0
Novavax Inc Common Stock 670002401   263 25,601 SH   SOLE   25,601 0 0
NVIDIA Corp Common Stock 67066G104   7,459 51,039 SH   SOLE   51,039 0 0
NXP Semiconductors NV Common Stock N6596X109   799 5,056 SH   SOLE   5,056 0 0
Ocugen Inc Common Stock 67577C105   168 129,498 SH   SOLE   129,498 0 0
Old Dominion Freight Line Inc Common Stock 679580100   350 1,232 SH   SOLE   1,232 0 0
ON Semiconductor Corp Common Stock 682189105   1,029 16,504 SH   SOLE   16,504 0 0
Oracle Corp Common Stock 68389X105   1,257 15,378 SH   SOLE   15,378 0 0
O'Reilly Automotive Inc Common Stock 67103H107   605 717 SH   SOLE   717 0 0
Palo Alto Networks Inc Common Stock 697435105   401 2,873 SH   SOLE   2,873 0 0
Paychex Inc Common Stock 704326107   769 6,657 SH   SOLE   6,657 0 0
PACCAR Inc Common Stock 693718108   395 3,994 SH   SOLE   3,994 0 0
Vaxcyte Inc Common Stock 92243G108   476 9,933 SH   SOLE   9,933 0 0
Pinduoduo Inc ADR 722304102   296,426 3,634,894 SH   DFND   3,634,894 0 0
PepsiCo Inc Common Stock 713448108   2,846 15,754 SH   SOLE   15,754 0 0
Pfizer Inc Common Stock 717081103   663 12,939 SH   SOLE   12,939 0 0
Procter & Gamble Co/The Common Stock 742718109   696 4,595 SH   SOLE   4,595 0 0
Prologis Inc REIT 74340W103   200 1,776 SH   SOLE   1,776 0 0
Philip Morris International In Common Stock 718172109   304 3,001 SH   SOLE   3,001 0 0
PMV Pharmaceuticals Inc Common Stock 69353Y103   121 13,884 SH   SOLE   13,884 0 0
Point Biopharma Global Inc Common Stock 730541109   113 15,530 SH   SOLE   15,530 0 0
Prothena Corp PLC Common Stock G72800108   436 7,243 SH   SOLE   7,243 0 0
PTC Therapeutics Inc Common Stock 69366J200   423 11,083 SH   SOLE   11,083 0 0
Protagonist Therapeutics Inc Common Stock 74366E102   169 15,482 SH   SOLE   15,482 0 0
PayPal Holdings Inc Common Stock 70450Y103   1,585 22,255 SH   SOLE   22,255 0 0
QUALCOMM Inc Common Stock 747525103   28,168 256,212 SH   SOLE   256,212 0 0
360 DigiTech Inc ADR 88557W101   14,366 705,588 SH   DFND   705,588 0 0
uniQure NV Common Stock N90064101   235 10,350 SH   SOLE   10,350 0 0
Ultragenyx Pharmaceutical Inc Common Stock 90400D108   482 10,398 SH   SOLE   10,398 0 0
Rocket Pharmaceuticals Inc Common Stock 77313F106   301 15,400 SH   SOLE   15,400 0 0
Royal Caribbean Cruises Ltd Common Stock V7780T103   452 9,137 SH   SOLE   9,137 0 0
Arcus Biosciences Inc Common Stock 03969F109   211 10,214 SH   SOLE   10,214 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107   1,395 1,933 SH   SOLE   1,933 0 0
iShares MSCI Global Gold Miner ETP 46434G855   3,672 164,424 SH   SOLE   164,424 0 0
Relay Therapeutics Inc Common Stock 75943R102   369 24,680 SH   SOLE   24,680 0 0
Avidity Biosciences Inc Common Stock 05370A108   276 12,446 SH   SOLE   12,446 0 0
Roivant Sciences Ltd Common Stock G76279101   105 13,110 SH   SOLE   13,110 0 0
Roper Technologies Inc Common Stock 776696106   461 1,066 SH   SOLE   1,066 0 0
Ross Stores Inc Common Stock 778296103   461 3,969 SH   SOLE   3,969 0 0
Raytheon Technologies Corp Common Stock 75513E101   287 2,839 SH   SOLE   2,839 0 0
REVOLUTION Medicines Inc Common Stock 76155X100   296 12,441 SH   SOLE   12,441 0 0
Prometheus Biosciences Inc Common Stock 74349U108   422 3,836 SH   SOLE   3,836 0 0
Recursion Pharmaceuticals Inc Common Stock 75629V104   209 27,111 SH   SOLE   27,111 0 0
Rhythm Pharmaceuticals Inc Common Stock 76243J105   468 16,056 SH   SOLE   16,056 0 0
Sage Therapeutics Inc Common Stock 78667J108   328 8,588 SH   SOLE   8,588 0 0
Sana Biotechnology Inc Common Stock 799566104   106 26,824 SH   SOLE   26,824 0 0
Starbucks Corp Common Stock 855244109   1,301 13,110 SH   SOLE   13,110 0 0
Charles Schwab Corp/The Common Stock 808513105   244 2,936 SH   SOLE   2,936 0 0
Sea Ltd ADR 81141R100   38,538 740,681 SH   SOLE   740,681 0 0
Seagen Inc Common Stock 81181C104   665 5,173 SH   SOLE   5,173 0 0
Sangamo Therapeutics Inc Common Stock 800677106   116 37,007 SH   SOLE   37,007 0 0
Sirius XM Holdings Inc Common Stock 82968B103   216 36,947 SH   SOLE   36,947 0 0
Syndax Pharmaceuticals Inc Common Stock 87164F105   353 13,863 SH   SOLE   13,863 0 0
Synopsys Inc Common Stock 871607107   954 2,987 SH   SOLE   2,987 0 0
S&P Global Inc Common Stock 78409V104   216 645 SH   SOLE   645 0 0
Sorrento Therapeutics Inc Common Stock 83587F202   198 223,808 SH   SOLE   223,808 0 0
Sarepta Therapeutics Inc Common Stock 803607100   463 3,573 SH   SOLE   3,573 0 0
STAAR Surgical Co Common Stock 852312305   43,797 902,296 SH   SOLE   902,296 0 0
SpringWorks Therapeutics Inc Common Stock 85205L107   434 16,705 SH   SOLE   16,705 0 0
Stryker Corp Common Stock 863667101   266 1,086 SH   SOLE   1,086 0 0
AT&T Inc Common Stock 00206R102   252 13,702 SH   SOLE   13,702 0 0
TAL Education Group ADR 874080104   20,634 2,926,782 SH   DFND   2,926,782 0 0
TE Connectivity Ltd Common Stock H84989104   366 3,184 SH   SOLE   3,184 0 0
TG Therapeutics Inc Common Stock 88322Q108   466 39,393 SH   SOLE   39,393 0 0
Tencent Music Entertainment Gr ADR 88034P109   74,986 9,056,308 SH   DFND   9,056,308 0 0
Thermo Fisher Scientific Inc Common Stock 883556102   523 950 SH   SOLE   950 0 0
T-Mobile US Inc Common Stock 872590104   1,817 12,977 SH   SOLE   12,977 0 0
Tesla Inc Common Stock 88160R101   4,032 32,734 SH   SOLE   32,734 0 0
TSMC ADR 874039100   32,254 433,000 SH   SOLE   433,000 0 0
Travere Therapeutics Inc Common Stock 89422G107   352 16,751 SH   SOLE   16,751 0 0
Twist Bioscience Corp Common Stock 90184D100   410 17,231 SH   SOLE   17,231 0 0
Texas Instruments Inc Common Stock 882508104   2,925 17,703 SH   SOLE   17,703 0 0
UnitedHealth Group Inc Common Stock 91324P102   1,065 2,008 SH   SOLE   2,008 0 0
Union Pacific Corp Common Stock 907818108   247 1,191 SH   SOLE   1,191 0 0
United Parcel Service Inc Common Stock 911312106   245 1,408 SH   SOLE   1,408 0 0
United States 12 Month Oil Fun ETP 91288V103   1,043 29,387 SH   SOLE   29,387 0 0
United States Oil Fund LP ETP 91232N207   1,744 24,869 SH   SOLE   24,869 0 0
United Therapeutics Corp Common Stock 91307C102   419 1,508 SH   SOLE   1,508 0 0
Visa Inc Common Stock 92826C839   3,399 16,361 SH   SOLE   16,361 0 0
Vericel Corp Common Stock 92346J108   241 9,131 SH   SOLE   9,131 0 0
Veracyte Inc Common Stock 92337F107   350 14,767 SH   SOLE   14,767 0 0
Verve Therapeutics Inc Common Stock 92539P101   378 19,523 SH   SOLE   19,523 0 0
Vipshop Holdings Ltd ADR 92763W103   33,333 2,443,723 SH   DFND   2,443,723 0 0
Vir Biotechnology Inc Common Stock 92764N102   409 16,178 SH   SOLE   16,178 0 0
Verisk Analytics Inc Common Stock 92345Y106   317 1,795 SH   SOLE   1,795 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100   1,337 4,630 SH   SOLE   4,630 0 0
Viatris Inc Common Stock 92556V106   137 12,294 SH   SOLE   12,294 0 0
Verizon Communications Inc Common Stock 92343V104   320 8,131 SH   SOLE   8,131 0 0
Weibo Corp ADR 948596101   10,379 542,816 SH   DFND   542,816 0 0
Walgreens Boots Alliance Inc Common Stock 931427108   360 9,638 SH   SOLE   9,638 0 0
Warner Bros Discovery Inc Common Stock 934423104   260 27,453 SH   SOLE   27,453 0 0
Workday Inc Common Stock 98138H101   321 1,919 SH   SOLE   1,919 0 0
Wells Fargo & Co Common Stock 949746101   305 7,377 SH   SOLE   7,377 0 0
Walmart Inc Common Stock 931142103   389 2,741 SH   SOLE   2,741 0 0
Wolfspeed Inc Common Stock 977852102   1,170 16,941 SH   SOLE   16,941 0 0
Xcel Energy Inc Common Stock 98389B100   440 6,281 SH   SOLE   6,281 0 0
Exxon Mobil Corp Common Stock 30231G102   880 7,974 SH   SOLE   7,974 0 0
Full Truck Alliance Co Ltd ADR 35969L108   47,517 5,939,632 SH   DFND   5,939,632 0 0
JOYY Inc ADR 46591M109   9,013 285,312 SH   DFND   285,312 0 0
Zentalis Pharmaceuticals Inc Common Stock 98943L107   242 12,016 SH   SOLE   12,016 0 0
Zoetis Inc Common Stock 98978V103   234 1,599 SH   SOLE   1,599 0 0
Dada Nexus Ltd ADR 23344D108   329 47,270 SH   SOLE   47,270 0 0
Daqo New Energy Corp ADR 23703Q203   1,566 40,552 SH   SOLE   40,552 0 0
Futu Holdings Ltd ADR 36118L106   225 5,533 SH   SOLE   5,533 0 0
H World Group Ltd ETP 44332N106   5,538 130,541 SH   SOLE   130,541 0 0
iShares iBoxx $ Investment Gra ADR 464287242   833 7,900 SH   SOLE   7,900 0 0
KE Holdings Inc ADR 52490G102   6,290 450,576 SH   SOLE   450,576 0 0
Legend Biotech Corp ADR 62914V106   1,649 33,033 SH   SOLE   33,033 0 0
NIO Inc ADR 89677Q107   9,029 926,083 SH   SOLE   926,083 0 0
Pinduoduo Inc ADR 98850P109   33,918 415,917 SH   SOLE   415,917 0 0
TAL Education Group ADR 98887Q104   2,151 305,039 SH   SOLE   305,039 0 0
Trip.com Group Ltd ADR 98980A105   12,686 368,783 SH   SOLE   368,783 0 0