The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Pinduoduo Inc ADR 722304102 207,389 3,355,809 SH   SOLE   3,355,809 0 0
KE Holdings Inc ADR 482497104 70,902 3,949,958 SH   SOLE   3,949,958 0 0
Kanzhun Ltd ADR 48553T106 61,027 2,322,212 SH   DFND   2,322,212 0 0
Full Truck Alliance Co Ltd ADR 35969L108 53,053 5,855,708 SH   DFND   5,855,708 0 0
STAAR Surgical Co Common Stock 852312305 51,942 732,296 SH   SOLE   732,296 0 0
Apple Inc Common Stock 037833100 34,879 255,115 SH   SOLE   255,115 0 0
Lufax Holding Ltd ADR 54975P102 32,055 5,342,534 SH   DFND   5,342,534 0 0
Microsoft Corp Common Stock 594918104 31,288 121,825 SH   SOLE   121,825 0 0
Vipshop Holdings Ltd ADR 92763W103 23,896 2,416,163 SH   DFND   2,416,163 0 0
Sea Ltd ADR 81141R100 22,866 342,000 SH   SOLE   342,000 0 0
Alphabet Inc Common Stock 02079K107 21,113 9,652 SH   SOLE   9,652 0 0
Tencent Music Entertainment Gr ADR 88034P109 20,160 4,015,963 SH   DFND   4,015,963 0 0
MercadoLibre Inc Common Stock 58733R102 20,049 31,481 SH   SOLE   31,481 0 0
Meta Platforms Inc Common Stock 30303M102 20,047 124,322 SH   SOLE   124,322 0 0
NIO Inc SPON ADS 62914V106 19,597 902,272 SH   SOLE   902,272 0 0
Pinduoduo Inc SPONSORED ADS 722304102 18,827 304,651 SH   SOLE   304,651 0 0
Autohome Inc ADR 05278C107 17,561 446,512 SH   DFND   446,512 0 0
Li Auto Inc SPONSORED ADS 50202M102 14,386 375,507 SH   SOLE   375,507 0 0
Yum China Holdings Inc COM 98850P109 14,176 292,285 SH   SOLE   292,285 0 0
360 DigiTech Inc ADR 88557W101 10,546 609,589 SH   DFND   609,589 0 0
Trip.com Group Ltd ADS 89677Q107 10,215 372,121 SH   SOLE   372,121 0 0
iQIYI Inc ADR 46267X108 9,721 2,314,661 SH   DFND   2,314,661 0 0
XPeng Inc ADS 98422D105 9,222 290,544 SH   SOLE   290,544 0 0
TAL Education Group ADR 874080104 9,006 1,849,330 SH   SOLE   1,849,330 0 0
JOYY Inc ADR 46591M109 8,843 296,152 SH   DFND   296,152 0 0
Weibo Corp ADR 948596101 8,832 381,849 SH   SOLE   381,849 0 0
Amazon.com Inc Common Stock 023135106 8,065 75,936 SH   SOLE   75,936 0 0
ZTO Express Cayman Inc SPONSORED ADS A 98980A105 7,949 289,575 SH   SOLE   289,575 0 0
Tesla Inc Common Stock 88160R101 7,621 11,317 SH   SOLE   11,317 0 0
QUALCOMM Inc Common Stock 747525103 7,344 57,494 SH   SOLE   57,494 0 0
NVIDIA Corp Common Stock 67066G104 7,068 46,625 SH   SOLE   46,625 0 0
DiDi Global Inc SPONSORED ADS 23292E108 6,500 2,203,522 SH   SOLE   2,203,522 0 0
Zhihu Inc ADR 98955N108 5,370 3,000,000 SH   SOLE   3,000,000 0 0
BeiGene Ltd SPONSORED ADS 07725L102 5,215 32,219 SH   SOLE   32,219 0 0
Huazhu Group Ltd SPONSORED ADS 44332N106 5,094 133,704 SH   SOLE   133,704 0 0
Alphabet Inc Common Stock 02079K305 5,075 2,329 SH   SOLE   2,329 0 0
I-Mab ADR 44975P103 4,657 412,157 SH   SOLE   412,157 0 0
United States Brent Oil Fund L ETP 91167Q100 4,043 123,500 SH   SOLE   123,500 0 0
iShares Gold Trust ETP 464285204 4,035 117,596 SH   SOLE   117,596 0 0
SPDR Gold MiniShares Trust ETP 98149E303 4,032 112,379 SH   SOLE   112,379 0 0
Broadcom Inc Common Stock 11135F101 3,983 8,198 SH   SOLE   8,198 0 0
United States Oil Fund LP ETP 91232N207 3,961 49,300 SH   SOLE   49,300 0 0
Invesco DB Oil Fund ETP 46140H403 3,958 217,000 SH   SOLE   217,000 0 0
KE Holdings Inc SPONSORED ADS 482497104 3,902 217,400 SH   SOLE   217,400 0 0
Cisco Systems Inc Common Stock 17275R102 3,554 83,346 SH   SOLE   83,346 0 0
Adobe Inc Common Stock 00724F101 3,474 9,489 SH   SOLE   9,489 0 0
Visa Inc Common Stock 92826C839 3,413 17,335 SH   SOLE   17,335 0 0
iShares MSCI Global Gold Miner ETP 46434G855 3,387 155,529 SH   SOLE   155,529 0 0
Intel Corp Common Stock 458140100 3,072 82,117 SH   SOLE   82,117 0 0
Daqo New Energy Corp SPNSRD ADS NEW 23703Q203 2,873 40,248 SH   SOLE   40,248 0 0
Mastercard Inc Common Stock 57636Q104 2,854 9,047 SH   SOLE   9,047 0 0
Texas Instruments Inc Common Stock 882508104 2,845 18,518 SH   SOLE   18,518 0 0
PepsiCo Inc Common Stock 713448108 2,658 15,949 SH   SOLE   15,949 0 0
Estee Lauder Cos Inc/The Common Stock 518439104 2,517 9,885 SH   SOLE   9,885 0 0
Advanced Micro Devices Inc Common Stock 007903107 2,490 32,563 SH   SOLE   32,563 0 0
Costco Wholesale Corp Common Stock 22160K105 2,451 5,113 SH   SOLE   5,113 0 0
JinkoSolar Holding Co Ltd SPONSORED ADR 47759T100 2,421 35,000 SH   SOLE   35,000 0 0
NIKE Inc Common Stock 654106103 2,345 22,947 SH   SOLE   22,947 0 0
Lululemon Athletica Inc Common Stock 550021109 2,316 8,496 SH   SOLE   8,496 0 0
Intuit Inc Common Stock 461202103 2,187 5,673 SH   SOLE   5,673 0 0
Zai Lab Ltd ADR 98887Q104 2,067 59,590 SH   SOLE   59,590 0 0
Amgen Inc Common Stock 031162100 2,044 8,400 SH   SOLE   8,400 0 0
Comcast Corp Common Stock 20030N101 2,024 51,586 SH   SOLE   51,586 0 0
Grab Holdings Ltd Common Stock G4124C109 2,024 800,000 SH   SOLE   800,000 0 0
VanEck Gold Miners ETF/USA ETP 92189F106 1,863 68,027 SH   SOLE   68,027 0 0
Accenture PLC Common Stock G1151C101 1,852 6,672 SH   SOLE   6,672 0 0
T-Mobile US Inc Common Stock 872590104 1,768 13,140 SH   SOLE   13,140 0 0
Automatic Data Processing Inc Common Stock 053015103 1,762 8,389 SH   SOLE   8,389 0 0
Legend Biotech Corp SPONSORED ADS 52490G102 1,729 31,444 SH   SOLE   31,444 0 0
Salesforce Inc Common Stock 79466L302 1,727 10,467 SH   SOLE   10,467 0 0
PayPal Holdings Inc Common Stock 70450Y103 1,624 23,249 SH   SOLE   23,249 0 0
Applied Materials Inc Common Stock 038222105 1,603 17,621 SH   SOLE   17,621 0 0
Analog Devices Inc Common Stock 032654105 1,531 10,482 SH   SOLE   10,482 0 0
Gilead Sciences Inc Common Stock 375558103 1,440 23,304 SH   SOLE   23,304 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100 1,425 5,056 SH   SOLE   5,056 0 0
TAL Education Group SPONSORED ADS 874080104 1,399 287,170 SH   SOLE   287,170 0 0
United States 12 Month Oil Fun ETP 91288V103 1,385 35,000 SH   SOLE   35,000 0 0
Honeywell International Inc Common Stock 438516106 1,365 7,852 SH   SOLE   7,852 0 0
International Business Machine Common Stock 459200101 1,338 9,474 SH   SOLE   9,474 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 1,290 2,183 SH   SOLE   2,183 0 0
Moderna Inc Common Stock 60770K107 1,243 8,703 SH   SOLE   8,703 0 0
Micron Technology Inc Common Stock 595112103 1,239 22,416 SH   SOLE   22,416 0 0
Lam Research Corp Common Stock 512807108 1,188 2,788 SH   SOLE   2,788 0 0
Oracle Corp Common Stock 68389X105 1,159 16,582 SH   SOLE   16,582 0 0
Marriott International Inc/MD Common Stock 571903202 1,140 8,380 SH   SOLE   8,380 0 0
AbbVie Inc Common Stock 00287Y109 1,112 7,258 SH   SOLE   7,258 0 0
Weibo Corp SPONSORED ADR 948596101 1,105 47,752 SH   SOLE   47,752 0 0
SPDR Gold Shares ETP 78463V107 1,097 6,510 SH   SOLE   6,510 0 0
Fiserv Inc Common Stock 337738108 1,095 12,305 SH   SOLE   12,305 0 0
UnitedHealth Group Inc Common Stock 91324P102 1,062 2,067 SH   SOLE   2,067 0 0
Johnson & Johnson Common Stock 478160104 1,029 5,798 SH   SOLE   5,798 0 0
ProShares Ultra Gold ETP 74347W601 1,012 17,903 SH   SOLE   17,903 0 0
Starbucks Corp Common Stock 855244109 1,010 13,223 SH   SOLE   13,223 0 0
ServiceNow Inc Common Stock 81762P102 1,004 2,112 SH   SOLE   2,112 0 0
Mondelez International Inc Common Stock 609207105 991 15,963 SH   SOLE   15,963 0 0
Berkshire Hathaway Inc Common Stock 084670702 981 3,593 SH   SOLE   3,593 0 0
KLA Corp Common Stock 482480100 957 2,998 SH   SOLE   2,998 0 0
Synopsys Inc Common Stock 871607107 933 3,073 SH   SOLE   3,073 0 0
Intuitive Surgical Inc Common Stock 46120E602 927 4,621 SH   SOLE   4,621 0 0
Biogen Inc Common Stock 09062X103 898 4,404 SH   SOLE   4,404 0 0
Netflix Inc Common Stock 64110L106 896 5,124 SH   SOLE   5,124 0 0
iShares iBoxx $ Investment Gr IBOXX INV CP ETF 464287242 869 7,900 SH   SOLE   7,900 0 0
Seagen Inc Common Stock 81181C104 867 4,899 SH   SOLE   4,899 0 0
Charter Communications Inc Common Stock 16119P108 859 1,833 SH   SOLE   1,833 0 0
Cadence Design Systems Inc Common Stock 127387108 832 5,543 SH   SOLE   5,543 0 0
Fortinet Inc Common Stock 34959E109 832 14,705 SH   SOLE   14,705 0 0
Booking Holdings Inc Common Stock 09857L108 822 470 SH   SOLE   470 0 0
NXP Semiconductors NV Common Stock N6596X109 779 5,265 SH   SOLE   5,265 0 0
Paychex Inc Common Stock 704326107 778 6,832 SH   SOLE   6,832 0 0
Autodesk Inc Common Stock 052769106 751 4,366 SH   SOLE   4,366 0 0
HUTCHMED China Ltd SPONSORED ADR 44842L103 744 58,861 SH   SOLE   58,861 0 0
CSX Corp Common Stock 126408103 729 25,090 SH   SOLE   25,090 0 0
Exxon Mobil Corp Common Stock 30231G102 716 8,365 SH   SOLE   8,365 0 0
Cognizant Technology Solutions Common Stock 192446102 706 10,456 SH   SOLE   10,456 0 0
Activision Blizzard Inc Common Stock 00507V109 702 9,019 SH   SOLE   9,019 0 0
Pfizer Inc Common Stock 717081103 688 13,119 SH   SOLE   13,119 0 0
Procter & Gamble Co/The Common Stock 742718109 685 4,764 SH   SOLE   4,764 0 0
JPMorgan Chase & Co Common Stock 46625H100 657 5,832 SH   SOLE   5,832 0 0
Direxion Daily Gold Miners Ind ETP 25460G781 654 19,048 SH   SOLE   19,048 0 0
Microchip Technology Inc Common Stock 595017104 647 11,147 SH   SOLE   11,147 0 0
Global Blood Therapeutics Inc Common Stock 37890U108 618 19,349 SH   SOLE   19,349 0 0
Eli Lilly & Co Common Stock 532457108 616 1,899 SH   SOLE   1,899 0 0
Incyte Corp Common Stock 45337C102 607 7,987 SH   SOLE   7,987 0 0
Fidelity National Information Common Stock 31620M106 589 6,429 SH   SOLE   6,429 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 582 52,755 SH   SOLE   52,755 0 0
Twist Bioscience Corp Common Stock 90184D100 572 16,351 SH   SOLE   16,351 0 0
American Electric Power Co Inc Common Stock 025537101 568 5,924 SH   SOLE   5,924 0 0
Chevron Corp Common Stock 166764100 565 3,902 SH   SOLE   3,902 0 0
Amicus Therapeutics Inc Common Stock 03152W109 563 52,439 SH   SOLE   52,439 0 0
Home Depot Inc/The Common Stock 437076102 563 2,052 SH   SOLE   2,052 0 0
Merck & Co Inc Common Stock 58933Y105 561 6,156 SH   SOLE   6,156 0 0
Novavax Inc Common Stock 670002401 554 10,780 SH   SOLE   10,780 0 0
Fate Therapeutics Inc Common Stock 31189P102 548 22,103 SH   SOLE   22,103 0 0
Karuna Therapeutics Inc Common Stock 48576A100 546 4,316 SH   SOLE   4,316 0 0
PTC Therapeutics Inc Common Stock 69366J200 543 13,553 SH   SOLE   13,553 0 0
Monster Beverage Corp Common Stock 61174X109 538 5,805 SH   SOLE   5,805 0 0
Intellia Therapeutics Inc Common Stock 45826J105 534 10,315 SH   SOLE   10,315 0 0
Keurig Dr Pepper Inc Common Stock 49271V100 531 15,011 SH   SOLE   15,011 0 0
Thermo Fisher Scientific Inc Common Stock 883556102 525 966 SH   SOLE   966 0 0
Ultragenyx Pharmaceutical Inc Common Stock 90400D108 524 8,779 SH   SOLE   8,779 0 0
Beam Therapeutics Inc Common Stock 07373V105 512 13,237 SH   SOLE   13,237 0 0
Exelon Corp Common Stock 30161N101 512 11,307 SH   SOLE   11,307 0 0
Arrowhead Pharmaceuticals Inc Common Stock 04280A100 505 14,347 SH   SOLE   14,347 0 0
Exelixis Inc Common Stock 30161Q104 503 24,138 SH   SOLE   24,138 0 0
Kraft Heinz Co/The Common Stock 500754106 499 13,088 SH   SOLE   13,088 0 0
Mirati Therapeutics Inc Common Stock 60468T105 498 7,413 SH   SOLE   7,413 0 0
SpringWorks Therapeutics Inc Common Stock 85205L107 493 20,031 SH   SOLE   20,031 0 0
Coca-Cola Co/The Common Stock 191216100 487 7,747 SH   SOLE   7,747 0 0
Alnylam Pharmaceuticals Inc Common Stock 02043Q107 483 3,315 SH   SOLE   3,315 0 0
BioMarin Pharmaceutical Inc Common Stock 09061G101 483 5,832 SH   SOLE   5,832 0 0
Apellis Pharmaceuticals Inc Common Stock 03753U106 482 10,651 SH   SOLE   10,651 0 0
Vir Biotechnology Inc Common Stock 92764N102 482 18,939 SH   SOLE   18,939 0 0
O'Reilly Automotive Inc Common Stock 67103H107 480 760 SH   SOLE   760 0 0
Abbott Laboratories Common Stock 002824100 476 4,385 SH   SOLE   4,385 0 0
Alkermes PLC Common Stock G01767105 475 15,946 SH   SOLE   15,946 0 0
Sarepta Therapeutics Inc Common Stock 803607100 475 6,333 SH   SOLE   6,333 0 0
Bridgebio Pharma Inc Common Stock 10806X102 472 51,948 SH   SOLE   51,948 0 0
BioCryst Pharmaceuticals Inc Common Stock 09058V103 470 44,408 SH   SOLE   44,408 0 0
Palo Alto Networks Inc Common Stock 697435105 470 951 SH   SOLE   951 0 0
United Therapeutics Corp Common Stock 91307C102 468 1,985 SH   SOLE   1,985 0 0
Ionis Pharmaceuticals Inc Common Stock 462222100 466 12,597 SH   SOLE   12,597 0 0
Editas Medicine Inc Common Stock 28106W103 465 39,341 SH   SOLE   39,341 0 0
Blueprint Medicines Corp Common Stock 09627Y109 460 9,109 SH   SOLE   9,109 0 0
Emergent BioSolutions Inc Common Stock 29089Q105 454 14,640 SH   SOLE   14,640 0 0
Natera Inc Common Stock 632307104 454 12,803 SH   SOLE   12,803 0 0
Veracyte Inc Common Stock 92337F107 454 22,816 SH   SOLE   22,816 0 0
Neurocrine Biosciences Inc Common Stock 64125C109 453 4,643 SH   SOLE   4,643 0 0
Arcus Biosciences Inc Common Stock 03969F109 450 17,775 SH   SOLE   17,775 0 0
Xcel Energy Inc Common Stock 98389B100 445 6,283 SH   SOLE   6,283 0 0
Biohaven Pharmaceutical Holdin Common Stock G11196105 443 3,039 SH   SOLE   3,039 0 0
IDEXX Laboratories Inc Common Stock 45168D104 442 1,259 SH   SOLE   1,259 0 0
Halozyme Therapeutics Inc Common Stock 40637H109 440 10,000 SH   SOLE   10,000 0 0
Roper Technologies Inc Common Stock 776696106 440 1,115 SH   SOLE   1,115 0 0
Bank of America Corp Common Stock 060505104 438 14,078 SH   SOLE   14,078 0 0
Dexcom Inc Common Stock 252131107 438 5,872 SH   SOLE   5,872 0 0
Cytokinetics Inc Common Stock 23282W605 436 11,086 SH   SOLE   11,086 0 0
ChemoCentryx Inc Common Stock 16383L106 433 17,480 SH   SOLE   17,480 0 0
Ironwood Pharmaceuticals Inc Common Stock 46333X108 430 37,265 SH   SOLE   37,265 0 0
Cintas Corp Common Stock 172908105 428 1,147 SH   SOLE   1,147 0 0
Bristol-Myers Squibb Co Common Stock 110122108 427 5,545 SH   SOLE   5,545 0 0
Danaher Corp Common Stock 235851102 425 1,678 SH   SOLE   1,678 0 0
Illumina Inc Common Stock 452327109 423 2,295 SH   SOLE   2,295 0 0
Verizon Communications Inc Common Stock 92343V104 423 8,339 SH   SOLE   8,339 0 0
Exact Sciences Corp Common Stock 30063P105 418 10,620 SH   SOLE   10,620 0 0
ANSYS Inc Common Stock 03662Q105 417 1,744 SH   SOLE   1,744 0 0
CRISPR Therapeutics AG Common Stock H17182108 417 6,868 SH   SOLE   6,868 0 0
CareDx Inc Common Stock 14167L103 414 19,289 SH   SOLE   19,289 0 0
Insmed Inc Common Stock 457669307 414 21,006 SH   SOLE   21,006 0 0
Horizon Therapeutics Plc Common Stock G46188101 409 5,126 SH   SOLE   5,126 0 0
Amphenol Corp Common Stock 032095101 405 6,290 SH   SOLE   6,290 0 0
Dollar Tree Inc Common Stock 256746108 404 2,591 SH   SOLE   2,591 0 0
Zentalis Pharmaceuticals Inc Common Stock 98943L107 403 14,356 SH   SOLE   14,356 0 0
JD.com Inc ADR 47215P106 402 6,264 SH   DFND   6,264 0 0
Sorrento Therapeutics Inc Common Stock 83587F202 395 196,273 SH   SOLE   196,273 0 0
Electronic Arts Inc Common Stock 285512109 393 3,231 SH   SOLE   3,231 0 0
PMV Pharmaceuticals Inc Common Stock 69353Y103 392 27,501 SH   SOLE   27,501 0 0
ASML Holding NV NY Reg Shrs N07059210 389 818 SH   SOLE   818 0 0
IVERIC bio Inc Common Stock 46583P102 387 40,201 SH   SOLE   40,201 0 0
ImmunoGen Inc Common Stock 45253H101 386 85,764 SH   SOLE   85,764 0 0
TE Connectivity Ltd Common Stock H84989104 384 3,391 SH   SOLE   3,391 0 0
Celldex Therapeutics Inc Common Stock 15117B202 383 14,200 SH   SOLE   14,200 0 0
Dynavax Technologies Corp Common Stock 268158201 382 30,319 SH   SOLE   30,319 0 0
Motorola Solutions Inc Common Stock 620076307 369 1,760 SH   SOLE   1,760 0 0
Walgreens Boots Alliance Inc Common Stock 931427108 367 9,671 SH   SOLE   9,671 0 0
AstraZeneca PLC ADR 046353108 365 5,518 SH   SOLE   5,518 0 0
HP Inc Common Stock 40434L105 364 11,096 SH   SOLE   11,096 0 0
McDonald's Corp Common Stock 580135101 363 1,469 SH   SOLE   1,469 0 0
Travere Therapeutics Inc Common Stock 89422G107 362 14,954 SH   SOLE   14,954 0 0
ACADIA Pharmaceuticals Inc Common Stock 004225108 361 25,621 SH   SOLE   25,621 0 0
Ocugen Inc Common Stock 67577C105 361 158,884 SH   SOLE   158,884 0 0
Marvell Technology Inc Common Stock 573874104 353 8,115 SH   SOLE   8,115 0 0
Sage Therapeutics Inc Common Stock 78667J108 352 10,895 SH   SOLE   10,895 0 0
Crowdstrike Holdings Inc Common Stock 22788C105 343 2,037 SH   SOLE   2,037 0 0
Denali Therapeutics Inc Common Stock 24823R105 343 11,641 SH   SOLE   11,641 0 0
Relay Therapeutics Inc Common Stock 75943R102 343 20,475 SH   SOLE   20,475 0 0
VeriSign Inc Common Stock 92343E102 343 2,049 SH   SOLE   2,049 0 0
Walt Disney Co/The Common Stock 254687106 341 3,617 SH   SOLE   3,617 0 0
CVS Health Corp Common Stock 126650100 340 3,664 SH   SOLE   3,664 0 0
Kymera Therapeutics Inc Common Stock 501575104 340 17,243 SH   SOLE   17,243 0 0
Walmart Inc Common Stock 931142103 339 2,788 SH   SOLE   2,788 0 0
Medtronic PLC Common Stock G5960L103 335 3,729 SH   SOLE   3,729 0 0
Fastenal Co Common Stock 311900104 331 6,638 SH   SOLE   6,638 0 0
Elevance Health Inc Common Stock 036752103 330 683 SH   SOLE   683 0 0
PACCAR Inc Common Stock 693718108 330 4,010 SH   SOLE   4,010 0 0
Global Payments Inc Common Stock 37940X102 329 2,973 SH   SOLE   2,973 0 0
Airbnb Inc Common Stock 009066101 325 3,650 SH   SOLE   3,650 0 0
Old Dominion Freight Line Inc Common Stock 679580100 324 1,265 SH   SOLE   1,265 0 0
Turning Point Therapeutics Inc Common Stock 90041T108 321 4,268 SH   SOLE   4,268 0 0
Verisk Analytics Inc Common Stock 92345Y106 316 1,823 SH   SOLE   1,823 0 0
Baidu Inc ADR 056752108 307 2,064 SH   SOLE   2,064 0 0
Align Technology Inc Common Stock 016255101 304 1,286 SH   SOLE   1,286 0 0
Philip Morris International In Common Stock 718172109 304 3,078 SH   SOLE   3,078 0 0
Agios Pharmaceuticals Inc Common Stock 00847X104 303 13,673 SH   SOLE   13,673 0 0
NextEra Energy Inc Common Stock 65339F101 302 3,901 SH   SOLE   3,901 0 0
CTI BioPharma Corp Common Stock 12648L601 300 50,171 SH   SOLE   50,171 0 0
Enanta Pharmaceuticals Inc Common Stock 29251M106 299 6,320 SH   SOLE   6,320 0 0
Skyworks Solutions Inc Common Stock 83088M102 299 3,225 SH   SOLE   3,225 0 0
AT&T Inc Common Stock 00206R102 298 14,215 SH   SOLE   14,215 0 0
TG Therapeutics Inc Common Stock 88322Q108 298 70,105 SH   SOLE   70,105 0 0
Wells Fargo & Co Common Stock 949746101 295 7,526 SH   SOLE   7,526 0 0
Copart Inc Common Stock 217204106 293 2,693 SH   SOLE   2,693 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 290 167,474 SH   SOLE   167,474 0 0
Vericel Corp Common Stock 92346J108 289 11,497 SH   SOLE   11,497 0 0
Linde PLC Common Stock G5494J103 288 1,000 SH   SOLE   1,000 0 0
Ligand Pharmaceuticals Inc Common Stock 53220K504 287 3,221 SH   SOLE   3,221 0 0
Allogene Therapeutics Inc Common Stock 019770106 285 25,006 SH   SOLE   25,006 0 0
Protagonist Therapeutics Inc Common Stock 74366E102 285 36,033 SH   SOLE   36,033 0 0
Raytheon Technologies Corp Common Stock 75513E101 284 2,953 SH   SOLE   2,953 0 0
Ross Stores Inc Common Stock 778296103 284 4,049 SH   SOLE   4,049 0 0
Enphase Energy Inc Common Stock 29355A107 278 1,422 SH   SOLE   1,422 0 0
Carnival Corp Common Stock 143658300 277 32,016 SH   SOLE   32,016 0 0
Lucid Group Inc Common Stock 549498103 273 15,926 SH   SOLE   15,926 0 0
Sana Biotechnology Inc Common Stock 799566104 273 42,452 SH   SOLE   42,452 0 0
Cigna Corp Common Stock 125523100 269 1,021 SH   SOLE   1,021 0 0
eBay Inc Common Stock 278642103 269 6,459 SH   SOLE   6,459 0 0
Union Pacific Corp Common Stock 907818108 266 1,247 SH   SOLE   1,247 0 0
United Parcel Service Inc Common Stock 911312106 266 1,459 SH   SOLE   1,459 0 0
Zoetis Inc Common Stock 98978V103 266 1,545 SH   SOLE   1,545 0 0
Workday Inc Common Stock 98138H101 265 1,900 SH   SOLE   1,900 0 0
Keysight Technologies Inc Common Stock 49338L103 264 1,916 SH   SOLE   1,916 0 0
Zoom Video Communications Inc Common Stock 98980L101 259 2,403 SH   SOLE   2,403 0 0
Datadog Inc Common Stock 23804L103 257 2,703 SH   SOLE   2,703 0 0
Atlassian Corp PLC Common Stock G06242104 256 1,365 SH   SOLE   1,365 0 0
Madrigal Pharmaceuticals Inc Common Stock 558868105 256 3,570 SH   SOLE   3,570 0 0
Prothena Corp PLC Common Stock G72800108 254 9,345 SH   SOLE   9,345 0 0
Corning Inc Common Stock 219350105 252 7,997 SH   SOLE   7,997 0 0
Krystal Biotech Inc Common Stock 501147102 250 3,808 SH   SOLE   3,808 0 0
Heron Therapeutics Inc Common Stock 427746102 242 86,581 SH   SOLE   86,581 0 0
Intercept Pharmaceuticals Inc Common Stock 45845P108 242 17,559 SH   SOLE   17,559 0 0
Karyopharm Therapeutics Inc Common Stock 48576U106 238 52,671 SH   SOLE   52,671 0 0
Becton Dickinson and Co Common Stock 075887109 237 963 SH   SOLE   963 0 0
American Tower Corp REIT 03027X100 236 923 SH   SOLE   923 0 0
Deciphera Pharmaceuticals Inc Common Stock 24344T101 236 17,953 SH   SOLE   17,953 0 0
S&P Global Inc Common Stock 78409V104 233 691 SH   SOLE   691 0 0
ConocoPhillips Common Stock 20825C104 231 2,573 SH   SOLE   2,573 0 0
iTeos Therapeutics Inc Common Stock 46565G104 231 11,236 SH   SOLE   11,236 0 0
Sirius XM Holdings Inc Common Stock 82968B103 231 37,608 SH   SOLE   37,608 0 0
Match Group Inc Common Stock 57667L107 230 3,294 SH   SOLE   3,294 0 0
ON Semiconductor Corp Common Stock 682189105 230 4,577 SH   SOLE   4,577 0 0
REVOLUTION Medicines Inc Common Stock 76155X100 230 11,805 SH   SOLE   11,805 0 0
Lowe's Cos Inc Common Stock 548661107 229 1,313 SH   SOLE   1,313 0 0
Myriad Genetics Inc Common Stock 62855J104 227 12,481 SH   SOLE   12,481 0 0
CDW Corp/DE Common Stock 12514G108 224 1,420 SH   SOLE   1,420 0 0
Cerevel Therapeutics Holdings Common Stock 15678U128 224 8,484 SH   SOLE   8,484 0 0
Stryker Corp Common Stock 863667101 224 1,124 SH   SOLE   1,124 0 0
Arista Networks Inc Common Stock 040413106 222 2,367 SH   SOLE   2,367 0 0
Humana Inc Common Stock 444859102 222 474 SH   SOLE   474 0 0
REGENXBIO Inc Common Stock 75901B107 221 8,967 SH   SOLE   8,967 0 0
Agenus Inc Common Stock 00847G705 219 112,839 SH   SOLE   112,839 0 0
Edwards Lifesciences Corp Common Stock 28176E108 218 2,297 SH   SOLE   2,297 0 0
Xencor Inc Common Stock 98401F105 217 7,917 SH   SOLE   7,917 0 0
Arcturus Therapeutics Holdings Common Stock 03969T109 216 13,735 SH   SOLE   13,735 0 0
Constellation Energy Corp Common Stock 21037T109 216 3,765 SH   SOLE   3,765 0 0
Royal Caribbean Cruises Ltd Common Stock V7780T103 216 6,175 SH   SOLE   6,175 0 0
Vaxart Inc Common Stock 92243A200 216 61,614 SH   SOLE   61,614 0 0
Avid Bioservices Inc Common Stock 05368M106 214 13,994 SH   SOLE   13,994 0 0
Morgan Stanley Common Stock 617446448 211 2,779 SH   SOLE   2,779 0 0
Gartner Inc Common Stock 366651107 206 850 SH   SOLE   850 0 0
Boston Scientific Corp Common Stock 101137107 205 5,493 SH   SOLE   5,493 0 0
Centene Corp Common Stock 15135B101 203 2,401 SH   SOLE   2,401 0 0
Goldman Sachs Group Inc/The Common Stock 38141G104 203 682 SH   SOLE   682 0 0
Lockheed Martin Corp Common Stock 539830109 203 471 SH   SOLE   471 0 0
Morphic Holding Inc Common Stock 61775R105 201 9,266 SH   SOLE   9,266 0 0
Zscaler Inc Common Stock 98980G102 201 1,347 SH   SOLE   1,347 0 0
Atara Biotherapeutics Inc Common Stock 046513107 200 25,622 SH   SOLE   25,622 0 0
Kura Oncology Inc Common Stock 50127T109 194 10,573 SH   SOLE   10,573 0 0
Anavex Life Sciences Corp Common Stock 032797300 193 19,244 SH   SOLE   19,244 0 0
uniQure NV Common Stock N90064101 193 10,364 SH   SOLE   10,364 0 0
Coherus Biosciences Inc Common Stock 19249H103 188 25,990 SH   SOLE   25,990 0 0
FibroGen Inc Common Stock 31572Q808 184 17,443 SH   SOLE   17,443 0 0
Hewlett Packard Enterprise Co Common Stock 42824C109 181 13,665 SH   SOLE   13,665 0 0
MannKind Corp Common Stock 56400P706 177 46,376 SH   SOLE   46,376 0 0
Alector Inc Common Stock 014442107 166 16,372 SH   SOLE   16,372 0 0
Catalyst Pharmaceuticals Inc Common Stock 14888U101 150 21,335 SH   SOLE   21,335 0 0
Myovant Sciences Ltd Common Stock G637AM102 150 12,091 SH   SOLE   12,091 0 0
Radius Health Inc Common Stock 750469207 142 13,662 SH   SOLE   13,662 0 0
Rigel Pharmaceuticals Inc Common Stock 766559603 141 124,818 SH   SOLE   124,818 0 0
Gossamer Bio Inc Common Stock 38341P102 137 16,419 SH   SOLE   16,419 0 0
Sangamo Therapeutics Inc Common Stock 800677106 131 31,592 SH   SOLE   31,592 0 0
Organogenesis Holdings Inc Common Stock 68621F102 126 25,808 SH   SOLE   25,808 0 0
Norwegian Cruise Line Holdings Common Stock G66721104 118 10,598 SH   SOLE   10,598 0 0
Viatris Inc Common Stock 92556V106 117 11,183 SH   SOLE   11,183 0 0
EQRx Inc Common Stock 26886C107 103 21,875 SH   SOLE   21,875 0 0
Praxis Precision Medicines Inc Common Stock 74006W108 64 26,064 SH   SOLE   26,064 0 0
Geron Corp Common Stock 374163103 60 38,992 SH   SOLE   38,992 0 0
MiMedx Group Inc Common Stock 602496101 42 11,994 SH   SOLE   11,994 0 0
Adagene Inc ADR 005329107 39 19,310 SH   SOLE   19,310 0 0