The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Alibaba Group Holding Ltd ADR 01609W102 1,098,911 9,250,871 SH   SOLE   9,250,871 0 0
JD.com Inc ADR 47215P106 278,230 3,970,745 SH   SOLE   3,970,745 0 0
Baidu Inc ADR 056752108 230,906 1,551,891 SH   DFND   1,551,891 0 0
Pinduoduo Inc ADR 722304102 178,302 3,058,357 SH   DFND   3,058,357 0 0
NetEase Inc ADR 64110W102 174,680 1,716,251 SH   SOLE   1,716,251 0 0
Trip.com Group Ltd ADR 89677Q107 69,896 2,839,002 SH   DFND   2,839,002 0 0
KE Holdings Inc ADR 482497104 52,746 2,621,590 SH   DFND   2,621,590 0 0
Apple Inc Common Stock 037833100 43,498 244,960 SH   SOLE   244,960 0 0
Bilibili Inc ADR 090040106 40,476 872,335 SH   DFND   872,335 0 0
Microsoft Corp Common Stock 594918104 38,932 115,759 SH   SOLE   115,759 0 0
Full Truck Alliance Co Ltd ADR 35969L108 38,670 4,620,023 SH   SOLE   4,620,023 0 0
Kanzhun Ltd ADR 48553T106 38,550 1,105,207 SH   DFND   1,105,207 0 0
Tencent Music Entertainment Gr ADR 88034P109 20,864 3,045,858 SH   DFND   3,045,858 0 0
I-Mab ADR 44975P103 18,424 388,773 SH   DFND   388,773 0 0
Vipshop Holdings Ltd ADR 92763W103 17,885 2,129,128 SH   DFND   2,129,128 0 0
Lufax Holding Ltd ADR 54975P102 17,524 3,112,525 SH   SOLE   3,112,525 0 0
Zhihu Inc ADR 98955N108 13,168 2,376,827 SH   SOLE   2,376,827 0 0
NVIDIA Corp Common Stock 67066G104 13,034 44,317 SH   SOLE   44,317 0 0
Amazon.com Inc Common Stock 023135106 12,797 3,838 SH   SOLE   3,838 0 0
STAAR Surgical Co Common Stock 852312305 12,079 132,296 SH   SOLE   132,296 0 0
JOYY Inc ADR 46591M109 11,221 247,003 SH   DFND   247,003 0 0
360 DigiTech Inc ADR 88557W101 10,830 472,277 SH   DFND   472,277 0 0
NIO Inc ADR 62914V106 10,718 338,309 SH   DFND   338,309 0 0
Autohome Inc ADR 05278C107 10,131 343,653 SH   DFND   343,653 0 0
Weibo Corp ADR 948596101 9,551 308,302 SH   DFND   308,302 0 0
Kingsoft Cloud Holdings Ltd ADR 49639K101 9,202 584,289 SH   DFND   584,289 0 0
Tesla Inc Common Stock 88160R101 9,138 8,647 SH   SOLE   8,647 0 0
TAL Education Group ADR 874080104 9,038 2,299,747 SH   DFND   2,299,747 0 0
United States Oil Fund LP ETP 91232N207 8,698 160,000 SH   SOLE   160,000 0 0
United States Brent Oil Fund L ETP 91167Q100 8,573 410,000 SH   SOLE   410,000 0 0
Meta Platforms Inc Common Stock 30303M102 8,514 25,312 SH   SOLE   25,312 0 0
Invesco DB Oil Fund ETP 46140H403 8,401 620,000 SH   SOLE   620,000 0 0
iQIYI Inc ADR 46267X108 7,921 1,737,130 SH   DFND   1,737,130 0 0
SPDR S&P 500 ETF Trust ETP 78462F103 7,552 15,900 SH   DFND   15,900 0 0
Invesco QQQ Trust Series 1 ETP 46090E103 7,480 18,800 SH   DFND   18,800 0 0
51job Inc ADR 316827104 7,337 149,964 SH   DFND   149,964 0 0
Alphabet Inc Common Stock 02079K107 7,000 2,419 SH   SOLE   2,419 0 0
Alphabet Inc Common Stock 02079K305 6,863 2,369 SH   SOLE   2,369 0 0
Hello Group Inc ADR 423403104 6,638 739,149 SH   DFND   739,149 0 0
Agora Inc ADR 00851L103 6,602 407,266 SH   DFND   407,266 0 0
Dada Nexus Ltd ADR 23344D108 5,409 411,070 SH   DFND   411,070 0 0
Vnet Group Inc ADR 90138A103 5,246 580,909 SH   DFND   580,909 0 0
Chindata Group Holdings Ltd ADR 16955F107 5,244 795,735 SH   DFND   795,735 0 0
Broadcom Inc Common Stock 11135F101 5,235 7,868 SH   SOLE   7,868 0 0
Yum China Holdings Inc Common Stock 98850P109 5,212 104,565 SH   DFND   104,565 0 0
Adobe Inc Common Stock 00724F101 5,169 9,115 SH   SOLE   9,115 0 0
Cisco Systems Inc/Delaware Common Stock 17275R102 5,113 80,692 SH   SOLE   80,692 0 0
iShares MSCI Global Gold Miner ETP 46434G855 5,047 187,129 SH   SOLE   187,129 0 0
iShares Gold Trust ETP 464285204 4,990 143,343 SH   SOLE   143,343 0 0
SPDR Gold MiniShares Trust ETP 98149E204 4,987 274,301 SH   SOLE   274,301 0 0
XPeng Inc ADR 98422D105 4,854 96,438 SH   DFND   96,438 0 0
Li Auto Inc ADR 50202M102 4,396 136,944 SH   DFND   136,944 0 0
PayPal Holdings Inc Common Stock 70450Y103 4,242 22,492 SH   SOLE   22,492 0 0
Intel Corp Common Stock 458140100 4,003 77,732 SH   SOLE   77,732 0 0
QUALCOMM Inc Common Stock 747525103 3,923 21,454 SH   SOLE   21,454 0 0
Visa Inc Common Stock 92826C839 3,544 16,353 SH   SOLE   16,353 0 0
Intuit Inc Common Stock 461202103 3,488 5,423 SH   SOLE   5,423 0 0
Advanced Micro Devices Inc Common Stock 007903107 3,335 23,177 SH   SOLE   23,177 0 0
Texas Instruments Inc Common Stock 882508104 3,334 17,689 SH   SOLE   17,689 0 0
BeiGene Ltd ADR 07725L102 3,135 11,572 SH   DFND   11,572 0 0
Netflix Inc Common Stock 64110L106 3,098 5,142 SH   SOLE   5,142 0 0
United States 12 Month Oil Fun ETP 91288V103 3,072 110,000 SH   SOLE   110,000 0 0
Estee Lauder Cos Inc/The Common Stock 518439104 3,056 8,255 SH   SOLE   8,255 0 0
ZTO Express Cayman Inc ADR 98980A105 3,048 108,002 SH   DFND   108,002 0 0
Mastercard Inc Common Stock 57636Q104 3,041 8,464 SH   SOLE   8,464 0 0
Lululemon Athletica Inc Common Stock 550021109 2,983 7,621 SH   SOLE   7,621 0 0
Costco Wholesale Corp Common Stock 22160K105 2,911 5,128 SH   SOLE   5,128 0 0
PepsiCo Inc Common Stock 713448108 2,788 16,052 SH   SOLE   16,052 0 0
Applied Materials Inc Common Stock 038222105 2,722 17,301 SH   SOLE   17,301 0 0
Comcast Corp Common Stock 20030N101 2,674 53,135 SH   SOLE   53,135 0 0
NIKE Inc Common Stock 654106103 2,563 15,380 SH   SOLE   15,380 0 0
Accenture PLC Common Stock G1151C101 2,554 6,162 SH   SOLE   6,162 0 0
VanEck Gold Miners ETF/USA ETP 92189F106 2,451 76,525 SH   SOLE   76,525 0 0
salesforce.com Inc Common Stock 79466L302 2,426 9,545 SH   SOLE   9,545 0 0
Micron Technology Inc Common Stock 595112103 1,997 21,438 SH   SOLE   21,438 0 0
Automatic Data Processing Inc Common Stock 053015103 1,991 8,074 SH   SOLE   8,074 0 0
Marriott International Inc/MD Common Stock 571903202 1,974 11,949 SH   SOLE   11,949 0 0
Lam Research Corp Common Stock 512807108 1,952 2,714 SH   SOLE   2,714 0 0
Analog Devices Inc Common Stock 032654105 1,810 10,298 SH   SOLE   10,298 0 0
Amgen Inc Common Stock 031162100 1,792 7,965 SH   SOLE   7,965 0 0
Honeywell International Inc Common Stock 438516106 1,667 7,997 SH   SOLE   7,997 0 0
Huazhu Group Ltd ADR 44332N106 1,667 44,648 SH   DFND   44,648 0 0
Intuitive Surgical Inc Common Stock 46120E602 1,616 4,498 SH   SOLE   4,498 0 0
Starbucks Corp Common Stock 855244109 1,599 13,668 SH   SOLE   13,668 0 0
T-Mobile US Inc Common Stock 872590104 1,509 13,013 SH   SOLE   13,013 0 0
Moderna Inc Common Stock 60770K107 1,454 5,723 SH   SOLE   5,723 0 0
Gilead Sciences Inc Common Stock 375558103 1,373 18,905 SH   SOLE   18,905 0 0
Oracle Corp Common Stock 68389X105 1,372 15,727 SH   SOLE   15,727 0 0
Charter Communications Inc Common Stock 16119P108 1,278 1,960 SH   SOLE   1,960 0 0
ServiceNow Inc Common Stock 81762P102 1,259 1,940 SH   SOLE   1,940 0 0
KLA Corp Common Stock 482480100 1,248 2,901 SH   SOLE   2,901 0 0
Fiserv Inc Common Stock 337738108 1,246 12,005 SH   SOLE   12,005 0 0
ProShares Ultra Gold ETP 74347W601 1,238 20,694 SH   SOLE   20,694 0 0
Direxion Daily Gold Miners Ind ETP 25460G781 1,233 24,101 SH   SOLE   24,101 0 0
Berkshire Hathaway Inc Common Stock 084670702 1,210 4,048 SH   SOLE   4,048 0 0
Zai Lab Ltd ADR 98887Q104 1,192 18,963 SH   DFND   18,963 0 0
Autodesk Inc Common Stock 052769106 1,184 4,211 SH   SOLE   4,211 0 0
UnitedHealth Group Inc Common Stock 91324P102 1,174 2,337 SH   SOLE   2,337 0 0
International Business Machine Common Stock 459200101 1,168 8,741 SH   SOLE   8,741 0 0
NXP Semiconductors NV Common Stock N6596X109 1,160 5,092 SH   SOLE   5,092 0 0
Booking Holdings Inc Common Stock 09857L108 1,149 479 SH   SOLE   479 0 0
Johnson & Johnson Common Stock 478160104 1,121 6,553 SH   SOLE   6,553 0 0
Synopsys Inc Common Stock 871607107 1,079 2,928 SH   SOLE   2,928 0 0
Mondelez International Inc Common Stock 609207105 1,070 16,140 SH   SOLE   16,140 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 1,053 1,667 SH   SOLE   1,667 0 0
GDS Holdings Ltd ADR 36165L108 1,045 22,167 SH   DFND   22,167 0 0
JPMorgan Chase & Co Common Stock 46625H100 1,034 6,532 SH   SOLE   6,532 0 0
Fortinet Inc Common Stock 34959E109 1,026 2,856 SH   SOLE   2,856 0 0
Xilinx Inc Common Stock 983919101 1,016 4,794 SH   SOLE   4,794 0 0
Cadence Design Systems Inc Common Stock 127387108 979 5,253 SH   SOLE   5,253 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100 970 4,418 SH   SOLE   4,418 0 0
CSX Corp Common Stock 126408103 969 25,759 SH   SOLE   25,759 0 0
Home Depot Inc/The Common Stock 437076102 968 2,333 SH   SOLE   2,333 0 0
Microchip Technology Inc Common Stock 595017104 934 10,728 SH   SOLE   10,728 0 0
Cognizant Technology Solutions Common Stock 192446102 892 10,050 SH   SOLE   10,050 0 0
SPDR Gold Shares ETP 78463V107 892 5,218 SH   SOLE   5,218 0 0
Paychex Inc Common Stock 704326107 890 6,520 SH   SOLE   6,520 0 0
Procter & Gamble Co/The Common Stock 742718109 876 5,356 SH   SOLE   5,356 0 0
Pfizer Inc Common Stock 717081103 868 14,704 SH   SOLE   14,704 0 0
AbbVie Inc Common Stock 00287Y109 848 6,263 SH   SOLE   6,263 0 0
Illumina Inc Common Stock 452327109 813 2,138 SH   SOLE   2,138 0 0
New Oriental Education & Tech ADR 647581107 805 383,295 SH   DFND   383,295 0 0
IDEXX Laboratories Inc Common Stock 45168D104 789 1,198 SH   SOLE   1,198 0 0
HUTCHMED China Ltd ADR 44842L103 753 21,465 SH   DFND   21,465 0 0
Align Technology Inc Common Stock 016255101 726 1,105 SH   SOLE   1,105 0 0
Dexcom Inc Common Stock 252131107 721 1,342 SH   SOLE   1,342 0 0
Biogen Inc Common Stock 09062X103 715 2,981 SH   SOLE   2,981 0 0
Bank of America Corp Common Stock 060505104 708 15,918 SH   SOLE   15,918 0 0
Thermo Fisher Scientific Inc Common Stock 883556102 707 1,059 SH   SOLE   1,059 0 0
Abbott Laboratories Common Stock 002824100 679 4,826 SH   SOLE   4,826 0 0
Marvell Technology Inc Common Stock 573874104 678 7,745 SH   SOLE   7,745 0 0
ANSYS Inc Common Stock 03662Q105 673 1,677 SH   SOLE   1,677 0 0
Hilton Worldwide Holdings Inc Common Stock 43300A203 670 4,296 SH   SOLE   4,296 0 0
Exelon Corp Common Stock 30161N101 658 11,388 SH   SOLE   11,388 0 0
Fidelity National Information Common Stock 31620M106 650 5,955 SH   SOLE   5,955 0 0
MercadoLibre Inc Common Stock 58733R102 630 467 SH   SOLE   467 0 0
Eli Lilly & Co Common Stock 532457108 623 2,256 SH   SOLE   2,256 0 0
Walt Disney Co/The Common Stock 254687106 621 4,010 SH   SOLE   4,010 0 0
ASML Holding NV NY Reg Shrs N07059210 610 766 SH   SOLE   766 0 0
Activision Blizzard Inc Common Stock 00507V109 600 9,025 SH   SOLE   9,025 0 0
Danaher Corp Common Stock 235851102 589 1,789 SH   SOLE   1,789 0 0
Lucid Group Inc Common Stock 549498103 589 15,480 SH   SOLE   15,480 0 0
Daqo New Energy Corp ADR 23703Q203 585 14,511 SH   DFND   14,511 0 0
Exxon Mobil Corp Common Stock 30231G102 572 9,342 SH   SOLE   9,342 0 0
Monster Beverage Corp Common Stock 61174X109 561 5,844 SH   SOLE   5,844 0 0
Merck & Co Inc Common Stock 58933Y105 558 7,280 SH   SOLE   7,280 0 0
O'Reilly Automotive Inc Common Stock 67103H107 553 783 SH   SOLE   783 0 0
Airbnb Inc Common Stock 009066101 543 3,261 SH   SOLE   3,261 0 0
American Electric Power Co Inc Common Stock 025537101 519 5,838 SH   SOLE   5,838 0 0
Cintas Corp Common Stock 172908105 517 1,167 SH   SOLE   1,167 0 0
Palo Alto Networks Inc Common Stock 697435105 516 927 SH   SOLE   927 0 0
TE Connectivity Ltd Common Stock H84989104 513 3,181 SH   SOLE   3,181 0 0
Amphenol Corp Common Stock 032095101 508 5,813 SH   SOLE   5,813 0 0
Coca-Cola Co/The Common Stock 191216100 508 8,573 SH   SOLE   8,573 0 0
VeriSign Inc Common Stock 92343E102 505 1,990 SH   SOLE   1,990 0 0
Walgreens Boots Alliance Inc Common Stock 931427108 505 9,684 SH   SOLE   9,684 0 0
Atlassian Corp PLC Common Stock G06242104 503 1,320 SH   SOLE   1,320 0 0
Chevron Corp Common Stock 166764100 501 4,267 SH   SOLE   4,267 0 0
Workday Inc Common Stock 98138H101 499 1,828 SH   SOLE   1,828 0 0
Keurig Dr Pepper Inc Common Stock 49271V100 488 13,229 SH   SOLE   13,229 0 0
Skyworks Solutions Inc Common Stock 83088M102 485 3,129 SH   SOLE   3,129 0 0
eBay Inc Common Stock 278642103 484 7,271 SH   SOLE   7,271 0 0
Kraft Heinz Co/The Common Stock 500754106 476 13,248 SH   SOLE   13,248 0 0
Verizon Communications Inc Common Stock 92343V104 475 9,136 SH   SOLE   9,136 0 0
Ross Stores Inc Common Stock 778296103 466 4,081 SH   SOLE   4,081 0 0
Seagen Inc Common Stock 81181C104 456 2,951 SH   SOLE   2,951 0 0
Walmart Inc Common Stock 931142103 456 3,153 SH   SOLE   3,153 0 0
Motorola Solutions Inc Common Stock 620076307 447 1,644 SH   SOLE   1,644 0 0
Bristol-Myers Squibb Co Common Stock 110122108 442 7,086 SH   SOLE   7,086 0 0
Electronic Arts Inc Common Stock 285512109 442 3,351 SH   SOLE   3,351 0 0
McDonald's Corp Common Stock 580135101 442 1,648 SH   SOLE   1,648 0 0
Verisk Analytics Inc Common Stock 92345Y106 436 1,907 SH   SOLE   1,907 0 0
Match Group Inc Common Stock 57667L107 434 3,280 SH   SOLE   3,280 0 0
Adagene Inc ADR 005329107 433 54,085 SH   SOLE   54,085 0 0
Datadog Inc Common Stock 23804L103 431 2,418 SH   SOLE   2,418 0 0
CVS Health Corp Common Stock 126650100 429 4,157 SH   SOLE   4,157 0 0
Fastenal Co Common Stock 311900104 427 6,661 SH   SOLE   6,661 0 0
HP Inc Common Stock 40434L105 423 11,239 SH   SOLE   11,239 0 0
Wells Fargo & Co Common Stock 949746101 423 8,813 SH   SOLE   8,813 0 0
Xcel Energy Inc Common Stock 98389B100 423 6,242 SH   SOLE   6,242 0 0
Zoom Video Communications Inc Common Stock 98980L101 423 2,298 SH   SOLE   2,298 0 0
Zscaler Inc Common Stock 98980G102 423 1,316 SH   SOLE   1,316 0 0
Medtronic PLC Common Stock G5960L103 421 4,066 SH   SOLE   4,066 0 0
Legend Biotech Corp ADR 52490G102 416 8,927 SH   DFND   8,927 0 0
Copart Inc Common Stock 217204106 405 2,668 SH   SOLE   2,668 0 0
NextEra Energy Inc Common Stock 65339F101 404 4,329 SH   SOLE   4,329 0 0
Lowe's Cos Inc Common Stock 548661107 396 1,531 SH   SOLE   1,531 0 0
Crowdstrike Holdings Inc Common Stock 22788C105 395 1,931 SH   SOLE   1,931 0 0
Linde PLC Common Stock G5494J103 393 1,135 SH   SOLE   1,135 0 0
AT&T Inc Common Stock 00206R102 388 15,756 SH   SOLE   15,756 0 0
Zoetis Inc Common Stock 98978V103 385 1,576 SH   SOLE   1,576 0 0
Global Payments Inc Common Stock 37940X102 382 2,826 SH   SOLE   2,826 0 0
Anthem Inc Common Stock 036752103 381 823 SH   SOLE   823 0 0
DiDi Global Inc ADR 23292E108 374 75,199 SH   DFND   75,199 0 0
Dollar Tree Inc Common Stock 256746108 370 2,631 SH   SOLE   2,631 0 0
Keysight Technologies Inc Common Stock 49338L103 370 1,790 SH   SOLE   1,790 0 0
EPAM Systems Inc Common Stock 29414B104 369 552 SH   SOLE   552 0 0
Incyte Corp Common Stock 45337C102 363 4,947 SH   SOLE   4,947 0 0
Carnival Corp Common Stock 143658300 358 17,780 SH   SOLE   17,780 0 0
Union Pacific Corp Common Stock 907818108 358 1,421 SH   SOLE   1,421 0 0
PACCAR Inc Common Stock 693718108 355 4,022 SH   SOLE   4,022 0 0
United Parcel Service Inc Common Stock 911312106 344 1,607 SH   SOLE   1,607 0 0
Philip Morris International In Common Stock 718172109 327 3,439 SH   SOLE   3,439 0 0
Stryker Corp Common Stock 863667101 324 1,212 SH   SOLE   1,212 0 0
Arena Pharmaceuticals Inc Common Stock 040047607 323 3,473 SH   SOLE   3,473 0 0
Arista Networks Inc Common Stock 040413106 314 2,186 SH   SOLE   2,186 0 0
Okta Inc Common Stock 679295105 313 1,395 SH   SOLE   1,395 0 0
Morgan Stanley Common Stock 617446448 311 3,173 SH   SOLE   3,173 0 0
Edwards Lifesciences Corp Common Stock 28176E108 309 2,385 SH   SOLE   2,385 0 0
Zebra Technologies Corp Common Stock 989207105 309 519 SH   SOLE   519 0 0
Cigna Corp Common Stock 125523100 300 1,305 SH   SOLE   1,305 0 0
American Tower Corp REIT 03027X100 293 1,000 SH   SOLE   1,000 0 0
BlackRock Inc Common Stock 09247X101 287 314 SH   SOLE   314 0 0
Goldman Sachs Group Inc/The Common Stock 38141G104 287 750 SH   SOLE   750 0 0
Raytheon Technologies Corp Common Stock 75513E101 286 3,327 SH   SOLE   3,327 0 0
Becton Dickinson and Co Common Stock 075887109 285 1,135 SH   SOLE   1,135 0 0
Corning Inc Common Stock 219350105 279 7,481 SH   SOLE   7,481 0 0
Charles Schwab Corp/The Common Stock 808513105 279 3,312 SH   SOLE   3,312 0 0
DocuSign Inc Common Stock 256163106 277 1,820 SH   SOLE   1,820 0 0
Prologis Inc REIT 74340W103 275 1,631 SH   SOLE   1,631 0 0
CDW Corp/DE Common Stock 12514G108 272 1,329 SH   SOLE   1,329 0 0
Gartner Inc Common Stock 366651107 270 808 SH   SOLE   808 0 0
HCA Healthcare Inc Common Stock 40412C101 266 1,035 SH   SOLE   1,035 0 0
Citigroup Inc Common Stock 172967424 265 4,386 SH   SOLE   4,386 0 0
Royal Caribbean Cruises Ltd Common Stock V7780T103 264 3,427 SH   SOLE   3,427 0 0
Boston Scientific Corp Common Stock 101137107 260 6,125 SH   SOLE   6,125 0 0
Teradyne Inc Common Stock 880770102 260 1,592 SH   SOLE   1,592 0 0
Humana Inc Common Stock 444859102 255 549 SH   SOLE   549 0 0
Target Corp Common Stock 87612E106 252 1,087 SH   SOLE   1,087 0 0
S&P Global Inc Common Stock 78409V104 250 529 SH   SOLE   529 0 0
Caterpillar Inc Common Stock 149123101 247 1,196 SH   SOLE   1,196 0 0
IQVIA Holdings Inc Common Stock 46266C105 246 873 SH   SOLE   873 0 0
Boeing Co/The Common Stock 097023105 245 1,215 SH   SOLE   1,215 0 0
Enphase Energy Inc Common Stock 29355A107 241 1,315 SH   SOLE   1,315 0 0
Biohaven Pharmaceutical Holdin Common Stock G11196105 240 1,739 SH   SOLE   1,739 0 0
Sirius XM Holdings Inc Common Stock 82968B103 239 37,608 SH   SOLE   37,608 0 0
Centene Corp Common Stock 15135B101 234 2,839 SH   SOLE   2,839 0 0
Agilent Technologies Inc Common Stock 00846U101 231 1,447 SH   SOLE   1,447 0 0
General Electric Co Common Stock 369604301 229 2,422 SH   SOLE   2,422 0 0
American Express Co Common Stock 025816109 227 1,387 SH   SOLE   1,387 0 0
3M Co Common Stock 88579Y101 227 1,276 SH   SOLE   1,276 0 0
Baxter International Inc Common Stock 071813109 225 2,618 SH   SOLE   2,618 0 0
Seagate Technology Holdings PL Common Stock G7997R103 225 1,993 SH   SOLE   1,993 0 0
Cytokinetics Inc Common Stock 23282W605 219 4,804 SH   SOLE   4,804 0 0
Mettler-Toledo International I Common Stock 592688105 219 129 SH   SOLE   129 0 0
McKesson Corp Common Stock 58155Q103 216 869 SH   SOLE   869 0 0
Cerner Corp Common Stock 156782104 215 2,312 SH   SOLE   2,312 0 0
Deere & Co Common Stock 244199105 215 626 SH   SOLE   626 0 0
Tyler Technologies Inc Common Stock 902252105 215 399 SH   SOLE   399 0 0
Trimble Inc Common Stock 896239100 213 2,440 SH   SOLE   2,440 0 0
ConocoPhillips Common Stock 20825C104 210 2,916 SH   SOLE   2,916 0 0
West Pharmaceutical Services I Common Stock 955306105 209 445 SH   SOLE   445 0 0
Turning Point Therapeutics Inc Common Stock 90041T108 208 4,366 SH   SOLE   4,366 0 0
Broadridge Financial Solutions Common Stock 11133T103 207 1,133 SH   SOLE   1,133 0 0
Monolithic Power Systems Inc Common Stock 609839105 207 420 SH   SOLE   420 0 0
BioCryst Pharmaceuticals Inc Common Stock 09058V103 206 14,885 SH   SOLE   14,885 0 0
Fate Therapeutics Inc Common Stock 31189P102 206 3,528 SH   SOLE   3,528 0 0
ResMed Inc Common Stock 761152107 205 787 SH   SOLE   787 0 0
Halozyme Therapeutics Inc Common Stock 40637H109 202 5,027 SH   SOLE   5,027 0 0
TJX Cos Inc/The Common Stock 872540109 201 2,651 SH   SOLE   2,651 0 0
Hewlett Packard Enterprise Co Common Stock 42824C109 200 12,712 SH   SOLE   12,712 0 0
Kymera Therapeutics Inc Common Stock 501575104 200 3,150 SH   SOLE   3,150 0 0
Laboratory Corp of America Hol Common Stock 50540R409 200 637 SH   SOLE   637 0 0
NetApp Inc Common Stock 64110D104 200 2,172 SH   SOLE   2,172 0 0
TG Therapeutics Inc Common Stock 88322Q108 199 10,466 SH   SOLE   10,466 0 0
IVERIC bio Inc Common Stock 46583P102 198 11,828 SH   SOLE   11,828 0 0
Amicus Therapeutics Inc Common Stock 03152W109 195 16,869 SH   SOLE   16,869 0 0
Bluebird Bio Inc Common Stock 09609G100 193 19,354 SH   SOLE   19,354 0 0
Exelixis Inc Common Stock 30161Q104 189 10,364 SH   SOLE   10,364 0 0
Dynavax Technologies Corp Common Stock 268158201 182 12,946 SH   SOLE   12,946 0 0
Ironwood Pharmaceuticals Inc Common Stock 46333X108 182 15,602 SH   SOLE   15,602 0 0
Deciphera Pharmaceuticals Inc Common Stock 24344T101 175 17,933 SH   SOLE   17,933 0 0
Vaxart Inc Common Stock 92243A200 174 27,743 SH   SOLE   27,743 0 0
Agenus Inc Common Stock 00847G705 173 53,590 SH   SOLE   53,590 0 0
Heron Therapeutics Inc Common Stock 427746102 168 18,367 SH   SOLE   18,367 0 0
Viatris Inc Common Stock 92556V106 167 12,354 SH   SOLE   12,354 0 0
Invitae Corp Common Stock 46185L103 165 10,779 SH   SOLE   10,779 0 0
Ocugen Inc Common Stock 67577C105 147 32,254 SH   SOLE   32,254 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 143 28,570 SH   SOLE   28,570 0 0
OPKO Health Inc Common Stock 68375N103 135 28,039 SH   SOLE   28,039 0 0
Sorrento Therapeutics Inc Common Stock 83587F202 129 27,832 SH   SOLE   27,832 0 0
Clovis Oncology Inc Common Stock 189464100 118 43,630 SH   SOLE   43,630 0 0
G1 Therapeutics Inc Common Stock 3621LQ109 116 11,327 SH   SOLE   11,327 0 0
MannKind Corp Common Stock 56400P706 116 26,451 SH   SOLE   26,451 0 0
Organogenesis Holdings Inc Common Stock 68621F102 116 12,549 SH   SOLE   12,549 0 0
Altimmune Inc Common Stock 02155H200 109 11,936 SH   SOLE   11,936 0 0
ImmunoGen Inc Common Stock 45253H101 100 13,448 SH   SOLE   13,448 0 0
Curis Inc Common Stock 231269200 93 19,506 SH   SOLE   19,506 0 0
ImmunityBio Inc Common Stock 45256X103 90 14,883 SH   SOLE   14,883 0 0
Seres Therapeutics Inc Common Stock 81750R102 89 10,744 SH   SOLE   10,744 0 0
Sangamo Therapeutics Inc Common Stock 800677106 88 11,718 SH   SOLE   11,718 0 0
Karyopharm Therapeutics Inc Common Stock 48576U106 80 12,391 SH   SOLE   12,391 0 0
Radius Health Inc Common Stock 750469207 74 10,757 SH   SOLE   10,757 0 0
VBI Vaccines Inc Common Stock 91822J103 63 26,828 SH   SOLE   26,828 0 0
Precigen Inc Common Stock 74017N105 58 15,670 SH   SOLE   15,670 0 0
Akebia Therapeutics Inc Common Stock 00972D105 55 24,397 SH   SOLE   24,397 0 0
Rigel Pharmaceuticals Inc Common Stock 766559603 43 16,074 SH   SOLE   16,074 0 0
Verastem Inc Common Stock 92337C104 38 18,695 SH   SOLE   18,695 0 0
VistaGen Therapeutics Inc Common Stock 92840H202 32 16,206 SH   SOLE   16,206 0 0
ZIOPHARM Oncology Inc Common Stock 98973P101 29 26,973 SH   SOLE   26,973 0 0
Geron Corp Common Stock 374163103 23 18,818 SH   SOLE   18,818 0 0