The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
360 DigiTech Inc ADR 88557W101 7,643 376,130 SH   DFND   7,643 0 0
3M Co Common Stock 88579Y101 222 1,264 SH   SOLE   222 0 0
51job Inc ADR 316827104 7,512 108,035 SH   DFND   7,512 0 0
Abbott Laboratories Common Stock 002824100 578 4,894 SH   SOLE   578 0 0
AbbVie Inc Common Stock 00287Y109 723 6,705 SH   SOLE   723 0 0
ACADIA Pharmaceuticals Inc Common Stock 004225108 177 10,673 SH   SOLE   177 0 0
Acceleron Pharma Inc Common Stock 00434H108 224 1,302 SH   SOLE   224 0 0
Accenture PLC Common Stock G1151C101 2,194 6,859 SH   SOLE   2,194 0 0
Activision Blizzard Inc Common Stock 00507V109 694 8,963 SH   SOLE   694 0 0
Adagene Inc ADR 005329107 851 58,670 SH   SOLE   851 0 0
Adobe Inc Common Stock 00724F101 5,503 9,558 SH   SOLE   5,503 0 0
Advanced Micro Devices Inc Common Stock 007903107 2,514 24,435 SH   SOLE   2,514 0 0
Agenus Inc Common Stock 00847G705 139 26,519 SH   SOLE   139 0 0
Agilent Technologies Inc Common Stock 00846U101 219 1,391 SH   SOLE   219 0 0
Agora Inc ADR 00851L103 7,441 256,580 SH   DFND   7,441 0 0
Akebia Therapeutics Inc Common Stock 00972D105 107 37,123 SH   SOLE   107 0 0
Alibaba Group Holding Ltd ADR 01609W102 947,037 6,396,735 SH   SOLE   947,037 0 0
Align Technology Inc Common Stock 016255101 727 1,093 SH   SOLE   727 0 0
Alphabet Inc Common Stock 02079K107 6,978 2,618 SH   SOLE   6,978 0 0
Alphabet Inc Common Stock 02079K305 6,732 2,518 SH   SOLE   6,732 0 0
Amazon.com Inc Common Stock 023135106 13,433 4,089 SH   SOLE   13,433 0 0
American Electric Power Co Inc Common Stock 025537101 472 5,814 SH   SOLE   472 0 0
American Express Co Common Stock 025816109 237 1,414 SH   SOLE   237 0 0
American Tower Corp REIT 03027X100 267 1,000 SH   SOLE   267 0 0
Amgen Inc Common Stock 031162100 1,690 7,946 SH   SOLE   1,690 0 0
Amicus Therapeutics Inc Common Stock 03152W109 151 15,771 SH   SOLE   151 0 0
Amphenol Corp Common Stock 032095101 473 6,442 SH   SOLE   473 0 0
Analog Devices Inc Common Stock 032654105 1,530 9,136 SH   SOLE   1,530 0 0
ANSYS Inc Common Stock 03662Q105 601 1,766 SH   SOLE   601 0 0
Anthem Inc Common Stock 036752103 332 891 SH   SOLE   332 0 0
Apple Inc Common Stock 037833100 38,692 273,444 SH   SOLE   38,692 0 0
Applied Materials Inc Common Stock 038222105 2,361 18,342 SH   SOLE   2,361 0 0
Arista Networks Inc Common Stock 040413106 203 592 SH   SOLE   203 0 0
ASML Holding NV NY Reg Shrs N07059210 547 734 SH   SOLE   547 0 0
AT&T Inc Common Stock 00206R102 424 15,694 SH   SOLE   424 0 0
Atlassian Corp PLC Common Stock G06242104 495 1,264 SH   SOLE   495 0 0
Autodesk Inc Common Stock 052769106 1,256 4,403 SH   SOLE   1,256 0 0
Autohome Inc ADR 05278C107 10,758 229,241 SH   DFND   10,758 0 0
Automatic Data Processing Inc Common Stock 053015103 1,727 8,603 SH   SOLE   1,727 0 0
Baidu Inc ADR 056752108 171,421 1,114,932 SH   DFND   171,421 0 0
Bank of America Corp Common Stock 060505104 691 16,277 SH   SOLE   691 0 0
Baxter International Inc Common Stock 071813109 217 2,696 SH   SOLE   217 0 0
Becton Dickinson and Co Common Stock 075887109 274 1,114 SH   SOLE   274 0 0
Berkshire Hathaway Inc Common Stock 084670702 1,112 4,074 SH   SOLE   1,112 0 0
Bilibili Inc ADR 090040106 47,917 724,157 SH   DFND   47,917 0 0
BioCryst Pharmaceuticals Inc Common Stock 09058V103 163 11,349 SH   SOLE   163 0 0
Biogen Inc Common Stock 09062X103 780 2,756 SH   SOLE   780 0 0
BlackRock Inc Common Stock 09247X101 263 314 SH   SOLE   263 0 0
Boeing Co/The Common Stock 097023105 263 1,198 SH   SOLE   263 0 0
Booking Holdings Inc Common Stock 09857L108 1,113 469 SH   SOLE   1,113 0 0
Boston Scientific Corp Common Stock 101137107 260 5,984 SH   SOLE   260 0 0
Bristol-Myers Squibb Co Common Stock 110122108 412 6,915 SH   SOLE   412 0 0
Broadcom Inc Common Stock 11135F101 4,010 8,270 SH   SOLE   4,010 0 0
Broadridge Financial Solutions Common Stock 11133T103 209 1,252 SH   SOLE   209 0 0
Cadence Design Systems Inc Common Stock 127387108 841 5,556 SH   SOLE   841 0 0
Carnival Corp Common Stock 143658300 445 17,780 SH   SOLE   445 0 0
Catalyst Pharmaceuticals Inc Common Stock 14888U101 57 10,838 SH   SOLE   57 0 0
Caterpillar Inc Common Stock 149123101 229 1,194 SH   SOLE   229 0 0
CDW Corp/DE Common Stock 12514G108 517 2,843 SH   SOLE   517 0 0
CEL-SCI Corp Common Stock 150837607 129 11,782 SH   SOLE   129 0 0
Centene Corp Common Stock 15135B101 213 3,422 SH   SOLE   213 0 0
Cerner Corp Common Stock 156782104 371 5,246 SH   SOLE   371 0 0
Charles Schwab Corp/The Common Stock 808513105 238 3,271 SH   SOLE   238 0 0
Charter Communications Inc Common Stock 16119P108 1,500 2,062 SH   SOLE   1,500 0 0
ChemoCentryx Inc Common Stock 16383L106 191 11,179 SH   SOLE   191 0 0
Chevron Corp Common Stock 166764100 428 4,215 SH   SOLE   428 0 0
Chindata Group Holdings Ltd ADR 16955F107 4,403 523,592 SH   DFND   4,403 0 0
Cigna Corp Common Stock 125523100 275 1,374 SH   SOLE   275 0 0
Cintas Corp Common Stock 172908105 444 1,167 SH   SOLE   444 0 0
Cisco Systems Inc/Delaware Common Stock 17275R102 4,673 85,848 SH   SOLE   4,673 0 0
Citigroup Inc Common Stock 172967424 308 4,394 SH   SOLE   308 0 0
Clovis Oncology Inc Common Stock 189464100 176 39,535 SH   SOLE   176 0 0
Coca-Cola Co/The Common Stock 191216100 447 8,463 SH   SOLE   447 0 0
Cognizant Technology Solutions Common Stock 192446102 805 10,842 SH   SOLE   805 0 0
Comcast Corp Common Stock 20030N101 2,949 52,728 SH   SOLE   2,949 0 0
Copart Inc Common Stock 217204106 368 2,653 SH   SOLE   368 0 0
Corning Inc Common Stock 219350105 301 8,259 SH   SOLE   301 0 0
Costco Wholesale Corp Common Stock 22160K105 2,320 5,164 SH   SOLE   2,320 0 0
Crowdstrike Holdings Inc Common Stock 22788C105 437 1,780 SH   SOLE   437 0 0
CSX Corp Common Stock 126408103 781 26,265 SH   SOLE   781 0 0
Curis Inc Common Stock 231269200 156 19,872 SH   SOLE   156 0 0
CVS Health Corp Common Stock 126650100 375 4,416 SH   SOLE   375 0 0
Cytokinetics Inc Common Stock 23282W605 209 5,840 SH   SOLE   209 0 0
Dada Nexus Ltd ADR 23344D108 5,987 298,800 SH   DFND   5,987 0 0
Danaher Corp Common Stock 235851102 545 1,788 SH   SOLE   545 0 0
Deere & Co Common Stock 244199105 208 620 SH   SOLE   208 0 0
Dexcom Inc Common Stock 252131107 728 1,332 SH   SOLE   728 0 0
Direxion Daily Gold Miners Ind ETP 25460G781 545 12,779 SH   SOLE   545 0 0
DocuSign Inc Common Stock 256163106 469 1,820 SH   SOLE   469 0 0
Dollar Tree Inc Common Stock 256746108 281 2,939 SH   SOLE   281 0 0
eBay Inc Common Stock 278642103 540 7,754 SH   SOLE   540 0 0
Edwards Lifesciences Corp Common Stock 28176E108 273 2,415 SH   SOLE   273 0 0
Electronic Arts Inc Common Stock 285512109 477 3,351 SH   SOLE   477 0 0
Eli Lilly & Co Common Stock 532457108 525 2,274 SH   SOLE   525 0 0
Enphase Energy Inc Common Stock 29355A107 223 1,490 SH   SOLE   223 0 0
Epizyme Inc Common Stock 29428V104 68 13,338 SH   SOLE   68 0 0
Estee Lauder Cos Inc/The Common Stock 518439104 2,282 7,607 SH   SOLE   2,282 0 0
Exelon Corp Common Stock 30161N101 550 11,388 SH   SOLE   550 0 0
Exxon Mobil Corp Common Stock 30231G102 543 9,233 SH   SOLE   543 0 0
Farfetch Ltd Common Stock 30744W107 379 10,104 SH   SOLE   379 0 0
Fastenal Co Common Stock 311900104 355 6,869 SH   SOLE   355 0 0
FibroGen Inc Common Stock 31572Q808 155 15,201 SH   SOLE   155 0 0
Fidelity National Information Common Stock 31620M106 812 6,673 SH   SOLE   812 0 0
Fiserv Inc Common Stock 337738108 1,385 12,764 SH   SOLE   1,385 0 0
FleetCor Technologies Inc Common Stock 339041105 235 898 SH   SOLE   235 0 0
Fortinet Inc Common Stock 34959E109 427 1,461 SH   SOLE   427 0 0
Full Truck Alliance Co Ltd ADR 35969L108 40,963 2,672,085 SH   SOLE   40,963 0 0
G1 Therapeutics Inc Common Stock 3621LQ109 156 11,607 SH   SOLE   156 0 0
Gartner Inc Common Stock 366651107 276 909 SH   SOLE   276 0 0
General Electric Co Common Stock 369604301 247 2,393 SH   SOLE   247 0 0
Geron Corp Common Stock 374163103 30 21,560 SH   SOLE   30 0 0
Gilead Sciences Inc Common Stock 375558103 1,295 18,537 SH   SOLE   1,295 0 0
Global Payments Inc Common Stock 37940X102 501 3,177 SH   SOLE   501 0 0
Goldman Sachs Group Inc/The Common Stock 38141G104 278 736 SH   SOLE   278 0 0
HCA Healthcare Inc Common Stock 40412C101 254 1,045 SH   SOLE   254 0 0
Hello Group Inc ADR 423403104 5,142 486,053 SH   DFND   5,142 0 0
Heron Therapeutics Inc Common Stock 427746102 158 14,805 SH   SOLE   158 0 0
Hewlett Packard Enterprise Co Common Stock 42824C109 202 14,077 SH   SOLE   202 0 0
Hilton Worldwide Holdings Inc Common Stock 43300A203 568 4,296 SH   SOLE   568 0 0
Home Depot Inc/The Common Stock 437076102 767 2,337 SH   SOLE   767 0 0
Honeywell International Inc Common Stock 438516106 1,713 8,070 SH   SOLE   1,713 0 0
HP Inc Common Stock 40434L105 355 12,908 SH   SOLE   355 0 0
Humana Inc Common Stock 444859102 234 600 SH   SOLE   234 0 0
Humanigen Inc Common Stock 444863203 149 25,054 SH   SOLE   149 0 0
IBM Common Stock 459200101 1,338 9,631 SH   SOLE   1,338 0 0
IDEXX Laboratories Inc Common Stock 45168D104 734 1,181 SH   SOLE   734 0 0
Illumina Inc Common Stock 452327109 815 2,010 SH   SOLE   815 0 0
I-Mab ADR 44975P103 24,911 343,647 SH   DFND   24,911 0 0
ImmunityBio Inc Common Stock 45256X103 123 12,638 SH   SOLE   123 0 0
ImmunoGen Inc Common Stock 45253H101 95 16,798 SH   SOLE   95 0 0
Immunovant Inc Common Stock 45258J102 91 10,474 SH   SOLE   91 0 0
Incyte Corp Common Stock 45337C102 471 6,846 SH   SOLE   471 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 155 21,682 SH   SOLE   155 0 0
Intel Corp Common Stock 458140100 4,341 81,484 SH   SOLE   4,341 0 0
Intuit Inc Common Stock 461202103 2,960 5,486 SH   SOLE   2,960 0 0
Intuitive Surgical Inc Common Stock 46120E602 1,486 1,495 SH   SOLE   1,486 0 0
Invesco DB Oil Fund ETP 46140H403 11,069 806,800 SH   SOLE   11,069 0 0
iQIYI Inc ADR 46267X108 9,938 1,237,679 SH   DFND   9,938 0 0
IQVIA Holdings Inc Common Stock 46266C105 218 911 SH   SOLE   218 0 0
Ironwood Pharmaceuticals Inc Common Stock 46333X108 185 14,130 SH   SOLE   185 0 0
iShares Gold Trust ETP 464285204 4,942 147,931 SH   SOLE   4,942 0 0
iShares MSCI Global Gold Miner ETP 46434G855 4,602 187,129 SH   SOLE   4,602 0 0
JD.com Inc ADR 47215P106 216,391 2,995,449 SH   DFND   216,391 0 0
Johnson & Johnson Common Stock 478160104 1,059 6,556 SH   SOLE   1,059 0 0
JOYY Inc ADR 46591M109 10,903 197,516 SH   DFND   10,903 0 0
JPMorgan Chase & Co Common Stock 46625H100 1,075 6,568 SH   SOLE   1,075 0 0
Kadmon Holdings Inc Common Stock 48283N106 122 14,053 SH   SOLE   122 0 0
Karyopharm Therapeutics Inc Common Stock 48576U106 119 20,522 SH   SOLE   119 0 0
KE Holdings Inc ADR 482497104 33,018 1,808,215 SH   DFND   33,018 0 0
Keurig Dr Pepper Inc Common Stock 49271V100 454 13,229 SH   SOLE   454 0 0
Keysight Technologies Inc Common Stock 49338L103 335 2,037 SH   SOLE   335 0 0
Kingsoft Cloud Holdings Ltd ADR 49639K101 8,838 312,067 SH   DFND   8,838 0 0
KLA Corp Common Stock 482480100 1,025 3,063 SH   SOLE   1,025 0 0
Kraft Heinz Co/The Common Stock 500754106 482 13,092 SH   SOLE   482 0 0
Lam Research Corp Common Stock 512807108 1,639 2,873 SH   SOLE   1,639 0 0
Linde PLC Common Stock G5494J103 333 1,135 SH   SOLE   333 0 0
Lineage Cell Therapeutics Inc Common Stock 53566P109 28 11,095 SH   SOLE   28 0 0
Lowe's Cos Inc Common Stock 548661107 315 1,553 SH   SOLE   315 0 0
Lufax Holding Ltd ADR 54975P102 15,886 2,276,048 SH   DFND   15,886 0 0
Lululemon Athletica Inc Common Stock 550021109 1,936 4,784 SH   SOLE   1,936 0 0
MannKind Corp Common Stock 56400P706 121 27,776 SH   SOLE   121 0 0
Marriott International Inc/MD Common Stock 571903202 1,508 10,186 SH   SOLE   1,508 0 0
Marvell Technology Inc Common Stock 573874104 454 7,523 SH   SOLE   454 0 0
Mastercard Inc Common Stock 57636Q104 3,256 9,365 SH   SOLE   3,256 0 0
Match Group Inc Common Stock 57667L107 485 3,089 SH   SOLE   485 0 0
McDonald's Corp Common Stock 580135101 396 1,641 SH   SOLE   396 0 0
Medtronic PLC Common Stock G5960L103 496 3,941 SH   SOLE   496 0 0
MercadoLibre Inc Common Stock 58733R102 788 469 SH   SOLE   788 0 0
Merck & Co Inc Common Stock 58933Y105 551 7,276 SH   SOLE   551 0 0
Meta Platforms Inc Common Stock 30303M102 6,903 20,338 SH   SOLE   6,903 0 0
Microchip Technology Inc Common Stock 595017104 829 5,400 SH   SOLE   829 0 0
Micron Technology Inc Common Stock 595112103 1,616 22,739 SH   SOLE   1,616 0 0
Microsoft Corp Common Stock 594918104 35,903 127,351 SH   SOLE   35,903 0 0
Moderna Inc Common Stock 60770K107 2,003 5,204 SH   SOLE   2,003 0 0
Mondelez International Inc Common Stock 609207105 939 16,057 SH   SOLE   939 0 0
Monolithic Power Systems Inc Common Stock 609839105 230 475 SH   SOLE   230 0 0
Monster Beverage Corp Common Stock 61174X109 517 5,822 SH   SOLE   517 0 0
Morgan Stanley Common Stock 617446448 308 3,162 SH   SOLE   308 0 0
Motorola Solutions Inc Common Stock 620076307 426 1,829 SH   SOLE   426 0 0
NetApp Inc Common Stock 64110D104 215 2,400 SH   SOLE   215 0 0
NetEase Inc ADR 64110W102 110,652 1,292,951 SH   DFND   110,652 0 0
Netflix Inc Common Stock 64110L106 3,148 5,157 SH   SOLE   3,148 0 0
NextEra Energy Inc Common Stock 65339F101 336 4,278 SH   SOLE   336 0 0
NIKE Inc Common Stock 654106103 2,115 14,541 SH   SOLE   2,115 0 0
NVIDIA Corp Common Stock 67066G104 10,484 50,607 SH   SOLE   10,484 0 0
NXP Semiconductors NV Common Stock N6596X109 1,059 5,394 SH   SOLE   1,059 0 0
Ocugen Inc Common Stock 67577C105 173 24,109 SH   SOLE   173 0 0
Okta Inc Common Stock 679295105 272 1,148 SH   SOLE   272 0 0
OPKO Health Inc Common Stock 68375N103 170 46,542 SH   SOLE   170 0 0
Oracle Corp Common Stock 68389X105 1,551 17,798 SH   SOLE   1,551 0 0
O'Reilly Automotive Inc Common Stock 67103H107 490 802 SH   SOLE   490 0 0
PACCAR Inc Common Stock 693718108 331 4,188 SH   SOLE   331 0 0
Paychex Inc Common Stock 704326107 771 6,858 SH   SOLE   771 0 0
Paycom Software Inc Common Stock 70432V102 263 530 SH   SOLE   263 0 0
PayPal Holdings Inc Common Stock 70450Y103 6,209 23,862 SH   SOLE   6,209 0 0
Peloton Interactive Inc Common Stock 70614W100 229 2,628 SH   SOLE   229 0 0
PepsiCo Inc Common Stock 713448108 2,425 16,122 SH   SOLE   2,425 0 0
Pfizer Inc Common Stock 717081103 652 15,163 SH   SOLE   652 0 0
Philip Morris International In Common Stock 718172109 326 3,399 SH   SOLE   326 0 0
Pinduoduo Inc ADR 722304102 195,382 2,154,867 SH   DFND   195,382 0 0
Procter & Gamble Co/The Common Stock 742718109 746 5,335 SH   SOLE   746 0 0
Prologis Inc REIT 74340W103 201 1,599 SH   SOLE   201 0 0
ProShares Ultra Gold ETP 74347W601 717 12,905 SH   SOLE   717 0 0
Qorvo Inc Common Stock 74736K101 203 1,214 SH   SOLE   203 0 0
QUALCOMM Inc Common Stock 747525103 2,985 23,146 SH   SOLE   2,985 0 0
Raytheon Technologies Corp Common Stock 75513E101 284 3,304 SH   SOLE   284 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 1,006 1,662 SH   SOLE   1,006 0 0
Rigel Pharmaceuticals Inc Common Stock 766559603 60 16,554 SH   SOLE   60 0 0
Ross Stores Inc Common Stock 778296103 444 4,081 SH   SOLE   444 0 0
Royal Caribbean Cruises Ltd Common Stock V7780T103 305 3,427 SH   SOLE   305 0 0
S&P Global Inc Common Stock 78409V104 225 529 SH   SOLE   225 0 0
salesforce.com Inc Common Stock 79466L302 2,806 10,347 SH   SOLE   2,806 0 0
Sangamo Therapeutics Inc Common Stock 800677106 100 11,046 SH   SOLE   100 0 0
Seagen Inc Common Stock 81181C104 488 2,872 SH   SOLE   488 0 0
Seres Therapeutics Inc Common Stock 81750R102 191 27,492 SH   SOLE   191 0 0
ServiceNow Inc Common Stock 81762P102 1,327 2,133 SH   SOLE   1,327 0 0
Sirius XM Holdings Inc Common Stock 82968B103 245 40,183 SH   SOLE   245 0 0
Skyworks Solutions Inc Common Stock 83088M102 544 3,303 SH   SOLE   544 0 0
Sorrento Therapeutics Inc Common Stock 83587F202 166 21,764 SH   SOLE   166 0 0
SPDR Gold MiniShares Trust ETP 98149E204 4,999 286,305 SH   SOLE   4,999 0 0
SPDR Gold Shares ETP 78463V107 1,530 9,317 SH   SOLE   1,530 0 0
Spectrum Pharmaceuticals Inc Common Stock 84763A108 83 38,190 SH   SOLE   83 0 0
Splunk Inc Common Stock 848637104 234 1,619 SH   SOLE   234 0 0
STAAR Surgical Co Common Stock 852312305 17,004 132,296 SH   SOLE   17,004 0 0
Starbucks Corp Common Stock 855244109 1,569 14,225 SH   SOLE   1,569 0 0
Stryker Corp Common Stock 863667101 316 1,194 SH   SOLE   316 0 0
Synopsys Inc Common Stock 871607107 925 3,090 SH   SOLE   925 0 0
TAL Education Group ADR 874080104 7,873 1,626,773 SH   DFND   7,873 0 0
Target Corp Common Stock 87612E106 249 1,087 SH   SOLE   249 0 0
TE Connectivity Ltd Common Stock H84989104 489 3,560 SH   SOLE   489 0 0
Teledyne Technologies Inc Common Stock 879360105 215 500 SH   SOLE   215 0 0
Tencent Music Entertainment Gr ADR 88034P109 15,547 2,144,447 SH   DFND   15,547 0 0
Tesla Inc Common Stock 88160R101 8,923 11,506 SH   SOLE   8,923 0 0
Texas Instruments Inc Common Stock 882508104 3,586 18,658 SH   SOLE   3,586 0 0
Thermo Fisher Scientific Inc Common Stock 883556102 623 1,090 SH   SOLE   623 0 0
T-Mobile US Inc Common Stock 872590104 1,704 13,336 SH   SOLE   1,704 0 0
Trimble Inc Common Stock 896239100 228 2,776 SH   SOLE   228 0 0
Trip.com Group Ltd ADR 89677Q107 61,901 2,013,025 SH   DFND   61,901 0 0
Union Pacific Corp Common Stock 907818108 277 1,411 SH   SOLE   277 0 0
United Parcel Service Inc Common Stock 911312106 287 1,577 SH   SOLE   287 0 0
United States 12 Month Oil Fun ETP 91288V103 3,680 136,000 SH   SOLE   3,680 0 0
United States Brent Oil Fund L ETP 91167Q100 11,082 536,900 SH   SOLE   11,082 0 0
United States Oil Fund LP ETP 91232N207 10,738 204,300 SH   SOLE   10,738 0 0
UnitedHealth Group Inc Common Stock 91324P102 934 2,390 SH   SOLE   934 0 0
VanEck Gold Miners ETF/USA ETP 92189F106 2,679 90,922 SH   SOLE   2,679 0 0
Vaxart Inc Common Stock 92243A200 157 19,803 SH   SOLE   157 0 0
VBI Vaccines Inc Common Stock 91822J103 80 25,873 SH   SOLE   80 0 0
Verastem Inc Common Stock 92337C104 74 23,942 SH   SOLE   74 0 0
VeriSign Inc Common Stock 92343E102 445 2,171 SH   SOLE   445 0 0
Verisk Analytics Inc Common Stock 92345Y106 382 1,907 SH   SOLE   382 0 0
Verizon Communications Inc Common Stock 92343V104 491 9,100 SH   SOLE   491 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100 832 4,586 SH   SOLE   832 0 0
Viatris Inc Common Stock 92556V106 161 11,881 SH   SOLE   161 0 0
Vipshop Holdings Ltd ADR 92763W103 25,341 2,274,809 SH   DFND   25,341 0 0
Visa Inc Common Stock 92826C839 4,048 18,175 SH   SOLE   4,048 0 0
VistaGen Therapeutics Inc Common Stock 92840H202 38 13,783 SH   SOLE   38 0 0
Vnet Group Inc ADR 90138A103 7,630 440,787 SH   DFND   7,630 0 0
Walgreens Boots Alliance Inc Common Stock 931427108 456 9,684 SH   SOLE   456 0 0
Walmart Inc Common Stock 931142103 438 3,141 SH   SOLE   438 0 0
Walt Disney Co/The Common Stock 254687106 676 3,994 SH   SOLE   676 0 0
Weibo Corp ADR 948596101 10,761 226,584 SH   DFND   10,761 0 0
Wells Fargo & Co Common Stock 949746101 419 9,026 SH   SOLE   419 0 0
Workday Inc Common Stock 98138H101 437 1,749 SH   SOLE   437 0 0
Xcel Energy Inc Common Stock 98389B100 393 6,242 SH   SOLE   393 0 0
Xilinx Inc Common Stock 983919101 732 4,848 SH   SOLE   732 0 0
Zebra Technologies Corp Common Stock 989207105 295 572 SH   SOLE   295 0 0
Zhihu Inc ADR 98955N108 12,133 1,314,461 SH   DFND   12,133 0 0
Zimmer Biomet Holdings Inc Common Stock 98956P102 201 1,369 SH   SOLE   201 0 0
ZIOPHARM Oncology Inc Common Stock 98973P101 41 22,684 SH   SOLE   41 0 0
Zoetis Inc Common Stock 98978V103 320 1,646 SH   SOLE   320 0 0
Zoom Video Communications Inc Common Stock 98980L101 580 2,219 SH   SOLE   580 0 0