144 0002050172 XXXXXXXX LIVE 0001842295 MAZE THERAPEUTICS, INC. 001-42490 171 OYSTER POINT BOULEVARD, SUITE 300 SOUTH SAN FRANCISCO CA 94080 650-850-5070 Harold Bernstein Officer Common Stock Morgan Stanley Smith Barney LLC

Executive Financial Services 1 New York Plaza, 8th Floor New York NY 10004

10685 283500 55549168 09/02/2026 NASDAQ Common Stock 09/01/2026 Restricted Stock Unit Vesting Issuer N 10685 09/01/2026 Compensation N Harold Bernstein

c/o Maze Therapeutics, Inc. 171 Oyster Point Boulevard, Suite 300 South San Francisco CA 94080

Common Stock 07/01/2026 14609 436864.07 Harold Bernstein

c/o Maze Therapeutics, Inc. 171 Oyster Point Boulevard, Suite 300 South San Francisco CA 94080

Common Stock 08/13/2026 16142 445620.89 Harold Bernstein

c/o Maze Therapeutics, Inc. 171 Oyster Point Boulevard, Suite 300 South San Francisco CA 94080

Common Stock 09/01/2026 16141 425512.27 The reported sale was mandated by the Issuer and includes an amount necessary to satisfy tax withholding obligations resulting from the vesting and settlement of restricted stock units granted pursuant to an equity incentive award. 09/02/2026 /s/ Harold Bernstein