144 0002050167 XXXXXXXX LIVE 0001842295 MAZE THERAPEUTICS, INC. 001-42490 171 OYSTER POINT BOULEVARD, SUITE 300 SOUTH SAN FRANCISCO CA 94080 650-850-5070 Atul Dandekar Officer Common Stock Morgan Stanley Smith Barney LLC

Executive Financial Services 1 New York Plaza, 8th Floor New York NY 10004

6679 177200 55549168 09/02/2026 NASDAQ Common Stock 09/01/2026 Restricted Stock Unit Vesting Issuer N 6679 09/01/2026 Compensation N Atul Dandekar

c/o Maze Therapeutics, Inc. 171 Oyster Point Boulevard, Suite 300 South San Francisco CA 94080

Common Stock 06/29/2026 7500 210150.00 Atul Dandekar

c/o Maze Therapeutics, Inc. 171 Oyster Point Boulevard, Suite 300 South San Francisco CA 94080

Common Stock 07/29/2026 7500 205031.44 Atul Dandekar

c/o Maze Therapeutics, Inc. 171 Oyster Point Boulevard, Suite 300 South San Francisco CA 94080

Common Stock 08/28/2026 7500 206823.75 The reported sale was mandated by the Issuer and includes an amount necessary to satisfy tax withholding obligations resulting from the vesting and settlement of restricted stock units granted pursuant to an equity incentive award. 09/02/2026 /s/ Atul Dandekar