<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001676170</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001842295</issuerCik>
      <issuerName>Maze Therapeutics, Inc.</issuerName>
      <secFileNumber>001-42490</secFileNumber>
      <issuerAddress>
        <com:street1>171 OYSTER POINT BOULEVARD, SUITE 300</com:street1>
        <com:city>SOUTH SAN FRANCISCO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94080</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>6508505070</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Coloma Jason V</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services Inc.</name>
        <address>
          <com:street1>Eleven Madison Avenue</com:street1>
          <com:street2>4th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10010</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>34501</noOfUnitsSold>
      <aggregateMarketValue>1034253.72</aggregateMarketValue>
      <noOfUnitsOutstanding>55345261</noOfUnitsOutstanding>
      <approxSaleDate>07/01/2026</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>09/22/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Gift</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Jason Coloma</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>Y</isGiftTransaction>
      <donarAcquiredDate>11/01/2018</donarAcquiredDate>
      <amountOfSecuritiesAcquired>2593</amountOfSecuritiesAcquired>
      <paymentDate>09/22/2021</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>09/22/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Gift</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Jason Coloma</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>Y</isGiftTransaction>
      <donarAcquiredDate>06/24/2019</donarAcquiredDate>
      <amountOfSecuritiesAcquired>31908</amountOfSecuritiesAcquired>
      <paymentDate>09/22/2021</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Coloma 2021 Irrevocable Trust DTD 09/20/2021</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD, SUITE 300</com:street1>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/15/2026</saleDate>
      <amountOfSecuritiesSold>116</amountOfSecuritiesSold>
      <grossProceeds>3016.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Coloma 2021 Irrevocable Trust DTD 09/20/2021</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD, SUITE 300</com:street1>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/22/2026</saleDate>
      <amountOfSecuritiesSold>2478</amountOfSecuritiesSold>
      <grossProceeds>64428.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Coloma Family Trust DTD 06/27/2016</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD, SUITE 300</com:street1>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/15/2026</saleDate>
      <amountOfSecuritiesSold>1822</amountOfSecuritiesSold>
      <grossProceeds>47372.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Coloma Family Trust DTD 06/27/2016</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD, SUITE 300</com:street1>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/22/2026</saleDate>
      <amountOfSecuritiesSold>4504</amountOfSecuritiesSold>
      <grossProceeds>117104.45</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Coloma Family Trust DTD 06/27/2016</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD, SUITE 300</com:street1>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/26/2026</saleDate>
      <amountOfSecuritiesSold>25582</amountOfSecuritiesSold>
      <grossProceeds>665515.73</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Coloma 2021 Irrevocable Trust DTD 09/20/2021</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/01/2026</saleDate>
      <amountOfSecuritiesSold>553</amountOfSecuritiesSold>
      <grossProceeds>14511.38</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Coloma 2021 Irrevocable Trust DTD 09/20/2021</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD</com:street1>
          <com:street2>SUITE 300</com:street2>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/22/2026</saleDate>
      <amountOfSecuritiesSold>2040</amountOfSecuritiesSold>
      <grossProceeds>53040.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Coloma Family Trust DTD 06/27/2016</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD</com:street1>
          <com:street2>SUITE 300</com:street2>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/01/2026</saleDate>
      <amountOfSecuritiesSold>6090</amountOfSecuritiesSold>
      <grossProceeds>159536.68</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Coloma Family Trust DTD 06/27/2016</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD</com:street1>
          <com:street2>SUITE 300</com:street2>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/22/2026</saleDate>
      <amountOfSecuritiesSold>1953</amountOfSecuritiesSold>
      <grossProceeds>50780.93</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Coloma Family Trust DTD 06/27/2016</name>
        <address>
          <com:street1>171 OYSTER POINT BOULEVARD</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/23/2026</saleDate>
      <amountOfSecuritiesSold>23865</amountOfSecuritiesSold>
      <grossProceeds>621673.70</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>2,593 shares for this filing were sold under The Coloma 2021 Irrevocable Trust DTD 09/20/2021 and 31,908 shares were sold under Coloma Family Trust DTD 06/27/2016</remarks>
    <noticeSignature>
      <noticeDate>07/01/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/06/2026</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ UBS Financial Services Inc., as attorney-in-fact for Jason Coloma as trustee</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
