144 0002050172 XXXXXXXX LIVE 0001842295 MAZE THERAPEUTICS, INC. 001-42490 171 Oyster Point Blvd Suite 300 South San Francisco CA 94080 650-850-5070 HAROLD BERNSTEIN Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

46892 1399257.28 55345261 07/01/2026 NASDAQ Common 07/01/2026 Exercise of Stock Options Issuer N 46892 07/01/2026 Cash N 10b5-1 Sales for HAROLD BERNSTEIN

171 Oyster Point Blvd Suite 300 South San Francisco CA 94080

Common 06/01/2026 14853 381113.13 10b5-1 Sales for HAROLD BERNSTEIN

171 Oyster Point Blvd Suite 300 South San Francisco CA 94080

Common 05/14/2026 15000 393354.00 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 07/01/2026 09/29/2025 /s/ Harold Bernstein