SCHEDULE 13G/A 0001415889-25-012489 0001845041 XXXXXXXX LIVE 1 Common Stock, par value $0.001 per share 12/31/2025 0001842295 MAZE THERAPEUTICS, INC. 578784100 171 OYSTER POINT BOULEVARD, SUITE 300 SOUTH SAN FRANCISCO CA 94080 Rule 13d-1(d) GV 2019, L.P. DE 0.00 784019.00 0.00 784019.00 784019.00 1.6 PN GV 2019 GP, L.P. DE 0.00 784019.00 0.00 784019.00 784019.00 1.6 PN GV 2019 GP, L.L.C. DE 0.00 784019.00 0.00 784019.00 784019.00 1.6 OO GV 2023, L.P. DE 0.00 604564.00 0.00 604564.00 604564.00 1.3 PN GV 2023 GP, L.P. DE 0.00 604564.00 0.00 604564.00 604564.00 1.3 PN GV 2023 GP, L.L.C. DE 0.00 604564.00 0.00 604564.00 604564.00 1.3 OO Alphabet Holdings LLC DE 0.00 1388583.00 0.00 1388583.00 1388583.00 2.9 OO XXVI Holdings Inc. DE 0.00 1388583.00 0.00 1388583.00 1388583.00 2.9 CO Alphabet Inc. DE 0.00 1388583.00 0.00 1388583.00 1388583.00 2.9 HC CO MAZE THERAPEUTICS, INC. 171 OYSTER POINT BOULEVARD, SUITE 300, SOUTH SAN FRANCISCO, CA, 94080. GV 2019, L.P., a Delaware limited partnership (the "2019 Partnership") GV 2019 GP, L.P., a Delaware limited partnership ("2019 GP") GV 2019 GP, L.L.C., a Delaware limited liability company ("2019 LLC") GV 2023, L.P., a Delaware limited partnership (the "2023 Partnership") GV 2023 GP, L.P., a Delaware limited partnership ("2023 GP") GV 2023 GP, L.L.C., a Delaware limited liability company ("2023 LLC") Alphabet Holdings LLC, a Delaware limited liability company ("Alphabet Holdings") XXVI Holdings Inc., a Delaware corporation ("XXVI") Alphabet Inc., a Delaware corporation ("Parent" and, together with the 2019 Partnership, 2019 GP, 2019 LLC, the 2023 Partnership, 2023 GP, 2023 LLC, Alphabet Holdings, and XXVI, the "Reporting Persons") 1600 Amphitheatre Parkway Mountain View, CA 94043 Each of the Reporting Persons is formed, organized or incorporated, as applicable, in the State of Delaware. Y Reference to "beneficial ownership" of securities for purposes of this statement (this "Statement") shall be understood to refer to beneficial ownership as that term is defined in Rule 13d-3 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"). As of December 31, 2025, the Reporting Persons may be deemed to beneficially own an aggregate 1,388,583 shares of the Common Stock of Maze Therapeutics, Inc. (the "Issuer"). As of December 31, 2025, the 2019 Partnership was the direct beneficial owner of 784,019 of the shares of the Issuer's Common Stock described in the preceding paragraph. 2019 GP is the general partner of the 2019 Partnership, and 2019 LLC is the general partner of 2019 GP. As such, 2019 GP and 2019 LLC may each be deemed to indirectly beneficially own the securities directly beneficially owned by the 2019 Partnership. As of December 31, 2025, the 2023 Partnership was the direct beneficial owner of 604,564 of the shares of the Issuer's Common Stock described in the second paragraph of this Item 4(a). 2023 GP is the general partner of the 2023 Partnership, and 2023 LLC is the general partner of 2023 GP. As such, 2023 GP and 2023 LLC may each be deemed to indirectly beneficially own the securities directly beneficially owned by the 2023 Partnership. Additionally: (i) Alphabet Holdings is the sole managing member of both 2019 LLC and 2023 LLC; (ii) XXVI is the sole managing member of Alphabet Holdings; and (iii) Parent is the controlling stockholder of XXVI. As such, as of December 31, 2025, for purposes of Section 13(d) of the Exchange Act, each of Alphabet Holdings, XXVI, and Parent may be deemed to indirectly beneficially own all of the Issuer's securities directly or indirectly beneficially owned by each of the other Reporting Persons, comprising an aggregate total of 1,388,583 shares of the Issuer's Common Stock. Notwithstanding, the filing of this Statement shall not be construed as an admission that: (i) the 2019 Partnership, 2019 GP and 2019 LLC (collectively, the "2019 Affiliates"), on the one hand, or (ii) the 2023 Partnership, 2023 GP and 2023 LLC (collectively, the "2023 Affiliates"), on the other hand, is or has been, for purposes of Sections 13(d) or 13(g) of the Exchange Act, or for any other purpose, the direct or indirect beneficial owner of any of the Issuer's securities reported herein as beneficially owned by the other. The 2019 Affiliates and the 2023 Affiliates (each, an "Affiliate Group") expressly disclaim beneficial ownership of the securities beneficially owned by the other Affiliate Group. As of December 31, 2025, the Reporting Persons were deemed to directly or indirectly beneficially own an aggregate 2.9% of the Issuer's outstanding Common Stock. Of that percentage, beneficial ownership was attributable as follows: (i) 1.6%, directly to the 2019 Partnership and indirectly to each of 2019 GP and 2019 LLC; (ii) 1.3%, directly to the 2023 Partnership and indirectly to each of 2023 GP and 2023 LLC; and (ii) 2.9%, indirectly to each of Alphabet Holdings, XXVI, and Parent. The aforementioned percentages were calculated in accordance with Rule 13(d)-3(d)(1)(i) promulgated under the Exchange Act and based on an aggregate total of 48,119,444 shares of the Issuer's Common Stock outstanding as of November 3, 2025 as reported by the Issuer in its Quarterly Report for the period ended September 30, 2025, filed with the SEC on Form 10-Q on November 6, 2025. 2019 Partnership: 0 2019 GP: 0 2019 LLC: 0 2023 Partnership: 0 2023 GP: 0 2023 LLC: 0 Alphabet Holdings: 0 XXVI: 0 Parent: 0 2019 Partnership: 784,019 2019 GP: 784,019 2019 LLC: 784,019 2023 Partnership: 604,564 2023 GP: 604,564 2023 LLC: 604,564 Alphabet Holdings: 1,388,583 XXVI: 1,388,583 Parent: 1,388,583 2019 Partnership: 0 2019 GP: 0 2019 LLC: 0 2023 Partnership: 0 2023 GP: 0 2023 LLC: 0 Alphabet Holdings: 0 XXVI: 0 Parent: 0 2019 Partnership: 784,019 2019 GP: 784,019 2019 LLC: 784,019 2023 Partnership: 604,564 2023 GP: 604,564 2023 LLC: 604,564 Alphabet Holdings: 1,388,583 XXVI: 1,388,583 Parent: 1,388,583 N Y Y Y Y Y Y GV 2019, L.P. /s/ Inga Goldbard 02/06/2026 GV 2019 GP, L.P. /s/ Inga Goldbard 02/06/2026 GV 2019 GP, L.L.C. /s/ Inga Goldbard 02/06/2026 GV 2023, L.P. /s/ Inga Goldbard 02/06/2026 GV 2023 GP, L.P. /s/ Inga Goldbard 02/06/2026 GV 2023 GP, L.L.C. /s/ Inga Goldbard 02/06/2026 Alphabet Holdings LLC /s/ Kathryn W. Hall 02/06/2026 XXVI Holdings Inc. /s/ Kathryn W. Hall 02/06/2026 Alphabet Inc. /s/ Kathryn W. Hall 02/06/2026