<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0002007349</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001841387</issuerCik>
<issuerName>CANDEL THERAPEUTICS, INC.</issuerName>
<secFileNumber>001-40629</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">117 Kendrick St</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 450</street2>
<city xmlns="http://www.sec.gov/edgar/common">Needham</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">02494</zipCode>
</issuerAddress>
<issuerContactPhone>617-916-5445</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Schoch Charles</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Morgan Stanley Smith Barney</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">2000 Westchester Ave</street1>
<city xmlns="http://www.sec.gov/edgar/common">Purchase</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">10577-2530</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>8761</noOfUnitsSold>
<aggregateMarketValue>63867.69</aggregateMarketValue>
<noOfUnitsOutstanding>29744731</noOfUnitsOutstanding>
<approxSaleDate>07/17/2024</approxSaleDate>
<securitiesExchangeName>NASDAQ</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>11/26/2023</acquiredDate>
<natureOfAcquisitionTransaction>RSU Award</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Candel Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>8761</amountOfSecuritiesAcquired>
<paymentDate>11/26/2023</paymentDate>
<natureOfPayment>Not Applicable</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units pursuant to the Issuer's mandatory sell to cover policy, which requires sales in an amount sufficient to cover tax withholding obligations associated with the vesting events, and the sales do not represent discretionary sales by the Reporting Person.</remarks>
<noticeSignature>
<noticeDate>07/17/2024</noticeDate>
<signature>/s/ Charles Schoch</signature>
</noticeSignature>
</formData>
</edgarSubmission>
