X0306 5 2021-12-31 0 0 0 0001841387 Candel Therapeutics, Inc. CADL 0001494695 Manning Paul B C/O CANDEL THERAPEUTICS, INC. 117 KENDRICK ST., SUITE 450 NEEDHAM MA 02494 1 0 1 0 Common Stock 2021-07-14 5 G 0 36752 D 642406 I By Paul B. Manning Revocable Trust Common Stock 553752 I By BKB Growth Investments, LLC Common Stock 1681000 D The shares reported herein reflect the final ownership of the Reporting Person as determined in accordance with the terms of the operating agreements of PBM ADV Holdings, LLC and PBM Capital Investments II, LLC. The shares are held by The Paul B. Manning Revocable Trust dated May 10, 2000 (the "Trust"). The Reporting Person is the trustee of the Trust and has sole voting and investment power with respect to the shares held by the Trust. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. The shares are held directly by BKB Growth Investments, LLC ("BKB"). The Reporting Person is a co-manager of Tiger Lily Capital, LLC, the manager of BKB, and has shared voting and investment power with respect to the shares held by BKB. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. Includes shares held jointly with spouse. /s/ John Canepa, Attorney-in-Fact 2022-02-14