10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 10-Q

n

(Mark One)

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2023 or

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from __________ to __________

Commission File Number: 001-40493

ATAI Life Sciences N.V.

(Exact name of registrant as specified in its charter)

The Netherlands	Not Applicable
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)
ATAI Life Sciences N.V. Wallstraße 16, 10179 Berlin, Germany	Not Applicable
(Address of principal executive offices)	(Zip Code)

+49 89 2153 9035

(Registrant’s telephone number, including area code)

N/A

(Former name, former address and former fiscal year, if changed since last report)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common shares, par value €0.10 per share	ATAI	The Nasdaq Stock Market LLC (Nasdaq Global Market)

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☐
Non-accelerated filer	☒	Smaller reporting company	☒
		Emerging growth company	☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

As of August 1, 2023, the registrant had 166,010,476 common shares, par value €0.10 per share, outstanding.

ATAI Life Sciences N.V.

FORM 10-Q

Table of Contents

		Page
Forward-Looking Statements		1
PART I. FINANCIAL INFORMATION		3
Item 1.	Financial Statements (Unaudited)	3
	Condensed Consolidated Balance Sheets as of June 30, 2023 and December 31, 2022	3
	Condensed Consolidated Statements of Operations for the Three and Six Months Ended June 30, 2023 and 2022	4
	Condensed Consolidated Statements of Comprehensive Loss for the Three and Six Months Ended June 30, 2023 and 2022	5
	Condensed Consolidated Statements of Changes in Stockholders' Equity for the Three and Six Months Ended June 30, 2023 and 2022	6
	Condensed Consolidated Statements of Cash Flows for the Six Months Ended June 30, 2023 and 2022	7
	Notes to Condensed Consolidated Financial Statements	8
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	36
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	54
Item 4.	Controls and Procedures	55
PART II. OTHER INFORMATION		56
Item 1.	Legal Proceedings	56
Item 1A.	Risk Factors	56
Item 2.	Unregistered Sales of Equity Securities, Use of Proceeds and Issuer Purchases of Equity Securities	56
Item 3.	Defaults Upon Senior Securities	56
Item 4.	Mine Safety Disclosures	56
Item 5.	Other Information	56
Item 6.	Exhibits	57
	Signatures	58

CAUTIONARY NOTE REGARDING FORWARD LOOKING STATEMENTS

This Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2023 (the “Quarterly Report") contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements contained in this Quarterly Report other than statements of historical fact should be considered forward-looking statements, including without limitation statements regarding our future operating results and financial position; the success, cost, and timing of development of our product candidates, including the progress of preclinical studies and clinical trials and related milestones; the commercialization of our current product candidates and any other product candidates we may identify and pursue, if approved, including our ability to successfully build a specialty sales force and commercial infrastructure to market our current product candidates and any other product candidates we may identify and pursue; the timing of and our ability to obtain and maintain regulatory approvals; our business strategy and plans, including the benefits of our corporate restructuring; potential acquisitions, partnerships and other strategic arrangements; the sufficiency of our cash and cash equivalents and short-term investments to fund our operations; available funding under the Hercules Capital, Inc. loan facility; and the plans and objectives of management for future operations and capital expenditures. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “could,” “would,” “project,” “plan,” “potentially,” “preliminary,” “likely,” and similar expressions are intended to identify forward-looking statements.

We have based these forward-looking statements largely on our current expectations and projections about future events and trends that we believe may affect our financial condition, results of operations, business strategy, short-term and long-term business operations and objectives, and financial needs. These forward-looking statements are neither promises nor guarantees, and are subject to a number of important factors that could cause actual results to differ materially from any future results, performance or achievements expressed or implied by the forward-looking statements, including without limitation: we are a clinical-stage biopharmaceutical company and have incurred significant losses since our inception, and we expect to incur losses for the foreseeable future and may never be profitable; if we are unable to obtain funding when needed and on acceptable terms, we could be forced to delay, limit or discontinue our product development efforts; our limited operating history may make it difficult to evaluate the success of our business and to assess our future viability; we rely on third parties to assist in conducting our clinical trials and some aspects of our research and preclinical testing, and those third parties may not perform satisfactorily, including failing to meet deadlines for the completion of such trials, research, or testing; we currently rely on qualified therapists working at third-party clinical trial sites to administer certain of our product candidates in our clinical trials and we expect this to continue upon approval, if any, of our current or future product candidates, and if third-party sites fail to recruit and retain a sufficient number of therapists or effectively manage their therapists, our business, financial condition and results of operations would be materially harmed; our product candidates are in preclinical or clinical development, which is a lengthy and expensive process with uncertain outcomes, and we cannot give any assurance that any of our product candidates will receive regulatory approval, which is necessary before they can be commercialized; research and development of drugs targeting the central nervous system, or CNS, is particularly difficult, and it can be difficult to predict and understand why a drug has a positive effect on some patients but not others; the production and sale of our product candidates may be considered illegal or may otherwise be restricted due to the use of controlled substances, which may also have consequences for the legality of investments from foreign jurisdictions; we face significant competition in an environment of rapid technological and scientific change, and there is a possibility that our competitors may achieve regulatory approval before we do or develop therapies that are safer, more advanced or more effective than ours, which may negatively impact our ability to successfully market or commercialize any product candidates we may develop and ultimately harm our financial condition; if we are unable to obtain and maintain sufficient intellectual property protection for our existing product candidates or any other product candidates that we may identify, or if the scope of the intellectual property protection we currently have or obtain in the future is not sufficiently broad, our competitors could develop and commercialize product candidates similar or identical to ours, and our ability to successfully commercialize our existing product candidates and any other product candidates that we may pursue may be impaired; third parties may claim that we are infringing, misappropriating or otherwise violating their intellectual property rights, the outcome of which would be uncertain and may prevent or delay our development and commercialization efforts; our future success depends on our ability to retain key employees, directors, consultants and advisors and to attract, retain and motivate qualified personnel; as a result of covenants to our loan agreement with Hercules Capital, Inc., our operating activities may be restricted and we may be required to repay the outstanding indebtedness in the event of a breach by us, or an event of default thereunder, which could have a materially adverse effect on our business; if we fail to maintain an effective system of disclosure controls and internal control over financial reporting our ability to produce timely and accurate financial statements or comply with applicable regulations could be impaired; our business is subject to economic, political, regulatory and other risks associated with international operations; a pandemic, epidemic, or outbreak of an infectious disease, such as the COVID-19 pandemic, may materially and adversely affect our business, including our preclinical studies, clinical trials, third parties on whom we rely, our supply chain, our ability to raise capital, our ability to conduct regular business and our financial results, and other risks, uncertainties, and assumptions described under “Risk Factors” in Item 1A of Part I, “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Item 7 of Part II and elsewhere in our Form 10-K for the year ended December 31, 2022 (the "Form 10-K") as further updated in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Item 2 of this Quarterly Report, and elsewhere in our filings with the Securities and Exchange Commission (“SEC”).

1

Any forward-looking statements made herein speak only as of the date of this Quarterly Report, and you should not rely on forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, performance, or achievements reflected in the forward-looking statements will be achieved or will occur. Except as required by applicable law, we undertake no obligation to update any of these forward-looking statements for any reason after the date of this Quarterly Report or to conform these statements to actual results or revised expectations.

GENERAL

Unless the context otherwise requires, all references in this Quarterly Report to “we,” “us,” “our,” “atai” or the “Company” refer to ATAI Life Sciences N.V. and its consolidated subsidiaries. References to "Quarterly Report" herein refer to this Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2023 and references to “Form 10-K” and “Annual Report” herein refer to our Annual Report on Form 10-K for the fiscal year ended December 31, 2022.

All reports we file with the SEC are available for download free of charge via the Electronic Data Gathering Analysis and Retrieval (EDGAR) System on the SEC’s website at www.sec.gov. We also make electronic copies of our reports available for download, free of charge, through our investor relations website at ir.atai.life as soon as reasonably practicable after filing such material with the SEC.

We may announce material business and financial information to our investors using our investor relations website at ir.atai.life. We therefore encourage investors and others interested in atai to review the information that we make available on our website, in addition to following our filings with the SEC, webcasts, press releases and conference calls. Information contained on our website is not incorporated into, and does not form a part of this Quarterly Report.

2

PART I - FINANCIAL INFORMATION

Item 1. Financial Statements

ATAI LIFE SCIENCES N.V.

CONDENSED CONSOLIDATED BALANCE SHEETS

(Amounts in thousands, except share and per share amounts)

	June 30,			December 31,
	2023			2022
	(unaudited)
Assets
Current assets:
Cash and cash equivalents	$	141,090		$	190,613
Securities carried at fair value		86,402			82,496
Prepaid expenses and other current assets		6,257			14,036
Short term notes receivable - related parties, net		9,021			—
Total current assets		242,770			287,145
Property and equipment, net		1,043			928
Operating lease right-of-use asset, net		1,367			226
Other investments		3,991			6,755
Long term notes receivable - related parties, net		1,157			7,262
Other assets		3,267			3,125
Total assets	$	253,595		$	305,441
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable		3,859			2,399
Accrued liabilities		12,855			17,306
Current portion of lease liability		322			180
Other current liabilities		890			12
Total current liabilities		17,926			19,897
Non-current portion of contingent consideration liability - related parties		842			953
Non-current portion of lease liability		1,095			44
Convertible promissory notes - related parties, net of discounts and deferred issuance costs		420			415
Long-term debt, net		14,868			14,702
Other liabilities		2,807			3,664
Total liabilities	$	37,958		$	39,675
Commitments and contingencies (Note 16)
Stockholders’ equity:
Common stock, €0.10 par value ($0.12 par value at June 30, 2023 and December 31, 2022, respectively); 750,000,000 shares authorized at June 30, 2023 and December 31, 2022, respectively; 166,010,476 and 165,935,914 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively		18,571			18,562
Additional paid-in capital		791,688			774,092
Share subscription receivable		—			(24	)
Accumulated other comprehensive loss		(20,818	)		(21,702	)
Accumulated deficit		(576,891	)		(510,188	)
Total stockholders’ equity attributable to ATAI Life Sciences N.V. stockholders		212,550			260,740
Noncontrolling interests		3,087			5,026
Total stockholders’ equity		215,637			265,766
Total liabilities and stockholders’ equity	$	253,595		$	305,441

See accompanying Notes to the unaudited Condensed Consolidated Financial Statements.

3

ATAI LIFE SCIENCES N.V.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(Amounts in thousands, except share and per share amounts)

(unaudited)

	Three Months Ended June 30,						Six Months Ended June 30,
	2023			2022			2023			2022
License revenue	$	172		$	170		$	209		$	170
Operating expenses:
Research and development		15,476			17,949			34,757			33,409
Acquisition of in-process research and development		—			357			—			357
General and administrative		16,558			17,221			30,529			35,203
Total operating expenses		32,034			35,527			65,286			68,969
Loss from operations		(31,862	)		(35,357	)		(65,077	)		(68,799	)
Other income (expense), net:
Interest income		303			117			579			215
Interest expense		(658	)		—			(1,280	)		—
Change in fair value of contingent consideration liability - related parties		76			95			111			95
Change in fair value of warrant liability		—			53			—			53
Change in fair value of securities carried at fair value		526			(584	)		1,490			(1,324	)
Foreign exchange gain (loss), net		(9	)		4,882			(846	)		7,045
Other income (expense), net		(34	)		(12	)		209			(12	)
Total other income (expense), net		204			4,551			263			6,072
Loss before income taxes		(31,658	)		(30,806	)		(64,814	)		(62,727	)
Provision for income taxes		(185	)		(51	)		(351	)		(92	)
Losses from investments in equity method investees, net of tax		(1,928	)		(6,652	)		(2,961	)		(12,248	)
Net loss		(33,771	)		(37,509	)		(68,126	)		(75,067	)
Net loss attributable to noncontrolling interests		(729	)		(891	)		(1,948	)		(1,580	)
Net loss attributable to ATAI Life Sciences N.V. stockholders	$	(33,042	)	$	(36,618	)	$	(66,178	)	$	(73,487	)
Net loss per share attributable to ATAI Life Sciences N.V. stockholders — basic and diluted	$	(0.21	)	$	(0.24	)	$	(0.42	)	$	(0.48	)
Weighted average common shares outstanding attributable to ATAI Life Sciences N.V. stockholders — basic and diluted		155,792,490			153,971,202			155,793,323			153,751,456

See accompanying Notes to the unaudited Condensed Consolidated Financial Statements.

4

ATAI LIFE SCIENCES N.V.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(Amounts in thousands)

(unaudited)

	Three Months Ended June 30,						Six Months Ended June 30,
	2023			2022			2023			2022
Net loss	$	(33,771	)	$	(37,509	)	$	(68,126	)	$	(75,067	)
Other comprehensive income (loss):
Foreign currency translation adjustments, net of tax		5			(8,482	)		884			(12,855	)
Comprehensive loss:	$	(33,766	)	$	(45,991	)	$	(67,242	)	$	(87,922	)
Comprehensive loss attributable to noncontrolling interests		(729	)		(891	)		(1,948	)		(1,580	)
Foreign currency translation adjustments, net of tax attributable to noncontrolling interests		1			30			9			19
Comprehensive loss attributable to noncontrolling interests		(728	)		(861	)		(1,939	)		(1,561	)
Comprehensive loss attributable to ATAI Life Sciences    N.V. stockholders	$	(33,038	)	$	(45,130	)	$	(65,303	)	$	(86,361	)

See accompanying Notes to the unaudited Condensed Consolidated Financial Statements.

5

ATAI LIFE SCIENCES N.V.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(Amounts in thousands, except share and per share amounts)

(unaudited)

																Total
										Accumulated						Stockholders’
					Additional		Share			Other						Equity Attributable to						Total
	Common Stock				Paid-In		Subscriptions			Comprehensive			Accumulated			ATAI Life Sciences N.V.			Noncontrolling			Stockholders’
	Shares		Amount		Capital		Receivable			Loss			Deficit			Stockholders			Interests			Equity
Balances at December 31, 2022		165,935,914	$	18,562	$	774,092	$	(24	)	$	(21,702	)	$	(510,188	)	$	260,740		$	5,026		$	265,766
Issuance of shares upon exercise of stock options		74,562		9		172		—			—			—			181			—			181
Settlement of issuance of shares upon    exercise of stock options		—		—		—		24			—			—			24			—			24
Stock-based compensation expense		—		—		8,662		—			—			—			8,662			—			8,662
Adjustment to accumulated deficit (pursuant to adoption of ASU 2016-13)		—		—		—		—			—			(526	)		(526	)		—			(526	)
Foreign currency translation adjustment,    net of tax		—		—		—		—			879			—			879			8			887
Net loss		—		—		—		—			—			(33,135	)		(33,135	)		(1,219	)		(34,354	)
Balances at March 31, 2023		166,010,476	$	18,571	$	782,926	$	—		$	(20,823	)	$	(543,849	)	$	236,825		$	3,815		$	240,640
Stock-based compensation expense		—		—		8,762		—			—			—			8,762			—			8,762
Foreign currency translation adjustment,    net of tax		—		—		—		—			5			—			5			1			6
Net loss		—		—		—		—			—			(33,042	)		(33,042	)		(729	)		(33,771	)
Balances at June 30, 2023		166,010,476	$	18,571	$	791,688	$	—		$	(20,818	)	$	(576,891	)	$	212,550		$	3,087		$	215,637

															Total
									Accumulated						Stockholders’
					Additional		Share		Other						Equity Attributable to						Total
	Common Stock				Paid-In		Subscriptions		Comprehensive			Accumulated			ATAI Life Sciences N.V.			Noncontrolling			Stockholders’
	Shares		Amount		Capital		Receivable		Loss			Deficit			Stockholders			Interests			Equity
Balances at December 31, 2021		160,677,001	$	18,002	$	725,045	$	—	$	(8,336	)	$	(357,803	)	$	376,908		$	9,051		$	385,959
Issuance of shares upon exercise of stock options		42,827		5		127		—		—			—			132			—			132
Stock-based compensation expense		—		—		10,208		—		—			—			10,208			—			10,208
Foreign currency translation adjustment,    net of tax		—		—		—		—		(4,373	)		—			(4,373	)		(11	)		(4,384	)
Net loss		—		—		—		—		—			(36,869	)		(36,869	)		(689	)		(37,558	)
Balances at March 31, 2022		160,719,828	$	18,007	$	735,380	$	—	$	(12,709	)	$	(394,672	)	$	346,006		$	8,351		$	354,357
Conversion of convertible notes to common stock		960,000		101		1,039		—		—			—			1,140			—			1,140
Issuance of shares upon exercise of stock options		47,957		6		112		—		—			—			118			—			118
Issuance of subsidiary preferred shares		—		—		—		—		—			—			—			600			600
Issuance of subsidiary common shares		—		—		—		—		—			—			—			357			357
Stock-based compensation expense		—		—		9,511		—		—			—			9,511			—			9,511
Foreign currency translation adjustment,    net of tax		—		—		—		—		(8,482	)		—			(8,482	)		30			(8,452	)
Net loss		—		—		—		—		—			(36,618	)		(36,618	)		(891	)		(37,509	)
Balances at June 30, 2022		161,727,785	$	18,114	$	746,042	$	—	$	(21,191	)	$	(431,290	)	$	311,675		$	8,447		$	320,122

See accompanying Notes to the unaudited Condensed Consolidated Financial Statements.

6

ATAI LIFE SCIENCES N.V.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Amounts in thousands)

(unaudited)

	Six Months Ended June 30,
	2023			2022
Cash flows from operating activities
Net loss	$	(68,126	)	$	(75,067	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense		144			79
Change in right-of-use asset		218			—
Amortization of debt discount		173			—
Change in fair value of contingent consideration liability—related parties		(111	)		(95	)
Change in fair value of securities carried at fair value		(1,490	)		1,324
Change in fair value of warrant liability		—			(53	)
Losses from investments in equity method investees		2,961			12,242
In-process research and development expense		—			357
Stock-based compensation expense		17,424			19,720
Unrealized foreign exchange (gains) losses		835			(4,966	)
Other		(244	)		(134	)
Changes in operating assets and liabilities:
Prepaid expenses and other current assets		7,798			939
Accounts payable		1,403			(2,591	)
Accrued liabilities		(4,710	)		2,328
Net cash used in operating activities		(43,725	)		(45,917	)
Cash flows from investing activities
Purchases of property and equipment		(251	)		(172	)
Capitalized internal-use software development costs		(320	)		(100	)
Cash paid for securities carried at fair value		(39,617	)		(229,678	)
Proceeds from sale and maturities of securities carried at fair value		37,201			—
Loans to related parties		(3,000	)		(3,000	)
Net cash used in investing activities		(5,987	)		(232,950	)
Cash flows from financing activities
Proceeds from issuance of shares upon exercise of stock options		206			249
Proceeds from issuance of subsidiary preferred shares		—			600
Proceeds from conversion of convertible notes to common stock		—			1,077
Financing costs paid		(100	)		—
Net cash provided by financing activities		106			1,926
Effect of foreign exchange rate changes on cash		83			(1,193	)
Net increase (decrease) in cash and cash equivalents		(49,523	)		(278,134	)
Cash and cash equivalents – beginning of the period		190,613			362,266
Cash and cash equivalents – end of the period	$	141,090		$	84,132
Supplemental disclosures:
Cash paid for taxes	$	1,402		$	—
Cash paid for interest	$	933		$	—
Supplemental disclosures of non cash investing and financing information:
Right of use asset obtained in exchange for operating lease liabilities	$	1,356		$	487
Issuance of subsidiary shares to non-controlling interests in connection with Columbia stock purchase agreement	$	—		$	357

See accompanying Notes to the unaudited Condensed Consolidated Financial Statements.

7

1. Organization and Description of Business

ATAI Life Sciences N.V. (“atai”) is the parent company of ATAI Life Sciences AG and, along with its subsidiaries, is a clinical-stage biopharmaceutical company aiming to transform the treatment of mental health disorders. atai was founded in 2018 as a response to the significant unmet need and lack of innovation in the mental health treatment landscape. atai is dedicated to developing innovative therapeutics to treat depression, anxiety, addiction, and other mental health disorders.

Since inception, atai has either created wholly owned subsidiaries or has made investments in certain controlled entities, including variable interest entities (“VIEs”) for which atai is the primary beneficiary under the VIE model (collectively, the “Company”). atai is headquartered in Berlin, Germany.

The Company has determined that it has one operating and reporting segment.

Liquidity and Going Concern

The Company has incurred significant losses and negative cash flows from operations since its inception. As of June 30, 2023, the Company had cash and cash equivalents of $141.1 million, short-term securities of $86.4 million and its accumulated deficit was $576.9 million. The Company has historically financed its operations through the sale of equity securities, debt financings, sale of convertible notes and revenue generated from licensing and collaboration arrangements. The Company has not generated any revenues to date from the sale of its product candidates and does not anticipate generating any revenues from the sale of its product candidates unless and until it successfully completes development and obtains regulatory approval to market its product candidates.

The Company currently expects that its existing cash and cash equivalents and short-term securities as of June 30, 2023 will be sufficient to fund its operating expenses and capital expenditure requirements for at least the next 12 months from the date the condensed consolidated financial statements are issued.

2. Basis of Presentation, Consolidation and Summary of Significant Accounting Policies

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial information and follow the requirements of the United States Securities and Exchange Commission (“SEC”) for interim financial reporting. Accordingly, these unaudited condensed consolidated financial statements do not include all of the information and disclosures required by U.S. GAAP for complete financial statements as certain footnotes or other financial information that are normally required by U.S. GAAP can be condensed or omitted. These unaudited condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on March 24, 2023.

The unaudited condensed consolidated financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for a fair statement of the Company’s financial position, its results of operations and comprehensive loss, and its cash flows for the periods presented. The results of operations for the three and six months ended June 30, 2023 are not necessarily indicative of the results to be expected for the year ending December 31, 2023 or for any other future annual or interim period.

Any reference in these notes to applicable accounting guidance is meant to refer to the authoritative U.S. GAAP included in the Accounting Standards Codification (“ASC”), and Accounting Standards Update (“ASU”) issued by the Financial Accounting Standards Board (“FASB”).

Reclassifications

Certain reclassifications were made to prior period amounts in the condensed consolidated financial statements and accompanying notes to conform with current year presentation due to the increase in the balances of the Company's operating right-of-use asset and related lease liability during the period.

Consolidation

The Company's condensed consolidated financial statements include the accounts of atai and its subsidiaries. All intercompany balances and transactions have been eliminated in the consolidation.

The Company's policy is to consolidate all entities that it controls by ownership of a majority of the outstanding voting stock. In addition, entities that meet the definition of a variable interest entity (“VIE”) for which atai is the primary beneficiary are consolidated. The primary beneficiary is the party who has the power to direct the activities of a VIE that most significantly impact the entity’s economic performance and who has an obligation to absorb losses of the entity or a right to receive benefits from the entity that could potentially be significant to

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the entity. For consolidated entities that are less than wholly-owned, the third-party’s holding of equity interest is presented as Noncontrolling interests in the Company's condensed consolidated balance sheets and condensed consolidated statements of stockholders' equity. The portion of net earnings attributable to the noncontrolling interests is presented as Net loss attributable to noncontrolling interests in the Company's condensed consolidated statements of operations.

In situations in which atai has significant influence, but not control, of an entity that does not qualify as a VIE, the Company applies the cost and equity method of accounting, with its portion of net losses recorded in Losses from investments in equity method investees, net of tax in the Company's condensed consolidated statements of operations.

Significant Accounting Policies

During the six months ended June 30, 2023, there were no significant changes to the Company’s significant accounting policies as described in the Company’s audited consolidated financial statements as of and for the year ended December 31, 2022 except as described below.

Use of Estimates

The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Significant estimates and assumptions made in the accompanying condensed consolidated financial statements include, but are not limited to the fair value of the Company’s investment in Intelgenx Technologies Corp. (“IntelGenx”), securities carried at fair value, contingent consideration liability—related parties, in-process research and development assets (“IPRD”) and noncontrolling interests recognized in acquisitions, the valuation of share-based awards, and accruals for research and development costs.

The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable. Actual results may differ from those estimates or assumptions.

Cash and Cash Equivalents

The Company considers all highly liquid investments purchased with original maturities of three months or less from the purchase date to be cash equivalents. As of June 30, 2023 and December 31, 2022, cash and cash equivalents consisted of cash on deposit and cash held in high-yield savings accounts and money market funds. The substantial majority of the Company’s cash is held in financial institutions in the United States and at times in excess of federally insured limits.

Investment Securities Portfolio

The following table sets forth the fair value of atai's available-for-sale securities portfolio at the dates indicated:

	Fair Value
	June 30, 2023		December 31, 2022
Money Market Funds	$	60,920	$	72,334
U.S. Treasuries		31,843		—
Commercial Paper		—		5,958
Corporate Notes/Bonds		4,900		17,719
U.S. Government Agencies		49,659		58,819
	$	147,322	$	154,830

In January 2022, the Company invested in a certain investment portfolio, which is comprised of Money Market Funds, U.S. Treasury securities, Commercial Paper, Corporate Notes/Bonds, and U.S. government agencies securities. The Company classified securities in the investment portfolio as available-for-sale securities. Furthermore, the Company elected the fair value option for the available-for-sale securities in the investment portfolio (see Note 7). The decision to elect the fair value option, which is irrevocable once elected, is determined on an instrument-by-instrument basis and applied to an entire instrument. The net gains or losses, if any, on an investment for which the fair value option has been elected are recognized as a change in fair value of securities carried at fair value on the Condensed Consolidated Statements of Operations and the amortized cost of investments approximates their fair value. The Company's securities in the investment portfolio will mature within two years.

Fair Value Measurements

Assets and liabilities recorded at fair value on a recurring basis in the condensed consolidated balance sheets are categorized based upon the level of judgment associated with the inputs used to measure their fair values. Fair value is defined as the exchange price that would be received for an asset or an exit price that would be paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value

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must maximize the use of observable inputs and minimize the use of unobservable inputs. The authoritative guidance on fair value measurements establishes a three-tier fair value hierarchy for disclosure of fair value measurements as follows:

Level 1—Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date;

Level 2—Inputs (other than quoted prices included in Level 1) are either directly or indirectly observable for the asset or liability. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active; and

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. Accordingly, the degree of judgment exercised by the Company in determining fair value is greatest for instruments categorized in Level 3. A financial instrument’s level within the fair value hierarchy is based on the lowest level of any input that is significant to the fair value measurement.

The Company’s contingent consideration liability—related parties, IntelGenx Initial Warrants and IntelGenx Additional Units Warrant are carried at fair value, determined according to Level 3 inputs in the fair value hierarchy described above (See Note 7). The IntelGenx common stock and securities carried at fair value are determined according to Level 2 inputs in the fair value hierarchy above. The carrying amount reflected in the accompanying condensed consolidated balance sheets for cash, prepaid expenses and other current assets, accounts payable and accrued liabilities approximate their fair values, due to their short-term nature.

The carrying amounts of the Company’s remaining outstanding convertible promissory notes—related parties (“2018 Convertible Notes”) do not approximate fair value because the fair value is driven by the underlying value of the Company’s common shares into which the notes are to be converted. As of June 30, 2023, the carrying amount and fair value amount of the 2018 Convertible Notes was $0.4 million and $6.5 million, respectively. As of December 31, 2022, the carrying amount and fair value amount of the 2018 Convertible Notes was $0.4 million and $13.1 million, respectively. In 2022, several noteholders of the 2018 Convertible Notes elected to convert their promissory notes into the Company's common shares. See Note 11 for additional discussion.

Fair Value Option

As permitted under Accounting Standards Codification 825, Financial Instruments, or ASC 825, the Company has elected the fair value option to account for its investment in common shares of IntelGenx, which otherwise would be subject to ASC 323. In accordance with ASC 825, the Company records this investment at fair value under Other investments held at fair value in the Company's condensed consolidated balance sheets and changes in fair value are recognized as a component of other income (expense), net in the condensed consolidated statements of operations. The carrying value of the investment remained at zero as of June 30, 2023 and December 31, 2022, respectively.

Furthermore, as noted above the Company also elected the fair value option for its investment securities portfolio.

Emerging Growth Company Status

The Company is an emerging growth company, as defined in the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”). Under the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period for complying with new or revised accounting standards that have different effective dates for public and private companies until the earlier of the date that it (i) is no longer an emerging growth company or (ii) affirmatively and irrevocably opts out of the extended transition period provided in the JOBS Act. As a result, these condensed consolidated financial statements may not be comparable to companies that comply with the new or revised accounting pronouncements as of public company effective dates.

As described in “Recently Adopted Accounting Pronouncements” below, the Company early adopted certain accounting standards, as the JOBS Act does not preclude an emerging growth company from adopting a new or revised accounting standard earlier than the time that such standard applies to private companies. The Company expects to use the extended transition period for any other new or revised accounting standards during the period in which it remains an emerging growth company.

Recently Adopted Accounting Pronouncements

ASU 2016-02 Leases (Topic 842)

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which is a comprehensive new lease standard that amends various aspects of existing accounting guidance for leases. The core principle of Topic 842 requires lessees to recognize on the condensed consolidated balance sheets a liability to make lease payments and a right-of-use asset representing its right to use the underlying asset for the lease term for both finance and operating leases with lease terms greater than twelve months. The lease liability is measured at the present value of the unpaid lease payments and the right-of-use asset is derived from the calculation of the lease liability. Topic 842 also requires lessees to disclose key information about leasing arrangements. For public entities, ASU 2016-02 is effective for fiscal years

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beginning after December 15, 2018. As a result of the Company having elected the extended transition period for complying with new or revised accounting standards pursuant to Section 107(b) of the JOBS Act, ASU 2016-02 is effective for the Company beginning after December 15, 2021. The Company adopted the new standard on January 1, 2022 using the modified transition approach as of the effective date.

The Company elected the “package of three practical expedients,” which permitted it to not reassess under the new standard its prior conclusions about lease identification, lease classification, and initial direct costs. As a result, the Company has continued to account for existing leases - i.e. leases for which the commencement date is before January 1, 2022 - in accordance with Topic 840 throughout the entire lease term, including periods after the effective date, with the exception that the Company applied the new balance sheet recognition guidance for operating leases and applied Topic 842 for remeasurements and modifications after the Transition Date. The Company also elected the hindsight expedient in determining the lease term and assessing impairment of right-of-use assets when transitioning to ASC 842. As a result, the Company evaluated the lease term for its existing leases as of the transition date, January 1, 2022.

The most significant impact of the initial adoption of Topic 842 on the Company’s condensed consolidated financial statements was the recognition of a $0.2 million operating lease right-of-use asset, a $0.1 million current operating lease liability, and a $0.1 million long-term operating lease liability on the Company’s condensed consolidated balance sheets related to its existing facility operating lease. The Company did not have a deferred rent liability recorded in connection with its existing facility operating lease. There was no material impact of the initial adoption to the Company’s condensed consolidated balance sheets, condensed consolidated statements of operations, and no cumulative-effect adjustment to accumulated deficit.

In May 2022, the Company entered into a five-year lease arrangement that commenced in January 2023 related to our principal executive office located at Wallstraße 16, 10179, Berlin, Germany. This lease will require lease payments over the term of approximately $1.8 million, which is further described in Note 10 of the notes to the Company's unaudited condensed consolidated financial statements.

ASU 2016-13 Financial Instruments - Credit Losses

In June 2016, the FASB issued ASU 2016-13, Financial Instruments — Credit Losses. This guidance requires immediate recognition of management’s estimates of current expected credit losses. Under the prior model, losses were recognized only when losses were deemed probable. The new model is applicable to most financial assets and certain other instruments that are not measured at fair value through net income.

The Company utilizes an undiscounted probability-of-default (“PD”) and loss-given-default (“LGD”) method for estimating credit losses on its assets pool, which is comprised of loans to other companies. Under the PD and LGD method, the expected credit loss percentage (or “loss rate”) is calculated as the probability of default (i.e., the probability the asset will default within the given time frame) multiplied by the loss given default (i.e., the percentage of the asset not expected to be collected because of default). To implement the PD and LGD method, the Company utilizes readily observable market information from term-matched public debt to derive market implied current expected credit losses (“MICECL”) grouped by Standard & Poor’s (“S&P”) credit rating scale. The MICECL framework considers risk characteristics of assets pool based on publicly available or estimated S&P credit ratings to calculate an appropriate credit loss reserve for the pool or group of assets.

ASU 2016-13 requires a cumulative effect adjustment to the statement of financial position as of the beginning of the first reporting period in which it is effective. On January 1, 2023, the Company adopted this guidance and applied a modified-retrospective transition approach through a cumulative-effect adjustment to retained earnings upon adoption. At transition, the new accounting guidance’s adoption resulted in an increase to accumulated deficit of $0.5 million, net of tax attributable to an increase in the allowance for credit losses related to its Short term notes receivable - related parties, net and Long term notes receivable - related parties, net.

Further, the FASB issued ASU 2019-04, ASU 2019-05, ASU 2019-11, ASU 2020-03 and ASU 2022-02 to provide additional clarification and guidance on the credit losses standard. We adopted ASU 2019-04, ASU 2019-05, ASU 2019-11, ASU 2020-03 and ASU 2022-02 on January 1, 2023. The adoption of these standards did not have a material impact on the Company’s consolidated financial statements or disclosures.

3. Dispositions

2022 Dispositions

Neuronasal, Inc.

In October 2020 and March 2021, the Company invested in Neuronasal, Inc. (“Neuronasal”) common stock for a cash contribution of $0.3 million and $0.5 million, respectively. In December 2019, October 2020 and May 2021, the Company invested in Neuronasal

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preferred stock for a cash contribution of $0.5 million, $0.8 million and $1.0 million, respectively. Upon the closing of the purchase on May 17, 2021, the Company obtained a controlling financial interest in Neuronasal. The Company derecognized its other investments in Neuronasal and began to consolidate the operations of Neuronasal into its consolidated financial statements.

In November 2022, the Company finalized and entered into a Redemption, Termination and Release Agreement (“Termination Agreement”) with Neuronasal through which atai disposed of its equity interests and residual SPA funding obligations. Pursuant to the Neuronasal Termination Agreement, the Company transferred all of its approximately 56.5% equity interest in Neuronasal in exchange for the redemption consideration in the form of certain warrants. The Termination Agreement entitles the Company to purchase common stock in Neuronasal upon the occurrence of certain contingencies, such as an initial public offering, a qualified financing event, or certain clinical studies. The Company has no further obligations to fund Neuronasal.

As a result of the disposition, the Company ceased having controlling financial interest in Neuronasal and the Company deconsolidated Neuronasal in November 2022 because it determined that it no longer was the primary beneficiary of Neuronsasal as it no longer had the power to direct the significant activities of Neuronasal. Upon the effective termination date, the Company derecognized all of Neuronasal's assets and liabilities from the Company's balance sheet, and recognized a gain of $1.5 million, which was recognized as a component of other income (expense), net in the Company's consolidated statements of operations for the year ended December 31, 2022. The Company determined that the value of the warrants received in connection with the Termination Agreement was de minimis as of the termination date. In connection with the deconsolidation of Neuronasal, the Company concluded that a loan loss had been incurred and the loan assets were impaired accordingly. The Company recognized an impairment of loan receivable of $0.9 million for the year ended December 31, 2022.

The Company concluded that the decision to deconsolidate Neuronasal, which was based on clinical data that did not meet expectations, did not represent a significant strategic shift. Therefore, the Company did not present the results of Neuronasal prior to deconsolidation as discontinued operations in its consolidated statements of operations for the year ended December 31, 2022.

4. Variable Interest Entities

Consolidated VIEs

At each reporting period, the Company reassesses whether it remains the primary beneficiary for Variable Interest Entities (“VIEs”) consolidated under the VIE model.

The entities consolidated by the Company are comprised of wholly and partially owned entities for which the Company is the primary beneficiary under the VIE model as the Company has (i) the power to direct the activities that most significantly impact the VIE’s economic performance and (ii) the obligation to absorb losses that could potentially be significant to the VIE, or the right to receive benefits from the VIE that could potentially be significant to the VIE. The results of operations of the consolidated entities are included within the Company’s condensed consolidated financial statements from the date of acquisition to June 30, 2023.

As of June 30, 2023 and December 31, 2022, the Company has accounted for the following consolidated investments as VIEs, excluding the wholly owned subsidiaries:

Consolidated Entities	Relationship as of June 30, 2023	Relationship as of December 31, 2022	Date Control Obtained	Ownership % June 30, 2023	Ownership % December 31, 2022
Perception Neuroscience Holdings, Inc.	Controlled VIE	Controlled VIE	November 2018	59.2%	58.9%
Kures, Inc.	Controlled VIE	Controlled VIE	August 2019	64.5%	64.5%
EntheogeniX Biosciences, Inc.	Controlled VIE	Controlled VIE	November 2019	80.0%	80.0%
DemeRx IB, Inc.	Controlled VIE	Controlled VIE	December 2019	59.5%	59.5%
Recognify Life Sciences, Inc.	Controlled VIE	Controlled VIE	November 2020	51.9%	51.9%
PsyProtix, Inc.	Controlled VIE	Controlled VIE	February 2021	75.0%	75.0%
Psyber, Inc.	Controlled VIE	Controlled VIE	February 2021	75.0%	75.0%
InnarisBio, Inc.	Controlled VIE	Controlled VIE	March 2021	82.0%	82.0%
TryptageniX Inc.	Controlled VIE	Controlled VIE	December 2021	65.0%	65.0%

As of June 30, 2023 and December 31, 2022, the assets of the consolidated VIEs can only be used to settle the obligations of the respective VIEs. The liabilities of the consolidated VIEs are obligations of the respective VIEs and their creditors have no recourse to the general credit or assets of atai.

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EntheogeniX Biosciences, Inc.

In November 2019, the Company entered into a series of agreements with Cyclica Inc. ("Cyclica") to form EntheogeniX Biosciences, Inc. ("EntheogeniX"), a company dedicated to developing the next generation of innovative mental health drugs employing an AI-enabled computational biophysics platform designed to optimize and accelerate drug discovery. Based on the Company's assessment of the transaction at the time of acquisition, the Company concluded that EntheogeniX was not a business and accounted for the Company's investment as an initial consolidation of a VIE that is not a business under ASC 810.

In February 2022 and September 2022, pursuant to the business plan as contemplated in the Stockholders Agreement and Subscription for Shares pursuant to the Contribution and Subscription Agreement, atai purchased additional shares of Class A common stock for an aggregate purchase price of $2.2 million. As a result of anti-dilution protection available to Cyclica, the Company's ownership percentage in EntheogeniX did not change due to its purchase of the Class A common stock.

In March 2023, pursuant to the business plan as contemplated in the Stockholders Agreement and Subscription for Shares pursuant to the Contribution and Subscription Agreement, atai purchased additional shares of Class A common stock for an aggregate purchase price of $1.0 million. As a result of anti-dilution protection available to Cyclica, the Company's ownership percentage in EntheogeniX did not change due to its purchase of the Class A common stock.

As of June 30, 2023 and December 31, 2022, the Company owned 80% of the outstanding common stock of EntheogeniX.

The purchase of additional Class A common stock was deemed to be a reconsideration event. The Company determined that EntheogeniX is still considered a VIE subsequent to the additional Class A common stock purchase as EntheogeniX does not have sufficient equity at risk to carry out its principal activities without additional subordinated financial support.

The following table presents the assets and liabilities (excluding intercompany balances that were eliminated in consolidation) for all VIEs as of June 30, 2023 (in thousands):

	Perception		Kures		EntheogeniX		DemeRx IB		Recognify		PsyProtix		Psyber		InnarisBio		TryptageniX
Assets:
Current assets:
Cash	$	2,483	$	56	$	458	$	10,395	$	4,108	$	14	$	541	$	503	$	82
Accounts receivable		205		—		—		—		—		—		—		—		—
Prepaid expenses and other current assets		310		286		147		69		1,155		—		—		488		2,700
Total current assets		2,998		342		605		10,464		5,263		14		541		991		2,782
Long term notes receivable		—		—		—		1,063		—		94		—		—		—
Other assets		—		—		—		—		—		—		706		—		—
Total assets	$	2,998	$	342	$	605	$	11,527	$	5,263	$	108	$	1,247	$	991	$	2,782
Liabilities:
Current liabilities:
Accounts payable	$	581	$	510	$	246	$	260	$	210	$	—	$	2	$	5	$	—
Accrued liabilities		1,189		62		103		284		396		45		118		327		118
Other current liabilities		—		—		—		—		—		—		—		—		—
Total current liabilities		1,770		572		349		544		606		45		120		332		118
Total liabilities	$	1,770	$	572	$	349	$	544	$	606	$	45	$	120	$	332	$	118

The following table presents the assets and liabilities (excluding intercompany balances that were eliminated in consolidation) for all consolidated VIEs as of December 31, 2022 (in thousands):

	Perception		Kures		EntheogeniX		DemeRx IB		Recognify		PsyProtix		Psyber		InnarisBio		TryptageniX
Assets:
Current assets:
Cash	$	8,703	$	220	$	467	$	12,251	$	7,526	$	1	$	683	$	719	$	513
Accounts receivable		197		—		—		—		—		—		—		—		—
Prepaid expenses and other current assets		466		174		91		21		1,742		66		—		13		2,850
Total current assets		9,366		394		558		12,272		9,268		67		683		732		3,363
Long term notes receivable		—		—		—		1,075		—		109		—		—		—
Other assets		—		—		—		—		—		—		353		—		—
Total assets	$	9,366	$	394	$	558	$	13,347	$	9,268	$	176	$	1,036	$	732	$	3,363
Liabilities:
Current liabilities:
Accounts payable	$	661	$	25	$	124	$	332	$	381	$	33	$	10	$	3	$	—
Accrued liabilities		1,738		266		121		671		596		46		37		158		154
Other current liabilities		121		2		—		133		2		1		1		1		—
Total current liabilities		2,520		293		245		1,136		979		80		48		162		154
Total liabilities	$	2,520	$	293	$	245	$	1,136	$	979	$	80	$	48	$	162	$	154

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Noncontrolling Interests

The Company recognizes noncontrolling interests related to its consolidated VIEs and provides a roll forward of the noncontrolling interests balance, as follows (in thousands):

	Perception			Kures			Recognify			Total
Balance as of December 31, 2022	$	1,731		$	451		$	2,844		$	5,026
Net loss attributable to noncontrolling    interests - common		—			—			—			—
Net loss attributable to noncontrolling    interests - preferred		(700	)		(93	)		(426	)		(1,219	)
Comprehensive loss attributable to noncontrolling    interests		6			2			—			8
Balance as of March 31, 2023	$	1,037		$	360		$	2,418		$	3,815
Net loss attributable to noncontrolling    interests - common		—			—			—			—
Net loss attributable to noncontrolling    interests - preferred		(266	)		(32	)		(431	)		(729	)
Comprehensive loss attributable to noncontrolling    interests		(1	)		2			—			1
Balance as of June 30, 2023	$	770		$	330		$	1,987		$	3,087

	Perception			Kures		Recognify			Total
Balance as of December 31, 2021	$	5,232		$	—	$	3,819		$	9,051
Net loss attributable to noncontrolling    interests - preferred		(571	)		—		(118	)		(689	)
Comprehensive loss attributable to noncontrolling    interests		(11	)		—		—			(11	)
Balance as of March 31, 2022	$	4,650		$	—	$	3,701		$	8,351
Issuance of noncontrolling interests		—			957		—			957
Net loss attributable to noncontrolling    interests - preferred		(800	)		—		(91	)		(891	)
Comprehensive loss attributable to noncontrolling    interests		30			—		—			30
Balance as of June 30, 2022	$	3,880		$	957	$	3,610		$	8,447

Non-consolidated VIEs

The Company evaluated the nature of its investments in Innoplexus AG (“Innoplexus”), DemeRx NB, Inc. (“DemeRx NB”) and IntelGenx and determined that the investments are VIEs as of the date of the Company’s initial investment through June 30, 2023. The Company is not the primary beneficiary of Innoplexus, DemeRx NB or IntelGenx as it did not have the power to direct the activities that most significantly impact the investments’ economic performance and therefore concluded that it did not have a controlling financial interest in each of Innoplexus, DemeRx NB or IntelGenx that would require consolidation as of June 30, 2023 and December 31, 2022.

The Company will reevaluate if the investments meet the definition of a VIE upon the occurrence of specific reconsideration events. The Company accounted for these investments under either the equity method, fair value option, or the measurement alternative included within ASC 321 (See Note 5). As of June 30, 2023, the Company’s maximum exposure for its non-consolidated VIEs was $3.9 million relating to the carrying values in Other investments and Other investments held at fair value, $9.0 million relating to the carrying value in Short term notes receivable - related party and $1.2 million relating to the carrying value in Long term notes receivable – related party in the condensed consolidated balance sheets. As of December 31, 2022, the Company’s maximum exposure for its non-consolidated VIEs was $6.8 million relating to the carrying values in its Other investments and $7.2 million relating to the carrying value in Long term notes receivable—related party in the condensed consolidated balance sheets.

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5. Equity Method Investments and Other Investments

Equity Method Investments

As of June 30, 2023 and December 31, 2022, the Company accounted for the following investments in the investee’s common stock under the equity method (amounts in thousands):

		As of June 30, 2023				As of December 31, 2022
	Date First	Common Stock		Carrying		Common Stock		Carrying
Investee	Acquired	Ownership %		Value		Ownership %		Value
Innoplexus A.G.	August 2018	35.0%		$	—	35.0%		$	—
COMPASS Pathways plc	December 2018	20.9%			—	22.4%			—
GABA Therapeutics, Inc	November 2020	7.5%	(1)		—	7.5%	(1)		—
Total				$	—			$	—

(1)The Company is deemed to have significant influence over this entity through its total ownership interest in the entity’s equity, including the Company’s investment in the respective entity’s preferred stock, described below in Other Investments. The Company’s total ownership interest, considering both preferred and common stock is 54.7%.

COMPASS Pathways plc

COMPASS Pathways plc (“COMPASS”) is a mental health care company dedicated to pioneering the development of a new model of psilocybin therapy with its product COMP360. The Company first acquired investments in COMPASS in December 2018.

Equity Investment

Through a series of open market transactions between November 23, 2021 and December 7, 2021, the Company purchased an additional 1,490,111 of COMPASS ADSs at an aggregate purchase price of $47.4 million. The additional shares acquired resulted in an increase in the Company’s ownership of COMPASS ADSs to 22.8%. The Company applied the cost accumulation model and recorded its investment at cost. At the date of the investment, a basis difference was identified as the cost basis of the Company’s investment in COMPASS exceeded the Company’s proportionate share of the underlying net assets in COMPASS. The Company concluded that the basis differences were primarily attributable to COMPASS’s IPR&D associated with COMP360, a psilocybin therapy, for which COMPASS recently completed a Phase IIb clinical trial. As the Company’s investment in COMPASS did not meet the definition of a business due to substantially all of the estimated fair value of the gross assets being concentrated in COMP360 and the associated IPR&D, the basis differences were attributable to the IPR&D with no alternative future use and were immediately expensed at the time of the additional investment. As of June 30, 2023, the Company owned 20.9% of COMPASS ADS. Based on quoted market prices, the market value of the Company’s ownership in COMPASS was $79.2 million as of June 30, 2023.

Upon the completion of the COMPASS IPO and through June 30, 2023, the Company is deemed to continue to have significant influence over COMPASS primarily through its ownership interest in COMPASS’ equity. Following the COMPASS 2022 annual shareholder meeting, the Company no longer has representation on the COMPASS board of directors. However, the Company maintains significant influence through its ownership interest. Accordingly, the Company’s investment in COMPASS’ ADS was accounted for in accordance with the equity method through June 30, 2023.

The carrying value of the Company's investment in COMPASS was reduced to zero as of December 31, 2022 and remained zero as of June 30, 2023 due to IPR&D charges with no alternative future use and the Company recognizing its proportionate share of COMPASS net losses. During the three months ended June 30, 2023 and 2022, the Company recognized its proportionate share of COMPASS’ net loss of $0 million and $4.7 million, respectively, as losses from investments in equity method investees, net of tax on the condensed consolidated statements of operations. During the six months ended June 30, 2023 and 2022, the Company recognized its proportionate share of COMPASS’ net loss of $0 million and $9.5 million, respectively, as losses from investments in equity method investees, net of tax on the condensed consolidated statements of operations.

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Other Investments

The Company has accounted for its other investments that do not have a readily determinable fair value under the measurement alternative. As of June 30, 2023 and December 31, 2022, the carrying values of other investments, which consisted of investments in the investee’s preferred stock and common stock not in the scope of ASC 323 were as follows (in thousands):

	June 30,		December 31,
	2023		2022
GABA Therapeutics, Inc.	$	2,623	$	5,387
DemeRx NB, Inc.		1,024		1,024
Juvenescence Limited		344		344
Total	$	3,991	$	6,755

The Company’s investments in the preferred stock of Innoplexus, GABA, and DemeRx NB are not considered as in-substance common stock due to the existence of substantial liquidation preferences and therefore did not have subordination characteristics that were substantially similar to the common stock. Although the Company’s investment in Juvenescence Limited (“Juvenescence”) is in common stock, it is not able to exercise significant influence over the operating and financial decisions of Juvenescence. The Company concluded that its ownership interests in the above Other Investments do not have a readily determinable fair value and are accounted for under the measurement alternative. Under the measurement alternative, the Company measured its other investments at cost, less any impairment, plus or minus, if any, observable price changes in orderly transactions for an identical or similar investment of the same issuer.

During the three and six months ended June 30, 2023 and 2022 there were no observable changes in price recorded related to the Company’s Other Investments.

During the three and six months ended June 30, 2023 and 2022, the Company evaluated all of its other investments to determine if certain events or changes in circumstance during these time periods in 2023 and 2022 had a significant adverse effect on the fair value of any of its investments in non-consolidated entities. Based on this analysis, the Company did not note any impairment indicators associated with the Company’s Other Investments.

Innoplexus AG

Innoplexus is a technology company that provides “Data as a Service” and “Continuous Analytics as a Service” solutions that aims to help healthcare organizations leverage their technologies and expedite the drug development process across all stages—preclinical, clinical, regulatory and commercial. The Company first acquired investments in Innoplexus in August 2018.

As of December 31, 2020, the Company owned 35.0% of the common stock issued by Innoplexus. The Company had significant influence over Innoplexus through its noncontrolling representation on the investee’s supervisory board. Accordingly, the Company’s investment in Innoplexus’ common stock was accounted for in accordance with the equity method. The Company’s investment in Innoplexus’ preferred stock did not meet the criteria for in-substance common stock. As such, the investment in Innoplexus’ preferred stock was accounted for under the measurement alternative as discussed below.

In February 2021, the Company entered into a Share Purchase and Assignment Agreement (the “Innoplexus SPA”) to sell its shares of common and preferred stock held in Innoplexus to a current investor of Innoplexus (the “Purchaser”) in exchange for an initial purchase price of approximately $2.4 million. In addition, the Company is entitled to receive contingent payments based on the occurrence of subsequent equity transactions or liquidity events at Innoplexus as determined under the Innoplexus SPA.

Pursuant to the Innoplexus SPA, the Purchaser is required to hold a minimum number of shares equivalent to the number of shares purchased from the Company through December 31, 2026. In the event that the Purchaser is in breach of this requirement, the purchaser is required to pay the Company an additional purchase price of approximately $9.6 million. The transaction was accounted for as a secured financing as it did not qualify for sale accounting under ASC Topic 860, Transfers and Servicing (ASC 860), due to the provision under the Innoplexus SPA which constrained the Purchaser from its right to pledge or exchange the underlying shares and provided more than a trivial benefit to the Company. The initial proceeds from the transaction are reflected as a secured borrowing liability of $2.3 million and $2.4 million as of June 30, 2023 and December 31, 2022, which is included in Other liabilities in the Company’s condensed consolidated balance sheets. The Company will continue to account for its investment in Innoplexus’ common stock under the equity method of accounting and its investment in Innoplexus’ preferred shares under the measurement alternative.

In addition, the Innoplexus SPA also provides the right for the Company to receive additional consideration with a maximum payment outcome of $22.3 million should the equity value of Innoplexus exceed certain thresholds upon the occurrence of certain events. The Company concluded that this feature met the definition of a derivative which required bifurcation. As the probability of the occurrence of certain events defined in the Innoplexus SPA was less than remote, the Company concluded that the fair value of the embedded derivative ascribed to this feature was de minimis as of June 30, 2023.

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The carrying value of the Company’s investment in Innoplexus was zero as of June 30, 2023 and December 31, 2022.

GABA Therapeutics, Inc.

GABA is a California based biotechnology company focused on developing GRX-917 for anxiety, depression and a broad range of neurological disorders. The Company is deemed to have significant influence over GABA through its total ownership interest in GABA’s equity, including the Company’s investment in GABA’s preferred stock, and the Company’s noncontrolling representation on GABA’s board of directors.

Common Stock Investment

The Company’s investment in GABA’s common stock was accounted for in accordance with the equity method.

In November 2020 the Company exercised its option to purchase additional shares of common stock of GABA at a price of approximately $1.8 million pursuant to an Omnibus Amendment Agreement under which the Right of First Refusal and Co-Sale Agreement was amended. Pursuant to the amended Right of First Refusal and Co-Sale Agreement, the Company also has the option but not the obligation to purchase additional shares of common stock for up to $2.0 million from the existing common shareholders.

The carrying value of the investment in GABA common stock was reduced to zero as of December 31, 2020 due to IPR&D charges with no alternative future use and remained zero as of June 30, 2023.

Preferred Stock Investment

The Company’s investment in GABA’s preferred stock did not meet the criteria for in-substance common stock. As such, the investment in GABA’s preferred stock is accounted for under the measurement alternative.

In August 2019, GABA and the Company entered into the Preferred Stock Purchase Agreement (the “GABA PSPA”), whereby GABA issued shares of its Series A preferred stock to the Company at a price of approximately $5.5 million. At closing, the Company had an overall ownership interest of over 20% in GABA and a noncontrolling representation on the board.

Pursuant to the GABA PSPA, the Company was obligated to purchase additional shares of Series A preferred stock for up to $10.0 million with the same price per share as its initial investment, upon the achievement of specified contingent clinical development milestones. In April 2021, pursuant to the GABA PSPA, the Company purchased additional shares of Series A preferred stock of GABA, for an aggregate cost of $5.0 million based on the achievement of certain development milestones. In May 2021, the Company exercised its option to purchase additional shares of Series A preferred stock prior to the achievement of certain development milestone for an aggregate cost of $5.0 million completing its obligation to purchase additional shares. The completion of the Series A Preferred stock purchase in May 2021 was deemed to be a reconsideration event at which point GABA was no longer deemed a VIE as GABA now had sufficient equity at risk to finance its activities through the initial development period without additional subordinated financial support. Entities that do not qualify as a VIE are assessed for consolidation under the voting interest model (“VOE model”). Under the VOE model, the Company consolidates the entity if it determines that it, directly or indirectly, has greater than 50% of the voting shares and that other equity holders do not have substantive voting, participating or liquidation rights. While the Company holds greater than 50% of the outstanding equity interest of GABA, the Company does not have the power to control the entity. Concurrent with the exercise of the option, the Company executed a side letter with the other equity holders of GABA agreeing to forego the rights to additional seats on the board of directors, resulting in the Company lacking the ability to control the investee. The Company concluded that it does not have a controlling financial interest that would require consolidation under the VOE model and accounted for the investments in GABA preferred stock under the measurement alternative per ASC 323. As of June 30, 2023 and December 31, 2022, the investment in GABA’s preferred stock was recorded in Other Investments on the condensed consolidated balance sheets.

In May 2021, GABA and the Company entered into an Amendment to Preferred Stock Purchase Agreement (the "Amended GABA PSPA”) under which the GABA PSPA was amended and shares of its Series A preferred stock were issued to the Company at a price of approximately $0.6 million. Pursuant to the Amended GABA PSPA, the Company is obligated to purchase additional shares of Series A preferred stock from GABA for up to $1.5 million with the same price per share as its initial investment upon the achievement of specified contingent clinical development milestones. In September 2022, pursuant to the Amended PSPA, GABA issued additional shares of its Series A preferred stock to the Company at a price of approximately $0.6 million based on the achievement of certain development milestones. As of June 30, 2023 the Company's remaining obligation to purchase additional shares of Series A preferred stock from GABA is for up to $0.9 million at the same price per share as its initial investment upon the achievement of specified contingent milestones.

In accordance with the Amended GABA PSPA, the Company also has the option but not the obligation to purchase the aforementioned additional shares of Series A preferred stock at any time prior to the achievement of any milestone at the same price per share as its initial investment.

GABA’s net losses attributable to the Company were determined based on the Company’s ownership percentage of preferred stock in GABA and recorded to the Company’s investments in GABA preferred stock. During the three months ended June 30, 2023 and 2022, the

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Company recognized its proportionate share of GABA’s net loss of $1.9 million and $1.9 million as losses from investments in equity method investees, net of tax on the condensed consolidated statements of operations. During the six months ended June 30, 2023 and 2022, the Company recognized its proportionate share of GABA’s net loss of $2.9 million and $2.7 million as losses from investments in equity method investees, net of tax on the condensed consolidated statements of operations.

DemeRx NB

In December 2019, the Company jointly formed DemeRx NB with DemeRx. DemeRx and DemeRx NB entered into a Contribution Agreement whereby DemeRx assigned all of its rights, title, and interests in and to all of its assets relating to DMX-1002, Noribogaine, in exchange for shares of common stock of DemeRx NB. DemeRx NB will use the contributed intellectual property to develop Noribogaine. Noribogaine is an active metabolite of ibogaine designed to have a longer plasma half-life and potentially reduced hallucinogenic effects compared to ibogaine.

In connection with the Contribution Agreement, the parties entered into a Series A Preferred Stock Purchase Agreement (the “DemeRx NB PSPA”) pursuant to which the Company purchased shares of Series A preferred stock of DemeRx NB at a purchase price of $1.0 million. At closing, the Company had less than 20% of ownership interest in DemeRx NB and a noncontrolling representation on DemeRx NB's board of directors. The investment in DemeRx NB was recorded in Other Investments on the condensed consolidated balance sheets under the measurement alternative under ASC 321.

Pursuant to the DemeRx NB PSPA, the Company also has the option but not the obligation to purchase additional shares of DemeRX NB's Series A preferred stock at a purchase price of up to an aggregate of $19.0 million with the same price per share as its initial investment in December 2019. As of June 30, 2023, the Company has not exercised its option to purchase any shares of Series A preferred stock of DemeRx NB.

Other Investments Held at Fair Value

IntelGenx Technologies Corp.

IntelGenx is a novel drug delivery company focused on the development and manufacturing of novel oral thin film products for the pharmaceutical market. In March 2021, IntelGenx and the Company entered into the Strategic Development Agreement and Purchaser Rights Agreement (“PPA”). In May 2021, IntelGenx and the Company executed a Securities Purchase Agreement (the “IntelGenx SPA”) after obtaining IntelGenx shareholder approval, whereby IntelGenx issued shares of its common stock and warrants to the Company at a price of approximately $12.3 million. Each warrant (the “Initial Warrants”) entitles the Company to purchase one share at a price of $0.35 per share for a period of three years from the closing of the initial investment in March 2021. Pursuant to the IntelGenx SPA, the Company has the right to purchase (in cash, or in certain circumstances, the Company’s equity) additional units for a period of three years from the closing of the initial investment (the “Additional Unit Warrants”). Each Additional Unit Warrant will be comprised of (i) one share of common stock and (ii) one half of one warrant (the “Additional Warrants”). The price for the Additional Unit Warrants will be (i) until the date which is 12 months following the closing and the purchase does not result in the Company owning more than 74,600,000 common shares of IntelGenx, $0.331 (subject to certain exceptions), and (ii) until the date which is 12 months following the closing and the purchase results in the Company owning more than 74,600,000 common shares of IntelGenx or following the date which is 12 months following the closing regardless of the number of shares held by the Company, the lower of (A) a 20% premium to the volume weighted average price of the common share for the thirty trading days immediately preceding the news release of the additional closing, and (B) $0.50 if purchased in the second year following closing or $0.75, if purchased in the third year following closing. Each Additional Warrant will entitle the Company, for a period of three years from the date of issuance, to purchase one share at the lesser of either (i) a 20% premium to the price of the corresponding additional share, or (ii) the price per share under which shares of IntelGenx are issued under convertible instruments that were outstanding on February 16, 2021, provided that the Company may not exercise Additional Warrants to purchase more than the lesser of (x) 44,000,000 common shares of IntelGenx, and (y) the number of common shares issued by IntelGenx under outstanding convertibles held by other investors as of February 16, 2021. Following the initial closing, the Company held a 25% voting interest in IntelGenx. Pursuant to the PPA, the Company is entitled to designate a number of directors to the IntelGenx’s board of directors in the same proportion as the shares of common stock held by the Company to the outstanding of IntelGenx common shares.

Pursuant to the Strategic Development Agreement, the Company engages IntelGenx to conduct research and development projects (“Development Project”) using IntelGenx’s proprietary oral thin film technology. Under the terms of the Strategic Development Agreement, the Company can select four (4) program products. As of the effective date of the Strategic Development Agreement, the Company nominated two (2) program products - DMT and Salvinorin A. 20% of any funds that IntelGenx received or will receive through the Company’s equity investment under the IntelGenx SPA will be available to be credited towards research and development services that IntelGenx conducts for the Company under the Development Projects. The Company is eligible to receive a total credit of $2.5 million. For the three and six months ended June 30, 2023, research and development expense relating to the Strategic Development Agreement were $0.1 million and $0.2 million, which was applied as a reduction in research and development expenses in accordance with the Strategic Development Agreement. For the three and six months ended June 30, 2022, there was an immaterial amount of research and development services performed in relation to the Strategic Development Agreement.

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The Company has significant influence over IntelGenx through ownership interest in IntelGenx’s equity and the Company’s noncontrolling representation on IntelGenx’s board of directors. The Company qualified for and elected to account for its investment in the IntelGenx common stock under the fair value option. The Company believes that the fair value option better reflects the underlying economics of the IntelGenx common stock investment. The Initial Warrants and Additional Units Warrant, (collectively the “Warrants”) are accounted for at fair value under ASC 321 and recorded in Other investments held at fair value on the condensed consolidated balance sheets. The Company applied a calibrated model and determined that the initial aggregate fair value is equal to the transaction price and recorded the common shares at $3.0 million, the Initial Warrants at $1.2 million and the Additional Unit Warrants at $8.2 million on a relative fair value basis resulting in no initial gain or loss recognized in the condensed consolidated statements of operations. The Company recognizes subsequent changes in fair value of the common shares and the Warrants as a component of other income (expense), net in the condensed consolidated statements of operations. The carrying amount of the investment was reduced to zero as of December 31, 2021, during the three and six months ended June 30, 2023, the Company recognized a zero mark-to-market (“MTM”) gain/loss in the condensed consolidated statements of operations. The carrying value of the investment remained at zero as of June 30, 2023 and December 31, 2022, respectively.

Summarized Financial Information

The following is a summary of financial data for investments accounted for under the equity method of accounting (in thousands):

Balance Sheets

	June 30, 2023
	COMPASS		GABA
Current assets	$	193,601	$	1,773
Non-current assets		16,233		—
Total assets	$	209,834	$	1,773
Current liabilities	$	12,775	$	1,751
Non-current liabilities		30,663		—
Total liabilities	$	43,438	$	1,751

	December 31, 2022
	COMPASS		GABA
Current assets	$	191,651	$	3,933
Non-current assets		5,643		—
Total assets	$	197,294	$	3,933
Current liabilities	$	15,596	$	1,542
Non-current liabilities		418		—
Total liabilities	$	16,014	$	1,542

Statements of operations

	Three Months Ended June 30, 2023
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(32,664	)	$	(1,928	)
Net loss	$	(28,335	)	$	(1,928	)
	Three Months Ended June 30, 2022
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(27,256	)	$	(1,964	)
Net loss	$	(21,037	)	$	(1,964	)

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	Six Months Ended June 30, 2023
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(64,452	)	$	(2,961	)
Net loss	$	(52,543	)	$	(2,961	)
	Six Months Ended June 30, 2022
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(52,676	)	$	(3,570	)
Net loss	$	(42,208	)	$	(3,570	)

6. Notes Receivable

Short Term Notes Receivable – Related Parties, net

Loan to IntelGenx Corp.

In March 2021, the Company and IntelGenx entered into a loan agreement under which the Company provided a loan to IntelGenx for an aggregate principal amount of $2.0 million (the “March Term Loan”). Pursuant to the loan agreement, IntelGenx may, by written notice, request an advance up to an additional $0.5 million as an additional term loan if no event of default has occurred as defined in the loan agreement. In May 2021, the Company paid an additional advance of $0.5 million as an additional term loan (the “May Term Loan”, and together with the March Term Loan the “Term Loans”). The Term Loans were originally due to mature 120 days following the special shareholder meeting of IntelGenx Tech Corp. to approve an additional investment in IntelGenx Tech Corp. by the Company ("Maturity Date"). In May 2021, the Company amended the loan agreement under which the Maturity Date will be the first business day following the first closing of a subscription for additional units if the proceeds from such subscription amount to at least $3.0 million. The loan bears an annualized interest rate of 8% and such interest is accrued daily. The principal amount of the Term Loans plus any accrued interest shall become due and payable on the Maturity Date. In September 2021, the Company entered into an amended and restated loan agreement, which among other things, increased the principal amount of loans available to IntelGenx by $6.0 million, up to a total of $8.5 million. The additional loan amount of $6.0 million are funded via two separate tranches of $3.0 million each in the beginning of 2022 and 2023 respectively, subject to certain conditions. In addition, the amendment further extended the Maturity Date to January 5, 2024. The first tranche was funded in January 2022 and the second tranche was funded in January 2023.

Pursuant to the terms of the Term Loans, upon the occurrence of an event of default, the Company may accelerate the Term Loans and declare the principal and any accrued and unpaid interests of the Term Loans to be immediately due and payable. In addition, IntelGenx may prepay the Term Loans in whole or in part at any time without premium or penalty. Any prepayment of the principal shall be accompanied by a payment of interest accrued to date thereon. The Company concluded that these embedded features do not meet the criteria to be bifurcated and separately accounted for as derivatives.

As of June 30, 2023, the Term Loans are recorded in Short term notes receivable – related parties, net on the Company's condensed consolidated balance sheets, which includes the principal balance of the Term Loans, accrued interest and allowance for credit losses. On January 1, 2023, the Company adopted ASU 2016-13 Financial Instruments — Credit Losses and applied a modified-retrospective transition approach through a cumulative-effect adjustment to retained earnings of $0.4 million, representing the allowance for credit losses for the Term Loans. During the three and six months ended June 30, 2023 and 2022, the Company recorded an immaterial increase to the allowance.

For the three months ended June 30, 2023 and 2022, the Company recognized $0.2 million and $0.1 million of interest income associated with the Term Loans. For the six months ended June 30, 2023 and 2022, the Company recognized $0.4 million and $0.2 million of interest income associated with the Term Loans. As of June 30, 2023 and December 31, 2022, the Term Loans have an outstanding balance of $8.5 million and $5.5 million.

Long Term Notes Receivable – Related Parties, net

Investment in DemeRx Promissory Note—Related Party

In January 2020, DemeRx IB loaned to DemeRx Inc. $1.0 million pursuant to the terms of a Promissory Note (the "DemeRx Note"). Pursuant to the terms of the DemeRx Note, the aggregate principal amount of $1.0 million together with all accrued and unpaid interest and any other amounts payable are due to be paid on the date that is the earlier of (i) 5 years from the initial closing and (ii) the closing of an initial public offering or a deemed liquidation event of DemeRx IB (the “DemeRx Maturity Date”). Pursuant to the terms of the DemeRx Note, DemeRx Inc. may, in its sole discretion pay any amount due under the DemeRx Note, in cash or through cancellation shares of common stock of DemeRx IB, par value $0.0001 per share, of the fair market value of such shares.

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The Company recorded the DemeRx Note at cost which included the principal balance of the DemeRx Note and accrued interest in Long term notes receivable - related parties, net on its condensed consolidated balance sheets. On January 1, 2023, the Company adopted ASU 2016-13 Financial Instruments — Credit Losses and applied a modified-retrospective transition approach through a cumulative-effect adjustment to retained earnings of $0.1 million, representing the allowance for credit losses for the DemeRx Note. During the three and six months ended June 30, 2023, the Company recorded an immaterial increase to the allowance.

For the three and six months ended June 30, 2023 and 2022, the Company did not recognize any interest income associated with the DemeRx Note. As of June 30, 2023, and December 31, 2022, respectively, the DemeRx Note had an outstanding balance of $1.1 million and $1.1 million, respectively.

7. Fair Value Measurement

The following table presents information about the Company’s financial assets and liabilities that are measured at fair value on a recurring basis and indicates the fair value hierarchy of the valuation (in thousands):

	Fair Value Measurements
	As of June 30, 2023
	Level 1		Level 2		Level 3		Total
Assets:
Cash equivalents:
Cash & Money market funds	$	60,920	$	—	$	—	$	60,920
Investment in securities at fair value:
U.S. Treasuries		—		31,843		—		31,843
Commercial Paper		—		—		—		—
Corporate Notes/Bonds		—		4,900		—		4,900
U.S. Government Agencies		—		49,659		—		49,659
Other investment at fair value		—		—		—		—
	$	60,920	$	86,402	$	—	$	147,322
Liabilities:
Contingent consideration liability - related parties	$	—	$	—	$	842	$	842
	$	—	$	—	$	842	$	842

	Fair Value Measurements
	As of December 31, 2022
	Level 1		Level 2		Level 3		Total
Assets:
Cash equivalents:
Cash & Money market funds	$	72,334	$	—	$	—	$	72,334
Investment in securities at fair value:
U.S. Treasuries		—		—		—		—
Commercial Paper		—		5,958		—		5,958
Corporate Notes/Bonds		—		17,719		—		17,719
U.S. Government Agencies		—		58,819		—		58,819
Other investment at fair value		—		—		—		—
	$	72,334	$	82,496	$	—	$	154,830
Liabilities:
Contingent consideration liability - related parties	$	—	$	—	$	953	$	953
	$	—	$	—	$	953	$	953

Investment Securities Portfolio - Fair Value Option

The Company elected the fair value option for the securities in the investment portfolio. The fair value is based on quoted market prices, when available. When a quoted market price is not readily available, the Company uses the market price from its last sale of similar assets. The cash and cash equivalents held by the Company are categorized as Level 1 investments as quoted market prices are readily available for these investments. All other investments in the investment portfolio are categorized as Level 2 investments as inputs utilized to fair value these securities are either directly or indirectly observable, such as the market price from the last sale of similar assets.

The Company purchases investment grade marketable debt securities which are rated by nationally recognized statistical credit rating organizations in accordance with its investment policy. This policy is designed to minimize the Company's exposure to credit losses and to ensure that the adequate liquidity is maintained at all times to meet anticipated cash flow needs.

The unrealized gains and losses on the available-for-sale securities, represented by change in the fair value of the investment portfolio, is reported in other income (expense), net in the condensed consolidated statements of operations. Since the investment in the

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available-for-sale securities are already measured at fair value, no separate credit losses would be recorded in the condensed consolidated financial statements.

Contingent Consideration Liability—Related Parties—Perception, InnarisBio, and TryptageniX

The contingent consideration liability—related parties in the table above relates to milestone and royalty payments in connection with the acquisition of Perception Neuroscience Holdings, Inc. (“Perception”), InnarisBio and TryptageniX. The fair value of the contingent consideration liability—related parties was determined based on significant inputs not observable in the market, which represent Level 3 measurements within the fair value hierarchy. The fair value of the contingent milestone and royalty liabilities was estimated based on the discounted cash flow valuation technique. The technique considered the following unobservable inputs:

•the probability and timing of achieving the specified milestones and royalties as of each valuation date,

•the probability of executing the license agreement,

•the expected first year of revenue, and

•market-based discount rates

The fair value of the contingent milestone and royalty liabilities for InnarisBio was estimated to be $0.1 million and $0.1 million as of June 30, 2023 and December 31, 2022, respectively.

The fair value of the Perception contingent milestone and royalty liabilities could change in future periods depending on prospects for the outcome of R-Ketamine milestone meetings with the FDA or other regulatory authorities, and whether the Company realizes a significant increase or decrease in sales upon commercialization. The most significant assumptions in the discounted cash flow valuation technique that impacts the fair value of the milestone contingent consideration are the projected milestone timing and the probability of the milestone being met. Further, significant assumptions in the discounted cash flow that impacts the fair value of the royalty contingent consideration are the projected revenue over ten years, the timing of royalties on commercial revenue, and the probability of success rate for a commercial R-Ketamine product. The valuations as of June 30, 2023 and December 31, 2022, respectively, used inputs that were unobservable inputs with the most significant being the discount rates for royalties on projected commercial revenue and clinical milestones and probability of success estimates over the following ten years, which represent Level 3 measurements within the fair value hierarchy.

The fair value of the contingent milestone and royalty liabilities for Perception was estimated to be $0.6 million and $0.6 million as of June 30, 2023 and December 31, 2022, respectively.

The fair value of the Perception contingent consideration liability - related parties was calculated using the following significant unobservable inputs:

		June 30, 2023	December 31, 2022
Valuation Technique	Significant Unobservable Inputs	Input Range	Input Range
Discounted cash flow	Milestone contingent consideration:
	Discount rate	14.0%	13.1%
	Probability of the milestone	28.0%	10.0% - 21.0%
Discounted cash flow    with SBM	Royalty contingent consideration:
	Discount rate for royalties	12.9% - 14.7%	20.0% - 21.1%
	Discount rate for royalties on milestones	12.9% - 14.7%	12.3% - 13.4%
	Probability of success rate	13.4% - 28.0%	10.1% - 21.0%

The fair value of the contingent liability for TryptageniX was estimated to be $0.2 million and $0.2 million as of June 30, 2023, and December 31, 2022, respectively. The contingent liability is comprised of R&D milestone success fee payments and royalties payments. The fair value of the success fee liability was estimated based on the scenario-based method within the income approach. The fair value of the contingent liability for TryptageniX was determined based on significant unobservable inputs, including the discount rate, estimated probabilities of success, and timing of achieving certain clinical milestones. The fair value of the royalties liability was determined to be de minimis as the products are in the early stages of development. The Company will continue to assess the appropriateness of the fair value of the contingent liability as the products continue through development.

IntelGenx Common Stock, Initial Warrants and Additional Unit Warrants

The Company’s investment in IntelGenx consists of Common Stock, Initial Warrants and Additional Unit Warrants (the Initial Warrants and the Additional Unit Warrants are collectively referred to as the “Warrants”). The Company determined that the Warrants do not meet the definition of a derivative instrument under ASC 815. The Company has classified the Common Stock as Level 2 assets and the

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Warrants as Level 3 assets in the fair value hierarchy. The Company determined that the initial aggregate fair value was equal to the transaction price and recorded the Common Stock at $3.0 million, the Initial Warrants at $1.2 million and the Additional Unit Warrants at $8.2 million on a relative fair value basis resulting in no initial gain or loss recognized in the condensed consolidated statements of operations. The Warrants are measured at fair value on a quarterly basis and any changes in the fair value will be recorded as a component of other income (expense), net in the condensed consolidated statements of operations.

The fair value of Common Stock is estimated by applying a discount for lack of marketability (“DLOM”) of 5.0% as of June 30, 2023 and December 31, 2022. The Company estimated a DLOM in connection with the valuation of the Common Stock to reflect the restrictions associated with the Common Stock. As of June 30, 2023 and December 31, 2022, the only restriction that remains is the unregistered nature of the Common Stock. The fair value of Common Stock, which is included in Other investments held at fair value in the condensed consolidated balance sheets, was zero as of June 30, 2023 and December 31, 2022.

The Initial Warrant asset was recorded at fair value utilizing the Black-Scholes option pricing model. The Black Scholes option pricing model is based on the estimated market value of the underlying common stock at the valuation measurement date, the remaining contractual term of the warrant, risk-free interest rates, expected dividends, and expected volatility of the price of the underlying common stock. The expected volatility is based on a peer group volatility which is a Level 3 input within the fair value hierarchy. The fair value of the Initial Warrants, which is included in Other investments held at fair value in the condensed consolidated balance sheets, was zero as of June 30, 2023 and December 31, 2022.

The following table summarizes significant unobservable inputs that are included in the valuation of the Initial Warrants as of June 30, 2023 and as of December 31, 2022:

	June 30, 2023			December 31, 2022
Value of Underlying	$	0.18		$	0.19
Expected Volatility		100	%		100	%

The fair value of the Additional Unit Warrants is estimated using a Binomial Lattice in a risk-neutral framework (a special case of the Income Approach). Specifically, the future stock price of the IntelGenx is modeled assuming a Geometric Brownian Motion in a risk-neutral framework. For each modeled future price, the Additional Unit Warrants are calculated based on the contractual terms (incorporating any optimal early exercise), and then discounted at the term-matched risk-free rate. Finally, the value of the Additional Unit Warrants is calculated as the probability-weighted present value over all future modeled payoffs. The fair value of the Additional Unit Warrants, which is included in Other investments held at fair value in the condensed consolidated balance sheets, was zero as of June 30, 2023 and December 31, 2022.

The following table summarizes significant unobservable inputs that are included in the valuation of the Additional Units Warrant as of June 30, 2023 and as of December 31, 2022:

	June 30, 2023			December 31, 2022
Value of Underlying	$	0.18		$	0.19
Expected Volatility		105	%		100	%

The following table provides a roll forward of the aggregate fair values of the Company’s financial instruments described above, for which fair value is determined using Level 3 inputs (in thousands):

	Contingent Consideration Liability - Related Parties
Balance as of December 31, 2022	$	953
Initial fair value of instrument		—
Change in fair value		(35	)
Extinguishment of liability		—
Balance as of March 31, 2023	$	918
Initial fair value of instrument		—
Change in fair value		(76	)
Extinguishment of liability		—
Balance as of June 30, 2023	$	842

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	Contingent Consideration Liability - Related Parties
Balance as of December 31, 2021	$	2,483
Initial fair value of instrument		—
Change in fair value		—
Extinguishment of liability		(50	)
Balance as of March 31, 2022	$	2,433
Initial fair value of instrument		—
Change in fair value		(95	)
Extinguishment of liability		—
Balance as of June 30, 2022	$	2,338

8. Prepaid Expenses and Other Current Assets

Prepaid expenses consist of the following (in thousands):

	June 30, 2023		December 31, 2022
Prepaid insurance	$	41	$	2,034
Prepaid research and development related expenses		3,019		4,626
Tax receivables		1,762		5,631
Other		1,435		1,745
Total	$	6,257	$	14,036

9. Accrued Liabilities

Accrued liabilities consist of the following (in thousands):

	June 30, 2023		December 31, 2022
Accrued accounting, legal, and other professional fees	$	3,023	$	3,566
Accrued external research and development expenses		4,886		5,550
Accrued restructuring costs		91		—
Accrued payroll		3,137		5,260
Taxes payable		808		2,224
Other liabilities		910		706
Total	$	12,855	$	17,306

10. Leases

In February 2016, the FASB issued ASU 2016-02, “Leases” Topic 842, which amends the guidance in former ASC Topic 840, Leases.

Operating lease Right-of-Use (“ROU”) assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes lease payments made, lease incentives, and initial direct costs incurred, if any.

The discount rate implicit within the Company’s leases is generally not determinable and therefore the Company determines the discount rate based on its incremental borrowing rate, which is based on the information available at commencement date. As of June 30, 2023, the operating lease liabilities reflect a weighted-average discount rate of 12.5%.

Operating Leases

The Company leases certain office space under long-term operating leases that expire at various dates through 2028. The Company generally has options to renew lease terms on its facilities, which may be exercised at the Company's sole discretion. The Company evaluates renewal and termination options at the lease commencement date to determine if it is reasonably certain to exercise the option and has concluded on all operating leases that is it not reasonably certain that any options will be exercised. The weighted-average remaining lease term for the Company’s operating leases as of June 30, 2023 was 4.5 years.

ROU assets and lease liabilities related to the Company’s operating leases are as follows (in thousands):

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	Balance Sheet Classification	June 30, 2023		December 31, 2022
Right-of-use assets	Operating lease right-of-use asset, net	$	1,367	$	226
Current lease liabilities	Current portion of lease liability		322		180
Non-current lease liabilities	Non-current portion of lease liability		1,095		44

Expenses related to leases is recorded on a straight-line basis over the lease term. The following table summarizes lease costs by component for the three and six months ended June 30, 2023 and 2022 (in thousands):

Lease Cost Components	Statement of Operations Classification	Three months ended June 30, 2023		Three months ended June 30, 2022		Six months ended June 30, 2023		Six months ended June 30, 2022
Operating lease cost	Operating expenses: General and administrative	$	145	$	77	$	280	$	124
Short-term lease cost	Operating expenses: General and administrative		88		122		180		221
Total lease cost		$	233	$	199	$	460	$	345

Future minimum commitments under all non-cancelable operating leases are as follows (in thousands):

Year Ended
2023 (excluding six months ended June 30, 2023)	$	249
2024		410
2025		366
2026		366
2027		366
2028		122
Total lease payments		1,879
Less: Imputed interest		(462	)
Present value of lease liabilities	$	1,417

Supplemental cash flow information related to the Company’s operating leases for the six months ended June 30, 2023 and 2022 are as follows (in thousands):

	Six months ended June 30, 2023		Six months ended June 30, 2022
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases	$	187	$	120
Right-of-use assets obtained in exchange for new operating lease liabilities		1,356		487

11. Debt

Convertible Promissory Notes

2018 Convertible Promissory Notes—Related Parties

Convertible promissory notes—related parties, net of discounts and deferred issuance costs, consisted of the following (in thousands):

	June 30, 2023		December 31, 2022
Convertible notes issued in October 2020	$	420	$	415
Total	$	420	$	415

In November 2018, the Company executed a terms and conditions agreement (the “Convertible Note Agreement”) under which it was authorized to issue up to €1.0 million or $1.2 million in convertible promissory notes to investors. An investor would become a party to the Convertible Note Agreement and would be issued a convertible promissory note by executing and delivering a subscription form. In November 2018 and October 2020, certain investors subscribed to the Convertible Note Agreement and the Company issued convertible promissory notes in the aggregate principal amount of €0.2 million or $0.2 million and €0.8 million or $1.0 million, respectively (collectively, the “2018 Convertible Notes”).

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The 2018 Convertible Notes are non-interest-bearing, unsecured and are due and payable on September 30, 2025, unless previously redeemed, converted, purchased or cancelled. Each 2018 Convertible Note has a notional value of €1 and is convertible into one share of ATAI Life Sciences AG upon the payment of €17.00. Conversion rights may be exercised by a noteholder at any time prior to maturity, except during certain periods subsequent to the consummation of the IPO. The 2018 Convertible Notes may be declared for early redemption by the noteholders upon occurrence of specified events of default, including payment default, insolvency and a material adverse change in the Company’s business, operations or financial or other condition. Upon early redemption, the conversion right with respect to the 2018 Convertible Notes may no longer be exercised. More information on these notes can be found in Note 10 of the Company’s audited consolidated financial statements included in the Company’s Annual Report on Form 10-K filed with the SEC on March 24, 2023.

In connection with the Convertible Note Agreement, the Company issued convertible notes in aggregate principal amounts of €0.5 million or $0.6 million to Apeiron, the family office of the Company’s co-founder, and €0.3 million or $0.4 million to one other shareholder of the Company who is the founder of COMPASS in October 2020.

Conversion of 2018 Convertible Promissory Notes - Related Parties

Upon the Company's 2021 corporate reorganization, atai became the sole shareholder of ATAI Life Sciences AG. In connection with the corporate reorganization, all former shareholders of ATAI Life Sciences AG contributed their shares of ATAI Life Sciences AG to atai and received sixteen shares in atai for every one share of ATAI Life Sciences AG. In 2021 and 2022, several noteholders elected to convert their convertible promissory notes into shares of atai. These investors paid €17.00 per share for an aggregate amount of €5.8 million or $6.9 million and €4.6 million or $4.6 million, respectively in order to convert their convertible promissory notes into ATAI Life Sciences AG common shares, which was in accordance with the original terms of the 2018 Convertible Note Agreements, and then exchange such shares in ATAI Life Sciences AG for shares of atai through a transfer and sale arrangement.

The Company accounted for the conversion of the 2018 Convertible Notes as a conversion such that carrying values of these notes were derecognized with an offset to common stock at par of ATAI Life Sciences AG and the excess of the carrying values of these notes over the common stock at par of ATAI Life Sciences AG was recorded as additional paid-in capital. Concurrently, with the conversion of the 2018 Convertible Notes into ATAI Life Sciences AG shares, the shares of ATAI Life Sciences AG that were issued to the noteholders were exchanged for shares of atai through a transfer and sale arrangement. As ATAI Life Sciences AG continued to remain a wholly owned subsidiary of atai, the transaction was accounted for as an equity transaction that resulted in no gain or loss recognition.

Term Loan

Hercules Loan and Security Agreement

In August 2022, the Company and certain subsidiaries, as guarantors, and Hercules Capital, Inc. entered into a Loan and Security Agreement the “Hercules Loan Agreement”. The Hercules Loan Agreement provides for term loans in an aggregate principal amount of up to $175.0 million under multiple tranches (the “2022 Term Loan Facility”).

On May 26, 2023, ATAI Life Sciences N.V. (the “Company”), ATAI Life Sciences AG (“ATAI AG” and together with the Company, the “Borrowers”) and certain subsidiary guarantors of the Company (collectively, the “Subsidiary Guarantors”) entered into the Second Amendment to Loan and Security Agreement (the “Amendment”), with the several banks and other financial institutions or entities from time to time parties to the Hercules Loan Agreement (collectively, the “Lenders”) and Hercules Capital, Inc., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and for the Lenders (the “Agent”) which amends that certain Loan and Security Agreement, dated August 9, 2022 (as amended by that certain First Amendment to Loan and Security Agreement dated as of March 13, 2023, the “Existing Loan Agreement,” and as amended by the Amendment, the “Agreement”) to, among other things, (i) extend the availability of Tranche 1B of $10.0 million, from May 1, 2023, under the Existing Loan Agreement, to November 15, 2024, (ii) extend the availability of Tranche 1C of $15.0 million, from December 15, 2023, under the Existing Loan Agreement, to December 15, 2024, (iii) provide Tranche 1D of $20.0 million, available upon the earlier of (x) the full draw of Tranche 1C and (y) the expiration of Tranche 1C availability, through February 15, 2025, (iv) extend the availability of Tranche 2 of $15.0 million, from June 30, 2024, under the Existing Loan Agreement, subject to certain conditions under the Agreement, to the earlier of (x) the full draw of Tranche 1D and (y) the expiration of Tranche 1D availability, through March 15, 2025, subject to the Tranche 2 Draw Test, (v) extend the timeline to achieve the second amortization extension condition, from June 30, 2024, in the Existing Loan Agreement, to December 15, 2024, (vi) amend the Tranche 2 Draw Test, satisfaction of which is a condition to draw Tranche 2 under the Agreement and (vii) extend the financial covenant commencement date, from the later of (x) July 1, 2023, and (y) the date that the outstanding debt under the facility is equal to or greater than $40.0 million, in the Existing Loan Agreement, to the later of (x) May 1, 2024, and (y) the date that the outstanding debt under the facility is equal to or greater than $30.0 million, provided, that the financial covenant is waived if the Company has a market capitalization of at least $550.0 million.

The 2022 Term Loan Facility will mature on August 1, 2026 (the “Maturity Date”), which may be extended until February 1, 2027 if the Company achieves certain performance milestones, raises at least $175.0 million of unrestricted new net cash proceeds from certain

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permitted sources after the Closing Date and prior to June 30, 2024, and satisfies certain other specified conditions. The outstanding principal balance of the 2022 Term Loan Facility bears interest at a floating interest rate per annum equal to the greater of either (i) the prime rate as reported in the Wall Street Journal plus 4.55% and (ii) 8.55%. Accrued interest is payable monthly following the funding of each term loan advance. The Company may make payments of interest only, without any loan amortization payments, for a period of thirty (30) months following the Closing Date, which period may be extended to (i) thirty-six months if certain additional performance milestones have been achieved; and (ii) forty-two months if certain additional performance milestones have been achieved. At the end of the interest only period, the Company is required to begin repayment of the outstanding principal of the 2022 Term Loan Facility in equal monthly installments.

The Hercules Loan Agreement contains customary closing and commitment fees, prepayment fees and provisions, events of default and representations, warranties and affirmative and negative covenants, including a financial covenant requiring the Company to maintain certain levels of cash in accounts subject to a control agreement in favor of the Agent (the “Qualified Cash”) at all times commencing from the Closing Date, which includes a cap on the amount of cash that can be held by, among others, certain of our foreign subsidiaries in Australia and the United Kingdom. In addition, the financial covenant under the Loan Agreement requires that beginning on the later of (i) July 1, 2023 and (ii) the date on which the aggregate outstanding amount borrowed under the 2022 Term Loan Facility is equal to or greater than $40.0 million, the Company shall maintain Qualified Cash in an amount no less than the sum of (1) 33% of the outstanding amount under the 2022 Term Loan Facility, and (2) the amount of the Borrowers’ and Subsidiary Guarantors’ accounts payable that have not been paid within 180 days from the invoice date of the relevant account payable, subject to certain exceptions; provided, that the financial covenant shall not apply on any day that the Company's market capitalization is at least $550.0 million measured on a consecutive 10-business day period immediately prior to such date of measurement and tested on a daily basis. Upon the occurrence of an event of default, including a material adverse effect, subject to certain exceptions, on ATAI NV and ATAI AG’s, taken together, business, operations, properties, assets or financial condition, and subject to any specified cure periods, all amounts owed by the Company may be declared immediately due and payable by the Lenders. As of June 30, 2023, the Company was in compliance with all applicable covenants under the Hercules Loan Agreement.

In addition, the Company is required to make a final payment fee (the “End of Term Charge”) upon the earlier of (i) the Maturity Date, (ii) the date that the Company prepays, in full or in part, the principal balance of the 2022 Term Loan Facility, or (iii) the date that the outstanding balance of the 2022 Term Loan Facility becomes due and payable. The End of Term Charge is 6.95% of the aggregate original principal amount of the term loans so repaid or prepaid under the Loan Agreement.

The Company may, at its option, prepay the term loans in full or in part, subject to a prepayment penalty equal to (i) 2.00% of the principal amount prepaid if the prepayment occurs on or prior to the first anniversary of the Closing Date, (ii) 1.0% of the principal amount prepaid if the prepayment occurs after the first anniversary and on or prior to the second anniversary of the Closing Date, and (iii) 0.5% of the principal amount prepaid if the prepayment occurs after the second anniversary and prior to the Maturity Date.

The Company incurred financing expenses related to the Hercules Loan Agreement, which are recorded as an offset to long-term debt on the Company's condensed consolidated balance sheets. These deferred financing costs are being amortized over the term of the debt using the effective interest method, and are included in other income (expense), net in the Company’s condensed consolidated statements of operations.

During the three and six months ended June 30, 2023, interest expense included $0.1 million and $0.2 million of amortized deferred financing costs related to the 2022 Term Loan Facility. As the Hercules Loan Agreement was executed in August 2022, during the three and six months ended June 30, 2022 the Company did not incur any interest expense or amortized deferred financing costs related to the 2022 Term Loan Facility.

Outstanding debt obligations are as follows (in thousands):

	June 30, 2023			December 31, 2022
Principal amount	$	15,000		$	15,000
End of the term charge		1,042			1,042
Less: unamortized issuance discount		(240	)		(274	)
Less: unamortized issuance costs		(99	)		(113	)
Less: unamortized end of term charge		(835	)		(952	)
Net carrying amount		14,868			14,702
Less: current maturities		—			—
Long-term debt, net of current maturities and unamortized debt discount and issuance costs	$	14,868		$	14,702

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The fair value of the outstanding debt obligations under the 2022 Term Loan Facility was $15.9 million as of June 30, 2023, and $14.9 million as of December 31, 2022, respectively. The fair value of the debt obligations under the 2022 Term Loan Facility represent Level 3 measurements within the fair value hierarchy.

12. Common Stock

All common shareholders have identical rights. Each common share entitles the holder to one vote on all matters submitted to the shareholders for a vote.

All holders of common shares are entitled to receive dividends, as may be declared by the Company’s board of supervisory directors. Upon liquidation, common shareholders will receive distribution on a pro rata basis. As of June 30, 2023 and December 31, 2022, no cash dividends have been declared or paid.

13. Stock-Based Compensation

atai Equity Incentive Plans

The Company has options and restricted stock units (“RSUs”) outstanding under various equity incentive plans, including the 2020 Incentive Plan, 2021 Incentive Plan, and HSOP Plan, which are further described in Note 12 of the Company’s audited consolidated financial statements included in the Company’s Annual Report on Form 10-K filed with the SEC on March 24, 2023.

As of June 30, 2023, there were no shares available for future grants under the 2020 Incentive Plan and any shares subject to outstanding options originally granted under the 2020 Equity Incentive Plan that terminate, expire or lapse for any reason without the delivery of shares to the holder thereof shall become available for issuance pursuant to the atai Life Sciences 2021 Incentive Award Plan.

Shares that are expired, terminated, surrendered, or canceled without having been fully exercised will be available for future awards. As of June 30, 2023, 30,929,033 shares were available for future grants under the 2021 Incentive Plan.

As of June 30, 2023, 257,419 HSOP Options were available for future grants under the HSOP Plan.

Stock Option activity under 2020 Incentive Plan and 2021 Incentive Plan

The stock options outstanding noted below consist primarily of both service and performance-based options to purchase common stock. These stock options have a five-year or ten-year contractual term. These awards are subject to the risk of forfeiture until vested by virtue of continued employment or service to the Company.

The following is a summary of stock option activity from December 31, 2022 to June 30, 2023:

	Number of Options				Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Outstanding as of December 31, 2022		34,880,604			$	5.98		5.71	$	10,647
Granted		9,862,628		(1)		1.29		—		—
Exercised		(74,562	)			2.44		—		—
Cancelled or forfeited		(2,775,481	)			7.47		—		—
Outstanding as of June 30, 2023		41,893,189		(2)	$	4.78		6.13	$	10,203
Options exercisable as of June 30, 2023		21,049,667			$	5.31		4.01	$	5,723

(1)Includes (a) 9,862,628 stock options that will vest over a four-year service period.

(2)The 20,843,522 outstanding unvested stock options includes (a) 19,301,248 that will continue to vest over a one to four-year service period, (b) 1,269,708 that will continue to vest over a three to four-year service period and upon the satisfaction of specified performance-based vesting conditions, (c) 100,000 stock options that will continue to vest over a two-year service period and upon the satisfaction of specified market-based conditions tied to price of the Company's publicly traded shares, and (d) 172,566 stock options that will continue to vest over a three-year service period and upon the satisfaction of specified performance-based vesting conditions, which were achieved in the fourth quarter of 2022.

The weighted-average grant-date fair value of options granted during the six months ended June 30, 2023 was $0.96.

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The Company estimates the fair value of each stock option using the Black-Scholes option-pricing model on the date of grant. During the six months ended June 30, 2023, the assumptions used in the Black-Scholes option pricing model were as follows:

	June 30,
	2023	2022
Weighted average expected term in years	6.07	5.93
Weighted average expected stock price volatility	86.4%	70.5%
Risk-free interest rate	3.50% - 3.92%	1.46% - 3.03%
Expected dividend yield	0%	0%

For the three months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $7.3 million and $8.1 million, respectively. For the six months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $14.7 million and $16.7 million, respectively.

As of June 30, 2023, total unrecognized compensation cost related to the unvested stock options was $52.8 million, which is expected to be recognized over a weighted average period of 1.91 years.

Stock Option activity under HSOP Plan

The HSOP Options outstanding noted below consist of service and performance-based options to request the distribution of HSOP Shares. These HSOP Options have a fifteen-year contractual term. These HSOP Options vest over a three to four-year service period. These awards are subject to the risk of forfeiture until vested by virtue of continued employment or service to the Company.

The following is a summary of stock option activity from December 31, 2022 to June 30, 2023:

	Number of Options		Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Outstanding as of December 31, 2022		6,921,829		6.64		13.01	$	—
Granted		—		—		—		—
Exercised		—		—		—		—
Cancelled or forfeited		—		—		—		—
Outstanding as of June 30, 2023		6,921,829	$	6.64		12.51	$	—
Options exercisable as of June 30, 2023		6,432,646	$	6.64		12.51	$	—

For the three months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $0.9 million and $1.2 million, respectively. For the six months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $1.8 million and $2.5 million, respectively.

As of June 30, 2023, total unrecognized compensation cost related to the unvested stock-based awards was $1.4 million which is expected to be recognized over a weighted average period of 0.2 years.

Restricted Stock Unit activity under the 2021 Incentive Plan

The restricted stock units noted below consist of service-based awards vesting over a two-year period, subject to the risk of forfeiture until vested by virtue of continued employment or service to the Company. The Company reflects restricted stock units as issued and outstanding common stock when vested and the shares have been delivered to the individual.

The following is a summary of restricted stock unit activity from December 31, 2022 to June 30, 2023:

	Restricted Stock Units		Weighted Average Grant Date Fair Value
Unvested at January 1, 2023		—	$	—
Granted		3,251,815		1.18
Vested		—		—
Forfeited		80,680		1.18
Unvested at June 30, 2023		3,171,135	$	1.18

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For the three months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $0.5 million and $0, respectively. For the six months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $0.6 million and $0, respectively.

The total fair value of restricted stock units vested during the six months ended June 30, 2023 was $0. As of June 30, 2023, total unrecognized compensation cost related to the unvested stock-based awards was $3.2 million, which is expected to be recognized over a weighted average period of 1.71 years.

Subsidiary Equity Incentive Plans

Certain controlled subsidiaries of the Company adopted their own equity incentive plans (each, an “EIP”). Each EIP is generally structured so that the applicable subsidiary, and its affiliates’ employees, directors, officers and consultants are eligible to receive non-qualified and incentive stock options and restricted stock unit awards under their respective EIP. Standard option grants have time-based vesting requirements, generally vesting over a period of four years with a contractual term of ten years. Such time-based stock options use the Black-Scholes option pricing model to determine grant date fair value. Certain awards issued to employees partially vest on date of grant, then over a three-year service period and upon the satisfaction of specified performance-based vesting conditions, which are not considered probable of achievement as of June 30, 2023.

For the three months ended June 30, 2023 and 2022, the Company recorded share-based compensation expense of $0.1 million and $0.2 million, respectively, in relation to subsidiary EIPs. For the six months ended June 30, 2023 and 2022, the Company recorded share-based compensation expense of $0.2 million and $0.4 million, respectively, in relation to subsidiary EIPs. As of June 30, 2023, there was $0.4 million of total unrecognized stock-based compensation expense related to unvested EIP awards to employees and non-employee directors expected to be recognized over a weighted-average period of approximately 0.9 years. As of June 30, 2023, the unrecognized stock-based compensation expense from EIP’s awards with liquidity-based performance vesting conditions issued to employees and non-employee directors was approximately $6.5 million, which will be recognized in future periods if and when the attainment of the performance vesting criteria becomes probable.

Stock-Based Compensation

Stock-based compensation expense is allocated to either research and development or general and administrative expense on the condensed consolidated statements of operations based on the cost center to which the option holder belongs.

The following table summarizes the total stock-based compensation expense by function for the three months ended June 30, 2023, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Three Months Ended June 30, 2023
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	3,168	$	—	$	107	$	3,275
General and administrative		4,580		894		13		5,487
Total share based compensation expense	$	7,748	$	894	$	120	$	8,762

The following table summarizes the total stock-based compensation expense by function for the three months ended June 30, 2022, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Three Months Ended June 30, 2022
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	3,717	$	—	$	149	$	3,866
General and administrative		4,395		1,176		74		5,645
Total share based compensation expense	$	8,112	$	1,176	$	223	$	9,511

The following table summarizes the total stock-based compensation expense by function for the six months ended June 30, 2023, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Six Months Ended June 30, 2023
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	6,528	$	—	$	213	$	6,741
General and administrative		8,890		1,768		25		10,683
Total share based compensation expense	$	15,418	$	1,768	$	238	$	17,424

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The following table summarizes the total stock-based compensation expense by function for the six months ended June 30, 2022, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Six Months Ended June 30, 2022
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	7,344	$	—	$	296	$	7,640
General and administrative		9,402		2,526		152		12,080
Total share based compensation expense	$	16,746	$	2,526	$	448	$	19,720

14. Income Taxes

The Company records its quarterly income tax expense by utilizing an estimated annual effective tax rate applied to its period to date earnings as adjusted for any discrete items arising during the quarter. The tax effect for discrete items are recorded in the period in which they occur. The Company recorded $185,000 and $51,000 of income tax expense for the three months ended June 30, 2023 and 2022 respectively. The Company recorded $351,000 and $92,000 of income tax expense for the six months ended June 30, 2023 and 2022 respectively. The income tax expense during these periods was primarily driven by current tax on earnings of subsidiaries in Australia, the United States, and the United Kingdom. The primary difference between the effective tax rate and the statutory tax rate relates to the income tax treatment of stock compensation expense, which impacts the current and overall tax expense due to the applicable valuation allowance. The Company continues to maintain a full valuation allowance against its deferred tax assets.

15. Net Loss Per Share

Basic and diluted net loss per share attributable to atai stockholders were calculated as follows (in thousands, except share and per share data):

	Three Months Ended June 30,						Six Months Ended June 30,
	2023			2022			2023			2022
Numerator:
Net loss	$	(33,771	)	$	(37,509	)	$	(68,126	)	$	(75,067	)
Net loss attributable to noncontrolling interests		(729	)		(891	)		(1,948	)		(1,580	)
Net loss attributable to ATAI Life Sciences    N.V. shareholders — basic and diluted	$	(33,042	)	$	(36,618	)	$	(66,178	)	$	(73,487	)
Denominator:
Weighted average common shares outstanding    attributable to ATAI Life Sciences N.V.    Stockholders — basic and diluted		155,792,490			153,971,202			155,793,323			153,751,456
Net loss per share attributable to ATAI Life    Sciences N.V. shareholders — basic and diluted	$	(0.21	)	$	(0.24	)	$	(0.42	)	$	(0.48	)

HSOP Shares issued to the Partnership and allocated to the HSOP Participants are not considered outstanding for accounting purposes and not included in the calculation of basic weighted average common shares outstanding in the table above because the HSOP Participants have a forfeitable right to distributions until the HSOP Options vest and are exercised, at which time the right becomes nonforfeitable.

The following also represents the maximum amount of outstanding shares of potentially dilutive securities that were excluded from the computation of diluted net income (loss) per share attributable to common shareholders for the periods presented because including them would have been antidilutive:

Potentially dilutive securities to the Company’s common shares:

	As of June 30,
	2023		2022
Options to purchase common stock		41,893,189		34,410,771
HSOP options to purchase common stock		6,921,829		7,046,496
2018 Convertible Promissory Notes - Related Parties (Note 11)		6,201,824		9,561,824
Unvested restricted stock units		3,171,135		—
		58,187,977		51,019,091

The outstanding 2018 Convertible Notes are issuable upon the exercise of conversion rights of convertible note holders for 387,614 shares of common stock of ATAI Life Sciences AG. Upon conversion of the 2018 Convertible Notes, it is expected that the shares of common

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stock of ATAI Life Sciences AG issuable upon conversion of the 2018 Convertible Notes would be exchanged on a one-for-sixteen basis for shares of atai which is reflected in the table above. See Note 11 for additional discussion.

16. Commitments and Contingencies

Research and Development Agreements

The Company may enter into contracts in the ordinary course of business with clinical research organizations for clinical trials, with contract manufacturing organizations for clinical supplies and with other vendors for preclinical studies, supplies and other services and products for operating purposes.

Indemnification

In the ordinary course of business, the Company may provide indemnifications of varying scope and terms to vendors, lessors, business partners, board members, officers and other parties with respect to certain matters, including, but not limited to, losses arising out of breach of such agreements, services to be provided by the Company, negligence or willful misconduct of the Company, violations of law by the Company, or intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with directors and certain officers and employees that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors, officers or employees. No demands have been made upon the Company to provide indemnification under such agreements, and thus, there are no claims that the Company is aware of that could have a material effect on the Company’s condensed consolidated financial statements.

The Company also maintains director and officer insurance, which may cover certain liabilities arising from its obligation to indemnify the Company’s directors. To date, the Company has not incurred any material costs and has not accrued any liabilities in the condensed consolidated financial statements as a result of these provisions.

Contingencies

From time to time, the Company may become involved in legal proceedings arising in the ordinary course of business. The Company is unable to predict the outcome of these matters or the ultimate legal and financial liability, and at this time cannot reasonably estimate the possible loss or range of loss and accordingly has not accrued a related liability. At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company accrues a liability when a loss is considered probable and the amount can be reasonably estimated. When a material loss contingency is reasonably possible but not probable, the Company does not record a liability, but instead discloses the nature and the amount of the claim, and an estimate of the loss or range of loss, if such an estimate can be made. Legal fees are expensed as incurred. The Company currently believes that the outcome of any future potential legal proceedings, either individually or in the aggregate, will not have a material effect on its consolidated financial position, results of operations or cash flows.

17. License Agreements

Otsuka License and Collaboration Agreement

In March 2021, Perception entered into a license and collaboration agreement (the “Otsuka Agreement”) with Otsuka under which Perception granted exclusive rights to Otsuka to develop and commercialize products containing arketamine, known as PCN-101 in Japan for the treatment of any depression, including treatment-resistant depression, or major depressive disorder or any of their related symptoms or conditions at its own cost and expense. Perception retained all rights to PCN-101 outside of Japan.

With the execution of the Otsuka Agreement, Perception received an upfront, non-refundable payment of $20.0 million. Perception is also entitled to receive aggregate payments of up to $35.0 million if certain development and regulatory milestones are achieved for the current or a new intravenous formulation of a product and up to $66.0 million in commercial milestones upon the achievement of certain commercial sales thresholds. Otsuka is obligated to pay Perception a tiered, double-digit royalty on net sales of products containing PCN-101 in Japan, subject to reduction in certain circumstances. More information for this license can be found in Note 16 of the Company’s audited consolidated financial statements included in the Company’s Annual Report on Form 10-K filed with the SEC on March 24, 2023.

For the three and six months ended June 30, 2023 and 2022 there were no milestones achieved under the Otsuka Agreement and we recognized $0.2 million and $0.2 million of revenue related to certain research and development services, respectively, which included recognizing the remaining deferred revenue balance related to the Otsuka Agreement.

National University Corporation Chiba University License Agreement

In August 2017, Perception entered into a license agreement (the “CHIBA License”), with the National University Corporation Chiba University (“CHIBA”), relating to Perception’s drug discovery and development initiatives. Under the CHIBA License, Perception has

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been granted a worldwide exclusive license under certain patents and know-how of CHIBA to research, develop, manufacture, use and commercialize therapeutic products.

During the three and six months ended June 30, 2023 and 2022, respectively, the Company made no material payments pursuant to the CHIBA License.

Allergan License Agreement

In February 2020, Recognify entered into an amended and restated license agreement (the “Allergan License Agreement”), with Allergan Sales, LLC (“Allergan”), under which Allergan granted Recognify an exclusive (non-exclusive as to know-how), sublicensable and worldwide license under certain patent rights and know-how controlled by Allergan to develop, manufacture and commercialize certain products for use in all fields including the treatment of certain diseases and conditions of the central nervous system.

During the three and six months ended June 30, 2023 and 2022, respectively, Recognify made no material payments pursuant to the Allergan License Agreement.

Columbia Stock Purchase and License Agreement

In June 2020, Kures entered into a license agreement with Trustees of Columbia University (“Columbia”), pursuant to which, Kures obtained an exclusive license under certain patents and technical information to discover, develop, manufacture, use and commercialize such patents or other products in all uses and applications (“Columbia IP”). In addition, in consideration for the rights to the Columbia IP, Kures entered into a Stock Purchase Agreement (the “SPA”) with Columbia in contemplation of the license agreement. Pursuant to the SPA, Kures issued to Columbia certain shares of the Kures’ capital stock, representing 5.0% of Kures common stock on a fully diluted basis. Furthermore, the SPA provided that from time to time, Kures shall issue to Columbia additional shares of Kures’ common stock, at a per share price equal to the then fair market value of each such share, which price shall be deemed to have been paid in partial consideration for the execution, delivery and performance by Columbia of the License Agreement, such that the common stock held by Columbia shall equal to 5.0% of the common stock on a fully diluted basis, at all times up to and through the achievement of certain funding threshold.

During the three and six months ended June 30, 2023, Kures made no material payments or share issuances in connection with the Columbia agreement.

During the three months ended June 30, 2022, Kures issued shares of Series A-2 Preferred Stock to certain investors upon the achievement of Series A-2 milestone events. Accordingly, the Company issued certain anti-dilution common stock to Columbia worth $0.3 million. The Company expensed the cost incurred for acquiring license as research & development expense at inception.

Since, the additional anti-dilution shares were issued as partial consideration towards the same license arrangement, the cost of such additional shares was also expensed as research & development expense during the three and six months ended June 30, 2022. During the three and six months ended June 30, 2022, the Company recognized $0.4 million and $0.4 million, respectively, of in-process research & development expense in connection with the SPA and the License Agreement.

Accelerate License Agreement

In April 2021, Psyber entered into a license arrangement with Accelerate Technologies Pte. Ltd. (“Accelerate”), whereby Accelerate grants Psyber non-exclusive rights to license and use the technology to commercialize of Psyber’s BCI-enabled companion digital therapeutics in United States of America, Singapore, Member Countries of the European Union, Canada, Australia and New Zealand as a potential treatment for mental health and behavior change, such as substance use disorders including opioid use disorder, mood and anxiety disorders including post-traumatic stress disorder, and treatment-resistant depression.

During the three and six months ended June 30, 2023 and 2022, respectively, Psyber made no material payments pursuant to the Accelerate License agreement.

Dalriada License Agreement

In December 2021, Invyxis, Inc. (“Invyxis”), a wholly owned subsidiary of the Company, entered into an exclusive services and license agreement (the “Invyxis ESLA”) with Dalriada Drug Discovery Inc. (“Dalriada”). Under the Invyxis ESLA, Dalriada is to exclusively collaborate with Invyxis to develop products, services and processes with the specific purpose of generating products consisting of new chemical entities. Invyxis will pay Dalriada up to $12.8 million in service fees for research and support services. In addition, Invyxis will pay Dalriada success milestone payments and low single digit royalty payments based on net product sales. Invyxis has the right, but not the obligation, to settle future royalty payments based on net product sales with the Company's common stock. Invyxis and Dalriada will determine the equity settlement based on a price per share determined by both parties.

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In January 2022, in accordance with the Invyxis ESLA, Invyxis paid an upfront deposit of $1.1 million, which was capitalized as prepaid research and development expense. In December 2022, the Company executed an amendment to the Invyxis ESLA, which reduced the upfront deposit from $1.1 million to $0.5 million. As such, the remaining $0.6 million was applied against research and development expense incurred. The Company will expense the remaining deposit as the services are performed as a component of research and development expense in the consolidated statements of operations.

During the three months ended June 30, 2023 and 2022, the Company recorded $0.6 million and $1.4 million, respectively, as research and development expense in the condensed consolidated statement of operations. During the six months ended June 30, 2023 and 2022, the Company recorded $1.1 million and $1.8 million, respectively as research and development expense in the condensed consolidated statement of operations.

During the three and six months ended June 30, 2022, Invyxis made no other service fee payments to Dalriada.

18. Related Party Transactions

atai Formation

In connection with the formation of atai in 2018, the Company entered into a series of transactions with its shareholders, Apeiron, Galaxy Group Investments LLC. (“Galaxy”) and HCS Beteiligungsgesellschaft mbH (“HCS”) whereby these shareholders contributed their investments in COMPASS, Innoplexus and Juvenescence to the Company in exchange for the Company's common stock of equivalent value. Apeiron is the family office of the Company’s co-founder who owns 20.4% and 19.7% of the outstanding common stock in the Company as of June 30, 2023 and December 31, 2022, respectively. Galaxy is a NYC-based multi-strategy investment firm that owns 6.5% and 6.5% of the outstanding common stock in the Company as of June 30, 2023 and December 31, 2022, respectively.

Directed Share Program

In connection with ATAI’s initial public offering, the underwriters reserved 27% of the common shares for sale at the initial offering price to the Company’s managing directors, supervisory directors and certain other parties. Apeiron participated in the program and purchased $10.5 million common shares.

Consulting Agreement with Mr. Angermayer

In January 2021, the Company entered into a consulting agreement, (the “Consulting Agreement”), with Mr. Angermayer, one of the Company’s co-founders and supervisory director. Apeiron is the family office and merchant banking business of Mr. Angermayer. Pursuant to the Consulting Agreement, Mr. Angermayer agreed to render services to the Company on business and financing strategies in exchange for 624,000 shares under the 2020 Incentive Plan upon achievement of certain performance targets. The Consulting Agreement expires on March 31, 2024.

As a result of the Consulting Agreement, for the three months ended June 30, 2023 and 2022, the Company recorded $0.2 million and $0.2 million, respectively, of stock-based compensation included in general and administrative expense in its condensed consolidated statements of operations. Additionally, as a result of the Consulting Agreement, for the six months ended June 30, 2023 and 2022, the Company recorded $0.4 million and $0.4 million, respectively, of stock-based compensation included in general and administrative expense in its condensed consolidated statements of operations.

For the three months ended June 30, 2023 and 2022, the Company recorded $0.1 million and $0.2 million, respectively, of stock-based compensation included in general and administrative expense in its condensed consolidated statements of operations related to Mr. Angermayer's service as Chairman of the supervisory board. For the six months ended June 30, 2023 and 2022, the Company recorded $0.3 million and $0.3 million, respectively, of stock-based compensation included in general and administrative expense in its condensed consolidated statements of operations related to Mr. Angermayer's service as Chairman of the supervisory board.

19. Defined Contribution Plan

The Company has a defined contribution retirement savings plan under Section 401(k) of the Internal Revenue Code. This plan allows eligible employees to defer a portion of their annual compensation. Employees may make contributions by having the Company withhold a percentage of their salary up to the Internal Revenue Service annual limit. The Company recognized $0.1 million and $0.1 million of related compensation expense for the three months ended June 30, 2023 and 2022. The Company recognized $0.3 million and $0.2 million of related compensation expense for the six months ended June 30, 2023 and 2022.

20. Corporate Restructuring

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In February 2023, the Company restructured its workforce and eliminated approximately 30% of its global workforce in order to more effectively allocate its research and development and other resources supporting the revised business and program priorities and to reduce operational costs.

Restructuring expense related to the workforce reduction was incurred primarily during the six months ended June 30, 2023, resulting in $3.2 million of restructuring expense, which consisted of $3.0 million of cash expenditures for severance and other employee separation-related costs and $0.2 million of stock-based compensation expense. Of the restructuring expense, for the three and six months ended June 30, 2023, $1.8 million and $1.4 million were recorded in research and development expenses and general and administrative expenses, respectively, in the condensed consolidated statement of operations.

As of June 30, 2023, net restructuring liabilities totaled approximately $0.1 million included in accrued expenses on the Company's condensed consolidated balance sheets.

A reconciliation of the restructuring charges and related payments for the six months ended June 30, 2023 is as follows:

	Six Months Ended June 30, 2023
Restructuring liability as of December 31, 2022	$	—
Restructuring costs expensed during the period		3,194
Non-cash impact of stock-based compensation		(195	)
Cash payments of restructuring liabilities, net		(2,908	)
Restructuring liability as of June 30, 2023	$	91

21. Subsequent Events

None.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.

You should read the following discussion and analysis of our financial condition and results of operations together with our unaudited condensed consolidated financial statements and related notes thereto included in this Quarterly Report and our audited consolidated financial statements and related notes thereto for the year ended December 31, 2022, included in our Form 10-K filed with the SEC on March 24, 2023. This discussion contains forward-looking statements based upon current expectations that involve risks and uncertainties. Our actual results may differ materially from those anticipated in these forward-looking statements as a result of various factors, including those set forth in the section titled "Risk Factors" in our Annual Report on Form 10-K dated and filed with the SEC on March 24, 2023, and may be updated from time to time in our other filings with the SEC.

All references to years, unless otherwise noted, refer to our fiscal years, which end on December 31. Unless the context otherwise requires, all references in this subsection to “we,” “us,” “our,” “atai” or the “Company” refer to atai and its consolidated subsidiaries.

Business Overview

We are a clinical-stage biopharmaceutical company aiming to transform the treatment of mental health disorders. We were founded in 2018 in response to the significant unmet need and lack of innovation in the mental health treatment landscape, as well as the emergence of therapies that previously may have been overlooked or underused.

We have a bold and ambitious vision: to heal mental health disorders so that everyone, everywhere can live a more fulfilled life.

Mental health disorders such as depression, substance use disorder, or SUD, and anxiety, which are among our initial focus indications, are highly prevalent and estimated to affect more than one billion people globally. In addition, the total costs of mental health disorders are significant and expected to increase substantially. Between 2009 and 2019, spending on mental health care in the United States increased by more than 50%, reaching $225 billion, and a Lancet Commission report estimates the global economic cost will reach $16 trillion by 2030. While current treatments, such as selective serotonin reuptake inhibitors, or SSRIs, and serotonin-norepinephrine reuptake inhibitors, or SNRIs, are well established and effective for certain patients, a significant percentage of patients either respond inadequately or relapse, translating to a significant unmet patient need.

Since our inception in 2018, we have focused substantially all of our efforts and financial resources on acquiring and developing product and technology rights, establishing our platform, building our intellectual property portfolio and conducting research and development activities for our product candidates within our atai companies that we consolidate based on our controlling financial interest of such entities. We operate a decentralized model to enable scalable drug or technological development at our atai companies. Our atai companies drive the development of our programs and enabling technologies for which we have either acquired a controlling or significant interest in or created de novo. We believe that this model provides our development teams the support and incentives to rapidly advance their therapeutic candidates or technologies in a cost-efficient manner. We look to optimize deployment of our capital in order to maximize value for our stakeholders.

We provide our development teams with access to shared services including scientific, intellectual property, clinical, and regulatory support, as well as project management, research and development, market strategy, and development and corporate finance. Our global team of subject matter professionals provides deep domain expertise in areas such as mental health drug development and life sciences intellectual property. Development teams have access to relevant expertise specific to each stage of their development. We believe our knowledge and specialization in psychedelics and mental health continuously enhance the quality of the services we provide through the sharing of learnings and experiences across the teams.

We have incurred significant operating losses since our inception. Our net loss attributable to ATAI Life Sciences N.V. stockholders was $33.1 million and $36.6 million for the three months ended June 30, 2023 and 2022, respectively. Our net loss attributable to ATAI Life Sciences N.V. stockholders was $66.2 million and $73.5 million for the six months ended June 30, 2023 and 2022, respectively. As of June 30, 2023 and December 31, 2022, our accumulated deficit was $576.9 million and $510.2 million, respectively. Our ability to generate product revenue sufficient to achieve profitability will depend substantially on the successful development and eventual commercialization of product candidates at our atai companies that we consolidate based on our controlling financial interest of such entities as determined under the variable interest entity model ("VIE model") or voting interest entity model ("VOE model"). We expect to continue to incur significant expenses and increasing operating losses for at least the next several years.

Our historical losses resulted principally from costs incurred in connection with research and development activities, as well as general and administrative costs associated with our operations. In the future, we intend to continue to conduct research and development, preclinical testing, clinical trials, regulatory compliance, market access, commercialization and business development activities that, together with anticipated general and administrative expenses, will result in incurring further significant losses for at least the next several years. Our operating losses stem primarily from the development of our mental health research programs. Furthermore, we expect to incur additional costs associated with operating as a public company, including audit, legal, regulatory, and tax-related services associated with maintaining

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compliance with exchange listing and SEC requirements, director and officer insurance premiums, and investor relations costs. As a result, we will need substantial additional funding to support our continuing operations and pursue our growth strategy. Until such time as we can generate significant revenue from sales of our product candidates, if ever, we expect to finance our operations through a combination of equity offerings, debt financings, strategic collaborations and alliances or licensing arrangements. Our inability to raise capital as and when needed could have a negative impact on our financial condition and our ability to pursue our business strategies. There can be no assurances, however, that our current operating plan will be achieved or that additional funding will be available on terms acceptable to us, or at all.

As of June 30, 2023, we had cash and cash equivalents of $141.1 million and short-term securities of $86.4 million. We believe that our existing cash and cash equivalents and short-term securities will be sufficient for us to fund our operating expenses and capital expenditure requirements for at least the next 12 months following the filing of this Quarterly Report. We have based this estimate on assumptions that may prove to be wrong, and we could exhaust our available capital resources sooner than we expect. See “Liquidity and Capital Resources—Liquidity Risk” below.

We do not have any products approved for sale and have not generated any revenue from product sales. We have funded our operations to date primarily with proceeds from the sale of our common shares, issuances of convertible notes and a term loan.

Our Model and Strategy

We have a team of experienced drug discoverers, developers and innovators working towards our goal to heal mental health disorders. We operate a decentralized model to enable scalable drug or technological development at our atai companies. Our atai companies drive development of programs that we have either acquired a controlling or significant interest in or created de novo. We believe that this model provides our development teams the support and incentives to rapidly advance their programs in a cost-efficient manner. To grow our business, we intend to acquire development programs and companies that may further our goal of advancing transformative treatments for patients that suffer from mental health disorders.

This model enables a modular approach to capturing value as we advance therapies through commercialization. While our primary goal is to pursue commercialization of products independently, we also intend to continue opportunistically establishing collaborations and/or divest atai companies entirely based on several factors, including, without limitation, the strategic rationale and financial return potential. The model is designed to maximize the value of each drug that we successfully develop and generate returns for shareholders through these value-capturing strategies.

Impactful Capital Allocation and Strategic Value Capture

Consistent with our strategy, we provide the necessary funding and operational support to our programs to maximize their probability of success in clinical development and commercialization. We also regularly review the status of our programs to assess whether there are alternative forms of ownership, partnership or other forms of collaboration that would optimize our economic interests and the success of our programs. To that end, we are focusing on clinical phase programs and business development that we expect to generate meaningful data in the near term, and therefore prioritizing programs and opportunities that we believe have the highest return potential and value.

In addition, in February 2023 we conducted a reduction in force of approximately 30% of our global workforce in order to more effectively allocate our research and development and other resources supporting the revised business and program priorities and to reduce operational costs. Refer to Note 20 in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 for further information.

Our Core Clinical Programs

Our pipeline currently consists of therapeutic candidates across multiple neuropsychiatric indications. The table below summarizes the status of our core product candidate portfolio as of the date of this Quarterly Report.

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Note: DMT = N,N-dimethyltryptamine; MDMA = 3.4-Methlenedioxymethamphetamine.

1. Recognify and DemeRx IB are both variable interest entities; GABA is a non-consolidated VIE with operational involvement through Master Service Agreement (MSA) model; EmpathBio and Viridia are wholly-owned subsidiaries; COMPASS Pathways is a non-controlling equity interest.

2. RL-007 compound is (2R, 3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one(L)-(+) tartrate salts.

3. Developing COMP360, a formulation of psilocybin, administered with psychological support from specially trained therapists.

Clinical Pipeline Recent Advancements

The following details recent advancements regarding certain of our clinical programs:

DMX-1002 (ibogaine) for Opioid Use Disorder - DemeRx IB)

Recent Advancements:

•Today, we announced results from the Phase 1 study of DMX-1002 (ibogaine HCI), a cholinergic, glutamatergic and monoaminergic receptor modulator being developed for the treatment of Opioid Use Disorder (OUD).

•The single-blinded Phase 1 study assessed safety, tolerability and pharmacokinetics of single-ascending doses of DMX-1002 in healthy volunteers. Oral doses of 3 mg/kg, 6 mg/kg & 9 mg/kg were evaluated in 20 participants.

•Results of the Phase 1 trial demonstrated that oral doses of DMX-1002 at 9 mg/kg achieved plasma concentrations in line with those described in previous studies, in which subjects reported psychedelic experiences and obtained therapeutic benefit in OUD.

•The treatment-related adverse events (AEs) were similar to those observed in prior trials of DMX-1002, and a majority (>94%) were rated mild-to-moderate in severity. There were no serious adverse events reported.

•In one of the two participants who received 9 mg/kg of DMX-1002, QTc prolongation reached levels near those seen at the 10 mg/kg dose in the published literature (median change: 95 ms). In this participant, QTcF prolongation of 90-94ms was observed, up to QTcF interval of 493-501 msec. The patient was asymptomatic, with no cardiac arrythmias, and the QTc change resolved without intervention or sequalae.

•During the study we closely worked with cardiology experts who concluded that while QT prolongation of this order is a clinical risk, monitoring can help mitigate the risk to ensure the safety of patients, especially in a medical setting. The benefit of the drug will need to be defined in efficacy trials and will need to be weighed against the risks that have been defined.

•The company plans to engage regulatory authorities to assess progressing DMX-1002 into an efficacy study in patients with OUD.

RL-007 (Pro-Cognitive Neuromodulator for Cognitive Impairment Associated with Schizophrenia - Recognify Life Sciences)

Recent Advancements:

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•In the first quarter of 2023, the first patient was dosed in the Phase 2b study of RL-007 in patients with Cognitive Impairment Associated with Schizophrenia (CIAS).

•The ongoing Phase 2b study is a randomized, placebo-controlled, double-blind study. The primary endpoint of the study is the change in baseline in the MATRICS Consensus Cognitive Battery (MCCB) neurocognitive composite score, a well-established regulatory endpoint.

•We anticipate reporting top-line results from this study in the second half of 2024.

VLS-01 (N,N-Dimethyltryptamine; (“DMT”) for Treatment Resistant Depression - Viridia Life Sciences)

Recent Advancements:

•We recently completed Part 1 and Part 2 of an ongoing Phase 1 open-label, single-ascending dose study of VLS-01 in healthy adult participants. The ongoing Phase 1 study is designed to evaluate the safety, tolerability, PK and PD of VLS-01 delivered by intravenous (IV) infusion and our proprietary oral transmucosal film (OTF) formulation.

•In Part 1 (IV) and Part 2 (OTF), VLS-01 was well-tolerated, with no dose-limiting toxicity and a favorable safety profile. VLS-01 produced generally dose-dependent increases in exposure, and administration resulted in subjective psychedelic experiences in the majority of subjects. Part 3 is exploring further optimization of PK and PD of our proprietary OTF formulation, including further dose ranging.

•We expect to report additional clinical data in the third quarter of 2023.

EMP-01 (3,4-methylenedioxy-methamphetamine [MDMA] derivative for Post Traumatic Stress Disorder - EmpathBio)

Recent Advancements:

•The ongoing Phase 1 study is designed to evaluate the safety and tolerability of single-ascending doses of EMP-01 in healthy adult participants.

•Enrollment has been recently completed and we expect to report initial clinical data in the fourth quarter of 2023.

PCN-101 (R-Ketamine for Treatment Resistant Depression – Perception Neurosciences)

Recent Advancements:

•We recently announced completion of the Phase 1 open-label bridging study designed to assess the safety, tolerability, and pharmacokinetic profile of 60mg, 90mg and 120mg of PCN-101 delivered subcutaneously (SQ) as compared to 60mg of PCN-101 delivered IV.

•Pharmacokinetic (PK) analysis indicates that 120mg of PCN-101 delivered SQ resulted in an approximate doubling of drug exposure (AUC) while maintaining approximately the same maximum concentration (Cmax) as the 60mg IV dose.

•At the highest SQ dose of 120mg, rates of sedation (defined as MOAA/S score <5) and dissociation (defined as CADSS total score >4 and change from baseline >0) were each 14%. Overall, we believe the data supports testing the concept of at-home use of PCN-101 in future studies.

•We continue to work with Perception Neuroscience to explore strategic partnership options.

Financial Overview

Since our inception in 2018, we have focused substantially all of our efforts and financial resources on acquiring and developing product and technology rights, establishing our platform, building our intellectual property portfolio and conducting research and development activities for our product candidates within our atai companies that we consolidate based on our controlling financial interest of such entities. We operate a decentralized model to enable scalable drug or technological development at our atai companies. Our atai companies drive development of our programs and enabling technologies that we have either acquired a controlling or significant interest in or created de novo. We believe that this model provides our development teams the support and incentives to rapidly advance their therapeutic candidates or technologies in a cost-efficient manner. We look to optimize deployment of our capital in order to maximize value for our stakeholders.

Wholly owned subsidiaries and VIEs with greater than 50% ownership and deemed control are consolidated in our financial statements, and our net income (loss) is reduced for the non-controlling interest of the VIE’s share, resulting in net income (loss) attributable to atai stockholders.

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Investments, where we have ownership in the underlying company’s equity greater than 20% and less than 50%, or where we have significant influence, are recorded under the cost and equity method. We then record losses from investments in equity method investees, net of tax, for our proportionate share of the underlying company’s net results until the investment balance is adjusted to zero. If we make subsequent additional investments in that same company, we may record additional gains(losses) based on changes to our investment basis and also may record additional income(loss) in equity method investments.

We do not have any products approved for sale and have not generated any revenue from product sales. We have funded our operations to date primarily with proceeds from the sale of our common shares and from issuances of convertible notes and term loans.

Factors and Trends Affecting our Results of Operations

We believe that the most significant factors affecting our results of operations include:

Research and Development Expenses

Our ability to successfully develop innovative product candidates through our programs will be the primary factor affecting our future growth. Our approach to the discovery and development of our product candidates is still being demonstrated. As such, we do not know whether we will be able to successfully develop any of our product candidates. Developing novel product candidates requires a significant investment of resources over a prolonged period of time, and a core part of our strategy is to continue making sustained investments in this area. We have chosen to leverage our platform to initially focus on advancing our product candidates in the area of mental health.

All of our product candidates are still in development stages, and we have incurred and will continue to incur significant research and development costs for preclinical studies and clinical trials. We expect that our research and development expenses will constitute the most substantial part of our expenses in future periods in line with the advancement and expansion of the development of our product candidates.

Acquisitions/Investments

To continue to grow our business and to aid in the development of our various product candidates, we are strategically acquiring and investing in companies that share our common goal towards advancing transformative treatments, including psychedelic compounds and digital therapeutics, for patients that suffer from mental health disorders.

Acquisition of In-Process Research and Development Expenses

In an asset acquisition, including the initial consolidation of a VIE that is not a business, acquired in-process research and development, or IPR&D, with no alternative future use is charged to the condensed consolidated statements of operations as a component of operating expenses at the acquisition date.

Stock-Based Compensation

In August 2020, we adopted the 2020 Equity Incentive Plan (the “2020 Incentive Plan”) and the Hurdle Share Option Plan (the “HSOP Plan”), which allowed us to grant stock-based awards to executive officers, directors, employees and consultants. Prior to our IPO, we issued stock options that vest over a two to four-year service period, only if and when a “Liquidity Event” (as defined in the plans) occurs, with accelerated vesting if a Liquidity Event occurred by specified dates. Upon the closing of our IPO, the stock-based award vesting contingent upon a Liquidity Event was no longer deferred.

Effective April 23, 2021, we adopted and our shareholders approved the 2021 Incentive Award Plan (the “2021 Incentive Plan”). The 2021 Incentive Plan enables us to grant incentive stock options or nonqualified stock options, restricted stock awards and other stock-based awards to our executive officers, directors and other employees and consultants. Any shares subject to outstanding options originally granted under the 2020 Incentive Plan that terminate, expire or lapse for any reason without the delivery of shares to the holder thereof shall become available for issuance pursuant to the 2021 Incentive Plan. For the three months ended June 30, 2023 and 2022, we incurred $8.8 million and $9.5 million of stock-based compensation expense, respectively. For the six months ended June 30, 2023 and 2022, we incurred $17.4 million and $19.7 million of stock-based compensation expense, respectively.

Basis of Presentation and Consolidation

Since our inception, we have created wholly owned subsidiaries or made investments in certain controlled entities, including partially-owned subsidiaries for which we have majority voting interest under the VOE model or for which we are the primary beneficiary under the VIE model, which we refer to collectively as our consolidated entities. Ownership interests in consolidated entities that are held by entities other than us are reported as noncontrolling interests in our condensed consolidated balance sheets and condensed consolidated statements of stockholders' equity. The portion of net earnings attributable to the noncontrolling interests is presented as Net loss attributable to noncontrolling interests in our condensed consolidated statements of operations.

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Ownership interests in entities over which we have significant influence, but not a controlling financial interest, are accounted for as cost and equity method investments with our portion of net losses recorded in Losses from investments in equity method investees, net of tax in our condensed consolidated statements of operations.

Components of Our Results of Operations

Revenue

In March 2021, Perception Neuroscience, Inc. (“Perception”) entered into a license and collaboration agreement (the "Otsuka Agreement"), with Otsuka Pharmaceutical Co., LTD (“Otsuka”), under which we granted exclusive rights to Otsuka to develop and commercialize certain products containing arketamine, known as PCN-101, in Japan for the treatment of depression and other select indications. Perception received an upfront, non-refundable payment of $20.0 million in June 2021 and we are also eligible to receive up to $35.0 million if certain development and regulatory milestones are achieved and up to $66.0 million in commercial milestones upon the achievement of certain commercial sales thresholds. Perception is eligible to receive tiered, royalties ranging from low-teens to high-teens on net sales of licensed products subject to reduction in certain circumstances.

For the three and six months ended June 30, 2023 and 2022 there were no milestones achieved under the Otsuka Agreement and we recognized $0.2 million and $0.2 million of revenue related to certain research and development services, respectively, which included recognizing the remaining deferred revenue balance related to the Otsuka Agreement.

For the foreseeable future, we may generate revenue from reimbursements of services under the Otsuka Agreement, as well as milestone payments under our current and/or future collaboration agreements. We do not expect to generate any revenue from the sale of products unless and until such time that our product candidates have advanced through clinical development and regulatory approval, if ever. We expect that any revenue we generate, if at all, will fluctuate from year-to-year as a result of the timing and amount of payments relating to such services and milestones and the extent to which any of our products are approved and successfully commercialized. Our ability to generate future revenues will also depend on our ability to complete preclinical and clinical development of product candidates or obtain regulatory approval for them.

Operating Expenses

Research and Development Expenses

Research and development expenses consist primarily of costs incurred for our research activities, including our discovery efforts and the development of our product candidates, which include:

•employee-related expenses, including salaries, related benefits and stock-based compensation, for employees engaged in research and development functions;

•expenses incurred in connection with the preclinical and clinical development of our product candidates, including our agreements with third parties, such as consultants and contract research organizations (“CROs”);

•expenses incurred under agreements with consultants who supplement our internal capabilities;

•the cost of lab supplies and acquiring, developing and manufacturing preclinical study materials and clinical trial materials;

•costs related to compliance with regulatory requirements; and

•payments made in connection with third-party licensing agreements.

Research and development costs, including costs reimbursed under the Otsuka Agreement, are expensed as incurred, with reimbursements of such amounts being recognized as revenue. We account for nonrefundable advance payments for goods and services that will be used in future research and development activities as expenses when the service has been performed or when the goods have been received.

Our direct research and development expenses are tracked on a program-by-program basis for our product candidates and consist primarily of external costs, such as fees paid to outside consultants, CROs, contract manufacturing organizations (“CMOs”) and research laboratories in connection with our preclinical development, process development, manufacturing and clinical development activities. Our direct research and development expenses by program also include fees incurred under third-party license agreements.

We do not allocate internal research and development expenses consisting of employee and contractor-related costs, to specific product candidate programs because these costs are deployed across multiple product candidate programs under research and development and, as such, are separately classified.

Research and development activities are central to our business model. Product candidates in later stages of clinical development generally have higher development costs than those in earlier stages of clinical development, primarily due to the increased size and duration of

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later-stage clinical trials. We expect that our research and development expenses will continue to increase for the foreseeable future in connection with our planned preclinical and clinical development activities in the near term and in the future.

The successful development of our product candidates is highly uncertain. As such, at this time, we cannot reasonably estimate or know the nature, timing and estimated costs of the efforts that will be necessary to complete the remainder of the development of these product candidates. We are also unable to predict when, if ever, material net cash inflows will commence from our product candidates. This is due to the numerous risks and uncertainties associated with developing products, including the uncertainty of whether (i) any clinical trials will be conducted or progress as planned or completed on schedule, if at all, (ii) we obtain regulatory approval for our product candidates and (iii) we successfully commercialize product candidates.

Acquisition of In-Process Research and Development Expenses

Acquisition of IPR&D expenses consist of acquired in-process research and development with no future alternative use based on the probability of clinical success.

General and Administrative Expenses

General and administrative expenses consist primarily of salaries and other related costs, including stock-based compensation, for personnel in our executive, finance, corporate and business development and administrative functions, professional fees for legal, patent, accounting, auditing, tax and consulting services, travel expenses and facility-related expenses, advertising, and information technology-related expenses.

Subsequent to our February 2023 reduction in force, we expect that our general and administrative expenses will not materially increase in the near future. We may add more general and administrative head count in the future to support the potential commercialization of our product candidates.

Other Income (Expense), Net

Interest Income

Interest income consists of interest earned on cash balances held in interest-bearing accounts and interest earned on notes receivable. We expect that our interest income will fluctuate based on the timing and ability to raise additional funds as well as the amount of expenditures for our research and development of our product candidates and ongoing business operations.

Interest Expense

Interest expense consists primarily of interest expense incurred in connection with our term loan under the Loan Agreement (as defined below) entered into in August 2022. Upon closing of the Loan Agreement, Hercules Capital, Inc. issued a term loan advance in the amount of $15.0 million. See “—Liquidity and Capital Resources—Indebtedness” below for further discussion of the 2022 Term Loan Facility.

Change in Fair Value of Contingent Consideration Liability—Related Parties

Changes in fair value of contingent consideration liability—related parties, consists of subsequent remeasurement of our contingent consideration liability—related parties with Perception, TryptageniX and InnarisBio for which we record at fair value. See “—Liquidity and Capital Resources—Indebtedness” below for further discussion of our contingent consideration liability—related parties.

Change in Fair Value of Warrant Liability

Changes in fair value consist of subsequent remeasurement of our warrant liability relating to issued and outstanding warrants to purchase shares of Neuronasal's common stock acquired in connection with the acquisition of Neuronasal in May 2021.

Change in Fair Value of Securities carried at Fair Value

Changes in fair value of securities consists of changes in fair value of available for sale securities. We first purchased securities in January 2022.

Foreign exchange gain (loss), net

Foreign exchange gain (loss), net consists of the impact of changes in foreign currency exchange rates on our foreign exchange denominated assets and liabilities, relative to the U.S. dollar. The impact of foreign currency exchange rates on our results of operations fluctuates period over period based on our foreign currency exposures resulting from changes in applicable exchange rates associated with our foreign denominated assets and liabilities.

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Other Income (Expense)

Other income consists principally of the impact of our adoption of ASU 2016-13, Financial Instruments — Credit Losses and service revenue generated for general and administrative services performed by atai on behalf of our platform companies. See Note 2 of our condensed consolidated financial statements for additional discussion regarding our adoption of ASU 2016-13.

Provision For Income Taxes

For our consolidated entities, deferred income taxes are provided for the effects of temporary differences between the amounts of assets and liabilities recognized for financial reporting purposes and the amounts recognized for income tax purposes. Deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes.

We regularly assess the need to record a valuation allowance against net deferred tax assets if, based upon the available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized. Accordingly, we maintain a full valuation allowance against net deferred tax assets for all entities as of June 30, 2023. In assessing the realizability on deferred tax assets, we consider whether it is more-likely-than-not that some or all of deferred tax assets will not be realized. The future realization of deferred tax assets is subject to the existence of sufficient taxable income of the appropriate character (e.g., ordinary income or capital gain) as provided under the carryforward provisions of local tax law. We consider the scheduled reversal of deferred tax liabilities (including the effect in available carryback and carryforward periods), future projected taxable income, including the character and jurisdiction of such income, and tax-planning strategies in making this assessment.

Unrecognized tax benefits arise when the estimated benefit recorded in the financial statements differs from the amounts taken or expected to be taken in a tax return because of the considerations described above. As of June 30, 2023 and December 31, 2022, we had no unrecognized tax benefits.

Losses from Investments in Equity Method Investees, Net of Tax

Losses from investments in equity method investees, net of tax consists of our share of equity method investees losses on the basis of our equity ownership percentage, IPR&D charges resulting from basis differences and impairment related to our equity method investments.

Net Loss Attributable to Noncontrolling Interests

Net loss attributable to noncontrolling interests in our condensed consolidated statements of operations is a result of our investments in certain of our consolidated VIEs and consists of the portion of the net loss of these consolidated entities that is not allocated to us. Net losses in consolidated VIEs are attributed to noncontrolling interests considering the liquidation preferences of the different classes of equity held by the shareholders in the VIE and their respective interests in the net assets of the consolidated VIE in the event of liquidation, and their pro rata ownership. Changes in the amount of net loss attributable to noncontrolling interests are directly impacted by changes in the net loss of our VIEs and our ownership percentage changes.

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Results of Operations

Comparison of the Three Months Ended June 30, 2023 and 2022 (unaudited)

	Three Months Ended June 30,
	2023			2022			$ Change			% Change
	(in thousands, except percentages)
License revenue	$	172		$	170		$	2			1.2	%
Operating expenses:
Research and development		15,476			17,949			(2,473	)		-13.8	%
Acquisition of in-process research and development		—			357			(357	)		-100.0	%
General and administrative		16,558			17,221			(663	)		-3.8	%
Total operating expenses		32,034			35,527			(3,493	)		-9.8	%
Loss from operations		(31,862	)		(35,357	)		3,495			-9.9	%
Other income (expense), net:
Interest income		303			117			186			159.0	%
Interest expense		(658	)		—			(658	)		-100.0	%
Change in fair value of contingent consideration liability - related parties		76			95			(19	)		-20.0	%
Change in fair value of warrant liability		—			53			(53	)		100.0	%
Change in fair value of securities carried at fair value		526			(584	)		1,110			-190.1	%
Foreign exchange gain (loss), net		(9	)		4,882			(4,891	)		-100.2	%
Other income (expense), net		(34	)		(12	)		(22	)		183.3	%
Total other income (expense), net		204			4,551			(4,347	)		-95.5	%
Loss before income taxes		(31,658	)		(30,806	)		(852	)		2.8	%
Provision for income taxes		(185	)		(51	)		(134	)		262.7	%
Losses from investments in equity method investees, net of tax		(1,928	)		(6,652	)		4,724			-71.0	%
Net loss		(33,771	)		(37,509	)		3,738			-10.0	%
Net loss attributable to noncontrolling interests		(729	)		(891	)		162			-18.2	%
Net loss attributable to ATAI Life Sciences N.V. stockholders	$	(33,042	)	$	(36,618	)	$	3,576			-9.8	%

License Revenue

We recognized $0.2 million and $0.2 million of license revenue for the three months ended June 30, 2023 and 2022, respectively, which included recognizing the remaining deferred revenue balance related to the Otsuka Agreement.

Research and Development Expenses

The table and discussion below present research and development expenses for the three months ended June 30, 2023 and 2022:

	Three Months Ended June 30,
	2023		2022			$ Change			% Change
	(in thousands, except percentages)
Direct research and development expenses by program:
Our Core Clinical Programs
VLS-01 (Viridia)	$	2,104	$	(214	)	$	2,318			1083.2	%
RL-007 (Recognify)		1,651		312			1,339			429.2	%
DMX-1002 (DemeRx IB)		480		924			(444	)		-48.1	%
EMP-01 (EmpathBio)		933		1,089			(156	)		-14.3	%
Our Other Clinical Programs
PCN-101 (Perception)		1,963		3,609			(1,646	)		-45.6	%
KUR-101 (Kures)		93		1,214			(1,121	)		-92.3	%
RLS-01 (Revixia)		39		953			(914	)		-95.9	%
Enabling Technologies and Drug Discovery Platforms		1,069		2,868			(1,799	)		-62.7	%
Unallocated research and development expenses:
Personnel expenses		6,417		6,733			(316	)		-4.7	%
Professional and consulting services		615		363			252			69.4	%
Other		112		98			14			14.3	%
Total research and development expenses	$	15,476	$	17,949		$	(2,473	)		-13.8	%

Research and development expenses were $15.5 million for the three months ended June 30, 2023, compared to $17.9 million for the three months ended June 30, 2022. The decrease of $2.4 million was primarily attributable to a $1.8 million decrease of costs related to our

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enabling technologies and drug discovery platform as discussed below, $0.6 million decrease of direct costs in our clinical programs as discussed below, and $0.3 million decrease in personnel expenses (including $0.6 million decrease in stock-based compensation), partially offset by $0.3 million increase in professional and consulting services.

Our Core Clinical Programs:

Viridia Life Sciences: VLS-01 (N,N-Dimethyltryptamine; DMT) for Treatment Resistant Depression (TRD)

The $2.3 million increase in direct costs for VLS-01 was primarily due to an increase of $1.1 million of clinical development costs, $1.0 million increase in manufacturing costs and $0.2 million increase in preclinical development costs relating to our ongoing Phase 1 three-part trial of VLS-01 designed to evaluate the safety, tolerability, PK and PD of VLS-01 delivered by intravenous (IV) infusion and using our proprietary oral transmucosal film (OTF) formulation.

RL-007 (Recognify Life Sciences)

The $1.3 million increase in direct costs for the RL-007 program was primarily due to an increase of $1.3 million of clinical development costs related to the on-going Phase 2b proof-of-concept clinical trial for RL-007 in CIAS.

DemeRx IB: DMX-1002 (ibogaine) for OUD

The $0.4 million decrease in direct costs for the DMX-1002 program was primarily due to a decrease of $0.4 million of clinical development costs.

EmpathBio: EMP-01 (MDMA derivative) for PTSD

The $0.2 million decrease in direct costs for EMP-01 was primarily due to a decrease of $0.7 million preclinical activities and $0.1 million decrease of manufacturing costs, partially offset by a $0.7 million increase in clinical development costs relating to our on-going Phase 1 single ascending dose trial to assess the safety and tolerability of orally administered EMP-01.

Our Other Clinical Programs

Perception Neuroscience: PCN-101(R-Ketamine) for TRD

The $1.6 million decrease in direct costs for PCN-101 was primarily due to a decrease of $1.2 million of clinical development costs, $0.3 million decrease in manufacturing costs and $0.2 million decrease in personnel related costs, partially offset by $0.1 million increase in preclinical costs.

Kures: KUR-101(deuterated mitragynine) for OUD

The $1.1 million decrease in direct costs for KUR-101 was primarily due to a $1.0 million decrease of clinical development costs and $0.1 million decrease in manufacturing costs.

Revixia Life Sciences: RLS-01 for TRD

The $0.9 million decrease in direct costs for RLS-01 was primarily due to a $0.8 million decrease of manufacturing costs and $0.1 million decrease of preclinical development costs.

Enabling Technologies and Drug Discovery Platforms

The $1.8 million decrease in our enabling technologies and drug discovery platforms primarily relates to decreased direct costs of $0.9 million in our Invyxis program, $0.4 million in our TryptageniX program, $0.3 million in our InnarisBio program, $0.1 million in our PsyProtix program and $0.1 million in our EntheogeniX program.

Acquisition of In-Process Research and Development Expense

Acquisition of in-process research and development expenses were $0 for the three months ended June 30, 2023 and $0.4 million for the three months ended June 30, 2022, which related to license costs incurred by Kures.

General and Administrative Expenses

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General and administrative expenses were $16.6 million for the three months ended June 30, 2023 compared to $17.2 million for the three months ended June 30, 2022. The decrease of $0.6 million was largely attributable to a decrease of $0.6 million decrease in investor relations and public company compliance fees, $0.6 million decrease in personnel and travel related costs (including $0.2 million decrease in stock-based compensation), and $0.4 million decrease in D&O insurance, partially offset by a $1.0 million increase in legal and professional service expenses.

Interest Income

Interest income for the three months ended June 30, 2023 and 2022 primarily consisted of interest earned on our cash balances and notes receivable during these periods. We recognized interest income of $0.3 million and $0.1 million for the three months ended June 30, 2023 and 2022.

Interest Expense

Interest expense was $0.7 million for the three months ended June 30, 2023, which consists primarily of interest expense incurred in connection with our term loan under the Loan Agreement entered into in August 2022. We recognized an immaterial amount of interest expense during the three months ended June 30, 2022, respectively.

Change in Fair Value of Contingent Consideration Liability—Related Parties

The milestone and royalty payments in relation to the acquisition of Perception, InnarisBio and TryptageniX were recorded at the acquisition date or at the exercise date related to the call option, and is subsequently remeasured to fair value. For the three months ended June 30, 2023 and 2022 we recognized a $0.1 million and $0.1 million of income related to the change in fair value, respectively, due to updates to certain assumptions used to calculate the Perception contingent consideration liability.

Change in Fair Value of Warrant Liability

Changes in fair value consist of subsequent remeasurement of our warrant liability relating to issued and outstanding warrants to purchase shares of Neuronasal's common stock acquired in connection with the acquisition of Neuronasal in May 2021. The change in fair value of warrant liability for the three months ended June 30, 2022 was not material.

Change in Fair Value of Securities carried at Fair Value

Changes in fair value of securities consists of changes in fair value of available for sale securities. We purchased the securities in January 2022. During the three months ended June 30, 2023 and 2022 we recognized a gain of $0.5 million and a loss of $0.6 million, respectively, relating to the change in fair value of securities.

Foreign Exchange Gain (Loss), net

We recorded a loss of $0.1 million related to foreign currency exchange rates for the three months ended June 30, 2023 and a gain of $4.9 million related to foreign currency exchange rate for the three months ended June 30, 2022. This was due to the impact of fluctuations in the foreign currency exchange rate between the Euro and the U.S. dollar on our foreign denominated balances.

Other Income (Expense)

We recognized an immaterial amount of other expense during the three months ended June 30, 2023 and 2022.

Provision For Income Taxes

We incurred current income tax expense of $185,000 for the three months ended June 30, 2023 compared to $51,000 for the three months ended June 30, 2022. Our current income tax expense relates to book profits and thus taxable profits generated in our United States, Australian, and United Kingdom based subsidiaries.

Losses from Investments in Equity Method Investees

Losses from investment in equity method investees for the three months ended June 30, 2023 and 2022 was $1.9 million and $6.7 million, respectively. Loss from investment in equity method investees represents our share of equity method investee losses on the basis of our equity ownership percentages or based on our proportionate share of the respective class of securities in our other investments in the event that the carrying amount of our equity method investments was zero.

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Comparison of the Six Months Ended June 30, 2023 and 2022 (unaudited)

	Six Months Ended June 30,
	2023			2022			$ Change			% Change
	(in thousands, except percentages)
License revenue	$	209		$	170			39			22.9	%
Operating expenses:
Research and development		34,757			33,409			1,348			4.0	%
Acquisition of in-process research and development		—			357			(357	)		-100.0	%
General and administrative		30,529			35,203			(4,674	)		-13.3	%
Total operating expenses		65,286			68,969			(3,683	)		-5.3	%
Loss from operations		(65,077	)		(68,799	)		3,722			-5.4	%
Other income (expense), net:
Interest income		579			215			364			169.3	%
Interest expense		(1,280	)		—			(1,280	)		100.0	%
Change in fair value of contingent consideration liability - related parties		111			95			16			16.8	%
Change in fair value of warrant liability		—			53			(53	)		-100.0	%
Change in fair value of securities carried at fair value		1,490			(1,324	)		2,814			-212.5	%
Foreign exchange gain (loss), net		(846	)		7,045			(7,891	)		-112.0	%
Other income (expense), net		209			(12	)		221			-1841.7	%
Total other income (expense), net		263			6,072			(5,809	)		-95.7	%
Loss before income taxes		(64,814	)		(62,727	)		(2,087	)		3.3	%
Provision for income taxes		(351	)		(92	)		(259	)		281.5	%
Losses from investments in equity method investees, net of tax		(2,961	)		(12,248	)		9,287			-75.8	%
Net loss		(68,126	)		(75,067	)		6,941			-9.2	%
Net loss attributable to noncontrolling interests		(1,948	)		(1,580	)		(368	)		23.3	%
Net loss attributable to ATAI Life Sciences N.V. stockholders	$	(66,178	)	$	(73,487	)	$	7,309			-9.9	%

License Revenue

We recognized $0.2 million and $0.2 million of license revenue during the six months ended June 30, 2023 and 2022, respectively, which included recognizing the remaining deferred revenue balance related to the Otsuka Agreement.

Research and Development Expenses

The table and discussion below present research and development expenses for the six months ended June 30, 2023 and 2022:

	Six Months Ended June 30,
	2023		2022		Change			% Change
	(in thousands, except percentages)
Direct research and development expenses by program:
Our Core Clinical Programs
VLS-01 (Viridia)	$	5,172	$	1,576	$	3,596			228.2	%
RL-007 (Recognify)		3,379		707		2,672			377.9	%
DMX-1002 (DemeRx IB)		956		1,490		(534	)		-35.8	%
EMP-01 (EmpathBio)		1,568		2,443		(875	)		-35.8	%
Our Other Clinical Programs
PCN-101 (Perception)		5,006		5,800		(794	)		-13.7	%
KUR-101 (Kures)		230		2,008		(1,778	)		-88.5	%
RLS-01 (Revixia)		83		1,344		(1,261	)		-93.8	%
Enabling Technologies and Drug Discovery Platforms		3,059		4,208		(1,149	)		-27.3	%
Unallocated research and development expenses:
Personnel expenses		14,109		13,054		1,055			8.1	%
Professional and consulting services		916		498		418			83.9	%
Other		279		281		(2	)		-0.7	%
Total research and development expenses	$	34,757	$	33,409	$	1,348			4.0	%

Research and development expenses were $34.8 million for the six months ended June 30, 2023, compared to $33.4 million for the six months ended June 30, 2022. The increase of $1.4 million was primarily attributable to a $1.1 million increase in personnel costs, (which

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included $1.8 million of restructuring costs related to the reduction in force in February 2023 and a $0.8 million decrease in stock-based compensation), $1.0 million increase of direct costs in our clinical programs as discussed below, and $0.5 million increase in professional and consulting services fees, partially offset by a $1.2 million decrease of costs related to our enabling technologies and drug discovery platforms as discussed below.

Our Core Clinical Programs:

Viridia Life Sciences: VLS-01 (N,N-Dimethyltryptamine; DMT) for Treatment Resistant Depression (TRD)

The $3.6 million increase in direct costs for VLS-01 was primarily due to an increase of $2.2 million of clinical development costs, a $1.1 million increase in preclinical development costs and a $0.2 million increase in manufacturing costs relating to our on-going Phase 1 three-part trial of VLS-01 designed to evaluate the safety, tolerability, PK and PD of VLS-01 delivered by intravenous (IV) infusion and using our proprietary oral transmucosal film (OTF) formulation.

RL-007 (Recognify Life Sciences)

The $2.7 million increase in direct costs for the RL-007 program was primarily due to an increase of $2.6 million of clinical development costs and a $0.1 million increase in manufacturing costs related to the on-going Phase 2b proof-of-concept clinical trial for RL-007 in CIAS.

DemeRx IB: DMX-1002 (ibogaine) for OUD

The $0.5 million decrease in direct costs for the DMX-1002 program was primarily due to a decrease of $0.5 million of clinical development costs.

EmpathBio: EMP-01 (MDMA derivative) for PTSD

The $0.9 million decrease in direct costs for EMP-01 was primarily due to a decrease of $1.3 million in preclinical development costs and $0.5 million decrease in manufacturing costs, partially offset by a $0.9 million increase in clinical development costs relating to our on-going Phase 1 single ascending dose trial to assess the safety and tolerability of orally administered EMP-01.

Our Other Clinical Programs

Perception Neuroscience: PCN-101(R-Ketamine) for TRD

The $0.8 million decrease in direct costs for PCN-101 was primarily due to a decrease of $1.3 million of clinical development costs, and $0.4 million decrease in manufacturing costs, partially offset by a $0.8 million increase in preclinical development costs and $0.1 million increase in personnel costs.

Kures: KUR-101(deuterated mitragynine) for OUD

The $1.8 million decrease in direct costs for KUR-101 was primarily due to a $1.1 million decrease in clinical development costs, $0.5 million decrease in preclinical development costs, $0.1 million decrease in manufacturing costs and $0.1 million decrease in personnel costs.

Revixia Life Sciences: RLS-01 for TRD

The $1.3 million decrease in direct costs for RLS-01 was primarily due to a $1.1 million decrease in manufacturing costs and $0.2 million decrease in preclinical costs.

Enabling Technologies and Drug Discovery Platforms

The $1.2 million decrease in our enabling technologies and drug discovery platforms primarily relates to decreased direct costs of $0.7 million related to our Invyxis program, $0.3 million decrease in costs related to our PsyProtix program, $0.2 million decrease in costs related to our TryptageniX program, and $0.2 million decrease in costs related to our Introspect program, partially offset by a $0.2 million increase in our EntheogeniX program..

Acquisition of In-Process Research and Development Expense

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Acquisition of in-process research and development expenses were $0 for the six months ended June 30, 2023 and $0.4 million for the six months ended June 30, 2022, which related to license costs incurred by Kures.

General and Administrative Expenses

General and administrative expenses were $30.5 million for the six months ended June 30, 2023 compared to $35.2 million for the six months ended June 30, 2022. The decrease of $4.7 million was largely attributable to a decrease of $2.6 million in personnel related costs (including $1.4 million decrease in stock-based compensation), $2.1 million decrease in VAT and other non-income taxes, and $1.1 million decrease in D&O and other insurance costs, partially offset by $1.4 million of restructuring costs related to the reduction in force in February 2023 and an increase of $0.2 million in legal and professional service expenses.

Interest Income

Interest income for the six months ended June 30, 2023 and 2022 primarily consisted of interest earned on our cash balances and notes receivable during these periods. We recognized interest income of $0.6 million and $0.2 million for the six months ended June 30, 2023 and 2022.

Interest Expense

Interest expense was $1.3 million for the six months ended June 30, 2023, which consists primarily of interest expense incurred in connection with our term loan under the Loan Agreement entered into in August 2022. We recognized an immaterial amount of interest expense during the six months ended June 30, 2022.

Change in Fair Value of Contingent Consideration Liability—Related Parties

The milestone and royalty payments in relation to the acquisition of Perception, InnarisBio and TryptageniX were recorded at the acquisition date or at the exercise date related to the call option, and is subsequently remeasured to fair value. For the six months ended June 30, 2023 and 2022 we recognized a $0.1 million and $0.1 million of income related to the change in fair value, respectively, due to updates to certain assumptions used to calculate the Perception contingent consideration liability.

Change in Fair Value of Warrant Liability

Changes in fair value consist of subsequent remeasurement of our warrant liability relating to issued and outstanding warrants to purchase shares of Neuronasal's common stock acquired in connection with the acquisition of Neuronasal in May 2021. The change in fair value of warrant liability for the six months ended June 30, 2022 was not material.

Change in Fair Value of Securities carried at Fair Value

Changes in fair value of securities consists of changes in fair value of available for sale securities. We purchased the securities in January 2022. During the six months ended June 30, 2023 and 2022 we recognized a gain of $1.5 million and a loss of $1.3 million, respectively, relating to the change in fair value of securities.

Foreign Exchange Gain (Loss), net

We recorded a loss of $0.9 million related to foreign currency exchange rates for the six months ended June 30, 2023 and a gain of $7.0 million related to foreign currency exchange rate for the six months ended June 30, 2022. This was due to the impact of fluctuations in the foreign currency exchange rate between the Euro and the U.S. dollar on our foreign denominated balances.

Other Income (Expense)

We recognized other income of $0.2 million for the six months ended June 30, 2023, which consists principally of a $0.1 million gain recorded as a result of the Company's remeasurement of our expected credit loss allowance as of June 30, 2023 and $0.1 million of service revenue generated for general and administrative services performed by atai on behalf of our platform companies. See Note 2 to our unaudited condensed consolidated financial statements appearing in Part 1, Item 1 for additional discussion regarding our adoption of ASU 2016-13, Financial Instruments — Credit Losses. We recognized an immaterial amount of other expense during the six months ended June 30, 2022.

Provision For Income Taxes

We incurred current income tax expense of $351,000 for the six months ended June 30, 2023 compared to $92,000 for the six months ended June 30, 2022. Our current income tax expense relates to book profits and thus taxable profits generated in our United States, Australian, and United Kingdom based subsidiaries.

Losses from Investments in Equity Method Investees

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Losses from investment in equity method investees for the six months ended June 30, 2023 and 2022 was $3.0 million and $12.3 million, respectively. Loss from investment in equity method investees represents our share of equity method investee losses on the basis of our equity ownership percentages or based on our proportionate share of the respective class of securities in our other investments in the event that the carrying amount of our equity method investments was zero.

Liquidity and Capital Resources

Sources of Liquidity

Initial Public Offering

In June 2021, we completed our IPO and issued and sold 17,250,000 of our common shares at a price to the public of $15.00 per share, which included the exercise in full by the underwriters of their option to purchase 2,250,000 additional common shares. We received aggregate net proceeds of $231.6 million, after underwriting discounts and commissions of $18.1 million and offering costs of $9.0 million. As of June 30, 2023, we had cash and cash equivalents of $141.1 million and short-term securities of $86.4 million.

Convertible Promissory Notes

In November 2018, we issued an aggregate principal amount of $0.2 million of convertible notes, or the 2018 Convertible Notes. The 2018 Convertible Notes are non-interest-bearing and have a maturity date of September 30, 2025, unless previously redeemed, converted, purchased or cancelled. In October 2020, we issued an additional aggregate principal amount of $1.0 million of the 2018 Convertible Notes. Each note has a face value of €1 and is convertible into one ordinary share of ATAI Life Sciences AG upon the payment of €17.00. In 2021, several noteholders elected to convert their 2018 Convertible Notes into shares of ATAI Life Sciences N.V. These investors paid €17.00 per share for an aggregate amount of €5.8 million ($6.9 million) in order to convert their 2018 Convertible Notes into common shares of ATAI Life Sciences AG, which was in accordance with the original terms of the 2018 Convertible Note Agreements. In May and July 2022, certain noteholders elected to convert some of their 2018 Convertible Notes into shares of ATAI Life Sciences N.V. The investors paid €17.00 per share for an aggregate amount of €4.6 million ($4.6 million) in order to convert their 2018 Convertible Notes into common shares of ATAI Life Sciences AG. Concurrently with the conversion of the 2018 Convertible Notes into common shares of ATAI Life Sciences AG, the shares of ATAI Life Sciences AG that were issued to the noteholders were exchanged for shares of ATAI Life Sciences N.V. through a transfer and sale arrangement such that ATAI Life Sciences AG continued to remain a wholly owned subsidiary of ATAI Life Sciences N.V and the transaction was accounted for as an equity transaction that resulted in no gain or loss recognition. The aggregate principal amount of 2018 Convertible Notes outstanding as of June 30, 2023 was $0.4 million.

Investments

While a significant potential source of liquidity resides in our investment in COMPASS ordinary shares, we do not expect that our investment in COMPASS will be a material source of liquidity in the near term. Based on quoted market prices, the market value of our ownership in COMPASS was $79.2 million as of June 30, 2023. As of June 30, 2023, the carrying value of our investment in COMPASS was $0 under the equity method. As of June 30, 2023, our voting interest in COMPASS was 20.9%.

Hercules Term Loan

In August 2022, we entered into a Loan and Security Agreement, with Hercules Capital, Inc., which was most recently amended in May 2023. See “ – Liquidity Risks – Indebtedness– Hercules Term Loan” for additional information.

Liquidity Risks

As of June 30, 2023, we had cash and cash equivalents of $141.1 million and short-term securities of $86.4 million. We believe that our cash and cash equivalents will be sufficient to fund our projected operating expenses and capital expenditures through at least the next 12 months from the date of this Quarterly Report.

We expect to continue to incur substantial additional expenditures in the near term to support our ongoing activities. Additionally, we have incurred and expect to continue to incur additional costs as a result of operating as a public company. We expect to continue to incur net losses for the foreseeable future. Our ability to fund our product development and clinical operations as well as commercialization of our product candidates, will depend on the amount and timing of cash received from planned financings.

Our future capital requirements will depend on many factors, including:

•the time and cost necessary to complete ongoing and planned clinical trials;

•the outcome, timing and cost of meeting regulatory requirements established by the FDA, the EMA and other comparable foreign regulatory authorities;

•the progress, timing, scope and costs of our preclinical studies, clinical trials and other related activities for our ongoing and planned clinical trials, and potential future clinical trials;

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•the costs of commercialization activities for any of our product candidates that receive marketing approval, including the costs and timing of establishing product sales, marketing, distribution and manufacturing capabilities, or entering into strategic collaborations with third parties to leverage or access these capabilities;

•the amount and timing of sales and other revenues from our product candidates, if approved, including the sales price and the availability of coverage and adequate third party reimbursement;

•the cash requirements for purchasing additional equity from certain of our atai companies upon the achievement of specified development milestone events;

•the cash requirements for developing our programs and our ability and willingness to finance their continued development;

•the cash requirements for any future acquisitions or discovery of product candidates; and

•the time and cost necessary to respond to technological and market developments, including other products that may compete with one or more of our product candidates.

A change in the outcome of any of these or other variables with respect to the development of any of our product candidates could significantly change the costs and timing associated with the development of that product candidate. Further, our operating plans may change in the future, and we may need additional funds to meet operational needs and capital requirements associated with such operating plans. If we are unable to obtain this funding when needed on acceptable terms or at all, we could be forced to delay, limit or terminate our product development efforts.

Until such time, if ever, as we can generate substantial product revenue, we expect to finance our operations through a combination of equity financings, debt financings, collaborations with other companies and other strategic transactions. Debt financing and preferred equity financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making acquisitions or capital expenditures or declaring dividends. If we are unable to raise additional funds through equity or debt financings or other arrangements when needed, we may be required to delay, limit, reduce or terminate our product development or future commercialization efforts or grant rights to develop and market product candidates that we would otherwise prefer to develop and market ourselves.

Further, our operating plans may change, and we may need additional funds to meet operational needs and capital requirements for clinical trials and other research and development activities. Because of the numerous risks and uncertainties associated with the development and commercialization of our product candidates, we are unable to estimate the amounts of increased capital outlays and operating expenditures associated with our current and anticipated product development programs.

Cash Flows

The following table summarizes our cash flows for the six months ended June 30, 2023 and 2022:

	June 30,
	2023			2022
	(in thousands)
Net cash used in operating activities	$	(43,725	)	$	(45,917	)
Net cash used in investing activities		(5,987	)		(232,950	)
Net cash provided by financing activities		106			1,926
Effect of foreign exchange rate changes on cash		83			(1,193	)
Net increase (decrease) in cash	$	(49,523	)	$	(278,134	)

Net Cash Used in Operating Activities

Net cash used in operating activities was $43.7 million for the six months ended June 30, 2023, which consisted of a net loss of $68.2 million, adjusted by non-cash charges of $19.9 million and net cash inflows from the change in operating assets and liabilities of $4.5 million. The non-cash charges primarily consisted of $17.4 million of stock-based compensation, $3.0 million of losses from our equity method investments, $0.8 million of unrealized foreign exchange losses, $0.2 million change in right-of-use asset and $0.2 million amortization of debt discount, partially offset by a $1.5 million gain relating to the change in the fair value of our short-term securities during the period. The net cash inflows from the change in operating assets and liabilities were primarily due to a decrease of $7.8 million in prepaid expenses and other current assets and a $1.4 million increase in accounts payable, partially offset by a $4.7 million decrease in accrued liabilities.

Net cash used in operating activities was $45.9 million for the six months ended June 30, 2022, which consisted of a net loss of $75.0 million, adjusted by non-cash charges of $28.5 million and net cash inflows from the change in operating assets and liabilities of $0.7 million. The non-cash charges primarily consisted of $19.7 million of stock-based compensation, $12.2 million of losses from our equity

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method investments and a $1.3 million loss relating to the change in the fair value of our short-term debt securities during the period, partially offset by $5.0 million of unrealized foreign exchange gains. The net cash inflows from the change in operating assets and liabilities were primarily due to a $2.6 million decrease in accounts payable and a decrease of $0.9 million in prepaid expenses and other current assets, partially offset by a $2.3 million increase in accrued liabilities.

Net Cash Used in Investing Activities

Net cash used in investing activities was $6.0 million for the six months ended June 30, 2023, primarily driven by $39.6 million of cash paid for securities at fair value, $3.0 million of loans to related parties, $0.3 million of capitalized internal-use software development costs and $0.2 million of purchases of property plant and equipment, partially offset by $37.2 million of proceeds from the sale and maturities of securities carried at fair value.

Net cash used in investing activities was $232.9 million for the six months ended June 30, 2022, primarily driven by $229.7 million of cash paid for securities carried at fair value, $3.0 million of loans remitted to related parties, $0.2 million of purchases of property and equipment and $0.1 million of capitalized internal-use software development costs.

Net Cash Provided by Financing Activities

Net cash provided by financing activities was $0.1 million for the six months ended June 30, 2023, due to $0.2 million of proceeds from stock option exercises, partially offset by $0.1 million of financing costs paid.

Net cash provided by financing activities was $1.9 million for the six months ended June 30, 2022, due to $1.0 million of proceeds from the conversion of convertible notes to common stock, $0.6 million from the issuance of subsidiary preferred shares, and $0.3 million of proceeds from stock option exercises.

Indebtedness

Convertible Notes

In November 2018, we issued an aggregate principal amount of $0.2 million of 2018 Convertible Notes. In October 2020, we issued an additional principal amount of $1.0 million of 2018 Convertible Notes. The 2018 Convertible Notes are non-interest-bearing and have a maturity date of September 30, 2025, unless previously redeemed, converted, purchased or cancelled. Each note has a face value of €1 and is convertible into one common share of ATAI Life Sciences AG upon the payment of €17.00. Conversion rights may be exercised by a noteholder at any time prior to maturity, except during certain periods subsequent to the consummation of the IPO.

In 2021 and 2022, several noteholders elected to convert their 2018 Convertible Notes into common shares of ATAI Life Sciences N.V. These investors paid €17.00 per share for the aggregate amount of €5.8 million or $6.9 million and €4.6 million ($4.6 million), respectively, in order to convert their 2018 Convertible Notes into common shares of ATAI Life Sciences AG, which was in accordance with the original terms of the 2018 Convertible Note Agreements. Concurrent with the conversion of the 2018 Convertible Notes into common shares of ATAI Life Sciences AG, the common shares of ATAI Life Sciences AG that were issued to the noteholders were exchanged for 5,478,176 shares of ATAI Life Sciences N.V. through a transfer and sale arrangement such that ATAI Life Sciences AG continued to remain a wholly owned subsidiary of ATAI Life Sciences N.V and the transaction was accounted for as an equity transaction that resulted in no gain or loss recognition.

As of June 30, 2023 an aggregate principal amount of $0.4 million remained outstanding under the 2018 Convertible Notes.

Hercules Term Loan

On August 9, 2022 (the “Closing Date”), we, ATAI Life Sciences AG (“ATAI AG” and together with the Company, the “Borrowers”) and certain of our subsidiary guarantors (collectively, the “Subsidiary Guarantors”) entered into a Loan and Security Agreement (the “Loan Agreement”) with Hercules Capital, Inc. (“Hercules”), in its capacity as administrative agent and collateral agent (the “Agent”) and as a lender, and certain other financial institutions that from time to time become parties to the Loan Agreement as lenders (collectively, the “Lenders”). The Loan Agreement provides for term loans in an aggregate principal amount of up to $175.0 million under multiple tranches (the “2022 Term Loan Facility”).

On May 26, 2023, "the “Company”, ATAI Life Sciences AG (“ATAI AG” and together with the Company, the “Borrowers”) and certain subsidiary guarantors of the Company (collectively, the “Subsidiary Guarantors”) entered into the Second Amendment to Loan and Security Agreement (the “Amendment”), with the several banks and other financial institutions or entities from time to time parties to the Loan Agreement (collectively, the “Lenders”) and Hercules Capital, Inc., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and for the Lenders (the “Agent”) which amends that certain Loan and Security Agreement, dated August 9, 2022 (as amended by that certain First Amendment to Loan and Security Agreement dated as of March 13, 2023, the “Existing Loan Agreement,” and as amended by the Amendment, the “Agreement”) to, among other things, (i) extend the availability of Tranche 1B of

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$10.0 million, from May 1, 2023, under the Existing Loan Agreement, to November 15, 2024, (ii) extend the availability of Tranche 1C of $15.0 million, from December 15, 2023, under the Existing Loan Agreement, to December 15, 2024, (iii) provide Tranche 1D of $20.0 million, available upon the earlier of (x) the full draw of Tranche 1C and (y) the expiration of Tranche 1C availability, through February 15, 2025, (iv) extend the availability of Tranche 2 of $15.0 million, from June 30, 2024, under the Existing Loan Agreement, subject to certain conditions under the Agreement, to the earlier of (x) the full draw of Tranche 1D and (y) the expiration of Tranche 1D availability, through March 15, 2025, subject to the Tranche 2 Draw Test, (v) extend the timeline to achieve the second amortization extension condition, from June 30, 2024, in the Existing Loan Agreement, to December 15, 2024, (vi) amend the Tranche 2 Draw Test, satisfaction of which is a condition to draw Tranche 2 under the Agreement and (vii) extend the financial covenant commencement date, from the later of (x) July 1, 2023, and (y) the date that the outstanding debt under the facility is equal to or greater than $40.0 million, in the Existing Loan Agreement, to the later of (x) May 1, 2024, and (y) the date that the outstanding debt under the facility is equal to or greater than $30.0 million, provided, that the financial covenant is waived if the Company has a market capitalization of at least $550.0 million.

We are permitted to engage in certain specified transactions (subject to mandatory prepayment in certain instances as well as certain limitations, including the pledge of equity interests of certain subsidiaries and VIEs), including but not limited to, (i) entering into non-exclusive and certain specified exclusive licensing arrangements with respect to intellectual property without the consent of the Lenders; and (ii) entering into certain permitted acquisitions.

The 2022 Term Loan Facility will mature on August 1, 2026 (the “Maturity Date”), which may be extended until February 1, 2027 if we achieve certain performance milestones, raise at least $175.0 million of unrestricted new net cash proceeds from certain permitted sources after the Closing Date and prior to June 30, 2024, and satisfy certain other specified conditions. The outstanding principal balance of the 2022 Term Loan Facility bears interest at a floating interest rate per annum equal to the greater of either (i) the prime rate as reported in the Wall Street Journal plus 4.55% and (ii) 8.55%. Accrued interest is payable monthly following the funding of each term loan advance. We may make payments of interest only, without any loan amortization payments, for a period of thirty (30) months following the Closing Date, which period may be extended to (i) thirty-six months if certain additional performance milestones have been achieved; and (ii) forty-two months if certain additional performance milestones have been achieved. At the end of the interest only period, we are required to begin repayment of the outstanding principal of the 2022 Term Loan Facility in equal monthly installments.

As collateral for the obligations under the 2022 Term Loan Facility, we have granted to the Agent for the benefit of the Lenders a senior security interest in substantially all of our, ATAI AG and each Subsidiary Guarantor’s property (including a pledge of equity interests of certain subsidiaries and VIEs), exclusive of intellectual property, with certain limited exceptions set forth in the Loan Agreement.

The Loan Agreement contains customary closing and commitment fees, prepayment fees and provisions, events of default and representations, warranties and affirmative and negative covenants, including a financial covenant requiring us to maintain certain levels of cash in accounts subject to a control agreement in favor of the Agent (the “Qualified Cash”) at all times commencing from the Closing Date, which includes a cap on the amount of cash that can be held by, among others, certain of our foreign subsidiaries in Australia and the United Kingdom. In addition, the financial covenant under the Loan Agreement requires that beginning on the later of (i) July 1, 2023 and (ii) the date on which the aggregate outstanding amount borrowed under the 2022 Term Loan Facility is equal to or greater than $40.0 million, we shall maintain Qualified Cash in an amount no less than the sum of (1) 33% of the outstanding amount under the 2022 Term Loan Facility, and (2) the amount of the Borrowers’ and Subsidiary Guarantors’ accounts payable that have not been paid within 180 days from the invoice date of the relevant account payable, subject to certain exceptions; provided, that the financial covenant shall not apply on any day that our market capitalization is at least $600.0 million measured on a consecutive 10-business day period immediately prior to such date of measurement and tested on a daily basis. Upon the occurrence of an event of default, including a material adverse effect, subject to certain exceptions, on our and ATAI AG’s, taken together, business, operations, properties, assets or financial condition, and subject to any specified cure periods, all amounts owed by us may be declared immediately due and payable by the Lenders. As of the Closing Date, we were in compliance with all applicable covenants under the Loan Agreement.

In addition, we are required to make a final payment fee (the “End of Term Charge”) upon the earlier of (i) the Maturity Date, (ii) the date that we prepay, in full or in part, the principal balance of the 2022 Term Loan Facility, or (iii) the date that the outstanding balance of the 2022 Term Loan Facility becomes due and payable. The End of Term Charge is 6.95% of the aggregate original principal amount of the term loans so repaid or prepaid under the Loan Agreement.

We may, at our option, prepay the term loans in full or in part, subject to a prepayment penalty equal to (i) 2.00% of the principal amount prepaid if the prepayment occurs on or prior to the first anniversary of the Closing Date, (ii) 1.0% of the principal amount prepaid if the prepayment occurs after the first anniversary and on or prior to the second anniversary of the Closing Date, and (iii) 0.5% of the principal amount prepaid if the prepayment occurs after the second anniversary and prior to the Maturity Date.

Material Cash Requirements from Known Contractual and Other Obligations and Commitments

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Our commitments and obligations were reported in our Annual Report on Form 10-K for the year ended December 31, 2022, which was filed with the SEC on March 24, 2023. During the six months ended June 30, 2023, there have been no material changes from the contractual commitments and obligations previously disclosed in our Form 10-K, with the exception of the five year lease that commenced in February 2023 that is further described in Note 10 of the notes to our unaudited condensed consolidated financial statements appearing under Part 1, Item 1.

Recently Adopted Accounting Pronouncements

See Note 2, “Summary of Significant Accounting Policies—Recently Adopted Accounting Pronouncements” to our unaudited condensed consolidated financial statements appearing under Part 1, Item 1 for more information.

Critical Accounting Policies and Estimates

Our critical accounting policies are described under the heading “Management’s Discussion and Analysis of Financial Condition and Results of Operations – Critical Accounting Policies and Estimates” in our Form 10-K and in Note 2 to our consolidated financial statements included in our Form 10-K. As disclosed in Note 2 to our consolidated financial statements included in our Form 10-K, the preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions about future events that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ significantly from those estimates. During the period covered by this Quarterly Report, there were no material changes to our critical accounting policies from those discussed in our Form 10-K.

JOBS Act

We are an emerging growth company, as defined in the JOBS Act. We intend to rely on certain of the exemptions and reduced reporting requirements provided by the JOBS Act. We have elected to use the extended transition period for complying with new or revised accounting standards that have different effective dates for public and private companies until the earlier of the date that (i) we are no longer an emerging growth company or (ii) we affirmatively and irrevocably opt out of the extended transition period provided in the JOBS Act. As a result, our condensed consolidated financial statements may not be comparable to companies that comply with the new or revised accounting pronouncements as of public company effective dates.

As described in Note 2 to our unaudited condensed consolidated financial statements included in Part 1, Item 1, we have early adopted certain accounting standards, as the JOBS Act does not preclude an emerging growth company from adopting a new or revised accounting standard earlier than the time that such standard applies to private companies. We expect to use the extended transition period for any other new or revised accounting standards during the period in which we remain an emerging growth company.

Item 3. Quantitative and Qualitative Disclosures About Market Risk.

We are exposed to market risks in the ordinary course of our business. Market risk represents the risk of loss that may impact our financial position due to adverse changes in financial market prices and rates. Our market risk exposure is primarily the result of fluctuations in interest rates and foreign currency exchange rates. In addition, our portfolio of notes receivables is exposed to credit risk in the form of non-payment or non-performance. In mitigating our credit risk, we consider multiple factors, including the duration and terms of the note and the nature of and our relationship with the counterparty.

Interest Rate Sensitivity

Our primary exposure to market risk is interest rate sensitivity, which is affected by changes in the general level of U.S. interest rates. As of June 30, 2023 we had cash and cash equivalents of $141.1 million and short-term securities of $86.4 million. We generally hold our cash in interest-bearing demand deposit accounts and short-term securities. Due to the nature of our cash and investment portfolio, a hypothetical 100 basis point change in interest rates would not have a material effect on the fair value of our cash. Our cash is held for working capital purposes. The Company purchases investment grade marketable debt securities which are rated by nationally recognized statistical credit rating organizations in accordance with its investment policy. This policy is designed to minimize the Company's exposure to credit losses and to ensure that the adequate liquidity is maintained at all times to meet anticipated cash flow needs.

As of June 30, 2023, we had $0.4 million in convertible promissory notes – related parties, net, which was comprised of non-interest-bearing borrowings under the 2018 Convertible Notes. Based on the principal amounts of the convertible promissory notes and the interest rate assigned to the convertible promissory notes, a hypothetical 10% change in interest rates would not have a material impact on our convertible promissory notes, financial position or results of operations.

As of June 30, 2023, the carrying amount of our short and long-term notes receivables was an aggregate amount of $10.2 million. Based on the principal amounts of the notes receivable and the interest rates assigned to each note receivable as per their respective contracts, a hypothetical 10% change in the interest rates would not have a material impact on our notes receivables, financial position or results of operations.

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Foreign Currency Exchange Risk

Our reporting and functional currency is the U.S. dollar, and the functional currency of our foreign subsidiaries is generally the respective local currency. The assets and liabilities of each of our foreign subsidiaries are translated into U.S. dollars at exchange rates in effect at each balance sheet date. Adjustments resulting from translating foreign functional currency financial statements into U.S. dollars are recorded as a separate component on the Condensed Consolidated Statements of Comprehensive Loss. Equity transactions are translated using historical exchange rates. Expenses are translated using the average exchange rate during the previous month. Gains or losses due to transactions in foreign currencies are included in interest and other income (expense), net in our Condensed Consolidated Statements of Operations.

The volatility of exchange rates depends on many factors that we cannot forecast with reliable accuracy. We have experienced and will continue to experience fluctuations in foreign exchange gains and losses related to changes in foreign currency exchange rates. In the event our foreign currency denominated assets, liabilities, revenue, or expenses increase, our results of operations may be more greatly affected by fluctuations in the exchange rates of the currencies in which we do business, resulting in unrealized foreign exchange gains or losses. We have not engaged in the hedging of foreign currency transactions to date, although we may choose to do so in the future.

A hypothetical 10% change in the relative value of the U.S. dollar to other currencies during any of the periods presented would not have had a material effect on our condensed consolidated financial statements, but could result in significant unrealized foreign exchange gains or losses for any given period.

Item 4. Controls and Procedures.

Evaluation of Disclosure Controls and Procedures

We maintain disclosure controls and procedures (as that term is defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act) that are designed to ensure that information required to be disclosed in our reports under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosures. In designing and evaluating our disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives. In addition, the design of disclosure controls and procedures must reflect the fact that there are resource constraints and that management is required to apply judgment in evaluating the benefits of possible controls and procedures relative to their costs.

Our management, with the participation of our Chief Executive Officer and our Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures as of June 30, 2023, the end of the period covered by this Quarterly Report. Based on this evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures were effective as of June 30, 2023 at the reasonable assurance level.

Changes in Internal Control Over Financial Reporting

There was no change in our internal control over financial reporting (as that term is defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) that occurred during the fiscal quarter ended June 30, 2023 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

55

PART II- OTHER INFORMATION

Item 1. Legal Proceedings.

From time to time, we have been and may again become involved in legal proceedings arising in the ordinary course of our business. Although the results of litigation and claims cannot be predicted with certainty, we do not believe we are party to any claim or litigation the outcome of which, if determined adversely to us, would individually or in the aggregate be reasonably expected to have a material adverse impact on our financial position, results of operations or cash flows. Regardless of the outcome, litigation can have an adverse effect on us because of defense and settlement costs, diversion of management resources and other factors.

Item lA. Risk Factors.

Investing in our common shares involves a high degree of risk. In addition to the other information set forth in this Quarterly Report and in other documents that we file with the SEC, you should carefully consider the factors described in the section titled "Risk Factors" in our Form 10-K. There have been no material changes to the risk factors described in Part I, Item 1A of our Form 10-K. If any of the risk factors described in the Form 10-K actually materializes, our business, financial condition and results of operations could be materially adversely affected. In such an event, the market price of our common shares could decline and you may lose all or part of your investment. Additional risks that we currently do not know about or that we currently believe to be immaterial may also impair our business. We may disclose changes to such risk factors or disclose additional risk factors from time to time in our future filings with the SEC.

Item 2. Unregistered Sales of Equity Securities, Use of Proceeds and Issuer Purchases of Equity Securities.

None.

Item 3. Defaults Upon Senior Securities.

None.

Item 4. Mine Safety Disclosures.

Not applicable.

Item 5. Other Information.

a)None.

b)None.

c)Not applicable.

56

Item 6. Exhibits.

		Incorporated by Reference
Exhibit  Number	Description	Form	File No.	Exhibit	Filing Date	Filed/Furnished Herewith
3.1	Articles of Association of ATAI Life Sciences N.V. (translated into English), currently in effect	S-3	333-265970	3.1	7/01/2022
3.2	Rules of the Management Board of ATAI Life Sciences N.V.	S-1/A	333- 255383	3.2	6/11/2021
3.3	Rules of the Supervisory Board of ATAI Life Sciences N.V.	S-1/A	333- 255383	3.3	6/11/2021
10.1†	Second Amendment to the Loan and Security Agreement between the Registrant, ATAI Life Sciences AG, certain of the Registrant’s subsidiaries from time to time party thereto as a guarantor, Hercules Capital, Inc., and the several banks and other financial institutions or entities from time to time party thereto, and Hercules Capital, Inc. as administrative agent and collateral agent for itself and the lenders, dated May 26, 2023.	8-K	001-40493	10.1	5/31/2023
31.1	Certification of Principal Executive Officer pursuant to Exchange Act Rule 13a-14(a)					*
31.2	Certification of Principal Financial Officer pursuant to Exchange Act Rule 13a-14(a)					*
32.1	Certification of Principal Executive Officer pursuant to 18 U.S.C. Section 1350					**
32.2	Certification of Principal Financial Officer pursuant to 18 U.S.C. Section 1350					**
101.INS	Inline XBRL Instance Document - the Instance Document does not appear in the interactive data file because its XBRL tags are embedded within the Inline XBRL document					*
101.SCH	Inline XBRL Taxonomy Extension Schema Document					*
101.CAL	Inline XBRL Taxonomy Extension Calculation Linkbase Document					*
101.DEF	Inline XBRL Taxonomy Extension Definition Linkbase Document					*
101.LAB	Inline XBRL Taxonomy Extension Label Linkbase Document					*
101.PRE	Inline XBRL Taxonomy Extension Presentation Linkbase Document					*
104	Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)					*

† Certain confidential portions (indicated by brackets and asterisks) have been omitted from this exhibit pursuant to Item 601(b)(10)(iv).

* Filed herewith.

** Furnished herewith.

57

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	ATAI LIFE SCIENCES N.V.
Date: August 10, 2023	By:	/s/ Florian Brand
		Florian Brand
		Chief Executive Officer and Managing Director (Principal Executive Officer)
Date: August 10, 2023	By:	/s/ Stephen Bardin
		Stephen Bardin
		Chief Financial Officer and Managing Director (Principal Financial Officer)
Date: August 10, 2023	By:	/s/ Anne Johnson
		Anne Johnson
		Chief Accounting Officer
		(Principal Accounting Officer)

58

EX-31.1

Exhibit 31.1

CERTIFICATION

I, Florian Brand, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of ATAI Life Sciences N.V.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 10, 2023	By:	/s/ Florian Brand
		Florian Brand Chief Executive Officer (Principal Executive Officer)

EX-31.2

Exhibit 31.2

CERTIFICATION

I, Stephen Bardin, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of ATAI Life Sciences N.V.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 10, 2023	By:	/s/ Stephen Bardin
		Stephen Bardin
		Chief Financial Officer
		(Principal Financial Officer)

EX-32.1

Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of ATAI Life Sciences N.V. (the “Company”) for the period ended June 30, 2023 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: August 10, 2023	By:	/s/ Florian Brand
		Florian Brand
		Chief Executive Officer
		(Principal Executive Officer)

EX-32.2

Exhibit 32.2

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of ATAI Life Sciences N.V. (the “Company”) for the period ended June 30, 2023 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: August 10, 2023	By:	/s/ Stephen Bardin
		Stephen Bardin
		Chief Financial Officer
		(Principal Financial Officer)

XML

Cover Page - shares	6 Months Ended
	Jun. 30, 2023	Aug. 01, 2023
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2023
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q2
Trading Symbol	ATAI
Title of 12(b) Security	Common shares, par value €0.10 per share
Security Exchange Name	NASDAQ
Entity Registrant Name	ATAI Life Sciences N.V.
Entity Central Index Key	0001840904
Current Fiscal Year End Date	--12-31
Entity Current Reporting Status	Yes
Entity Filer Category	Non-accelerated Filer
Entity Common Stock, Shares Outstanding		166,010,476
Entity Interactive Data Current	Yes
Entity Shell Company	false
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity File Number	001-40493
Entity Incorporation, State or Country Code	P7
Document Transition Report	false
Entity Address, Address Line One	ATAI Life Sciences N.V.
Entity Address, Address Line Two	Wallstraße 16, 10179
Entity Address, City or Town	Berlin
City Area Code	49 89
Local Phone Number	2153 9035
Entity Address, Country	DE
Entity Address, Postal Zip Code	00000
Entity Tax Identification Number	00-0000000

XML

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 141,090	$ 190,613
Securities carried at fair value	86,402	82,496
Prepaid expenses and other current assets	6,257	14,036
Short term notes receivable - related parties, net	9,021	0
Total current assets	242,770	287,145
Property and equipment, net	1,043	928
Operating lease right-of-use asset, net	1,367	226
Other investments	3,991	6,755
Long term notes receivable - related parties, net	1,157	7,262
Notes Receivable, Related Parties, Noncurrent	1,157	7,262
Other assets	3,267	3,125
Total assets	253,595	305,441
Current liabilities:
Accounts payable	3,859	2,399
Accrued liabilities	12,855	17,306
Current portion of lease liability	322	180
Other current liabilities	890	12
Total current liabilities	17,926	19,897
Non-current portion of contingent consideration liability - related parties	842	953
Non-current portion of lease liability	1,095	44
Convertible promissory notes - related parties, net of discounts and deferred issuance costs	420	415
Long-term debt, net	14,868	14,702
Other liabilities	2,807	3,664
Total liabilities	37,958	39,675
Commitments and contingencies (Note 16)
Stockholders' equity:
Common stock,0.10 par value ($0.12 par value at June 30, 2023 and December 31, 2022, respectively); 750,000,000 shares authorized at June 30, 2023 and December 31, 2022, respectively; 166,010,476 and 165,935,914 shares issued and outstanding at June 30, 2023 and December 31, 2022 respectively	18,571	18,562
Additional paid-in capital	791,688	774,092
Share subscription receivable	0	(24)
Accumulated other comprehensive loss	(20,818)	(21,702)
Adjustment to accumulated deficit (pursuant to adoption of ASU 2016-13)	(576,891)	(510,188)
Total stockholders' equity attributable to ATAI Life Sciences N.V. stockholders	212,550	260,740
Noncontrolling interests	3,087	5,026
Total stockholders' equity	215,637	265,766
Total liabilities and stockholders' equity	$ 253,595	$ 305,441

XML

Condensed Consolidated Balance Sheets (Parenthetical)	Jun. 30, 2023 € / shares shares	Jun. 30, 2023 $ / shares shares	Dec. 31, 2022 € / shares shares	Dec. 31, 2022 $ / shares shares
Common Stock, Par or Stated Value Per Share | (per share)	€ 0.10	$ 0.12	€ 0.10	$ 0.12
Common stock, shares authorized	750,000,000	750,000,000	750,000,000	750,000,000
Common stock, shares, issued	166,010,476	166,010,476	165,935,914	165,935,914
Common stock, shares, outstanding	166,010,476	166,010,476	165,935,914	165,935,914

XML

Condensed Consolidated Statements of Operations (Unaudited) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Income Statement [Abstract]
License revenue	$ 172,000	$ 170,000	$ 209,000	$ 170,000
Operating expenses:
Research and development	15,476,000	17,949,000	34,757,000	33,409,000
Acquisition of In Process Research and Development	0	357,000	0	357,000
General and administrative	16,558,000	17,221,000	30,529,000	35,203,000
Total operating expenses	32,034,000	35,527,000	65,286,000	68,969,000
Loss from operations	(31,862,000)	(35,357,000)	(65,077,000)	(68,799,000)
Other income (expense), net:
Interest income	303,000	117,000	579,000	215,000
Interest expense	(658,000)	0	(1,280,000)	0
Change in fair value of contingent consideration liability - related parties	76,000	95,000	111,000	95,000
Change in Fair Value of Warrant Liability	0	53,000	0	53,000
Change in fair value of securities carried at fair value	526,000	(584,000)	1,490,000	(1,324,000)
Foreign exchange gain (loss), net	(9,000)	4,882,000	(846,000)	7,045,000
Other income (expense), net	34,000	12,000	209,000	12,000
Total other income (expense), net	204,000	4,551,000	263,000	6,072,000
Loss before income taxes	(31,658,000)	(30,806,000)	(64,814,000)	(62,727,000)
Provision for income taxes	(185,000)	(51,000)	(351,000)	(92,000)
Losses from investments in equity method investees, net of tax	(1,928,000)	(6,652,000)	(2,961,000)	(12,248,000)
Net loss	(33,771,000)	(37,509,000)	(68,126,000)	(75,067,000)
Net loss attributable to noncontrolling interests	(729,000)	(891,000)	(1,948,000)	(1,580,000)
Net loss attributable to ATAI Life Sciences N.V. stockholders	$ (33,042,000)	$ (36,618,000)	$ (66,178,000)	$ (73,487,000)
Net loss per share attributable to ATAI Life Sciences N.V. stockholders - basic	$ (0.21)	$ (0.24)	$ (0.42)	$ (0.48)
Net loss per share attributable to ATAI Life Sciences N.V. stockholders - diluted	$ (0.21)	$ (0.24)	$ (0.42)	$ (0.48)
Weighted average common shares outstanding attributable to ATAI Life Sciences N.V. Stockholders - basic	155,792,490	153,971,202	155,793,323	153,751,456
Weighted average common shares outstanding attributable to ATAI Life Sciences N.V. stockholders - diluted	155,792,490	153,971,202	155,793,323	153,751,456

XML

Condensed Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Statement of Comprehensive Income [Abstract]
Net loss	$ (33,771)	$ (37,509)	$ (68,126)	$ (75,067)
Other comprehensive income (loss):
Foreign currency translation adjustments, net of tax	5	(8,482)	884	(12,855)
Comprehensive loss	(33,766)	(45,991)	(67,242)	(87,922)
Comprehensive loss attributable to noncontrolling interests	(729)	(891)	(1,948)	(1,580)
Foreign currency translation adjustments, net of tax attributable to noncontrolling interests	1	30	9	19
Comprehensive loss attributable to noncontrolling interests	(728)	(861)	(1,939)	(1,561)
Comprehensive loss attributable to ATAI Life Sciences N.V. stockholders	$ (33,038)	$ (45,130)	$ (65,303)	$ (86,361)

XML

Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Share Subscriptions Receivable [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Total Stockholders' Equity Attributable to ATAI Life Sciences N.V. Stockholders [Member]	Noncontrolling Interests [Member]
Beginning Balance at Dec. 31, 2021	$ 385,959	$ 18,002	$ 725,045		$ (8,336)	$ (357,803)	$ 376,908	$ 9,051
Beginning Balance, Shares at Dec. 31, 2021		160,677,001
Issuance of shares upon exercise of stock options, shares		42,827
Issuance of shares upon exercise of stock options	132	$ 5	127		0	0	132	0
Stock-based compensation expense	10,208	0	10,208		0	0	10,208	0
Foreign currency translation adjustment, net of tax	(4,384)	0	0		(4,373)	0	(4,373)	(11)
Net income (loss)	(37,558)	$ 0	0		0	(36,869)	(36,869)	(689)
Ending Balance, Shares at Mar. 31, 2022		160,719,828
Ending Balance at Mar. 31, 2022	354,357	$ 18,007	735,380		(12,709)	(394,672)	346,006	8,351
Issuance of shares upon exercise of stock options, shares		47,957
Issuance of shares upon exercise of stock options	118	$ 6	112				118
Issuance of noncontrolling interest	957
Conversion of convertible notes to common stock	1,140	$ 101	1,039				1,140
Conversion of convertible notes to common stock, Shares		960,000
Issuance of subsidiary preferred shares	600							600
Issuance of subsidiary common shares	357							357
Stock-based compensation expense	9,511		9,511				9,511
Foreign currency translation adjustment, net of tax	(8,452)				(8,482)		(8,482)	(30)
Net income (loss)	(37,509)					(36,618)	(36,618)	(891)
Ending Balance, Shares at Jun. 30, 2022		161,727,785
Ending Balance at Jun. 30, 2022	320,122	$ 18,114	746,042		(21,191)	(431,290)	311,675	8,447
Beginning Balance at Dec. 31, 2022	265,766	$ 18,562	774,092	$ (24)	(21,702)	(510,188)	260,740	5,026
Beginning Balance, Shares at Dec. 31, 2022		165,935,914
Settlement of issuance of shares upon exercise of stock options	24			24			24
Issuance of shares upon exercise of stock options, shares		74,562
Issuance of shares upon exercise of stock options	181	$ 9	172		0	0	181	0
Adjustment to accumulated deficit (pursuant to adoption of ASU 2016-13)	(526)					(526)	(526)
Stock-based compensation expense	8,662	0	8,662		0	0	8,662	0
Foreign currency translation adjustment, net of tax	887	0	0		879	0	879	8
Net income (loss)	(34,354)	$ 0	0		0	(33,135)	(33,135)	(1,219)
Ending Balance, Shares at Mar. 31, 2023		166,010,476
Ending Balance at Mar. 31, 2023	240,640	$ 18,571	782,926		(20,823)	(543,849)	236,825	3,815
Beginning Balance at Dec. 31, 2022	265,766	$ 18,562	774,092	$ (24)	(21,702)	(510,188)	260,740	5,026
Beginning Balance, Shares at Dec. 31, 2022		165,935,914
Ending Balance, Shares at Jun. 30, 2023		166,010,476
Ending Balance at Jun. 30, 2023	215,637	$ 18,571	791,688		(20,818)	(576,891)	212,550	3,087
Beginning Balance at Mar. 31, 2023	240,640	$ 18,571	782,926		(20,823)	(543,849)	236,825	3,815
Beginning Balance, Shares at Mar. 31, 2023		166,010,476
Stock-based compensation expense	8,762		8,762				8,762
Foreign currency translation adjustment, net of tax	6				5		5	1
Net income (loss)	(33,771)					(33,042)	(33,042)	(729)
Ending Balance, Shares at Jun. 30, 2023		166,010,476
Ending Balance at Jun. 30, 2023	$ 215,637	$ 18,571	$ 791,688		$ (20,818)	$ (576,891)	$ 212,550	$ 3,087

XML

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities
Net loss	$ (68,126)	$ (75,067)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	144	79
Change in right-of-use asset	218	0
Amortization of debt discount	173	0
Change in fair value of contingent consideration liability - related parties	(111)	(95)
Change in fair value of securities carried at fair value	(1,490)	1,324
Change in Fair Value Of Warrant Liabilities	0	(53)
Losses from investments in equity method investees	2,961	12,242
In-process research and development expense	0	357
Stock-based compensation expense	17,424	19,720
Unrealized foreign exchange (gains) losses	835	(4,966)
Other	(244)	(134)
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	7,798	(939)
Accounts payable	1,403	(2,591)
Accrued liabilities	(4,710)	2,328
Net cash used in operating activities	(43,725)	(45,917)
Cash flows from investing activities
Purchases of property and equipment	(251)	(172)
Capitalized internal-use software development costs	(320)	(100)
Cash paid for securities carried at fair value	(39,617)	(229,678)
Proceeds from sale and maturities of securities carried at fair value	37,201	0
Loans to related parties	(3,000)	(3,000)
Net cash provided by investing activities	(5,987)	(232,950)
Cash flows from financing activities
Proceeds from issuance of shares upon exercise of stock options	206	249
Proceeds from issuance of subsidiary preferred shares	0	600
Proceeds from conversion of convertible notes to common stock	0	1,077
Financing costs paid	(100)	0
Net cash provided by financing activities	106	1,926
Effect of foreign exchange rate changes on cash	83	(1,193)
Net increase (decrease) in cash and cash equivalents	(49,523)	(278,134)
Cash and cash equivalents – beginning of the period	190,613	362,266
Cash and cash equivalents – end of the period	141,090	84,132
Supplemental disclosures:
Cash paid for interest	933	0
Cash paid for taxes	1,402	0
Supplemental disclosures of non cash investing and financing information:
Right of use asset obtained in exchange for operating lease liabilities	1,356	487
Issuance of subsidiary shares to non-controlling interests in connection with Columbia stock purchase agreement	$ 0	$ 357

XML

Organization and Description of Business

6 Months Ended

Jun. 30, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Organization and Description of Business

1. Organization and Description of Business

ATAI Life Sciences N.V. (“atai”) is the parent company of ATAI Life Sciences AG and, along with its subsidiaries, is a clinical-stage biopharmaceutical company aiming to transform the treatment of mental health disorders. atai was founded in 2018 as a response to the significant unmet need and lack of innovation in the mental health treatment landscape. atai is dedicated to developing innovative therapeutics to treat depression, anxiety, addiction, and other mental health disorders.

Since inception, atai has either created wholly owned subsidiaries or has made investments in certain controlled entities, including variable interest entities (“VIEs”) for which atai is the primary beneficiary under the VIE model (collectively, the “Company”). atai is headquartered in Berlin, Germany.

The Company has determined that it has one operating and reporting segment.

Liquidity and Going Concern

The Company has incurred significant losses and negative cash flows from operations since its inception. As of June 30, 2023, the Company had cash and cash equivalents of $141.1 million, short-term securities of $86.4 million and its accumulated deficit was $576.9 million. The Company has historically financed its operations through the sale of equity securities, debt financings, sale of convertible notes and revenue generated from licensing and collaboration arrangements. The Company has not generated any revenues to date from the sale of its product candidates and does not anticipate generating any revenues from the sale of its product candidates unless and until it successfully completes development and obtains regulatory approval to market its product candidates.

The Company currently expects that its existing cash and cash equivalents and short-term securities as of June 30, 2023 will be sufficient to fund its operating expenses and capital expenditure requirements for at least the next 12 months from the date the condensed consolidated financial statements are issued.

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Basis of Presentation and Summary of Significant Accounting Policies

6 Months Ended

Jun. 30, 2023

Accounting Policies [Abstract]

Basis of Presentation and Summary of Significant Accounting Policies

2. Basis of Presentation, Consolidation and Summary of Significant Accounting Policies

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial information and follow the requirements of the United States Securities and Exchange Commission (“SEC”) for interim financial reporting. Accordingly, these unaudited condensed consolidated financial statements do not include all of the information and disclosures required by U.S. GAAP for complete financial statements as certain footnotes or other financial information that are normally required by U.S. GAAP can be condensed or omitted. These unaudited condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on March 24, 2023.

The unaudited condensed consolidated financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for a fair statement of the Company’s financial position, its results of operations and comprehensive loss, and its cash flows for the periods presented. The results of operations for the three and six months ended June 30, 2023 are not necessarily indicative of the results to be expected for the year ending December 31, 2023 or for any other future annual or interim period.

Any reference in these notes to applicable accounting guidance is meant to refer to the authoritative U.S. GAAP included in the Accounting Standards Codification (“ASC”), and Accounting Standards Update (“ASU”) issued by the Financial Accounting Standards Board (“FASB”).

Reclassifications

Certain reclassifications were made to prior period amounts in the condensed consolidated financial statements and accompanying notes to conform with current year presentation due to the increase in the balances of the Company's operating right-of-use asset and related lease liability during the period.

Consolidation

The Company's condensed consolidated financial statements include the accounts of atai and its subsidiaries. All intercompany balances and transactions have been eliminated in the consolidation.

The Company's policy is to consolidate all entities that it controls by ownership of a majority of the outstanding voting stock. In addition, entities that meet the definition of a variable interest entity (“VIE”) for which atai is the primary beneficiary are consolidated. The primary beneficiary is the party who has the power to direct the activities of a VIE that most significantly impact the entity’s economic performance and who has an obligation to absorb losses of the entity or a right to receive benefits from the entity that could potentially be significant to

the entity. For consolidated entities that are less than wholly-owned, the third-party’s holding of equity interest is presented as Noncontrolling interests in the Company's condensed consolidated balance sheets and condensed consolidated statements of stockholders' equity. The portion of net earnings attributable to the noncontrolling interests is presented as Net loss attributable to noncontrolling interests in the Company's condensed consolidated statements of operations.

In situations in which atai has significant influence, but not control, of an entity that does not qualify as a VIE, the Company applies the cost and equity method of accounting, with its portion of net losses recorded in Losses from investments in equity method investees, net of tax in the Company's condensed consolidated statements of operations.

Significant Accounting Policies

During the six months ended June 30, 2023, there were no significant changes to the Company’s significant accounting policies as described in the Company’s audited consolidated financial statements as of and for the year ended December 31, 2022 except as described below.

Use of Estimates

The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Significant estimates and assumptions made in the accompanying condensed consolidated financial statements include, but are not limited to the fair value of the Company’s investment in Intelgenx Technologies Corp. (“IntelGenx”), securities carried at fair value, contingent consideration liability—related parties, in-process research and development assets (“IPRD”) and noncontrolling interests recognized in acquisitions, the valuation of share-based awards, and accruals for research and development costs.

The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable. Actual results may differ from those estimates or assumptions.

Cash and Cash Equivalents

The Company considers all highly liquid investments purchased with original maturities of three months or less from the purchase date to be cash equivalents. As of June 30, 2023 and December 31, 2022, cash and cash equivalents consisted of cash on deposit and cash held in high-yield savings accounts and money market funds. The substantial majority of the Company’s cash is held in financial institutions in the United States and at times in excess of federally insured limits.

Investment Securities Portfolio

The following table sets forth the fair value of atai's available-for-sale securities portfolio at the dates indicated:

	Fair Value
	June 30, 2023		December 31, 2022
Money Market Funds	$	60,920	$	72,334
U.S. Treasuries		31,843		—
Commercial Paper		—		5,958
Corporate Notes/Bonds		4,900		17,719
U.S. Government Agencies		49,659		58,819
	$	147,322	$	154,830

In January 2022, the Company invested in a certain investment portfolio, which is comprised of Money Market Funds, U.S. Treasury securities, Commercial Paper, Corporate Notes/Bonds, and U.S. government agencies securities. The Company classified securities in the investment portfolio as available-for-sale securities. Furthermore, the Company elected the fair value option for the available-for-sale securities in the investment portfolio (see Note 7). The decision to elect the fair value option, which is irrevocable once elected, is determined on an instrument-by-instrument basis and applied to an entire instrument. The net gains or losses, if any, on an investment for which the fair value option has been elected are recognized as a change in fair value of securities carried at fair value on the Condensed Consolidated Statements of Operations and the amortized cost of investments approximates their fair value. The Company's securities in the investment portfolio will mature within two years.

Fair Value Measurements

Assets and liabilities recorded at fair value on a recurring basis in the condensed consolidated balance sheets are categorized based upon the level of judgment associated with the inputs used to measure their fair values. Fair value is defined as the exchange price that would be received for an asset or an exit price that would be paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value

must maximize the use of observable inputs and minimize the use of unobservable inputs. The authoritative guidance on fair value measurements establishes a three-tier fair value hierarchy for disclosure of fair value measurements as follows:

Level 1—Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date;

Level 2—Inputs (other than quoted prices included in Level 1) are either directly or indirectly observable for the asset or liability. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active; and

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. Accordingly, the degree of judgment exercised by the Company in determining fair value is greatest for instruments categorized in Level 3. A financial instrument’s level within the fair value hierarchy is based on the lowest level of any input that is significant to the fair value measurement.

The Company’s contingent consideration liability—related parties, IntelGenx Initial Warrants and IntelGenx Additional Units Warrant are carried at fair value, determined according to Level 3 inputs in the fair value hierarchy described above (See Note 7). The IntelGenx common stock and securities carried at fair value are determined according to Level 2 inputs in the fair value hierarchy above. The carrying amount reflected in the accompanying condensed consolidated balance sheets for cash, prepaid expenses and other current assets, accounts payable and accrued liabilities approximate their fair values, due to their short-term nature.

The carrying amounts of the Company’s remaining outstanding convertible promissory notes—related parties (“2018 Convertible Notes”) do not approximate fair value because the fair value is driven by the underlying value of the Company’s common shares into which the notes are to be converted. As of June 30, 2023, the carrying amount and fair value amount of the 2018 Convertible Notes was $0.4 million and $6.5 million, respectively. As of December 31, 2022, the carrying amount and fair value amount of the 2018 Convertible Notes was $0.4 million and $13.1 million, respectively. In 2022, several noteholders of the 2018 Convertible Notes elected to convert their promissory notes into the Company's common shares. See Note 11 for additional discussion.

Fair Value Option

As permitted under Accounting Standards Codification 825, Financial Instruments, or ASC 825, the Company has elected the fair value option to account for its investment in common shares of IntelGenx, which otherwise would be subject to ASC 323. In accordance with ASC 825, the Company records this investment at fair value under Other investments held at fair value in the Company's condensed consolidated balance sheets and changes in fair value are recognized as a component of other income (expense), net in the condensed consolidated statements of operations. The carrying value of the investment remained at zero as of June 30, 2023 and December 31, 2022, respectively.

Furthermore, as noted above the Company also elected the fair value option for its investment securities portfolio.

Emerging Growth Company Status

The Company is an emerging growth company, as defined in the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”). Under the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period for complying with new or revised accounting standards that have different effective dates for public and private companies until the earlier of the date that it (i) is no longer an emerging growth company or (ii) affirmatively and irrevocably opts out of the extended transition period provided in the JOBS Act. As a result, these condensed consolidated financial statements may not be comparable to companies that comply with the new or revised accounting pronouncements as of public company effective dates.

As described in “Recently Adopted Accounting Pronouncements” below, the Company early adopted certain accounting standards, as the JOBS Act does not preclude an emerging growth company from adopting a new or revised accounting standard earlier than the time that such standard applies to private companies. The Company expects to use the extended transition period for any other new or revised accounting standards during the period in which it remains an emerging growth company.

Recently Adopted Accounting Pronouncements

ASU 2016-02 Leases (Topic 842)

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which is a comprehensive new lease standard that amends various aspects of existing accounting guidance for leases. The core principle of Topic 842 requires lessees to recognize on the condensed consolidated balance sheets a liability to make lease payments and a right-of-use asset representing its right to use the underlying asset for the lease term for both finance and operating leases with lease terms greater than twelve months. The lease liability is measured at the present value of the unpaid lease payments and the right-of-use asset is derived from the calculation of the lease liability. Topic 842 also requires lessees to disclose key information about leasing arrangements. For public entities, ASU 2016-02 is effective for fiscal years

beginning after December 15, 2018. As a result of the Company having elected the extended transition period for complying with new or revised accounting standards pursuant to Section 107(b) of the JOBS Act, ASU 2016-02 is effective for the Company beginning after December 15, 2021. The Company adopted the new standard on January 1, 2022 using the modified transition approach as of the effective date.

The Company elected the “package of three practical expedients,” which permitted it to not reassess under the new standard its prior conclusions about lease identification, lease classification, and initial direct costs. As a result, the Company has continued to account for existing leases - i.e. leases for which the commencement date is before January 1, 2022 - in accordance with Topic 840 throughout the entire lease term, including periods after the effective date, with the exception that the Company applied the new balance sheet recognition guidance for operating leases and applied Topic 842 for remeasurements and modifications after the Transition Date. The Company also elected the hindsight expedient in determining the lease term and assessing impairment of right-of-use assets when transitioning to ASC 842. As a result, the Company evaluated the lease term for its existing leases as of the transition date, January 1, 2022.

The most significant impact of the initial adoption of Topic 842 on the Company’s condensed consolidated financial statements was the recognition of a $0.2 million operating lease right-of-use asset, a $0.1 million current operating lease liability, and a $0.1 million long-term operating lease liability on the Company’s condensed consolidated balance sheets related to its existing facility operating lease. The Company did not have a deferred rent liability recorded in connection with its existing facility operating lease. There was no material impact of the initial adoption to the Company’s condensed consolidated balance sheets, condensed consolidated statements of operations, and no cumulative-effect adjustment to accumulated deficit.

In May 2022, the Company entered into a five-year lease arrangement that commenced in January 2023 related to our principal executive office located at Wallstraße 16, 10179, Berlin, Germany. This lease will require lease payments over the term of approximately $1.8 million, which is further described in Note 10 of the notes to the Company's unaudited condensed consolidated financial statements.

ASU 2016-13 Financial Instruments - Credit Losses

In June 2016, the FASB issued ASU 2016-13, Financial Instruments — Credit Losses. This guidance requires immediate recognition of management’s estimates of current expected credit losses. Under the prior model, losses were recognized only when losses were deemed probable. The new model is applicable to most financial assets and certain other instruments that are not measured at fair value through net income.

The Company utilizes an undiscounted probability-of-default (“PD”) and loss-given-default (“LGD”) method for estimating credit losses on its assets pool, which is comprised of loans to other companies. Under the PD and LGD method, the expected credit loss percentage (or “loss rate”) is calculated as the probability of default (i.e., the probability the asset will default within the given time frame) multiplied by the loss given default (i.e., the percentage of the asset not expected to be collected because of default). To implement the PD and LGD method, the Company utilizes readily observable market information from term-matched public debt to derive market implied current expected credit losses (“MICECL”) grouped by Standard & Poor’s (“S&P”) credit rating scale. The MICECL framework considers risk characteristics of assets pool based on publicly available or estimated S&P credit ratings to calculate an appropriate credit loss reserve for the pool or group of assets.

ASU 2016-13 requires a cumulative effect adjustment to the statement of financial position as of the beginning of the first reporting period in which it is effective. On January 1, 2023, the Company adopted this guidance and applied a modified-retrospective transition approach through a cumulative-effect adjustment to retained earnings upon adoption. At transition, the new accounting guidance’s adoption resulted in an increase to accumulated deficit of $0.5 million, net of tax attributable to an increase in the allowance for credit losses related to its Short term notes receivable - related parties, net and Long term notes receivable - related parties, net.

Further, the FASB issued ASU 2019-04, ASU 2019-05, ASU 2019-11, ASU 2020-03 and ASU 2022-02 to provide additional clarification and guidance on the credit losses standard. We adopted ASU 2019-04, ASU 2019-05, ASU 2019-11, ASU 2020-03 and ASU 2022-02 on January 1, 2023. The adoption of these standards did not have a material impact on the Company’s consolidated financial statements or disclosures.

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Acquisitions

6 Months Ended

Jun. 30, 2023

Business Combinations [Abstract]

Acquisitions

3. Dispositions

2022 Dispositions

Neuronasal, Inc.

In October 2020 and March 2021, the Company invested in Neuronasal, Inc. (“Neuronasal”) common stock for a cash contribution of $0.3 million and $0.5 million, respectively. In December 2019, October 2020 and May 2021, the Company invested in Neuronasal

preferred stock for a cash contribution of $0.5 million, $0.8 million and $1.0 million, respectively. Upon the closing of the purchase on May 17, 2021, the Company obtained a controlling financial interest in Neuronasal. The Company derecognized its other investments in Neuronasal and began to consolidate the operations of Neuronasal into its consolidated financial statements.

In November 2022, the Company finalized and entered into a Redemption, Termination and Release Agreement (“Termination Agreement”) with Neuronasal through which atai disposed of its equity interests and residual SPA funding obligations. Pursuant to the Neuronasal Termination Agreement, the Company transferred all of its approximately 56.5% equity interest in Neuronasal in exchange for the redemption consideration in the form of certain warrants. The Termination Agreement entitles the Company to purchase common stock in Neuronasal upon the occurrence of certain contingencies, such as an initial public offering, a qualified financing event, or certain clinical studies. The Company has no further obligations to fund Neuronasal.

As a result of the disposition, the Company ceased having controlling financial interest in Neuronasal and the Company deconsolidated Neuronasal in November 2022 because it determined that it no longer was the primary beneficiary of Neuronsasal as it no longer had the power to direct the significant activities of Neuronasal. Upon the effective termination date, the Company derecognized all of Neuronasal's assets and liabilities from the Company's balance sheet, and recognized a gain of $1.5 million, which was recognized as a component of other income (expense), net in the Company's consolidated statements of operations for the year ended December 31, 2022. The Company determined that the value of the warrants received in connection with the Termination Agreement was de minimis as of the termination date. In connection with the deconsolidation of Neuronasal, the Company concluded that a loan loss had been incurred and the loan assets were impaired accordingly. The Company recognized an impairment of loan receivable of $0.9 million for the year ended December 31, 2022.

The Company concluded that the decision to deconsolidate Neuronasal, which was based on clinical data that did not meet expectations, did not represent a significant strategic shift. Therefore, the Company did not present the results of Neuronasal prior to deconsolidation as discontinued operations in its consolidated statements of operations for the year ended December 31, 2022.

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Variable Interest Entities and a Voting Interest Entity

6 Months Ended

Jun. 30, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Variable Interest Entities and a Voting Interest Entity

4. Variable Interest Entities

Consolidated VIEs

At each reporting period, the Company reassesses whether it remains the primary beneficiary for Variable Interest Entities (“VIEs”) consolidated under the VIE model.

The entities consolidated by the Company are comprised of wholly and partially owned entities for which the Company is the primary beneficiary under the VIE model as the Company has (i) the power to direct the activities that most significantly impact the VIE’s economic performance and (ii) the obligation to absorb losses that could potentially be significant to the VIE, or the right to receive benefits from the VIE that could potentially be significant to the VIE. The results of operations of the consolidated entities are included within the Company’s condensed consolidated financial statements from the date of acquisition to June 30, 2023.

As of June 30, 2023 and December 31, 2022, the Company has accounted for the following consolidated investments as VIEs, excluding the wholly owned subsidiaries:

Consolidated Entities	Relationship as of June 30, 2023	Relationship as of December 31, 2022	Date Control Obtained	Ownership % June 30, 2023	Ownership % December 31, 2022
Perception Neuroscience Holdings, Inc.	Controlled VIE	Controlled VIE	November 2018	59.2%	58.9%
Kures, Inc.	Controlled VIE	Controlled VIE	August 2019	64.5%	64.5%
EntheogeniX Biosciences, Inc.	Controlled VIE	Controlled VIE	November 2019	80.0%	80.0%
DemeRx IB, Inc.	Controlled VIE	Controlled VIE	December 2019	59.5%	59.5%
Recognify Life Sciences, Inc.	Controlled VIE	Controlled VIE	November 2020	51.9%	51.9%
PsyProtix, Inc.	Controlled VIE	Controlled VIE	February 2021	75.0%	75.0%
Psyber, Inc.	Controlled VIE	Controlled VIE	February 2021	75.0%	75.0%
InnarisBio, Inc.	Controlled VIE	Controlled VIE	March 2021	82.0%	82.0%
TryptageniX Inc.	Controlled VIE	Controlled VIE	December 2021	65.0%	65.0%

As of June 30, 2023 and December 31, 2022, the assets of the consolidated VIEs can only be used to settle the obligations of the respective VIEs. The liabilities of the consolidated VIEs are obligations of the respective VIEs and their creditors have no recourse to the general credit or assets of atai.

EntheogeniX Biosciences, Inc.

In November 2019, the Company entered into a series of agreements with Cyclica Inc. ("Cyclica") to form EntheogeniX Biosciences, Inc. ("EntheogeniX"), a company dedicated to developing the next generation of innovative mental health drugs employing an AI-enabled computational biophysics platform designed to optimize and accelerate drug discovery. Based on the Company's assessment of the transaction at the time of acquisition, the Company concluded that EntheogeniX was not a business and accounted for the Company's investment as an initial consolidation of a VIE that is not a business under ASC 810.

In February 2022 and September 2022, pursuant to the business plan as contemplated in the Stockholders Agreement and Subscription for Shares pursuant to the Contribution and Subscription Agreement, atai purchased additional shares of Class A common stock for an aggregate purchase price of $2.2 million. As a result of anti-dilution protection available to Cyclica, the Company's ownership percentage in EntheogeniX did not change due to its purchase of the Class A common stock.

In March 2023, pursuant to the business plan as contemplated in the Stockholders Agreement and Subscription for Shares pursuant to the Contribution and Subscription Agreement, atai purchased additional shares of Class A common stock for an aggregate purchase price of $1.0 million. As a result of anti-dilution protection available to Cyclica, the Company's ownership percentage in EntheogeniX did not change due to its purchase of the Class A common stock.

As of June 30, 2023 and December 31, 2022, the Company owned 80% of the outstanding common stock of EntheogeniX.

The purchase of additional Class A common stock was deemed to be a reconsideration event. The Company determined that EntheogeniX is still considered a VIE subsequent to the additional Class A common stock purchase as EntheogeniX does not have sufficient equity at risk to carry out its principal activities without additional subordinated financial support.

The following table presents the assets and liabilities (excluding intercompany balances that were eliminated in consolidation) for all VIEs as of June 30, 2023 (in thousands):

	Perception		Kures		EntheogeniX		DemeRx IB		Recognify		PsyProtix		Psyber		InnarisBio		TryptageniX
Assets:
Current assets:
Cash	$	2,483	$	56	$	458	$	10,395	$	4,108	$	14	$	541	$	503	$	82
Accounts receivable		205		—		—		—		—		—		—		—		—
Prepaid expenses and other current assets		310		286		147		69		1,155		—		—		488		2,700
Total current assets		2,998		342		605		10,464		5,263		14		541		991		2,782
Long term notes receivable		—		—		—		1,063		—		94		—		—		—
Other assets		—		—		—		—		—		—		706		—		—
Total assets	$	2,998	$	342	$	605	$	11,527	$	5,263	$	108	$	1,247	$	991	$	2,782
Liabilities:
Current liabilities:
Accounts payable	$	581	$	510	$	246	$	260	$	210	$	—	$	2	$	5	$	—
Accrued liabilities		1,189		62		103		284		396		45		118		327		118
Other current liabilities		—		—		—		—		—		—		—		—		—
Total current liabilities		1,770		572		349		544		606		45		120		332		118
Total liabilities	$	1,770	$	572	$	349	$	544	$	606	$	45	$	120	$	332	$	118

The following table presents the assets and liabilities (excluding intercompany balances that were eliminated in consolidation) for all consolidated VIEs as of December 31, 2022 (in thousands):

	Perception		Kures		EntheogeniX		DemeRx IB		Recognify		PsyProtix		Psyber		InnarisBio		TryptageniX
Assets:
Current assets:
Cash	$	8,703	$	220	$	467	$	12,251	$	7,526	$	1	$	683	$	719	$	513
Accounts receivable		197		—		—		—		—		—		—		—		—
Prepaid expenses and other current assets		466		174		91		21		1,742		66		—		13		2,850
Total current assets		9,366		394		558		12,272		9,268		67		683		732		3,363
Long term notes receivable		—		—		—		1,075		—		109		—		—		—
Other assets		—		—		—		—		—		—		353		—		—
Total assets	$	9,366	$	394	$	558	$	13,347	$	9,268	$	176	$	1,036	$	732	$	3,363
Liabilities:
Current liabilities:
Accounts payable	$	661	$	25	$	124	$	332	$	381	$	33	$	10	$	3	$	—
Accrued liabilities		1,738		266		121		671		596		46		37		158		154
Other current liabilities		121		2		—		133		2		1		1		1		—
Total current liabilities		2,520		293		245		1,136		979		80		48		162		154
Total liabilities	$	2,520	$	293	$	245	$	1,136	$	979	$	80	$	48	$	162	$	154

Noncontrolling Interests

The Company recognizes noncontrolling interests related to its consolidated VIEs and provides a roll forward of the noncontrolling interests balance, as follows (in thousands):

	Perception			Kures			Recognify			Total
Balance as of December 31, 2022	$	1,731		$	451		$	2,844		$	5,026
Net loss attributable to noncontrolling    interests - common		—			—			—			—
Net loss attributable to noncontrolling    interests - preferred		(700	)		(93	)		(426	)		(1,219	)
Comprehensive loss attributable to noncontrolling    interests		6			2			—			8
Balance as of March 31, 2023	$	1,037		$	360		$	2,418		$	3,815
Net loss attributable to noncontrolling    interests - common		—			—			—			—
Net loss attributable to noncontrolling    interests - preferred		(266	)		(32	)		(431	)		(729	)
Comprehensive loss attributable to noncontrolling    interests		(1	)		2			—			1
Balance as of June 30, 2023	$	770		$	330		$	1,987		$	3,087

	Perception			Kures		Recognify			Total
Balance as of December 31, 2021	$	5,232		$	—	$	3,819		$	9,051
Net loss attributable to noncontrolling    interests - preferred		(571	)		—		(118	)		(689	)
Comprehensive loss attributable to noncontrolling    interests		(11	)		—		—			(11	)
Balance as of March 31, 2022	$	4,650		$	—	$	3,701		$	8,351
Issuance of noncontrolling interests		—			957		—			957
Net loss attributable to noncontrolling    interests - preferred		(800	)		—		(91	)		(891	)
Comprehensive loss attributable to noncontrolling    interests		30			—		—			30
Balance as of June 30, 2022	$	3,880		$	957	$	3,610		$	8,447

Non-consolidated VIEs

The Company evaluated the nature of its investments in Innoplexus AG (“Innoplexus”), DemeRx NB, Inc. (“DemeRx NB”) and IntelGenx and determined that the investments are VIEs as of the date of the Company’s initial investment through June 30, 2023. The Company is not the primary beneficiary of Innoplexus, DemeRx NB or IntelGenx as it did not have the power to direct the activities that most significantly impact the investments’ economic performance and therefore concluded that it did not have a controlling financial interest in each of Innoplexus, DemeRx NB or IntelGenx that would require consolidation as of June 30, 2023 and December 31, 2022.

The Company will reevaluate if the investments meet the definition of a VIE upon the occurrence of specific reconsideration events. The Company accounted for these investments under either the equity method, fair value option, or the measurement alternative included within ASC 321 (See Note 5). As of June 30, 2023, the Company’s maximum exposure for its non-consolidated VIEs was $3.9 million relating to the carrying values in Other investments and Other investments held at fair value, $9.0 million relating to the carrying value in Short term notes receivable - related party and $1.2 million relating to the carrying value in Long term notes receivable – related party in the condensed consolidated balance sheets. As of December 31, 2022, the Company’s maximum exposure for its non-consolidated VIEs was $6.8 million relating to the carrying values in its Other investments and $7.2 million relating to the carrying value in Long term notes receivable—related party in the condensed consolidated balance sheets.

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Equity Method Investments and Other Investments

6 Months Ended

Jun. 30, 2023

Cash and Cash Equivalents [Abstract]

Equity Method Investments and Other Investments

5. Equity Method Investments and Other Investments

Equity Method Investments

As of June 30, 2023 and December 31, 2022, the Company accounted for the following investments in the investee’s common stock under the equity method (amounts in thousands):

		As of June 30, 2023				As of December 31, 2022
	Date First	Common Stock		Carrying		Common Stock		Carrying
Investee	Acquired	Ownership %		Value		Ownership %		Value
Innoplexus A.G.	August 2018	35.0%		$	—	35.0%		$	—
COMPASS Pathways plc	December 2018	20.9%			—	22.4%			—
GABA Therapeutics, Inc	November 2020	7.5%	(1)		—	7.5%	(1)		—
Total				$	—			$	—

(1)The Company is deemed to have significant influence over this entity through its total ownership interest in the entity’s equity, including the Company’s investment in the respective entity’s preferred stock, described below in Other Investments. The Company’s total ownership interest, considering both preferred and common stock is 54.7%.

COMPASS Pathways plc

COMPASS Pathways plc (“COMPASS”) is a mental health care company dedicated to pioneering the development of a new model of psilocybin therapy with its product COMP360. The Company first acquired investments in COMPASS in December 2018.

Equity Investment

Through a series of open market transactions between November 23, 2021 and December 7, 2021, the Company purchased an additional 1,490,111 of COMPASS ADSs at an aggregate purchase price of $47.4 million. The additional shares acquired resulted in an increase in the Company’s ownership of COMPASS ADSs to 22.8%. The Company applied the cost accumulation model and recorded its investment at cost. At the date of the investment, a basis difference was identified as the cost basis of the Company’s investment in COMPASS exceeded the Company’s proportionate share of the underlying net assets in COMPASS. The Company concluded that the basis differences were primarily attributable to COMPASS’s IPR&D associated with COMP360, a psilocybin therapy, for which COMPASS recently completed a Phase IIb clinical trial. As the Company’s investment in COMPASS did not meet the definition of a business due to substantially all of the estimated fair value of the gross assets being concentrated in COMP360 and the associated IPR&D, the basis differences were attributable to the IPR&D with no alternative future use and were immediately expensed at the time of the additional investment. As of June 30, 2023, the Company owned 20.9% of COMPASS ADS. Based on quoted market prices, the market value of the Company’s ownership in COMPASS was $79.2 million as of June 30, 2023.

Upon the completion of the COMPASS IPO and through June 30, 2023, the Company is deemed to continue to have significant influence over COMPASS primarily through its ownership interest in COMPASS’ equity. Following the COMPASS 2022 annual shareholder meeting, the Company no longer has representation on the COMPASS board of directors. However, the Company maintains significant influence through its ownership interest. Accordingly, the Company’s investment in COMPASS’ ADS was accounted for in accordance with the equity method through June 30, 2023.

The carrying value of the Company's investment in COMPASS was reduced to zero as of December 31, 2022 and remained zero as of June 30, 2023 due to IPR&D charges with no alternative future use and the Company recognizing its proportionate share of COMPASS net losses. During the three months ended June 30, 2023 and 2022, the Company recognized its proportionate share of COMPASS’ net loss of $0 million and $4.7 million, respectively, as losses from investments in equity method investees, net of tax on the condensed consolidated statements of operations. During the six months ended June 30, 2023 and 2022, the Company recognized its proportionate share of COMPASS’ net loss of $0 million and $9.5 million, respectively, as losses from investments in equity method investees, net of tax on the condensed consolidated statements of operations.

Other Investments

The Company has accounted for its other investments that do not have a readily determinable fair value under the measurement alternative. As of June 30, 2023 and December 31, 2022, the carrying values of other investments, which consisted of investments in the investee’s preferred stock and common stock not in the scope of ASC 323 were as follows (in thousands):

	June 30,		December 31,
	2023		2022
GABA Therapeutics, Inc.	$	2,623	$	5,387
DemeRx NB, Inc.		1,024		1,024
Juvenescence Limited		344		344
Total	$	3,991	$	6,755

The Company’s investments in the preferred stock of Innoplexus, GABA, and DemeRx NB are not considered as in-substance common stock due to the existence of substantial liquidation preferences and therefore did not have subordination characteristics that were substantially similar to the common stock. Although the Company’s investment in Juvenescence Limited (“Juvenescence”) is in common stock, it is not able to exercise significant influence over the operating and financial decisions of Juvenescence. The Company concluded that its ownership interests in the above Other Investments do not have a readily determinable fair value and are accounted for under the measurement alternative. Under the measurement alternative, the Company measured its other investments at cost, less any impairment, plus or minus, if any, observable price changes in orderly transactions for an identical or similar investment of the same issuer.

During the three and six months ended June 30, 2023 and 2022 there were no observable changes in price recorded related to the Company’s Other Investments.

During the three and six months ended June 30, 2023 and 2022, the Company evaluated all of its other investments to determine if certain events or changes in circumstance during these time periods in 2023 and 2022 had a significant adverse effect on the fair value of any of its investments in non-consolidated entities. Based on this analysis, the Company did not note any impairment indicators associated with the Company’s Other Investments.

Innoplexus AG

Innoplexus is a technology company that provides “Data as a Service” and “Continuous Analytics as a Service” solutions that aims to help healthcare organizations leverage their technologies and expedite the drug development process across all stages—preclinical, clinical, regulatory and commercial. The Company first acquired investments in Innoplexus in August 2018.

As of December 31, 2020, the Company owned 35.0% of the common stock issued by Innoplexus. The Company had significant influence over Innoplexus through its noncontrolling representation on the investee’s supervisory board. Accordingly, the Company’s investment in Innoplexus’ common stock was accounted for in accordance with the equity method. The Company’s investment in Innoplexus’ preferred stock did not meet the criteria for in-substance common stock. As such, the investment in Innoplexus’ preferred stock was accounted for under the measurement alternative as discussed below.

In February 2021, the Company entered into a Share Purchase and Assignment Agreement (the “Innoplexus SPA”) to sell its shares of common and preferred stock held in Innoplexus to a current investor of Innoplexus (the “Purchaser”) in exchange for an initial purchase price of approximately $2.4 million. In addition, the Company is entitled to receive contingent payments based on the occurrence of subsequent equity transactions or liquidity events at Innoplexus as determined under the Innoplexus SPA.

Pursuant to the Innoplexus SPA, the Purchaser is required to hold a minimum number of shares equivalent to the number of shares purchased from the Company through December 31, 2026. In the event that the Purchaser is in breach of this requirement, the purchaser is required to pay the Company an additional purchase price of approximately $9.6 million. The transaction was accounted for as a secured financing as it did not qualify for sale accounting under ASC Topic 860, Transfers and Servicing (ASC 860), due to the provision under the Innoplexus SPA which constrained the Purchaser from its right to pledge or exchange the underlying shares and provided more than a trivial benefit to the Company. The initial proceeds from the transaction are reflected as a secured borrowing liability of $2.3 million and $2.4 million as of June 30, 2023 and December 31, 2022, which is included in Other liabilities in the Company’s condensed consolidated balance sheets. The Company will continue to account for its investment in Innoplexus’ common stock under the equity method of accounting and its investment in Innoplexus’ preferred shares under the measurement alternative.

In addition, the Innoplexus SPA also provides the right for the Company to receive additional consideration with a maximum payment outcome of $22.3 million should the equity value of Innoplexus exceed certain thresholds upon the occurrence of certain events. The Company concluded that this feature met the definition of a derivative which required bifurcation. As the probability of the occurrence of certain events defined in the Innoplexus SPA was less than remote, the Company concluded that the fair value of the embedded derivative ascribed to this feature was de minimis as of June 30, 2023.

The carrying value of the Company’s investment in Innoplexus was zero as of June 30, 2023 and December 31, 2022.

GABA Therapeutics, Inc.

GABA is a California based biotechnology company focused on developing GRX-917 for anxiety, depression and a broad range of neurological disorders. The Company is deemed to have significant influence over GABA through its total ownership interest in GABA’s equity, including the Company’s investment in GABA’s preferred stock, and the Company’s noncontrolling representation on GABA’s board of directors.

Common Stock Investment

The Company’s investment in GABA’s common stock was accounted for in accordance with the equity method.

In November 2020 the Company exercised its option to purchase additional shares of common stock of GABA at a price of approximately $1.8 million pursuant to an Omnibus Amendment Agreement under which the Right of First Refusal and Co-Sale Agreement was amended. Pursuant to the amended Right of First Refusal and Co-Sale Agreement, the Company also has the option but not the obligation to purchase additional shares of common stock for up to $2.0 million from the existing common shareholders.

The carrying value of the investment in GABA common stock was reduced to zero as of December 31, 2020 due to IPR&D charges with no alternative future use and remained zero as of June 30, 2023.

Preferred Stock Investment

The Company’s investment in GABA’s preferred stock did not meet the criteria for in-substance common stock. As such, the investment in GABA’s preferred stock is accounted for under the measurement alternative.

In August 2019, GABA and the Company entered into the Preferred Stock Purchase Agreement (the “GABA PSPA”), whereby GABA issued shares of its Series A preferred stock to the Company at a price of approximately $5.5 million. At closing, the Company had an overall ownership interest of over 20% in GABA and a noncontrolling representation on the board.

Pursuant to the GABA PSPA, the Company was obligated to purchase additional shares of Series A preferred stock for up to $10.0 million with the same price per share as its initial investment, upon the achievement of specified contingent clinical development milestones. In April 2021, pursuant to the GABA PSPA, the Company purchased additional shares of Series A preferred stock of GABA, for an aggregate cost of $5.0 million based on the achievement of certain development milestones. In May 2021, the Company exercised its option to purchase additional shares of Series A preferred stock prior to the achievement of certain development milestone for an aggregate cost of $5.0 million completing its obligation to purchase additional shares. The completion of the Series A Preferred stock purchase in May 2021 was deemed to be a reconsideration event at which point GABA was no longer deemed a VIE as GABA now had sufficient equity at risk to finance its activities through the initial development period without additional subordinated financial support. Entities that do not qualify as a VIE are assessed for consolidation under the voting interest model (“VOE model”). Under the VOE model, the Company consolidates the entity if it determines that it, directly or indirectly, has greater than 50% of the voting shares and that other equity holders do not have substantive voting, participating or liquidation rights. While the Company holds greater than 50% of the outstanding equity interest of GABA, the Company does not have the power to control the entity. Concurrent with the exercise of the option, the Company executed a side letter with the other equity holders of GABA agreeing to forego the rights to additional seats on the board of directors, resulting in the Company lacking the ability to control the investee. The Company concluded that it does not have a controlling financial interest that would require consolidation under the VOE model and accounted for the investments in GABA preferred stock under the measurement alternative per ASC 323. As of June 30, 2023 and December 31, 2022, the investment in GABA’s preferred stock was recorded in Other Investments on the condensed consolidated balance sheets.

In May 2021, GABA and the Company entered into an Amendment to Preferred Stock Purchase Agreement (the "Amended GABA PSPA”) under which the GABA PSPA was amended and shares of its Series A preferred stock were issued to the Company at a price of approximately $0.6 million. Pursuant to the Amended GABA PSPA, the Company is obligated to purchase additional shares of Series A preferred stock from GABA for up to $1.5 million with the same price per share as its initial investment upon the achievement of specified contingent clinical development milestones. In September 2022, pursuant to the Amended PSPA, GABA issued additional shares of its Series A preferred stock to the Company at a price of approximately $0.6 million based on the achievement of certain development milestones. As of June 30, 2023 the Company's remaining obligation to purchase additional shares of Series A preferred stock from GABA is for up to $0.9 million at the same price per share as its initial investment upon the achievement of specified contingent milestones.

In accordance with the Amended GABA PSPA, the Company also has the option but not the obligation to purchase the aforementioned additional shares of Series A preferred stock at any time prior to the achievement of any milestone at the same price per share as its initial investment.

GABA’s net losses attributable to the Company were determined based on the Company’s ownership percentage of preferred stock in GABA and recorded to the Company’s investments in GABA preferred stock. During the three months ended June 30, 2023 and 2022, the

Company recognized its proportionate share of GABA’s net loss of $1.9 million and $1.9 million as losses from investments in equity method investees, net of tax on the condensed consolidated statements of operations. During the six months ended June 30, 2023 and 2022, the Company recognized its proportionate share of GABA’s net loss of $2.9 million and $2.7 million as losses from investments in equity method investees, net of tax on the condensed consolidated statements of operations.

DemeRx NB

In December 2019, the Company jointly formed DemeRx NB with DemeRx. DemeRx and DemeRx NB entered into a Contribution Agreement whereby DemeRx assigned all of its rights, title, and interests in and to all of its assets relating to DMX-1002, Noribogaine, in exchange for shares of common stock of DemeRx NB. DemeRx NB will use the contributed intellectual property to develop Noribogaine. Noribogaine is an active metabolite of ibogaine designed to have a longer plasma half-life and potentially reduced hallucinogenic effects compared to ibogaine.

In connection with the Contribution Agreement, the parties entered into a Series A Preferred Stock Purchase Agreement (the “DemeRx NB PSPA”) pursuant to which the Company purchased shares of Series A preferred stock of DemeRx NB at a purchase price of $1.0 million. At closing, the Company had less than 20% of ownership interest in DemeRx NB and a noncontrolling representation on DemeRx NB's board of directors. The investment in DemeRx NB was recorded in Other Investments on the condensed consolidated balance sheets under the measurement alternative under ASC 321.

Pursuant to the DemeRx NB PSPA, the Company also has the option but not the obligation to purchase additional shares of DemeRX NB's Series A preferred stock at a purchase price of up to an aggregate of $19.0 million with the same price per share as its initial investment in December 2019. As of June 30, 2023, the Company has not exercised its option to purchase any shares of Series A preferred stock of DemeRx NB.

Other Investments Held at Fair Value

IntelGenx Technologies Corp.

IntelGenx is a novel drug delivery company focused on the development and manufacturing of novel oral thin film products for the pharmaceutical market. In March 2021, IntelGenx and the Company entered into the Strategic Development Agreement and Purchaser Rights Agreement (“PPA”). In May 2021, IntelGenx and the Company executed a Securities Purchase Agreement (the “IntelGenx SPA”) after obtaining IntelGenx shareholder approval, whereby IntelGenx issued shares of its common stock and warrants to the Company at a price of approximately $12.3 million. Each warrant (the “Initial Warrants”) entitles the Company to purchase one share at a price of $0.35 per share for a period of three years from the closing of the initial investment in March 2021. Pursuant to the IntelGenx SPA, the Company has the right to purchase (in cash, or in certain circumstances, the Company’s equity) additional units for a period of three years from the closing of the initial investment (the “Additional Unit Warrants”). Each Additional Unit Warrant will be comprised of (i) one share of common stock and (ii) one half of one warrant (the “Additional Warrants”). The price for the Additional Unit Warrants will be (i) until the date which is 12 months following the closing and the purchase does not result in the Company owning more than 74,600,000 common shares of IntelGenx, $0.331 (subject to certain exceptions), and (ii) until the date which is 12 months following the closing and the purchase results in the Company owning more than 74,600,000 common shares of IntelGenx or following the date which is 12 months following the closing regardless of the number of shares held by the Company, the lower of (A) a 20% premium to the volume weighted average price of the common share for the thirty trading days immediately preceding the news release of the additional closing, and (B) $0.50 if purchased in the second year following closing or $0.75, if purchased in the third year following closing. Each Additional Warrant will entitle the Company, for a period of three years from the date of issuance, to purchase one share at the lesser of either (i) a 20% premium to the price of the corresponding additional share, or (ii) the price per share under which shares of IntelGenx are issued under convertible instruments that were outstanding on February 16, 2021, provided that the Company may not exercise Additional Warrants to purchase more than the lesser of (x) 44,000,000 common shares of IntelGenx, and (y) the number of common shares issued by IntelGenx under outstanding convertibles held by other investors as of February 16, 2021. Following the initial closing, the Company held a 25% voting interest in IntelGenx. Pursuant to the PPA, the Company is entitled to designate a number of directors to the IntelGenx’s board of directors in the same proportion as the shares of common stock held by the Company to the outstanding of IntelGenx common shares.

Pursuant to the Strategic Development Agreement, the Company engages IntelGenx to conduct research and development projects (“Development Project”) using IntelGenx’s proprietary oral thin film technology. Under the terms of the Strategic Development Agreement, the Company can select four (4) program products. As of the effective date of the Strategic Development Agreement, the Company nominated two (2) program products - DMT and Salvinorin A. 20% of any funds that IntelGenx received or will receive through the Company’s equity investment under the IntelGenx SPA will be available to be credited towards research and development services that IntelGenx conducts for the Company under the Development Projects. The Company is eligible to receive a total credit of $2.5 million. For the three and six months ended June 30, 2023, research and development expense relating to the Strategic Development Agreement were $0.1 million and $0.2 million, which was applied as a reduction in research and development expenses in accordance with the Strategic Development Agreement. For the three and six months ended June 30, 2022, there was an immaterial amount of research and development services performed in relation to the Strategic Development Agreement.

The Company has significant influence over IntelGenx through ownership interest in IntelGenx’s equity and the Company’s noncontrolling representation on IntelGenx’s board of directors. The Company qualified for and elected to account for its investment in the IntelGenx common stock under the fair value option. The Company believes that the fair value option better reflects the underlying economics of the IntelGenx common stock investment. The Initial Warrants and Additional Units Warrant, (collectively the “Warrants”) are accounted for at fair value under ASC 321 and recorded in Other investments held at fair value on the condensed consolidated balance sheets. The Company applied a calibrated model and determined that the initial aggregate fair value is equal to the transaction price and recorded the common shares at $3.0 million, the Initial Warrants at $1.2 million and the Additional Unit Warrants at $8.2 million on a relative fair value basis resulting in no initial gain or loss recognized in the condensed consolidated statements of operations. The Company recognizes subsequent changes in fair value of the common shares and the Warrants as a component of other income (expense), net in the condensed consolidated statements of operations. The carrying amount of the investment was reduced to zero as of December 31, 2021, during the three and six months ended June 30, 2023, the Company recognized a zero mark-to-market (“MTM”) gain/loss in the condensed consolidated statements of operations. The carrying value of the investment remained at zero as of June 30, 2023 and December 31, 2022, respectively.

Summarized Financial Information

The following is a summary of financial data for investments accounted for under the equity method of accounting (in thousands):

Balance Sheets

	June 30, 2023
	COMPASS		GABA
Current assets	$	193,601	$	1,773
Non-current assets		16,233		—
Total assets	$	209,834	$	1,773
Current liabilities	$	12,775	$	1,751
Non-current liabilities		30,663		—
Total liabilities	$	43,438	$	1,751

	December 31, 2022
	COMPASS		GABA
Current assets	$	191,651	$	3,933
Non-current assets		5,643		—
Total assets	$	197,294	$	3,933
Current liabilities	$	15,596	$	1,542
Non-current liabilities		418		—
Total liabilities	$	16,014	$	1,542

Statements of operations

	Three Months Ended June 30, 2023
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(32,664	)	$	(1,928	)
Net loss	$	(28,335	)	$	(1,928	)
	Three Months Ended June 30, 2022
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(27,256	)	$	(1,964	)
Net loss	$	(21,037	)	$	(1,964	)

	Six Months Ended June 30, 2023
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(64,452	)	$	(2,961	)
Net loss	$	(52,543	)	$	(2,961	)
	Six Months Ended June 30, 2022
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(52,676	)	$	(3,570	)
Net loss	$	(42,208	)	$	(3,570	)

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Notes Receivable

6 Months Ended

Jun. 30, 2023

Receivables [Abstract]

Notes Receivable

6. Notes Receivable

Short Term Notes Receivable – Related Parties, net

Loan to IntelGenx Corp.

In March 2021, the Company and IntelGenx entered into a loan agreement under which the Company provided a loan to IntelGenx for an aggregate principal amount of $2.0 million (the “March Term Loan”). Pursuant to the loan agreement, IntelGenx may, by written notice, request an advance up to an additional $0.5 million as an additional term loan if no event of default has occurred as defined in the loan agreement. In May 2021, the Company paid an additional advance of $0.5 million as an additional term loan (the “May Term Loan”, and together with the March Term Loan the “Term Loans”). The Term Loans were originally due to mature 120 days following the special shareholder meeting of IntelGenx Tech Corp. to approve an additional investment in IntelGenx Tech Corp. by the Company ("Maturity Date"). In May 2021, the Company amended the loan agreement under which the Maturity Date will be the first business day following the first closing of a subscription for additional units if the proceeds from such subscription amount to at least $3.0 million. The loan bears an annualized interest rate of 8% and such interest is accrued daily. The principal amount of the Term Loans plus any accrued interest shall become due and payable on the Maturity Date. In September 2021, the Company entered into an amended and restated loan agreement, which among other things, increased the principal amount of loans available to IntelGenx by $6.0 million, up to a total of $8.5 million. The additional loan amount of $6.0 million are funded via two separate tranches of $3.0 million each in the beginning of 2022 and 2023 respectively, subject to certain conditions. In addition, the amendment further extended the Maturity Date to January 5, 2024. The first tranche was funded in January 2022 and the second tranche was funded in January 2023.

Pursuant to the terms of the Term Loans, upon the occurrence of an event of default, the Company may accelerate the Term Loans and declare the principal and any accrued and unpaid interests of the Term Loans to be immediately due and payable. In addition, IntelGenx may prepay the Term Loans in whole or in part at any time without premium or penalty. Any prepayment of the principal shall be accompanied by a payment of interest accrued to date thereon. The Company concluded that these embedded features do not meet the criteria to be bifurcated and separately accounted for as derivatives.

As of June 30, 2023, the Term Loans are recorded in Short term notes receivable – related parties, net on the Company's condensed consolidated balance sheets, which includes the principal balance of the Term Loans, accrued interest and allowance for credit losses. On January 1, 2023, the Company adopted ASU 2016-13 Financial Instruments — Credit Losses and applied a modified-retrospective transition approach through a cumulative-effect adjustment to retained earnings of $0.4 million, representing the allowance for credit losses for the Term Loans. During the three and six months ended June 30, 2023 and 2022, the Company recorded an immaterial increase to the allowance.

For the three months ended June 30, 2023 and 2022, the Company recognized $0.2 million and $0.1 million of interest income associated with the Term Loans. For the six months ended June 30, 2023 and 2022, the Company recognized $0.4 million and $0.2 million of interest income associated with the Term Loans. As of June 30, 2023 and December 31, 2022, the Term Loans have an outstanding balance of $8.5 million and $5.5 million.

Long Term Notes Receivable – Related Parties, net

Investment in DemeRx Promissory Note—Related Party

In January 2020, DemeRx IB loaned to DemeRx Inc. $1.0 million pursuant to the terms of a Promissory Note (the "DemeRx Note"). Pursuant to the terms of the DemeRx Note, the aggregate principal amount of $1.0 million together with all accrued and unpaid interest and any other amounts payable are due to be paid on the date that is the earlier of (i) 5 years from the initial closing and (ii) the closing of an initial public offering or a deemed liquidation event of DemeRx IB (the “DemeRx Maturity Date”). Pursuant to the terms of the DemeRx Note, DemeRx Inc. may, in its sole discretion pay any amount due under the DemeRx Note, in cash or through cancellation shares of common stock of DemeRx IB, par value $0.0001 per share, of the fair market value of such shares.

The Company recorded the DemeRx Note at cost which included the principal balance of the DemeRx Note and accrued interest in Long term notes receivable - related parties, net on its condensed consolidated balance sheets. On January 1, 2023, the Company adopted ASU 2016-13 Financial Instruments — Credit Losses and applied a modified-retrospective transition approach through a cumulative-effect adjustment to retained earnings of $0.1 million, representing the allowance for credit losses for the DemeRx Note. During the three and six months ended June 30, 2023, the Company recorded an immaterial increase to the allowance.

For the three and six months ended June 30, 2023 and 2022, the Company did not recognize any interest income associated with the DemeRx Note. As of June 30, 2023, and December 31, 2022, respectively, the DemeRx Note had an outstanding balance of $1.1 million and $1.1 million, respectively.

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Fair Value Measurement

6 Months Ended

Jun. 30, 2023

Fair Value Disclosures [Abstract]

Fair Value Measurement

7. Fair Value Measurement

The following table presents information about the Company’s financial assets and liabilities that are measured at fair value on a recurring basis and indicates the fair value hierarchy of the valuation (in thousands):

	Fair Value Measurements
	As of June 30, 2023
	Level 1		Level 2		Level 3		Total
Assets:
Cash equivalents:
Cash & Money market funds	$	60,920	$	—	$	—	$	60,920
Investment in securities at fair value:
U.S. Treasuries		—		31,843		—		31,843
Commercial Paper		—		—		—		—
Corporate Notes/Bonds		—		4,900		—		4,900
U.S. Government Agencies		—		49,659		—		49,659
Other investment at fair value		—		—		—		—
	$	60,920	$	86,402	$	—	$	147,322
Liabilities:
Contingent consideration liability - related parties	$	—	$	—	$	842	$	842
	$	—	$	—	$	842	$	842

	Fair Value Measurements
	As of December 31, 2022
	Level 1		Level 2		Level 3		Total
Assets:
Cash equivalents:
Cash & Money market funds	$	72,334	$	—	$	—	$	72,334
Investment in securities at fair value:
U.S. Treasuries		—		—		—		—
Commercial Paper		—		5,958		—		5,958
Corporate Notes/Bonds		—		17,719		—		17,719
U.S. Government Agencies		—		58,819		—		58,819
Other investment at fair value		—		—		—		—
	$	72,334	$	82,496	$	—	$	154,830
Liabilities:
Contingent consideration liability - related parties	$	—	$	—	$	953	$	953
	$	—	$	—	$	953	$	953

Investment Securities Portfolio - Fair Value Option

The Company elected the fair value option for the securities in the investment portfolio. The fair value is based on quoted market prices, when available. When a quoted market price is not readily available, the Company uses the market price from its last sale of similar assets. The cash and cash equivalents held by the Company are categorized as Level 1 investments as quoted market prices are readily available for these investments. All other investments in the investment portfolio are categorized as Level 2 investments as inputs utilized to fair value these securities are either directly or indirectly observable, such as the market price from the last sale of similar assets.

The Company purchases investment grade marketable debt securities which are rated by nationally recognized statistical credit rating organizations in accordance with its investment policy. This policy is designed to minimize the Company's exposure to credit losses and to ensure that the adequate liquidity is maintained at all times to meet anticipated cash flow needs.

The unrealized gains and losses on the available-for-sale securities, represented by change in the fair value of the investment portfolio, is reported in other income (expense), net in the condensed consolidated statements of operations. Since the investment in the

available-for-sale securities are already measured at fair value, no separate credit losses would be recorded in the condensed consolidated financial statements.

Contingent Consideration Liability—Related Parties—Perception, InnarisBio, and TryptageniX

The contingent consideration liability—related parties in the table above relates to milestone and royalty payments in connection with the acquisition of Perception Neuroscience Holdings, Inc. (“Perception”), InnarisBio and TryptageniX. The fair value of the contingent consideration liability—related parties was determined based on significant inputs not observable in the market, which represent Level 3 measurements within the fair value hierarchy. The fair value of the contingent milestone and royalty liabilities was estimated based on the discounted cash flow valuation technique. The technique considered the following unobservable inputs:

•the probability and timing of achieving the specified milestones and royalties as of each valuation date,

•the probability of executing the license agreement,

•the expected first year of revenue, and

•market-based discount rates

The fair value of the contingent milestone and royalty liabilities for InnarisBio was estimated to be $0.1 million and $0.1 million as of June 30, 2023 and December 31, 2022, respectively.

The fair value of the Perception contingent milestone and royalty liabilities could change in future periods depending on prospects for the outcome of R-Ketamine milestone meetings with the FDA or other regulatory authorities, and whether the Company realizes a significant increase or decrease in sales upon commercialization. The most significant assumptions in the discounted cash flow valuation technique that impacts the fair value of the milestone contingent consideration are the projected milestone timing and the probability of the milestone being met. Further, significant assumptions in the discounted cash flow that impacts the fair value of the royalty contingent consideration are the projected revenue over ten years, the timing of royalties on commercial revenue, and the probability of success rate for a commercial R-Ketamine product. The valuations as of June 30, 2023 and December 31, 2022, respectively, used inputs that were unobservable inputs with the most significant being the discount rates for royalties on projected commercial revenue and clinical milestones and probability of success estimates over the following ten years, which represent Level 3 measurements within the fair value hierarchy.

The fair value of the contingent milestone and royalty liabilities for Perception was estimated to be $0.6 million and $0.6 million as of June 30, 2023 and December 31, 2022, respectively.

The fair value of the Perception contingent consideration liability - related parties was calculated using the following significant unobservable inputs:

		June 30, 2023	December 31, 2022
Valuation Technique	Significant Unobservable Inputs	Input Range	Input Range
Discounted cash flow	Milestone contingent consideration:
	Discount rate	14.0%	13.1%
	Probability of the milestone	28.0%	10.0% - 21.0%
Discounted cash flow    with SBM	Royalty contingent consideration:
	Discount rate for royalties	12.9% - 14.7%	20.0% - 21.1%
	Discount rate for royalties on milestones	12.9% - 14.7%	12.3% - 13.4%
	Probability of success rate	13.4% - 28.0%	10.1% - 21.0%

The fair value of the contingent liability for TryptageniX was estimated to be $0.2 million and $0.2 million as of June 30, 2023, and December 31, 2022, respectively. The contingent liability is comprised of R&D milestone success fee payments and royalties payments. The fair value of the success fee liability was estimated based on the scenario-based method within the income approach. The fair value of the contingent liability for TryptageniX was determined based on significant unobservable inputs, including the discount rate, estimated probabilities of success, and timing of achieving certain clinical milestones. The fair value of the royalties liability was determined to be de minimis as the products are in the early stages of development. The Company will continue to assess the appropriateness of the fair value of the contingent liability as the products continue through development.

IntelGenx Common Stock, Initial Warrants and Additional Unit Warrants

The Company’s investment in IntelGenx consists of Common Stock, Initial Warrants and Additional Unit Warrants (the Initial Warrants and the Additional Unit Warrants are collectively referred to as the “Warrants”). The Company determined that the Warrants do not meet the definition of a derivative instrument under ASC 815. The Company has classified the Common Stock as Level 2 assets and the

Warrants as Level 3 assets in the fair value hierarchy. The Company determined that the initial aggregate fair value was equal to the transaction price and recorded the Common Stock at $3.0 million, the Initial Warrants at $1.2 million and the Additional Unit Warrants at $8.2 million on a relative fair value basis resulting in no initial gain or loss recognized in the condensed consolidated statements of operations. The Warrants are measured at fair value on a quarterly basis and any changes in the fair value will be recorded as a component of other income (expense), net in the condensed consolidated statements of operations.

The fair value of Common Stock is estimated by applying a discount for lack of marketability (“DLOM”) of 5.0% as of June 30, 2023 and December 31, 2022. The Company estimated a DLOM in connection with the valuation of the Common Stock to reflect the restrictions associated with the Common Stock. As of June 30, 2023 and December 31, 2022, the only restriction that remains is the unregistered nature of the Common Stock. The fair value of Common Stock, which is included in Other investments held at fair value in the condensed consolidated balance sheets, was zero as of June 30, 2023 and December 31, 2022.

The Initial Warrant asset was recorded at fair value utilizing the Black-Scholes option pricing model. The Black Scholes option pricing model is based on the estimated market value of the underlying common stock at the valuation measurement date, the remaining contractual term of the warrant, risk-free interest rates, expected dividends, and expected volatility of the price of the underlying common stock. The expected volatility is based on a peer group volatility which is a Level 3 input within the fair value hierarchy. The fair value of the Initial Warrants, which is included in Other investments held at fair value in the condensed consolidated balance sheets, was zero as of June 30, 2023 and December 31, 2022.

The following table summarizes significant unobservable inputs that are included in the valuation of the Initial Warrants as of June 30, 2023 and as of December 31, 2022:

	June 30, 2023			December 31, 2022
Value of Underlying	$	0.18		$	0.19
Expected Volatility		100	%		100	%

The fair value of the Additional Unit Warrants is estimated using a Binomial Lattice in a risk-neutral framework (a special case of the Income Approach). Specifically, the future stock price of the IntelGenx is modeled assuming a Geometric Brownian Motion in a risk-neutral framework. For each modeled future price, the Additional Unit Warrants are calculated based on the contractual terms (incorporating any optimal early exercise), and then discounted at the term-matched risk-free rate. Finally, the value of the Additional Unit Warrants is calculated as the probability-weighted present value over all future modeled payoffs. The fair value of the Additional Unit Warrants, which is included in Other investments held at fair value in the condensed consolidated balance sheets, was zero as of June 30, 2023 and December 31, 2022.

The following table summarizes significant unobservable inputs that are included in the valuation of the Additional Units Warrant as of June 30, 2023 and as of December 31, 2022:

	June 30, 2023			December 31, 2022
Value of Underlying	$	0.18		$	0.19
Expected Volatility		105	%		100	%

The following table provides a roll forward of the aggregate fair values of the Company’s financial instruments described above, for which fair value is determined using Level 3 inputs (in thousands):

	Contingent Consideration Liability - Related Parties
Balance as of December 31, 2022	$	953
Initial fair value of instrument		—
Change in fair value		(35	)
Extinguishment of liability		—
Balance as of March 31, 2023	$	918
Initial fair value of instrument		—
Change in fair value		(76	)
Extinguishment of liability		—
Balance as of June 30, 2023	$	842

	Contingent Consideration Liability - Related Parties
Balance as of December 31, 2021	$	2,483
Initial fair value of instrument		—
Change in fair value		—
Extinguishment of liability		(50	)
Balance as of March 31, 2022	$	2,433
Initial fair value of instrument		—
Change in fair value		(95	)
Extinguishment of liability		—
Balance as of June 30, 2022	$	2,338

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Prepaid Expenses and Other Current Assets

6 Months Ended

Jun. 30, 2023

Prepaid Expense and Other Assets, Current [Abstract]

Prepaid expenses and other current assets

8. Prepaid Expenses and Other Current Assets

Prepaid expenses consist of the following (in thousands):

	June 30, 2023		December 31, 2022
Prepaid insurance	$	41	$	2,034
Prepaid research and development related expenses		3,019		4,626
Tax receivables		1,762		5,631
Other		1,435		1,745
Total	$	6,257	$	14,036

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Accrued Liabilities

6 Months Ended

Jun. 30, 2023

Accrued Liabilities, Current [Abstract]

Accrued Liabilities

9. Accrued Liabilities

Accrued liabilities consist of the following (in thousands):

	June 30, 2023		December 31, 2022
Accrued accounting, legal, and other professional fees	$	3,023	$	3,566
Accrued external research and development expenses		4,886		5,550
Accrued restructuring costs		91		—
Accrued payroll		3,137		5,260
Taxes payable		808		2,224
Other liabilities		910		706
Total	$	12,855	$	17,306

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Leases

6 Months Ended

Jun. 30, 2023

Leases [Abstract]

Leases

10. Leases

In February 2016, the FASB issued ASU 2016-02, “Leases” Topic 842, which amends the guidance in former ASC Topic 840, Leases.

Operating lease Right-of-Use (“ROU”) assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes lease payments made, lease incentives, and initial direct costs incurred, if any.

The discount rate implicit within the Company’s leases is generally not determinable and therefore the Company determines the discount rate based on its incremental borrowing rate, which is based on the information available at commencement date. As of June 30, 2023, the operating lease liabilities reflect a weighted-average discount rate of 12.5%.

Operating Leases

The Company leases certain office space under long-term operating leases that expire at various dates through 2028. The Company generally has options to renew lease terms on its facilities, which may be exercised at the Company's sole discretion. The Company evaluates renewal and termination options at the lease commencement date to determine if it is reasonably certain to exercise the option and has concluded on all operating leases that is it not reasonably certain that any options will be exercised. The weighted-average remaining lease term for the Company’s operating leases as of June 30, 2023 was 4.5 years.

ROU assets and lease liabilities related to the Company’s operating leases are as follows (in thousands):

	Balance Sheet Classification	June 30, 2023		December 31, 2022
Right-of-use assets	Operating lease right-of-use asset, net	$	1,367	$	226
Current lease liabilities	Current portion of lease liability		322		180
Non-current lease liabilities	Non-current portion of lease liability		1,095		44

Expenses related to leases is recorded on a straight-line basis over the lease term. The following table summarizes lease costs by component for the three and six months ended June 30, 2023 and 2022 (in thousands):

Lease Cost Components	Statement of Operations Classification	Three months ended June 30, 2023		Three months ended June 30, 2022		Six months ended June 30, 2023		Six months ended June 30, 2022
Operating lease cost	Operating expenses: General and administrative	$	145	$	77	$	280	$	124
Short-term lease cost	Operating expenses: General and administrative		88		122		180		221
Total lease cost		$	233	$	199	$	460	$	345

Future minimum commitments under all non-cancelable operating leases are as follows (in thousands):

Year Ended
2023 (excluding six months ended June 30, 2023)	$	249
2024		410
2025		366
2026		366
2027		366
2028		122
Total lease payments		1,879
Less: Imputed interest		(462	)
Present value of lease liabilities	$	1,417

Supplemental cash flow information related to the Company’s operating leases for the six months ended June 30, 2023 and 2022 are as follows (in thousands):

	Six months ended June 30, 2023		Six months ended June 30, 2022
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases	$	187	$	120
Right-of-use assets obtained in exchange for new operating lease liabilities		1,356		487

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Debt

6 Months Ended

Jun. 30, 2023

Debt Disclosure [Abstract]

Debt

11. Debt

Convertible Promissory Notes

2018 Convertible Promissory Notes—Related Parties

Convertible promissory notes—related parties, net of discounts and deferred issuance costs, consisted of the following (in thousands):

	June 30, 2023		December 31, 2022
Convertible notes issued in October 2020	$	420	$	415
Total	$	420	$	415

In November 2018, the Company executed a terms and conditions agreement (the “Convertible Note Agreement”) under which it was authorized to issue up to €1.0 million or $1.2 million in convertible promissory notes to investors. An investor would become a party to the Convertible Note Agreement and would be issued a convertible promissory note by executing and delivering a subscription form. In November 2018 and October 2020, certain investors subscribed to the Convertible Note Agreement and the Company issued convertible promissory notes in the aggregate principal amount of €0.2 million or $0.2 million and €0.8 million or $1.0 million, respectively (collectively, the “2018 Convertible Notes”).

The 2018 Convertible Notes are non-interest-bearing, unsecured and are due and payable on September 30, 2025, unless previously redeemed, converted, purchased or cancelled. Each 2018 Convertible Note has a notional value of €1 and is convertible into one share of ATAI Life Sciences AG upon the payment of €17.00. Conversion rights may be exercised by a noteholder at any time prior to maturity, except during certain periods subsequent to the consummation of the IPO. The 2018 Convertible Notes may be declared for early redemption by the noteholders upon occurrence of specified events of default, including payment default, insolvency and a material adverse change in the Company’s business, operations or financial or other condition. Upon early redemption, the conversion right with respect to the 2018 Convertible Notes may no longer be exercised. More information on these notes can be found in Note 10 of the Company’s audited consolidated financial statements included in the Company’s Annual Report on Form 10-K filed with the SEC on March 24, 2023.

In connection with the Convertible Note Agreement, the Company issued convertible notes in aggregate principal amounts of €0.5 million or $0.6 million to Apeiron, the family office of the Company’s co-founder, and €0.3 million or $0.4 million to one other shareholder of the Company who is the founder of COMPASS in October 2020.

Conversion of 2018 Convertible Promissory Notes - Related Parties

Upon the Company's 2021 corporate reorganization, atai became the sole shareholder of ATAI Life Sciences AG. In connection with the corporate reorganization, all former shareholders of ATAI Life Sciences AG contributed their shares of ATAI Life Sciences AG to atai and received sixteen shares in atai for every one share of ATAI Life Sciences AG. In 2021 and 2022, several noteholders elected to convert their convertible promissory notes into shares of atai. These investors paid €17.00 per share for an aggregate amount of €5.8 million or $6.9 million and €4.6 million or $4.6 million, respectively in order to convert their convertible promissory notes into ATAI Life Sciences AG common shares, which was in accordance with the original terms of the 2018 Convertible Note Agreements, and then exchange such shares in ATAI Life Sciences AG for shares of atai through a transfer and sale arrangement.

The Company accounted for the conversion of the 2018 Convertible Notes as a conversion such that carrying values of these notes were derecognized with an offset to common stock at par of ATAI Life Sciences AG and the excess of the carrying values of these notes over the common stock at par of ATAI Life Sciences AG was recorded as additional paid-in capital. Concurrently, with the conversion of the 2018 Convertible Notes into ATAI Life Sciences AG shares, the shares of ATAI Life Sciences AG that were issued to the noteholders were exchanged for shares of atai through a transfer and sale arrangement. As ATAI Life Sciences AG continued to remain a wholly owned subsidiary of atai, the transaction was accounted for as an equity transaction that resulted in no gain or loss recognition.

Term Loan

Hercules Loan and Security Agreement

In August 2022, the Company and certain subsidiaries, as guarantors, and Hercules Capital, Inc. entered into a Loan and Security Agreement the “Hercules Loan Agreement”. The Hercules Loan Agreement provides for term loans in an aggregate principal amount of up to $175.0 million under multiple tranches (the “2022 Term Loan Facility”).

On May 26, 2023, ATAI Life Sciences N.V. (the “Company”), ATAI Life Sciences AG (“ATAI AG” and together with the Company, the “Borrowers”) and certain subsidiary guarantors of the Company (collectively, the “Subsidiary Guarantors”) entered into the Second Amendment to Loan and Security Agreement (the “Amendment”), with the several banks and other financial institutions or entities from time to time parties to the Hercules Loan Agreement (collectively, the “Lenders”) and Hercules Capital, Inc., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and for the Lenders (the “Agent”) which amends that certain Loan and Security Agreement, dated August 9, 2022 (as amended by that certain First Amendment to Loan and Security Agreement dated as of March 13, 2023, the “Existing Loan Agreement,” and as amended by the Amendment, the “Agreement”) to, among other things, (i) extend the availability of Tranche 1B of $10.0 million, from May 1, 2023, under the Existing Loan Agreement, to November 15, 2024, (ii) extend the availability of Tranche 1C of $15.0 million, from December 15, 2023, under the Existing Loan Agreement, to December 15, 2024, (iii) provide Tranche 1D of $20.0 million, available upon the earlier of (x) the full draw of Tranche 1C and (y) the expiration of Tranche 1C availability, through February 15, 2025, (iv) extend the availability of Tranche 2 of $15.0 million, from June 30, 2024, under the Existing Loan Agreement, subject to certain conditions under the Agreement, to the earlier of (x) the full draw of Tranche 1D and (y) the expiration of Tranche 1D availability, through March 15, 2025, subject to the Tranche 2 Draw Test, (v) extend the timeline to achieve the second amortization extension condition, from June 30, 2024, in the Existing Loan Agreement, to December 15, 2024, (vi) amend the Tranche 2 Draw Test, satisfaction of which is a condition to draw Tranche 2 under the Agreement and (vii) extend the financial covenant commencement date, from the later of (x) July 1, 2023, and (y) the date that the outstanding debt under the facility is equal to or greater than $40.0 million, in the Existing Loan Agreement, to the later of (x) May 1, 2024, and (y) the date that the outstanding debt under the facility is equal to or greater than $30.0 million, provided, that the financial covenant is waived if the Company has a market capitalization of at least $550.0 million.

The 2022 Term Loan Facility will mature on August 1, 2026 (the “Maturity Date”), which may be extended until February 1, 2027 if the Company achieves certain performance milestones, raises at least $175.0 million of unrestricted new net cash proceeds from certain

permitted sources after the Closing Date and prior to June 30, 2024, and satisfies certain other specified conditions. The outstanding principal balance of the 2022 Term Loan Facility bears interest at a floating interest rate per annum equal to the greater of either (i) the prime rate as reported in the Wall Street Journal plus 4.55% and (ii) 8.55%. Accrued interest is payable monthly following the funding of each term loan advance. The Company may make payments of interest only, without any loan amortization payments, for a period of thirty (30) months following the Closing Date, which period may be extended to (i) thirty-six months if certain additional performance milestones have been achieved; and (ii) forty-two months if certain additional performance milestones have been achieved. At the end of the interest only period, the Company is required to begin repayment of the outstanding principal of the 2022 Term Loan Facility in equal monthly installments.

The Hercules Loan Agreement contains customary closing and commitment fees, prepayment fees and provisions, events of default and representations, warranties and affirmative and negative covenants, including a financial covenant requiring the Company to maintain certain levels of cash in accounts subject to a control agreement in favor of the Agent (the “Qualified Cash”) at all times commencing from the Closing Date, which includes a cap on the amount of cash that can be held by, among others, certain of our foreign subsidiaries in Australia and the United Kingdom. In addition, the financial covenant under the Loan Agreement requires that beginning on the later of (i) July 1, 2023 and (ii) the date on which the aggregate outstanding amount borrowed under the 2022 Term Loan Facility is equal to or greater than $40.0 million, the Company shall maintain Qualified Cash in an amount no less than the sum of (1) 33% of the outstanding amount under the 2022 Term Loan Facility, and (2) the amount of the Borrowers’ and Subsidiary Guarantors’ accounts payable that have not been paid within 180 days from the invoice date of the relevant account payable, subject to certain exceptions; provided, that the financial covenant shall not apply on any day that the Company's market capitalization is at least $550.0 million measured on a consecutive 10-business day period immediately prior to such date of measurement and tested on a daily basis. Upon the occurrence of an event of default, including a material adverse effect, subject to certain exceptions, on ATAI NV and ATAI AG’s, taken together, business, operations, properties, assets or financial condition, and subject to any specified cure periods, all amounts owed by the Company may be declared immediately due and payable by the Lenders. As of June 30, 2023, the Company was in compliance with all applicable covenants under the Hercules Loan Agreement.

In addition, the Company is required to make a final payment fee (the “End of Term Charge”) upon the earlier of (i) the Maturity Date, (ii) the date that the Company prepays, in full or in part, the principal balance of the 2022 Term Loan Facility, or (iii) the date that the outstanding balance of the 2022 Term Loan Facility becomes due and payable. The End of Term Charge is 6.95% of the aggregate original principal amount of the term loans so repaid or prepaid under the Loan Agreement.

The Company may, at its option, prepay the term loans in full or in part, subject to a prepayment penalty equal to (i) 2.00% of the principal amount prepaid if the prepayment occurs on or prior to the first anniversary of the Closing Date, (ii) 1.0% of the principal amount prepaid if the prepayment occurs after the first anniversary and on or prior to the second anniversary of the Closing Date, and (iii) 0.5% of the principal amount prepaid if the prepayment occurs after the second anniversary and prior to the Maturity Date.

The Company incurred financing expenses related to the Hercules Loan Agreement, which are recorded as an offset to long-term debt on the Company's condensed consolidated balance sheets. These deferred financing costs are being amortized over the term of the debt using the effective interest method, and are included in other income (expense), net in the Company’s condensed consolidated statements of operations.

During the three and six months ended June 30, 2023, interest expense included $0.1 million and $0.2 million of amortized deferred financing costs related to the 2022 Term Loan Facility. As the Hercules Loan Agreement was executed in August 2022, during the three and six months ended June 30, 2022 the Company did not incur any interest expense or amortized deferred financing costs related to the 2022 Term Loan Facility.

Outstanding debt obligations are as follows (in thousands):

	June 30, 2023			December 31, 2022
Principal amount	$	15,000		$	15,000
End of the term charge		1,042			1,042
Less: unamortized issuance discount		(240	)		(274	)
Less: unamortized issuance costs		(99	)		(113	)
Less: unamortized end of term charge		(835	)		(952	)
Net carrying amount		14,868			14,702
Less: current maturities		—			—
Long-term debt, net of current maturities and unamortized debt discount and issuance costs	$	14,868		$	14,702

The fair value of the outstanding debt obligations under the 2022 Term Loan Facility was $15.9 million as of June 30, 2023, and $14.9 million as of December 31, 2022, respectively. The fair value of the debt obligations under the 2022 Term Loan Facility represent Level 3 measurements within the fair value hierarchy.

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Common Stock

6 Months Ended

Jun. 30, 2023

Stockholders' Equity Note [Abstract]

Common Stock

12. Common Stock

All common shareholders have identical rights. Each common share entitles the holder to one vote on all matters submitted to the shareholders for a vote.

All holders of common shares are entitled to receive dividends, as may be declared by the Company’s board of supervisory directors. Upon liquidation, common shareholders will receive distribution on a pro rata basis. As of June 30, 2023 and December 31, 2022, no cash dividends have been declared or paid.

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Stock-Based Compensation

6 Months Ended

Jun. 30, 2023

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

13. Stock-Based Compensation

atai Equity Incentive Plans

The Company has options and restricted stock units (“RSUs”) outstanding under various equity incentive plans, including the 2020 Incentive Plan, 2021 Incentive Plan, and HSOP Plan, which are further described in Note 12 of the Company’s audited consolidated financial statements included in the Company’s Annual Report on Form 10-K filed with the SEC on March 24, 2023.

As of June 30, 2023, there were no shares available for future grants under the 2020 Incentive Plan and any shares subject to outstanding options originally granted under the 2020 Equity Incentive Plan that terminate, expire or lapse for any reason without the delivery of shares to the holder thereof shall become available for issuance pursuant to the atai Life Sciences 2021 Incentive Award Plan.

Shares that are expired, terminated, surrendered, or canceled without having been fully exercised will be available for future awards. As of June 30, 2023, 30,929,033 shares were available for future grants under the 2021 Incentive Plan.

As of June 30, 2023, 257,419 HSOP Options were available for future grants under the HSOP Plan.

Stock Option activity under 2020 Incentive Plan and 2021 Incentive Plan

The stock options outstanding noted below consist primarily of both service and performance-based options to purchase common stock. These stock options have a five-year or ten-year contractual term. These awards are subject to the risk of forfeiture until vested by virtue of continued employment or service to the Company.

The following is a summary of stock option activity from December 31, 2022 to June 30, 2023:

	Number of Options				Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Outstanding as of December 31, 2022		34,880,604			$	5.98		5.71	$	10,647
Granted		9,862,628		(1)		1.29		—		—
Exercised		(74,562	)			2.44		—		—
Cancelled or forfeited		(2,775,481	)			7.47		—		—
Outstanding as of June 30, 2023		41,893,189		(2)	$	4.78		6.13	$	10,203
Options exercisable as of June 30, 2023		21,049,667			$	5.31		4.01	$	5,723

(1)Includes (a) 9,862,628 stock options that will vest over a four-year service period.

(2)The 20,843,522 outstanding unvested stock options includes (a) 19,301,248 that will continue to vest over a one to four-year service period, (b) 1,269,708 that will continue to vest over a three to four-year service period and upon the satisfaction of specified performance-based vesting conditions, (c) 100,000 stock options that will continue to vest over a two-year service period and upon the satisfaction of specified market-based conditions tied to price of the Company's publicly traded shares, and (d) 172,566 stock options that will continue to vest over a three-year service period and upon the satisfaction of specified performance-based vesting conditions, which were achieved in the fourth quarter of 2022.

The weighted-average grant-date fair value of options granted during the six months ended June 30, 2023 was $0.96.

The Company estimates the fair value of each stock option using the Black-Scholes option-pricing model on the date of grant. During the six months ended June 30, 2023, the assumptions used in the Black-Scholes option pricing model were as follows:

	June 30,
	2023	2022
Weighted average expected term in years	6.07	5.93
Weighted average expected stock price volatility	86.4%	70.5%
Risk-free interest rate	3.50% - 3.92%	1.46% - 3.03%
Expected dividend yield	0%	0%

For the three months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $7.3 million and $8.1 million, respectively. For the six months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $14.7 million and $16.7 million, respectively.

As of June 30, 2023, total unrecognized compensation cost related to the unvested stock options was $52.8 million, which is expected to be recognized over a weighted average period of 1.91 years.

Stock Option activity under HSOP Plan

The HSOP Options outstanding noted below consist of service and performance-based options to request the distribution of HSOP Shares. These HSOP Options have a fifteen-year contractual term. These HSOP Options vest over a three to four-year service period. These awards are subject to the risk of forfeiture until vested by virtue of continued employment or service to the Company.

The following is a summary of stock option activity from December 31, 2022 to June 30, 2023:

	Number of Options		Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Outstanding as of December 31, 2022		6,921,829		6.64		13.01	$	—
Granted		—		—		—		—
Exercised		—		—		—		—
Cancelled or forfeited		—		—		—		—
Outstanding as of June 30, 2023		6,921,829	$	6.64		12.51	$	—
Options exercisable as of June 30, 2023		6,432,646	$	6.64		12.51	$	—

For the three months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $0.9 million and $1.2 million, respectively. For the six months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $1.8 million and $2.5 million, respectively.

As of June 30, 2023, total unrecognized compensation cost related to the unvested stock-based awards was $1.4 million which is expected to be recognized over a weighted average period of 0.2 years.

Restricted Stock Unit activity under the 2021 Incentive Plan

The restricted stock units noted below consist of service-based awards vesting over a two-year period, subject to the risk of forfeiture until vested by virtue of continued employment or service to the Company. The Company reflects restricted stock units as issued and outstanding common stock when vested and the shares have been delivered to the individual.

The following is a summary of restricted stock unit activity from December 31, 2022 to June 30, 2023:

	Restricted Stock Units		Weighted Average Grant Date Fair Value
Unvested at January 1, 2023		—	$	—
Granted		3,251,815		1.18
Vested		—		—
Forfeited		80,680		1.18
Unvested at June 30, 2023		3,171,135	$	1.18

For the three months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $0.5 million and $0, respectively. For the six months ended June 30, 2023 and 2022, the Company recorded stock-based compensation expense of $0.6 million and $0, respectively.

The total fair value of restricted stock units vested during the six months ended June 30, 2023 was $0. As of June 30, 2023, total unrecognized compensation cost related to the unvested stock-based awards was $3.2 million, which is expected to be recognized over a weighted average period of 1.71 years.

Subsidiary Equity Incentive Plans

Certain controlled subsidiaries of the Company adopted their own equity incentive plans (each, an “EIP”). Each EIP is generally structured so that the applicable subsidiary, and its affiliates’ employees, directors, officers and consultants are eligible to receive non-qualified and incentive stock options and restricted stock unit awards under their respective EIP. Standard option grants have time-based vesting requirements, generally vesting over a period of four years with a contractual term of ten years. Such time-based stock options use the Black-Scholes option pricing model to determine grant date fair value. Certain awards issued to employees partially vest on date of grant, then over a three-year service period and upon the satisfaction of specified performance-based vesting conditions, which are not considered probable of achievement as of June 30, 2023.

For the three months ended June 30, 2023 and 2022, the Company recorded share-based compensation expense of $0.1 million and $0.2 million, respectively, in relation to subsidiary EIPs. For the six months ended June 30, 2023 and 2022, the Company recorded share-based compensation expense of $0.2 million and $0.4 million, respectively, in relation to subsidiary EIPs. As of June 30, 2023, there was $0.4 million of total unrecognized stock-based compensation expense related to unvested EIP awards to employees and non-employee directors expected to be recognized over a weighted-average period of approximately 0.9 years. As of June 30, 2023, the unrecognized stock-based compensation expense from EIP’s awards with liquidity-based performance vesting conditions issued to employees and non-employee directors was approximately $6.5 million, which will be recognized in future periods if and when the attainment of the performance vesting criteria becomes probable.

Stock-Based Compensation

Stock-based compensation expense is allocated to either research and development or general and administrative expense on the condensed consolidated statements of operations based on the cost center to which the option holder belongs.

The following table summarizes the total stock-based compensation expense by function for the three months ended June 30, 2023, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Three Months Ended June 30, 2023
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	3,168	$	—	$	107	$	3,275
General and administrative		4,580		894		13		5,487
Total share based compensation expense	$	7,748	$	894	$	120	$	8,762

The following table summarizes the total stock-based compensation expense by function for the three months ended June 30, 2022, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Three Months Ended June 30, 2022
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	3,717	$	—	$	149	$	3,866
General and administrative		4,395		1,176		74		5,645
Total share based compensation expense	$	8,112	$	1,176	$	223	$	9,511

The following table summarizes the total stock-based compensation expense by function for the six months ended June 30, 2023, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Six Months Ended June 30, 2023
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	6,528	$	—	$	213	$	6,741
General and administrative		8,890		1,768		25		10,683
Total share based compensation expense	$	15,418	$	1,768	$	238	$	17,424

The following table summarizes the total stock-based compensation expense by function for the six months ended June 30, 2022, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Six Months Ended June 30, 2022
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	7,344	$	—	$	296	$	7,640
General and administrative		9,402		2,526		152		12,080
Total share based compensation expense	$	16,746	$	2,526	$	448	$	19,720

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Income Taxes

6 Months Ended

Jun. 30, 2023

Income Tax Disclosure [Abstract]

Income Taxes

14. Income Taxes

The Company records its quarterly income tax expense by utilizing an estimated annual effective tax rate applied to its period to date earnings as adjusted for any discrete items arising during the quarter. The tax effect for discrete items are recorded in the period in which they occur. The Company recorded $185,000 and $51,000 of income tax expense for the three months ended June 30, 2023 and 2022 respectively. The Company recorded $351,000 and $92,000 of income tax expense for the six months ended June 30, 2023 and 2022 respectively. The income tax expense during these periods was primarily driven by current tax on earnings of subsidiaries in Australia, the United States, and the United Kingdom. The primary difference between the effective tax rate and the statutory tax rate relates to the income tax treatment of stock compensation expense, which impacts the current and overall tax expense due to the applicable valuation allowance. The Company continues to maintain a full valuation allowance against its deferred tax assets.

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Net Loss Per Share

6 Months Ended

Jun. 30, 2023

Earnings Per Share [Abstract]

Net Loss Per Share

15. Net Loss Per Share

Basic and diluted net loss per share attributable to atai stockholders were calculated as follows (in thousands, except share and per share data):

	Three Months Ended June 30,						Six Months Ended June 30,
	2023			2022			2023			2022
Numerator:
Net loss	$	(33,771	)	$	(37,509	)	$	(68,126	)	$	(75,067	)
Net loss attributable to noncontrolling interests		(729	)		(891	)		(1,948	)		(1,580	)
Net loss attributable to ATAI Life Sciences    N.V. shareholders — basic and diluted	$	(33,042	)	$	(36,618	)	$	(66,178	)	$	(73,487	)
Denominator:
Weighted average common shares outstanding    attributable to ATAI Life Sciences N.V.    Stockholders — basic and diluted		155,792,490			153,971,202			155,793,323			153,751,456
Net loss per share attributable to ATAI Life    Sciences N.V. shareholders — basic and diluted	$	(0.21	)	$	(0.24	)	$	(0.42	)	$	(0.48	)

HSOP Shares issued to the Partnership and allocated to the HSOP Participants are not considered outstanding for accounting purposes and not included in the calculation of basic weighted average common shares outstanding in the table above because the HSOP Participants have a forfeitable right to distributions until the HSOP Options vest and are exercised, at which time the right becomes nonforfeitable.

The following also represents the maximum amount of outstanding shares of potentially dilutive securities that were excluded from the computation of diluted net income (loss) per share attributable to common shareholders for the periods presented because including them would have been antidilutive:

Potentially dilutive securities to the Company’s common shares:

	As of June 30,
	2023		2022
Options to purchase common stock		41,893,189		34,410,771
HSOP options to purchase common stock		6,921,829		7,046,496
2018 Convertible Promissory Notes - Related Parties (Note 11)		6,201,824		9,561,824
Unvested restricted stock units		3,171,135		—
		58,187,977		51,019,091

The outstanding 2018 Convertible Notes are issuable upon the exercise of conversion rights of convertible note holders for 387,614 shares of common stock of ATAI Life Sciences AG. Upon conversion of the 2018 Convertible Notes, it is expected that the shares of common

stock of ATAI Life Sciences AG issuable upon conversion of the 2018 Convertible Notes would be exchanged on a one-for-sixteen basis for shares of atai which is reflected in the table above. See Note 11 for additional discussion.

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Commitments and Contingencies

6 Months Ended

Jun. 30, 2023

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

16. Commitments and Contingencies

Research and Development Agreements

The Company may enter into contracts in the ordinary course of business with clinical research organizations for clinical trials, with contract manufacturing organizations for clinical supplies and with other vendors for preclinical studies, supplies and other services and products for operating purposes.

Indemnification

In the ordinary course of business, the Company may provide indemnifications of varying scope and terms to vendors, lessors, business partners, board members, officers and other parties with respect to certain matters, including, but not limited to, losses arising out of breach of such agreements, services to be provided by the Company, negligence or willful misconduct of the Company, violations of law by the Company, or intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with directors and certain officers and employees that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors, officers or employees. No demands have been made upon the Company to provide indemnification under such agreements, and thus, there are no claims that the Company is aware of that could have a material effect on the Company’s condensed consolidated financial statements.

The Company also maintains director and officer insurance, which may cover certain liabilities arising from its obligation to indemnify the Company’s directors. To date, the Company has not incurred any material costs and has not accrued any liabilities in the condensed consolidated financial statements as a result of these provisions.

Contingencies

From time to time, the Company may become involved in legal proceedings arising in the ordinary course of business. The Company is unable to predict the outcome of these matters or the ultimate legal and financial liability, and at this time cannot reasonably estimate the possible loss or range of loss and accordingly has not accrued a related liability. At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company accrues a liability when a loss is considered probable and the amount can be reasonably estimated. When a material loss contingency is reasonably possible but not probable, the Company does not record a liability, but instead discloses the nature and the amount of the claim, and an estimate of the loss or range of loss, if such an estimate can be made. Legal fees are expensed as incurred. The Company currently believes that the outcome of any future potential legal proceedings, either individually or in the aggregate, will not have a material effect on its consolidated financial position, results of operations or cash flows.

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License Agreements

6 Months Ended

Jun. 30, 2023

License Agreements [Abstract]

License Agreements

17. License Agreements

Otsuka License and Collaboration Agreement

In March 2021, Perception entered into a license and collaboration agreement (the “Otsuka Agreement”) with Otsuka under which Perception granted exclusive rights to Otsuka to develop and commercialize products containing arketamine, known as PCN-101 in Japan for the treatment of any depression, including treatment-resistant depression, or major depressive disorder or any of their related symptoms or conditions at its own cost and expense. Perception retained all rights to PCN-101 outside of Japan.

With the execution of the Otsuka Agreement, Perception received an upfront, non-refundable payment of $20.0 million. Perception is also entitled to receive aggregate payments of up to $35.0 million if certain development and regulatory milestones are achieved for the current or a new intravenous formulation of a product and up to $66.0 million in commercial milestones upon the achievement of certain commercial sales thresholds. Otsuka is obligated to pay Perception a tiered, double-digit royalty on net sales of products containing PCN-101 in Japan, subject to reduction in certain circumstances. More information for this license can be found in Note 16 of the Company’s audited consolidated financial statements included in the Company’s Annual Report on Form 10-K filed with the SEC on March 24, 2023.

For the three and six months ended June 30, 2023 and 2022 there were no milestones achieved under the Otsuka Agreement and we recognized $0.2 million and $0.2 million of revenue related to certain research and development services, respectively, which included recognizing the remaining deferred revenue balance related to the Otsuka Agreement.

National University Corporation Chiba University License Agreement

In August 2017, Perception entered into a license agreement (the “CHIBA License”), with the National University Corporation Chiba University (“CHIBA”), relating to Perception’s drug discovery and development initiatives. Under the CHIBA License, Perception has

been granted a worldwide exclusive license under certain patents and know-how of CHIBA to research, develop, manufacture, use and commercialize therapeutic products.

During the three and six months ended June 30, 2023 and 2022, respectively, the Company made no material payments pursuant to the CHIBA License.

Allergan License Agreement

In February 2020, Recognify entered into an amended and restated license agreement (the “Allergan License Agreement”), with Allergan Sales, LLC (“Allergan”), under which Allergan granted Recognify an exclusive (non-exclusive as to know-how), sublicensable and worldwide license under certain patent rights and know-how controlled by Allergan to develop, manufacture and commercialize certain products for use in all fields including the treatment of certain diseases and conditions of the central nervous system.

During the three and six months ended June 30, 2023 and 2022, respectively, Recognify made no material payments pursuant to the Allergan License Agreement.

Columbia Stock Purchase and License Agreement

In June 2020, Kures entered into a license agreement with Trustees of Columbia University (“Columbia”), pursuant to which, Kures obtained an exclusive license under certain patents and technical information to discover, develop, manufacture, use and commercialize such patents or other products in all uses and applications (“Columbia IP”). In addition, in consideration for the rights to the Columbia IP, Kures entered into a Stock Purchase Agreement (the “SPA”) with Columbia in contemplation of the license agreement. Pursuant to the SPA, Kures issued to Columbia certain shares of the Kures’ capital stock, representing 5.0% of Kures common stock on a fully diluted basis. Furthermore, the SPA provided that from time to time, Kures shall issue to Columbia additional shares of Kures’ common stock, at a per share price equal to the then fair market value of each such share, which price shall be deemed to have been paid in partial consideration for the execution, delivery and performance by Columbia of the License Agreement, such that the common stock held by Columbia shall equal to 5.0% of the common stock on a fully diluted basis, at all times up to and through the achievement of certain funding threshold.

During the three and six months ended June 30, 2023, Kures made no material payments or share issuances in connection with the Columbia agreement.

During the three months ended June 30, 2022, Kures issued shares of Series A-2 Preferred Stock to certain investors upon the achievement of Series A-2 milestone events. Accordingly, the Company issued certain anti-dilution common stock to Columbia worth $0.3 million. The Company expensed the cost incurred for acquiring license as research & development expense at inception.

Since, the additional anti-dilution shares were issued as partial consideration towards the same license arrangement, the cost of such additional shares was also expensed as research & development expense during the three and six months ended June 30, 2022. During the three and six months ended June 30, 2022, the Company recognized $0.4 million and $0.4 million, respectively, of in-process research & development expense in connection with the SPA and the License Agreement.

Accelerate License Agreement

In April 2021, Psyber entered into a license arrangement with Accelerate Technologies Pte. Ltd. (“Accelerate”), whereby Accelerate grants Psyber non-exclusive rights to license and use the technology to commercialize of Psyber’s BCI-enabled companion digital therapeutics in United States of America, Singapore, Member Countries of the European Union, Canada, Australia and New Zealand as a potential treatment for mental health and behavior change, such as substance use disorders including opioid use disorder, mood and anxiety disorders including post-traumatic stress disorder, and treatment-resistant depression.

During the three and six months ended June 30, 2023 and 2022, respectively, Psyber made no material payments pursuant to the Accelerate License agreement.

Dalriada License Agreement

In December 2021, Invyxis, Inc. (“Invyxis”), a wholly owned subsidiary of the Company, entered into an exclusive services and license agreement (the “Invyxis ESLA”) with Dalriada Drug Discovery Inc. (“Dalriada”). Under the Invyxis ESLA, Dalriada is to exclusively collaborate with Invyxis to develop products, services and processes with the specific purpose of generating products consisting of new chemical entities. Invyxis will pay Dalriada up to $12.8 million in service fees for research and support services. In addition, Invyxis will pay Dalriada success milestone payments and low single digit royalty payments based on net product sales. Invyxis has the right, but not the obligation, to settle future royalty payments based on net product sales with the Company's common stock. Invyxis and Dalriada will determine the equity settlement based on a price per share determined by both parties.

In January 2022, in accordance with the Invyxis ESLA, Invyxis paid an upfront deposit of $1.1 million, which was capitalized as prepaid research and development expense. In December 2022, the Company executed an amendment to the Invyxis ESLA, which reduced the upfront deposit from $1.1 million to $0.5 million. As such, the remaining $0.6 million was applied against research and development expense incurred. The Company will expense the remaining deposit as the services are performed as a component of research and development expense in the consolidated statements of operations.

During the three months ended June 30, 2023 and 2022, the Company recorded $0.6 million and $1.4 million, respectively, as research and development expense in the condensed consolidated statement of operations. During the six months ended June 30, 2023 and 2022, the Company recorded $1.1 million and $1.8 million, respectively as research and development expense in the condensed consolidated statement of operations.

During the three and six months ended June 30, 2022, Invyxis made no other service fee payments to Dalriada.

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Related Party Transactions

6 Months Ended

Jun. 30, 2023

Related Party Transactions [Abstract]

Related Party Transactions

18. Related Party Transactions

atai Formation

In connection with the formation of atai in 2018, the Company entered into a series of transactions with its shareholders, Apeiron, Galaxy Group Investments LLC. (“Galaxy”) and HCS Beteiligungsgesellschaft mbH (“HCS”) whereby these shareholders contributed their investments in COMPASS, Innoplexus and Juvenescence to the Company in exchange for the Company's common stock of equivalent value. Apeiron is the family office of the Company’s co-founder who owns 20.4% and 19.7% of the outstanding common stock in the Company as of June 30, 2023 and December 31, 2022, respectively. Galaxy is a NYC-based multi-strategy investment firm that owns 6.5% and 6.5% of the outstanding common stock in the Company as of June 30, 2023 and December 31, 2022, respectively.

Directed Share Program

In connection with ATAI’s initial public offering, the underwriters reserved 27% of the common shares for sale at the initial offering price to the Company’s managing directors, supervisory directors and certain other parties. Apeiron participated in the program and purchased $10.5 million common shares.

Consulting Agreement with Mr. Angermayer

In January 2021, the Company entered into a consulting agreement, (the “Consulting Agreement”), with Mr. Angermayer, one of the Company’s co-founders and supervisory director. Apeiron is the family office and merchant banking business of Mr. Angermayer. Pursuant to the Consulting Agreement, Mr. Angermayer agreed to render services to the Company on business and financing strategies in exchange for 624,000 shares under the 2020 Incentive Plan upon achievement of certain performance targets. The Consulting Agreement expires on March 31, 2024.

As a result of the Consulting Agreement, for the three months ended June 30, 2023 and 2022, the Company recorded $0.2 million and $0.2 million, respectively, of stock-based compensation included in general and administrative expense in its condensed consolidated statements of operations. Additionally, as a result of the Consulting Agreement, for the six months ended June 30, 2023 and 2022, the Company recorded $0.4 million and $0.4 million, respectively, of stock-based compensation included in general and administrative expense in its condensed consolidated statements of operations.

For the three months ended June 30, 2023 and 2022, the Company recorded $0.1 million and $0.2 million, respectively, of stock-based compensation included in general and administrative expense in its condensed consolidated statements of operations related to Mr. Angermayer's service as Chairman of the supervisory board. For the six months ended June 30, 2023 and 2022, the Company recorded $0.3 million and $0.3 million, respectively, of stock-based compensation included in general and administrative expense in its condensed consolidated statements of operations related to Mr. Angermayer's service as Chairman of the supervisory board.

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Defined Contribution Plan

6 Months Ended

Jun. 30, 2023

Retirement Benefits [Abstract]

Defined Contribution Plan

19. Defined Contribution Plan

The Company has a defined contribution retirement savings plan under Section 401(k) of the Internal Revenue Code. This plan allows eligible employees to defer a portion of their annual compensation. Employees may make contributions by having the Company withhold a percentage of their salary up to the Internal Revenue Service annual limit. The Company recognized $0.1 million and $0.1 million of related compensation expense for the three months ended June 30, 2023 and 2022. The Company recognized $0.3 million and $0.2 million of related compensation expense for the six months ended June 30, 2023 and 2022.

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Corporate Restructuring

6 Months Ended

Jun. 30, 2023

Restructuring and Related Activities [Abstract]

Corporate Restructuring

Corporate Restructuring

In February 2023, the Company restructured its workforce and eliminated approximately 30% of its global workforce in order to more effectively allocate its research and development and other resources supporting the revised business and program priorities and to reduce operational costs.

Restructuring expense related to the workforce reduction was incurred primarily during the six months ended June 30, 2023, resulting in $3.2 million of restructuring expense, which consisted of $3.0 million of cash expenditures for severance and other employee separation-related costs and $0.2 million of stock-based compensation expense. Of the restructuring expense, for the three and six months ended June 30, 2023, $1.8 million and $1.4 million were recorded in research and development expenses and general and administrative expenses, respectively, in the condensed consolidated statement of operations.

As of June 30, 2023, net restructuring liabilities totaled approximately $0.1 million included in accrued expenses on the Company's condensed consolidated balance sheets.

A reconciliation of the restructuring charges and related payments for the six months ended June 30, 2023 is as follows:

	Six Months Ended June 30, 2023
Restructuring liability as of December 31, 2022	$	—
Restructuring costs expensed during the period		3,194
Non-cash impact of stock-based compensation		(195	)
Cash payments of restructuring liabilities, net		(2,908	)
Restructuring liability as of June 30, 2023	$	91

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Subsequent Events

6 Months Ended

Jun. 30, 2023

Subsequent Events [Abstract]

Subsequent Events

21. Subsequent Events

None.

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Basis of Presentation and Summary of Significant Accounting Policies (Policies)

6 Months Ended

Jun. 30, 2023

Accounting Policies [Abstract]

Basis of Presentation

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial information and follow the requirements of the United States Securities and Exchange Commission (“SEC”) for interim financial reporting. Accordingly, these unaudited condensed consolidated financial statements do not include all of the information and disclosures required by U.S. GAAP for complete financial statements as certain footnotes or other financial information that are normally required by U.S. GAAP can be condensed or omitted. These unaudited condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on March 24, 2023.

The unaudited condensed consolidated financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for a fair statement of the Company’s financial position, its results of operations and comprehensive loss, and its cash flows for the periods presented. The results of operations for the three and six months ended June 30, 2023 are not necessarily indicative of the results to be expected for the year ending December 31, 2023 or for any other future annual or interim period.

Any reference in these notes to applicable accounting guidance is meant to refer to the authoritative U.S. GAAP included in the Accounting Standards Codification (“ASC”), and Accounting Standards Update (“ASU”) issued by the Financial Accounting Standards Board (“FASB”).

Reclassifications

Certain reclassifications were made to prior period amounts in the condensed consolidated financial statements and accompanying notes to conform with current year presentation due to the increase in the balances of the Company's operating right-of-use asset and related lease liability during the period.

Consolidation

The Company's condensed consolidated financial statements include the accounts of atai and its subsidiaries. All intercompany balances and transactions have been eliminated in the consolidation.

The Company's policy is to consolidate all entities that it controls by ownership of a majority of the outstanding voting stock. In addition, entities that meet the definition of a variable interest entity (“VIE”) for which atai is the primary beneficiary are consolidated. The primary beneficiary is the party who has the power to direct the activities of a VIE that most significantly impact the entity’s economic performance and who has an obligation to absorb losses of the entity or a right to receive benefits from the entity that could potentially be significant to

the entity. For consolidated entities that are less than wholly-owned, the third-party’s holding of equity interest is presented as Noncontrolling interests in the Company's condensed consolidated balance sheets and condensed consolidated statements of stockholders' equity. The portion of net earnings attributable to the noncontrolling interests is presented as Net loss attributable to noncontrolling interests in the Company's condensed consolidated statements of operations.

In situations in which atai has significant influence, but not control, of an entity that does not qualify as a VIE, the Company applies the cost and equity method of accounting, with its portion of net losses recorded in Losses from investments in equity method investees, net of tax in the Company's condensed consolidated statements of operations.

Significant Accounting Policies

Significant Accounting Policies

During the six months ended June 30, 2023, there were no significant changes to the Company’s significant accounting policies as described in the Company’s audited consolidated financial statements as of and for the year ended December 31, 2022 except as described below.

Use of Estimates

Use of Estimates

The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Significant estimates and assumptions made in the accompanying condensed consolidated financial statements include, but are not limited to the fair value of the Company’s investment in Intelgenx Technologies Corp. (“IntelGenx”), securities carried at fair value, contingent consideration liability—related parties, in-process research and development assets (“IPRD”) and noncontrolling interests recognized in acquisitions, the valuation of share-based awards, and accruals for research and development costs.

The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable. Actual results may differ from those estimates or assumptions.

Cash and Cash Equivalents

Cash and Cash Equivalents

The Company considers all highly liquid investments purchased with original maturities of three months or less from the purchase date to be cash equivalents. As of June 30, 2023 and December 31, 2022, cash and cash equivalents consisted of cash on deposit and cash held in high-yield savings accounts and money market funds. The substantial majority of the Company’s cash is held in financial institutions in the United States and at times in excess of federally insured limits.

Investment Securities Portfolio

Investment Securities Portfolio

The following table sets forth the fair value of atai's available-for-sale securities portfolio at the dates indicated:

	Fair Value
	June 30, 2023		December 31, 2022
Money Market Funds	$	60,920	$	72,334
U.S. Treasuries		31,843		—
Commercial Paper		—		5,958
Corporate Notes/Bonds		4,900		17,719
U.S. Government Agencies		49,659		58,819
	$	147,322	$	154,830

In January 2022, the Company invested in a certain investment portfolio, which is comprised of Money Market Funds, U.S. Treasury securities, Commercial Paper, Corporate Notes/Bonds, and U.S. government agencies securities. The Company classified securities in the investment portfolio as available-for-sale securities. Furthermore, the Company elected the fair value option for the available-for-sale securities in the investment portfolio (see Note 7). The decision to elect the fair value option, which is irrevocable once elected, is determined on an instrument-by-instrument basis and applied to an entire instrument. The net gains or losses, if any, on an investment for which the fair value option has been elected are recognized as a change in fair value of securities carried at fair value on the Condensed Consolidated Statements of Operations and the amortized cost of investments approximates their fair value. The Company's securities in the investment portfolio will mature within two years.

Fair Value Measurements

Fair Value Measurements

Assets and liabilities recorded at fair value on a recurring basis in the condensed consolidated balance sheets are categorized based upon the level of judgment associated with the inputs used to measure their fair values. Fair value is defined as the exchange price that would be received for an asset or an exit price that would be paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value

must maximize the use of observable inputs and minimize the use of unobservable inputs. The authoritative guidance on fair value measurements establishes a three-tier fair value hierarchy for disclosure of fair value measurements as follows:

Level 1—Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date;

Level 2—Inputs (other than quoted prices included in Level 1) are either directly or indirectly observable for the asset or liability. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active; and

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. Accordingly, the degree of judgment exercised by the Company in determining fair value is greatest for instruments categorized in Level 3. A financial instrument’s level within the fair value hierarchy is based on the lowest level of any input that is significant to the fair value measurement.

The Company’s contingent consideration liability—related parties, IntelGenx Initial Warrants and IntelGenx Additional Units Warrant are carried at fair value, determined according to Level 3 inputs in the fair value hierarchy described above (See Note 7). The IntelGenx common stock and securities carried at fair value are determined according to Level 2 inputs in the fair value hierarchy above. The carrying amount reflected in the accompanying condensed consolidated balance sheets for cash, prepaid expenses and other current assets, accounts payable and accrued liabilities approximate their fair values, due to their short-term nature.

The carrying amounts of the Company’s remaining outstanding convertible promissory notes—related parties (“2018 Convertible Notes”) do not approximate fair value because the fair value is driven by the underlying value of the Company’s common shares into which the notes are to be converted. As of June 30, 2023, the carrying amount and fair value amount of the 2018 Convertible Notes was $0.4 million and $6.5 million, respectively. As of December 31, 2022, the carrying amount and fair value amount of the 2018 Convertible Notes was $0.4 million and $13.1 million, respectively. In 2022, several noteholders of the 2018 Convertible Notes elected to convert their promissory notes into the Company's common shares. See Note 11 for additional discussion.

Fair Value Option

Fair Value Option

As permitted under Accounting Standards Codification 825, Financial Instruments, or ASC 825, the Company has elected the fair value option to account for its investment in common shares of IntelGenx, which otherwise would be subject to ASC 323. In accordance with ASC 825, the Company records this investment at fair value under Other investments held at fair value in the Company's condensed consolidated balance sheets and changes in fair value are recognized as a component of other income (expense), net in the condensed consolidated statements of operations. The carrying value of the investment remained at zero as of June 30, 2023 and December 31, 2022, respectively.

Furthermore, as noted above the Company also elected the fair value option for its investment securities portfolio.

Emerging Growth Company Status

Emerging Growth Company Status

The Company is an emerging growth company, as defined in the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”). Under the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period for complying with new or revised accounting standards that have different effective dates for public and private companies until the earlier of the date that it (i) is no longer an emerging growth company or (ii) affirmatively and irrevocably opts out of the extended transition period provided in the JOBS Act. As a result, these condensed consolidated financial statements may not be comparable to companies that comply with the new or revised accounting pronouncements as of public company effective dates.

As described in “Recently Adopted Accounting Pronouncements” below, the Company early adopted certain accounting standards, as the JOBS Act does not preclude an emerging growth company from adopting a new or revised accounting standard earlier than the time that such standard applies to private companies. The Company expects to use the extended transition period for any other new or revised accounting standards during the period in which it remains an emerging growth company.

Recently Adopted Accounting Pronouncements

Recently Adopted Accounting Pronouncements

ASU 2016-02 Leases (Topic 842)

In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which is a comprehensive new lease standard that amends various aspects of existing accounting guidance for leases. The core principle of Topic 842 requires lessees to recognize on the condensed consolidated balance sheets a liability to make lease payments and a right-of-use asset representing its right to use the underlying asset for the lease term for both finance and operating leases with lease terms greater than twelve months. The lease liability is measured at the present value of the unpaid lease payments and the right-of-use asset is derived from the calculation of the lease liability. Topic 842 also requires lessees to disclose key information about leasing arrangements. For public entities, ASU 2016-02 is effective for fiscal years

beginning after December 15, 2018. As a result of the Company having elected the extended transition period for complying with new or revised accounting standards pursuant to Section 107(b) of the JOBS Act, ASU 2016-02 is effective for the Company beginning after December 15, 2021. The Company adopted the new standard on January 1, 2022 using the modified transition approach as of the effective date.

The Company elected the “package of three practical expedients,” which permitted it to not reassess under the new standard its prior conclusions about lease identification, lease classification, and initial direct costs. As a result, the Company has continued to account for existing leases - i.e. leases for which the commencement date is before January 1, 2022 - in accordance with Topic 840 throughout the entire lease term, including periods after the effective date, with the exception that the Company applied the new balance sheet recognition guidance for operating leases and applied Topic 842 for remeasurements and modifications after the Transition Date. The Company also elected the hindsight expedient in determining the lease term and assessing impairment of right-of-use assets when transitioning to ASC 842. As a result, the Company evaluated the lease term for its existing leases as of the transition date, January 1, 2022.

The most significant impact of the initial adoption of Topic 842 on the Company’s condensed consolidated financial statements was the recognition of a $0.2 million operating lease right-of-use asset, a $0.1 million current operating lease liability, and a $0.1 million long-term operating lease liability on the Company’s condensed consolidated balance sheets related to its existing facility operating lease. The Company did not have a deferred rent liability recorded in connection with its existing facility operating lease. There was no material impact of the initial adoption to the Company’s condensed consolidated balance sheets, condensed consolidated statements of operations, and no cumulative-effect adjustment to accumulated deficit.

In May 2022, the Company entered into a five-year lease arrangement that commenced in January 2023 related to our principal executive office located at Wallstraße 16, 10179, Berlin, Germany. This lease will require lease payments over the term of approximately $1.8 million, which is further described in Note 10 of the notes to the Company's unaudited condensed consolidated financial statements.

Recently Issued Accounting Pronouncements Not Yet Adopted

ASU 2016-13 Financial Instruments - Credit Losses

In June 2016, the FASB issued ASU 2016-13, Financial Instruments — Credit Losses. This guidance requires immediate recognition of management’s estimates of current expected credit losses. Under the prior model, losses were recognized only when losses were deemed probable. The new model is applicable to most financial assets and certain other instruments that are not measured at fair value through net income.

The Company utilizes an undiscounted probability-of-default (“PD”) and loss-given-default (“LGD”) method for estimating credit losses on its assets pool, which is comprised of loans to other companies. Under the PD and LGD method, the expected credit loss percentage (or “loss rate”) is calculated as the probability of default (i.e., the probability the asset will default within the given time frame) multiplied by the loss given default (i.e., the percentage of the asset not expected to be collected because of default). To implement the PD and LGD method, the Company utilizes readily observable market information from term-matched public debt to derive market implied current expected credit losses (“MICECL”) grouped by Standard & Poor’s (“S&P”) credit rating scale. The MICECL framework considers risk characteristics of assets pool based on publicly available or estimated S&P credit ratings to calculate an appropriate credit loss reserve for the pool or group of assets.

ASU 2016-13 requires a cumulative effect adjustment to the statement of financial position as of the beginning of the first reporting period in which it is effective. On January 1, 2023, the Company adopted this guidance and applied a modified-retrospective transition approach through a cumulative-effect adjustment to retained earnings upon adoption. At transition, the new accounting guidance’s adoption resulted in an increase to accumulated deficit of $0.5 million, net of tax attributable to an increase in the allowance for credit losses related to its Short term notes receivable - related parties, net and Long term notes receivable - related parties, net.

Further, the FASB issued ASU 2019-04, ASU 2019-05, ASU 2019-11, ASU 2020-03 and ASU 2022-02 to provide additional clarification and guidance on the credit losses standard. We adopted ASU 2019-04, ASU 2019-05, ASU 2019-11, ASU 2020-03 and ASU 2022-02 on January 1, 2023. The adoption of these standards did not have a material impact on the Company’s consolidated financial statements or disclosures.

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Basis of Presentation and Summary of Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2023

Accounting Policies [Abstract]

Schedule of fair value of our available-for-sale debt securities portfolio

The following table sets forth the fair value of atai's available-for-sale securities portfolio at the dates indicated:

	Fair Value
	June 30, 2023		December 31, 2022
Money Market Funds	$	60,920	$	72,334
U.S. Treasuries		31,843		—
Commercial Paper		—		5,958
Corporate Notes/Bonds		4,900		17,719
U.S. Government Agencies		49,659		58,819
	$	147,322	$	154,830

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Variable Interest Entities and a Voting Interest Entity (Tables)

6 Months Ended

Jun. 30, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Summary of Primary Beneficiary for VIEs Consolidated Under the VIE Model

As of June 30, 2023 and December 31, 2022, the Company has accounted for the following consolidated investments as VIEs, excluding the wholly owned subsidiaries:

Consolidated Entities	Relationship as of June 30, 2023	Relationship as of December 31, 2022	Date Control Obtained	Ownership % June 30, 2023	Ownership % December 31, 2022
Perception Neuroscience Holdings, Inc.	Controlled VIE	Controlled VIE	November 2018	59.2%	58.9%
Kures, Inc.	Controlled VIE	Controlled VIE	August 2019	64.5%	64.5%
EntheogeniX Biosciences, Inc.	Controlled VIE	Controlled VIE	November 2019	80.0%	80.0%
DemeRx IB, Inc.	Controlled VIE	Controlled VIE	December 2019	59.5%	59.5%
Recognify Life Sciences, Inc.	Controlled VIE	Controlled VIE	November 2020	51.9%	51.9%
PsyProtix, Inc.	Controlled VIE	Controlled VIE	February 2021	75.0%	75.0%
Psyber, Inc.	Controlled VIE	Controlled VIE	February 2021	75.0%	75.0%
InnarisBio, Inc.	Controlled VIE	Controlled VIE	March 2021	82.0%	82.0%
TryptageniX Inc.	Controlled VIE	Controlled VIE	December 2021	65.0%	65.0%

Summary of the Assets and Liabilities for all Consolidated VIEs

The following table presents the assets and liabilities (excluding intercompany balances that were eliminated in consolidation) for all VIEs as of June 30, 2023 (in thousands):

	Perception		Kures		EntheogeniX		DemeRx IB		Recognify		PsyProtix		Psyber		InnarisBio		TryptageniX
Assets:
Current assets:
Cash	$	2,483	$	56	$	458	$	10,395	$	4,108	$	14	$	541	$	503	$	82
Accounts receivable		205		—		—		—		—		—		—		—		—
Prepaid expenses and other current assets		310		286		147		69		1,155		—		—		488		2,700
Total current assets		2,998		342		605		10,464		5,263		14		541		991		2,782
Long term notes receivable		—		—		—		1,063		—		94		—		—		—
Other assets		—		—		—		—		—		—		706		—		—
Total assets	$	2,998	$	342	$	605	$	11,527	$	5,263	$	108	$	1,247	$	991	$	2,782
Liabilities:
Current liabilities:
Accounts payable	$	581	$	510	$	246	$	260	$	210	$	—	$	2	$	5	$	—
Accrued liabilities		1,189		62		103		284		396		45		118		327		118
Other current liabilities		—		—		—		—		—		—		—		—		—
Total current liabilities		1,770		572		349		544		606		45		120		332		118
Total liabilities	$	1,770	$	572	$	349	$	544	$	606	$	45	$	120	$	332	$	118

The following table presents the assets and liabilities (excluding intercompany balances that were eliminated in consolidation) for all consolidated VIEs as of December 31, 2022 (in thousands):

	Perception		Kures		EntheogeniX		DemeRx IB		Recognify		PsyProtix		Psyber		InnarisBio		TryptageniX
Assets:
Current assets:
Cash	$	8,703	$	220	$	467	$	12,251	$	7,526	$	1	$	683	$	719	$	513
Accounts receivable		197		—		—		—		—		—		—		—		—
Prepaid expenses and other current assets		466		174		91		21		1,742		66		—		13		2,850
Total current assets		9,366		394		558		12,272		9,268		67		683		732		3,363
Long term notes receivable		—		—		—		1,075		—		109		—		—		—
Other assets		—		—		—		—		—		—		353		—		—
Total assets	$	9,366	$	394	$	558	$	13,347	$	9,268	$	176	$	1,036	$	732	$	3,363
Liabilities:
Current liabilities:
Accounts payable	$	661	$	25	$	124	$	332	$	381	$	33	$	10	$	3	$	—
Accrued liabilities		1,738		266		121		671		596		46		37		158		154
Other current liabilities		121		2		—		133		2		1		1		1		—
Total current liabilities		2,520		293		245		1,136		979		80		48		162		154
Total liabilities	$	2,520	$	293	$	245	$	1,136	$	979	$	80	$	48	$	162	$	154

Schedule of Non Controlling Interest Recognized to Its Consolidated VIEs Roll Forward

The Company recognizes noncontrolling interests related to its consolidated VIEs and provides a roll forward of the noncontrolling interests balance, as follows (in thousands):

	Perception			Kures			Recognify			Total
Balance as of December 31, 2022	$	1,731		$	451		$	2,844		$	5,026
Net loss attributable to noncontrolling    interests - common		—			—			—			—
Net loss attributable to noncontrolling    interests - preferred		(700	)		(93	)		(426	)		(1,219	)
Comprehensive loss attributable to noncontrolling    interests		6			2			—			8
Balance as of March 31, 2023	$	1,037		$	360		$	2,418		$	3,815
Net loss attributable to noncontrolling    interests - common		—			—			—			—
Net loss attributable to noncontrolling    interests - preferred		(266	)		(32	)		(431	)		(729	)
Comprehensive loss attributable to noncontrolling    interests		(1	)		2			—			1
Balance as of June 30, 2023	$	770		$	330		$	1,987		$	3,087

	Perception			Kures		Recognify			Total
Balance as of December 31, 2021	$	5,232		$	—	$	3,819		$	9,051
Net loss attributable to noncontrolling    interests - preferred		(571	)		—		(118	)		(689	)
Comprehensive loss attributable to noncontrolling    interests		(11	)		—		—			(11	)
Balance as of March 31, 2022	$	4,650		$	—	$	3,701		$	8,351
Issuance of noncontrolling interests		—			957		—			957
Net loss attributable to noncontrolling    interests - preferred		(800	)		—		(91	)		(891	)
Comprehensive loss attributable to noncontrolling    interests		30			—		—			30
Balance as of June 30, 2022	$	3,880		$	957	$	3,610		$	8,447

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Equity Method Investments and Other Investments (Tables)

6 Months Ended

Jun. 30, 2023

Equity Method Investments and Joint Ventures [Abstract]

Equity Method Investments

As of June 30, 2023 and December 31, 2022, the Company accounted for the following investments in the investee’s common stock under the equity method (amounts in thousands):

		As of June 30, 2023				As of December 31, 2022
	Date First	Common Stock		Carrying		Common Stock		Carrying
Investee	Acquired	Ownership %		Value		Ownership %		Value
Innoplexus A.G.	August 2018	35.0%		$	—	35.0%		$	—
COMPASS Pathways plc	December 2018	20.9%			—	22.4%			—
GABA Therapeutics, Inc	November 2020	7.5%	(1)		—	7.5%	(1)		—
Total				$	—			$	—

(1)The Company is deemed to have significant influence over this entity through its total ownership interest in the entity’s equity, including the Company’s investment in the respective entity’s preferred stock, described below in Other Investments. The Company’s total ownership interest, considering both preferred and common stock is 54.7%.

Investment

As of June 30, 2023 and December 31, 2022, the carrying values of other investments, which consisted of investments in the investee’s preferred stock and common stock not in the scope of ASC 323 were as follows (in thousands):

	June 30,		December 31,
	2023		2022
GABA Therapeutics, Inc.	$	2,623	$	5,387
DemeRx NB, Inc.		1,024		1,024
Juvenescence Limited		344		344
Total	$	3,991	$	6,755

Schedule Of Equity Method Investment Summarized Balance Sheet

The following is a summary of financial data for investments accounted for under the equity method of accounting (in thousands):

Balance Sheets

	June 30, 2023
	COMPASS		GABA
Current assets	$	193,601	$	1,773
Non-current assets		16,233		—
Total assets	$	209,834	$	1,773
Current liabilities	$	12,775	$	1,751
Non-current liabilities		30,663		—
Total liabilities	$	43,438	$	1,751

	December 31, 2022
	COMPASS		GABA
Current assets	$	191,651	$	3,933
Non-current assets		5,643		—
Total assets	$	197,294	$	3,933
Current liabilities	$	15,596	$	1,542
Non-current liabilities		418		—
Total liabilities	$	16,014	$	1,542

Shedule Of Equity Method Investment Summarized Statement Of Operations

Statements of operations

	Three Months Ended June 30, 2023
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(32,664	)	$	(1,928	)
Net loss	$	(28,335	)	$	(1,928	)
	Three Months Ended June 30, 2022
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(27,256	)	$	(1,964	)
Net loss	$	(21,037	)	$	(1,964	)

	Six Months Ended June 30, 2023
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(64,452	)	$	(2,961	)
Net loss	$	(52,543	)	$	(2,961	)
	Six Months Ended June 30, 2022
	COMPASS			GABA
Revenue	$	—		$	—
Loss from continuing operations	$	(52,676	)	$	(3,570	)
Net loss	$	(42,208	)	$	(3,570	)

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Fair Value Measurement (Tables)

6 Months Ended

Jun. 30, 2023

Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]

Summary of Fair Value Measurement on Recurring Basis

The following table presents information about the Company’s financial assets and liabilities that are measured at fair value on a recurring basis and indicates the fair value hierarchy of the valuation (in thousands):

	Fair Value Measurements
	As of June 30, 2023
	Level 1		Level 2		Level 3		Total
Assets:
Cash equivalents:
Cash & Money market funds	$	60,920	$	—	$	—	$	60,920
Investment in securities at fair value:
U.S. Treasuries		—		31,843		—		31,843
Commercial Paper		—		—		—		—
Corporate Notes/Bonds		—		4,900		—		4,900
U.S. Government Agencies		—		49,659		—		49,659
Other investment at fair value		—		—		—		—
	$	60,920	$	86,402	$	—	$	147,322
Liabilities:
Contingent consideration liability - related parties	$	—	$	—	$	842	$	842
	$	—	$	—	$	842	$	842

	Fair Value Measurements
	As of December 31, 2022
	Level 1		Level 2		Level 3		Total
Assets:
Cash equivalents:
Cash & Money market funds	$	72,334	$	—	$	—	$	72,334
Investment in securities at fair value:
U.S. Treasuries		—		—		—		—
Commercial Paper		—		5,958		—		5,958
Corporate Notes/Bonds		—		17,719		—		17,719
U.S. Government Agencies		—		58,819		—		58,819
Other investment at fair value		—		—		—		—
	$	72,334	$	82,496	$	—	$	154,830
Liabilities:
Contingent consideration liability - related parties	$	—	$	—	$	953	$	953
	$	—	$	—	$	953	$	953

Summary of Fair Value Measurement Inputs and Valuation Techniques

The fair value of the Perception contingent consideration liability - related parties was calculated using the following significant unobservable inputs:

		June 30, 2023	December 31, 2022
Valuation Technique	Significant Unobservable Inputs	Input Range	Input Range
Discounted cash flow	Milestone contingent consideration:
	Discount rate	14.0%	13.1%
	Probability of the milestone	28.0%	10.0% - 21.0%
Discounted cash flow    with SBM	Royalty contingent consideration:
	Discount rate for royalties	12.9% - 14.7%	20.0% - 21.1%
	Discount rate for royalties on milestones	12.9% - 14.7%	12.3% - 13.4%
	Probability of success rate	13.4% - 28.0%	10.1% - 21.0%

Summary of Fair Value Measurement on Recurring Basis, Unobservable Input Reconciliation

The following table provides a roll forward of the aggregate fair values of the Company’s financial instruments described above, for which fair value is determined using Level 3 inputs (in thousands):

	Contingent Consideration Liability - Related Parties
Balance as of December 31, 2022	$	953
Initial fair value of instrument		—
Change in fair value		(35	)
Extinguishment of liability		—
Balance as of March 31, 2023	$	918
Initial fair value of instrument		—
Change in fair value		(76	)
Extinguishment of liability		—
Balance as of June 30, 2023	$	842

	Contingent Consideration Liability - Related Parties
Balance as of December 31, 2021	$	2,483
Initial fair value of instrument		—
Change in fair value		—
Extinguishment of liability		(50	)
Balance as of March 31, 2022	$	2,433
Initial fair value of instrument		—
Change in fair value		(95	)
Extinguishment of liability		—
Balance as of June 30, 2022	$	2,338

Initial Warrants [Member]

Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]

Summary of Fair Value Measurement Inputs and Valuation Techniques

The following table summarizes significant unobservable inputs that are included in the valuation of the Initial Warrants as of June 30, 2023 and as of December 31, 2022:

	June 30, 2023			December 31, 2022
Value of Underlying	$	0.18		$	0.19
Expected Volatility		100	%		100	%

Additional Warrants [Member]

Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]

Summary of Fair Value Measurement Inputs and Valuation Techniques

The following table summarizes significant unobservable inputs that are included in the valuation of the Additional Units Warrant as of June 30, 2023 and as of December 31, 2022:

	June 30, 2023			December 31, 2022
Value of Underlying	$	0.18		$	0.19
Expected Volatility		105	%		100	%

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Prepaid Expenses and Other Current Assets (Tables)

6 Months Ended

Jun. 30, 2023

Prepaid Expense and Other Assets, Current [Abstract]

Summary of prepaid expenses and other current assets

Prepaid expenses consist of the following (in thousands):

	June 30, 2023		December 31, 2022
Prepaid insurance	$	41	$	2,034
Prepaid research and development related expenses		3,019		4,626
Tax receivables		1,762		5,631
Other		1,435		1,745
Total	$	6,257	$	14,036

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Accrued Liabilities (Tables)

6 Months Ended

Jun. 30, 2023

Accrued Liabilities, Current [Abstract]

Summary of accrued liabilities

Accrued liabilities consist of the following (in thousands):

	June 30, 2023		December 31, 2022
Accrued accounting, legal, and other professional fees	$	3,023	$	3,566
Accrued external research and development expenses		4,886		5,550
Accrued restructuring costs		91		—
Accrued payroll		3,137		5,260
Taxes payable		808		2,224
Other liabilities		910		706
Total	$	12,855	$	17,306

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Leases (Tables)

6 Months Ended

Jun. 30, 2023

Leases [Abstract]

Schedule of operating leases assets and liabilities lessee

ROU assets and lease liabilities related to the Company’s operating leases are as follows (in thousands):

	Balance Sheet Classification	June 30, 2023		December 31, 2022
Right-of-use assets	Operating lease right-of-use asset, net	$	1,367	$	226
Current lease liabilities	Current portion of lease liability		322		180
Non-current lease liabilities	Non-current portion of lease liability		1,095		44

Components of expenses related to leases is recorded on a straight-line basis over the lease term

The following table summarizes lease costs by component for the three and six months ended June 30, 2023 and 2022 (in thousands):

Lease Cost Components	Statement of Operations Classification	Three months ended June 30, 2023		Three months ended June 30, 2022		Six months ended June 30, 2023		Six months ended June 30, 2022
Operating lease cost	Operating expenses: General and administrative	$	145	$	77	$	280	$	124
Short-term lease cost	Operating expenses: General and administrative		88		122		180		221
Total lease cost		$	233	$	199	$	460	$	345

Schedule of future minimum commitments maturity operating leases

Future minimum commitments under all non-cancelable operating leases are as follows (in thousands):

Year Ended
2023 (excluding six months ended June 30, 2023)	$	249
2024		410
2025		366
2026		366
2027		366
2028		122
Total lease payments		1,879
Less: Imputed interest		(462	)
Present value of lease liabilities	$	1,417

Schedule of supplemental cash flow information related to operating leases

Supplemental cash flow information related to the Company’s operating leases for the six months ended June 30, 2023 and 2022 are as follows (in thousands):

	Six months ended June 30, 2023		Six months ended June 30, 2022
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases	$	187	$	120
Right-of-use assets obtained in exchange for new operating lease liabilities		1,356		487

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Debt (Tables)

6 Months Ended

Jun. 30, 2023

Debt Disclosure [Abstract]

Summary of convertible promissory notes

Convertible promissory notes—related parties, net of discounts and deferred issuance costs, consisted of the following (in thousands):

	June 30, 2023		December 31, 2022
Convertible notes issued in October 2020	$	420	$	415
Total	$	420	$	415

Schedule of Outstanding debt obligations

Outstanding debt obligations are as follows (in thousands):

	June 30, 2023			December 31, 2022
Principal amount	$	15,000		$	15,000
End of the term charge		1,042			1,042
Less: unamortized issuance discount		(240	)		(274	)
Less: unamortized issuance costs		(99	)		(113	)
Less: unamortized end of term charge		(835	)		(952	)
Net carrying amount		14,868			14,702
Less: current maturities		—			—
Long-term debt, net of current maturities and unamortized debt discount and issuance costs	$	14,868		$	14,702

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Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2023

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

Summary of Share-based Payment Arrangement, Option, Activity

The following is a summary of stock option activity from December 31, 2022 to June 30, 2023:

	Number of Options				Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Outstanding as of December 31, 2022		34,880,604			$	5.98		5.71	$	10,647
Granted		9,862,628		(1)		1.29		—		—
Exercised		(74,562	)			2.44		—		—
Cancelled or forfeited		(2,775,481	)			7.47		—		—
Outstanding as of June 30, 2023		41,893,189		(2)	$	4.78		6.13	$	10,203
Options exercisable as of June 30, 2023		21,049,667			$	5.31		4.01	$	5,723

(1)Includes (a) 9,862,628 stock options that will vest over a four-year service period.

(2)The 20,843,522 outstanding unvested stock options includes (a) 19,301,248 that will continue to vest over a one to four-year service period, (b) 1,269,708 that will continue to vest over a three to four-year service period and upon the satisfaction of specified performance-based vesting conditions, (c) 100,000 stock options that will continue to vest over a two-year service period and upon the satisfaction of specified market-based conditions tied to price of the Company's publicly traded shares, and (d) 172,566 stock options that will continue to vest over a three-year service period and upon the satisfaction of specified performance-based vesting conditions, which were achieved in the fourth quarter of 2022.

Summary of Employee Stock Ownership Plan (ESOP) Disclosures

The following is a summary of stock option activity from December 31, 2022 to June 30, 2023:

	Number of Options		Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Outstanding as of December 31, 2022		6,921,829		6.64		13.01	$	—
Granted		—		—		—		—
Exercised		—		—		—		—
Cancelled or forfeited		—		—		—		—
Outstanding as of June 30, 2023		6,921,829	$	6.64		12.51	$	—
Options exercisable as of June 30, 2023		6,432,646	$	6.64		12.51	$	—

Shedule of Restricted Stock Unit Activity

The following is a summary of restricted stock unit activity from December 31, 2022 to June 30, 2023:

	Restricted Stock Units		Weighted Average Grant Date Fair Value
Unvested at January 1, 2023		—	$	—
Granted		3,251,815		1.18
Vested		—		—
Forfeited		80,680		1.18
Unvested at June 30, 2023		3,171,135	$	1.18

Share-based Payment Arrangement, Expensed and Capitalized, Amount

The following table summarizes the total stock-based compensation expense by function for the three months ended June 30, 2023, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Three Months Ended June 30, 2023
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	3,168	$	—	$	107	$	3,275
General and administrative		4,580		894		13		5,487
Total share based compensation expense	$	7,748	$	894	$	120	$	8,762

The following table summarizes the total stock-based compensation expense by function for the three months ended June 30, 2022, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Three Months Ended June 30, 2022
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	3,717	$	—	$	149	$	3,866
General and administrative		4,395		1,176		74		5,645
Total share based compensation expense	$	8,112	$	1,176	$	223	$	9,511

The following table summarizes the total stock-based compensation expense by function for the six months ended June 30, 2023, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Six Months Ended June 30, 2023
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	6,528	$	—	$	213	$	6,741
General and administrative		8,890		1,768		25		10,683
Total share based compensation expense	$	15,418	$	1,768	$	238	$	17,424

The following table summarizes the total stock-based compensation expense by function for the six months ended June 30, 2022, which includes expense related to stock options and restricted stock unit awards (in thousands):

	Six Months Ended June 30, 2022
	Atai 2020 and 2021 Incentive Plans		Atai 2020 HSOP Partnership		Other Subsidiary Equity Plans		Total
Research and development	$	7,344	$	—	$	296	$	7,640
General and administrative		9,402		2,526		152		12,080
Total share based compensation expense	$	16,746	$	2,526	$	448	$	19,720

Two Thousand And Twenty Incentive Plan [Member]

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions

The Company estimates the fair value of each stock option using the Black-Scholes option-pricing model on the date of grant. During the six months ended June 30, 2023, the assumptions used in the Black-Scholes option pricing model were as follows:

	June 30,
	2023	2022
Weighted average expected term in years	6.07	5.93
Weighted average expected stock price volatility	86.4%	70.5%
Risk-free interest rate	3.50% - 3.92%	1.46% - 3.03%
Expected dividend yield	0%	0%

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Net Loss Per Share (Tables)

6 Months Ended

Jun. 30, 2023

Earnings Per Share [Abstract]

Schedule of Basis and Diluted Net Loss Per Share Attributable to ATAI Stockholders

Basic and diluted net loss per share attributable to atai stockholders were calculated as follows (in thousands, except share and per share data):

	Three Months Ended June 30,						Six Months Ended June 30,
	2023			2022			2023			2022
Numerator:
Net loss	$	(33,771	)	$	(37,509	)	$	(68,126	)	$	(75,067	)
Net loss attributable to noncontrolling interests		(729	)		(891	)		(1,948	)		(1,580	)
Net loss attributable to ATAI Life Sciences    N.V. shareholders — basic and diluted	$	(33,042	)	$	(36,618	)	$	(66,178	)	$	(73,487	)
Denominator:
Weighted average common shares outstanding    attributable to ATAI Life Sciences N.V.    Stockholders — basic and diluted		155,792,490			153,971,202			155,793,323			153,751,456
Net loss per share attributable to ATAI Life    Sciences N.V. shareholders — basic and diluted	$	(0.21	)	$	(0.24	)	$	(0.42	)	$	(0.48	)

Schedule of Computation of Diluted net Income (Loss) Per Share Attributable to Common Shareholders

Potentially dilutive securities to the Company’s common shares:

	As of June 30,
	2023		2022
Options to purchase common stock		41,893,189		34,410,771
HSOP options to purchase common stock		6,921,829		7,046,496
2018 Convertible Promissory Notes - Related Parties (Note 11)		6,201,824		9,561,824
Unvested restricted stock units		3,171,135		—
		58,187,977		51,019,091

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Corporate Restructuring (Tables)

6 Months Ended

Jun. 30, 2023

Restructuring and Related Activities [Abstract]

Schedule Of Reconciliation Of The Restructuring Charges And Related Payments

A reconciliation of the restructuring charges and related payments for the six months ended June 30, 2023 is as follows:

	Six Months Ended June 30, 2023
Restructuring liability as of December 31, 2022	$	—
Restructuring costs expensed during the period		3,194
Non-cash impact of stock-based compensation		(195	)
Cash payments of restructuring liabilities, net		(2,908	)
Restructuring liability as of June 30, 2023	$	91

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Organization and Description of Business - Additional Information (Detail) $ / shares in Units, $ in Thousands	Jun. 30, 2023 USD ($) $ / shares	Jun. 30, 2023 € / shares	Dec. 31, 2022 USD ($) $ / shares	Dec. 31, 2022 € / shares
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Common stock, par value | (per share)	$ 0.12	€ 0.10	$ 0.12	€ 0.10
Short-term debt securities	$ 86,400
Cash and cash equivalents	141,090		$ 190,613
Accumulated deficit	$ (576,891)		$ (510,188)

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Basis of Presentation and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ in Thousands	1 Months Ended
	May 31, 2022	Jun. 30, 2023	Jan. 01, 2023	Dec. 31, 2022	Jan. 01, 2022
Accounting Policies [Line Items]
Operating lease right-of-use asset, net		$ 1,367		$ 226	$ 200
Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]					Other Assets, Noncurrent
Current portion of lease liability		322		180	$ 100
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]					Other Liabilities, Current
Non-current portion of lease liability		1,095		44	$ 100
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]					Other Liabilities, Noncurrent
Carrying Value Of Investment		0		0
Cumulative Effect, Period of Adoption, Adjustment [Member]
Accounting Policies [Line Items]
Accumulated Deficit Net Of Tax			$ 500
Lease Agreements [Member]
Accounting Policies [Line Items]
Operating Lease Payment	$ 1,800
2018 Convertible Notes [Member]
Accounting Policies [Line Items]
Carrying amount of convertible promissory note		400		400
Fair value amount of convertible promissory note		$ 6,500		$ 13,100

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Basis of Presentation and Summary of Significant Accounting Policies - Schedule of fair value of our available-for-sale debt securities portfolio (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Accounting Policies [Line Items]
Fair value of available-for-sale debt securities	$ 147,322	$ 154,830
Money Market Funds [Member]
Accounting Policies [Line Items]
Fair value of available-for-sale debt securities	60,920	72,334
U.S. Treasuries [Member]
Accounting Policies [Line Items]
Fair value of available-for-sale debt securities	31,843	0
Commercial Paper [Member]
Accounting Policies [Line Items]
Fair value of available-for-sale debt securities	0	5,958
U.S. Government Agencies [Member]
Accounting Policies [Line Items]
Fair value of available-for-sale debt securities	49,659	58,819
Corporate Notes/Bonds [Member]
Accounting Policies [Line Items]
Fair value of available-for-sale debt securities	$ 4,900	$ 17,719

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Acquisitions - Additional Information (Detail) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended		12 Months Ended
	Nov. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022	May 31, 2021	Mar. 31, 2021	Oct. 31, 2020	Dec. 31, 2019
Business Combinations [Line Items]
Long-term notes receivable—related parties		$ 1,157		$ 1,157		$ 7,262
Non-operating income expense		$ 204	$ 4,551	$ 263	$ 6,072
Neuronasal, Inc. [Member]
Business Combinations [Line Items]
Ownership %	56.50%
Non-operating income expense						1,500
Impairment of loan receivable						$ 900
Neuronasal, Inc. [Member] | Common Stock [Member]
Business Combinations [Line Items]
Business acquisition, shares, cash contribution								$ 500	$ 300
Neuronasal, Inc. [Member] | Preferred Stock [Member]
Business Combinations [Line Items]
Business acquisition, shares, cash contribution							$ 1,000		$ 800	$ 500

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Variable Interest Entities and a Voting Interest Entity - Additional information (Detail) - USD ($) $ in Millions	3 Months Ended	9 Months Ended
	Mar. 31, 2023	Sep. 30, 2022	Jun. 30, 2023	Dec. 31, 2022
Variable Interest Entity [Line Items]
Variable Interest Entity, Reporting Entity Involvement, Maximum Loss Exposure, Amount			$ 3.9	$ 6.8
Variable Interest Entity, Nonconsolidated, Comparison of Carrying Amount of Assets and Liabilities to Maximum Loss Exposure				$ 7.2
Purchase of common stock	$ 1.0	$ 2.2
GABA Options [Member]
Variable Interest Entity [Line Items]
Equity method investment, ownership percentage			80.00%	80.00%
Short-Term [Member]
Variable Interest Entity [Line Items]
Variable Interest Entity, Nonconsolidated, Comparison of Carrying Amount of Assets and Liabilities to Maximum Loss Exposure			$ 9.0
Long-Term [Member]
Variable Interest Entity [Line Items]
Variable Interest Entity, Nonconsolidated, Comparison of Carrying Amount of Assets and Liabilities to Maximum Loss Exposure			$ 1.2

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Variable Interest Entities and a Voting Interest Entity - Summary of Primary Beneficiary for VIEs Consolidated Under the VIE Model (Detail)	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
Perception Neuroscience Holdings, Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	November 2018
Ownership %	59.20%	58.90%
Kures, Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	August 2019
Ownership %	64.50%	64.50%
EntheogeniX Biosciences, Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	November 2019
Ownership %	80.00%	80.00%
DemeRx IB, Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	December 2019
Ownership %	59.50%	59.50%
Recognify Life Sciences, Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	November 2020
Ownership %	51.90%	51.90%
PsyProtix, Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	February 2021
Ownership %	75.00%	75.00%
Psyber, Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	February 2021
Ownership %	75.00%	75.00%
InnarisBio, Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	March 2021
Ownership %	82.00%	82.00%
TryptageniX Inc. [Member]
Variable Interest Entity [Line Items]
Relationship	Controlled VIE	Controlled VIE
Date Control Obtained	December 2021
Ownership %	65.00%	65.00%

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Variable Interest Entities and a Voting Interest Entity - Summary of the Assets and Liabilities for all Consolidated VIEs (Detail) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Current assets:
Prepaid expenses and other current assets	$ 6,257	$ 14,036
Total current assets	242,770	287,145
Property and equipment, net	1,043	928
Other assets	3,267	3,125
Total assets	253,595	305,441
Current liabilities:
Accounts payable	3,859	2,399
Accrued liabilities	12,855	17,306
Short-term notes payable	86,400
Other current liabilities	890	12
Total current liabilities	17,926	19,897
Contingent consideration liability	842	953
Other non-current liabilities	2,807	3,664
Total liabilities	37,958	39,675
Perception [Member]
Current assets:
Cash	2,483	8,703
Accounts Receivable	205	197
Prepaid expenses and other current assets	310	466
Total current assets	2,998	9,366
Long term notes receivable	0	0
Other assets	0	0
Total assets	2,998	9,366
Current liabilities:
Accounts payable	581	661
Accrued liabilities	1,189	1,738
Other current liabilities	0	121
Total current liabilities	1,770	2,520
Total liabilities	1,770	2,520
Kures [Member]
Current assets:
Cash	56	220
Accounts Receivable	0	0
Prepaid expenses and other current assets	286	174
Total current assets	342	394
Long term notes receivable	0	0
Other assets	0	0
Total assets	342	394
Current liabilities:
Accounts payable	510	25
Accrued liabilities	62	266
Other current liabilities	0	2
Total current liabilities	572	293
Total liabilities	572	293
EntheogeniX [Member]
Current assets:
Cash	458	467
Accounts Receivable	0	0
Prepaid expenses and other current assets	147	91
Total current assets	605	558
Long term notes receivable	0	0
Other assets	0	0
Total assets	605	558
Current liabilities:
Accounts payable	246	124
Accrued liabilities	103	121
Other current liabilities	0	0
Total current liabilities	349	245
Total liabilities	349	245
DemeRx IB [Member]
Current assets:
Cash	10,395	12,251
Accounts Receivable	0	0
Prepaid expenses and other current assets	69	21
Total current assets	10,464	12,272
Long term notes receivable	1,063	1,075
Other assets	0	0
Total assets	11,527	13,347
Current liabilities:
Accounts payable	260	332
Accrued liabilities	284	671
Other current liabilities	0	133
Total current liabilities	544	1,136
Total liabilities	544	1,136
Recognify [Member]
Current assets:
Cash	4,108	7,526
Accounts Receivable	0	0
Prepaid expenses and other current assets	1,155	1,742
Total current assets	5,263	9,268
Long term notes receivable	0	0
Other assets	0	0
Total assets	5,263	9,268
Current liabilities:
Accounts payable	210	381
Accrued liabilities	396	596
Other current liabilities	0	2
Total current liabilities	606	979
Total liabilities	606	979
PsyProtix [Member]
Current assets:
Cash	14	1
Accounts Receivable	0	0
Prepaid expenses and other current assets	0	66
Total current assets	14	67
Long term notes receivable	94	109
Other assets	0	0
Total assets	108	176
Current liabilities:
Accounts payable	0	33
Accrued liabilities	45	46
Other current liabilities	0	1
Total current liabilities	45	80
Total liabilities	45	80
Psyber [Member]
Current assets:
Cash	541	683
Accounts Receivable	0	0
Prepaid expenses and other current assets	0	0
Total current assets	541	683
Long term notes receivable	0	0
Other assets	706	353
Total assets	1,247	1,036
Current liabilities:
Accounts payable	2	10
Accrued liabilities	118	37
Other current liabilities	0	1
Total current liabilities	120	48
Total liabilities	120	48
InnarisBio [Member]
Current assets:
Cash	503	719
Accounts Receivable	0	0
Prepaid expenses and other current assets	488	13
Total current assets	991	732
Long term notes receivable	0	0
Other assets	0	0
Total assets	991	732
Current liabilities:
Accounts payable	5	3
Accrued liabilities	327	158
Other current liabilities	0	1
Total current liabilities	332	162
Total liabilities	332	162
TryptageniX Inc. [Member]
Current assets:
Cash	82	513
Accounts Receivable	0	0
Prepaid expenses and other current assets	2,700	2,850
Total current assets	2,782	3,363
Long term notes receivable	0	0
Other assets	0	0
Total assets	2,782	3,363
Current liabilities:
Accounts payable	0	0
Accrued liabilities	118	154
Other current liabilities	0	0
Total current liabilities	118	154
Total liabilities	$ 118	$ 154

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Variable Interest Entities and a Voting Interest Entity - Schedule of Non Controlling Interest Recognized to Its Consolidated VIEs Roll Forward (Detail) - USD ($) $ in Thousands	3 Months Ended
	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Mar. 31, 2022
Noncontrolling Interest [Line Items]
Opening balance	$ 3,815	$ 5,026	$ 8,351	$ 9,051
Issuance of noncontrolling interests			957
Net loss attributable to noncontrolling interests - common	0	0
Net loss attributable to noncontrolling interests - preferred	(729)	(1,219)	(891)	(689)
Comprehensive loss attributable to noncontrolling interests	(1)	(8)	(30)	(11)
Closing balance	3,087	3,815	8,447	8,351
Perception [Member]
Noncontrolling Interest [Line Items]
Opening balance	1,037	1,731	4,650	5,232
Issuance of noncontrolling interests			0
Net loss attributable to noncontrolling interests - common	0	0
Net loss attributable to noncontrolling interests - preferred	(266)	(700)	(800)	(571)
Comprehensive loss attributable to noncontrolling interests	(1)	6	30	(11)
Closing balance	770	1,037	3,880	4,650
Kures [Member]
Noncontrolling Interest [Line Items]
Opening balance	360	451	0	0
Issuance of noncontrolling interests			957
Net loss attributable to noncontrolling interests - common	0	0
Net loss attributable to noncontrolling interests - preferred	(32)	(93)	0	0
Comprehensive loss attributable to noncontrolling interests	2	2	0	0
Closing balance	330	360	957	0
Recognify [Member]
Noncontrolling Interest [Line Items]
Opening balance	2,418	2,844	3,701	3,819
Issuance of noncontrolling interests			0
Net loss attributable to noncontrolling interests - common	0	0
Net loss attributable to noncontrolling interests - preferred	(431)	(426)	(91)	(118)
Comprehensive loss attributable to noncontrolling interests	0	0	0	0
Closing balance	$ 1,987	$ 2,418	$ 3,610	$ 3,701

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Variable Interest Entities and a Voting Interest Entity - Schedule of Roll Forward of the Redeemable Noncontrolling Interests Balance (Detail) - USD ($) $ in Thousands	3 Months Ended
	Jun. 30, 2023	Mar. 31, 2023
Redeemable Noncontrolling Interest [Line Items]
Net loss attributable to noncontrolling interests - common	$ 0	$ 0
Kures [Member]
Redeemable Noncontrolling Interest [Line Items]
Net loss attributable to noncontrolling interests - common	$ 0	$ 0

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Equity Method Investments and Other Investments - Summary of Equity Method Investments (Detail) - USD ($) $ in Thousands		6 Months Ended
		Jun. 30, 2023	Dec. 31, 2022	Dec. 07, 2021	Dec. 31, 2020
Schedule of Equity Method Investments [Line Items]
Equity Method Investments		$ 0	$ 0
COMPASS Pathways Plc Two [Member]
Schedule of Equity Method Investments [Line Items]
Equity Method Investment, Description of Principal Activities		December 2018
Equity Method Investments		$ 0	$ 0
Equity method investment, ownership percentage		20.90%	22.40%	22.80%
Innoplexus AG [Member]
Schedule of Equity Method Investments [Line Items]
Equity Method Investment, Description of Principal Activities		August 2018
Equity Method Investments		$ 0	$ 0
Equity method investment, ownership percentage		35.00%	35.00%		35.00%
GABA Therapeutics Inc [Member]
Schedule of Equity Method Investments [Line Items]
Equity Method Investment, Description of Principal Activities		November 2020
Equity Method Investments		$ 0	$ 0		$ 0
Equity method investment, ownership percentage	[1]	7.50%	7.50%

[1] The Company is deemed to have significant influence over this entity through its total ownership interest in the entity’s equity, including the Company’s investment in the respective entity’s preferred stock, described below in Other Investments. The Company’s total ownership interest, considering both preferred and common stock is 54.7%.

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Equity Method Investments and Other Investments - Summary of Equity Method Investments and Other Investments (Detail) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Investment [Line Items]
Other Long-term Investments	$ 3,991	$ 6,755
DemeRx NB Inc [Member]
Investment [Line Items]
Other Long-term Investments	1,024	1,024
Juvenescence Limited [Member]
Investment [Line Items]
Other Long-term Investments	344	344
GABA Therapeutics Inc [Member]
Investment [Line Items]
Other Long-term Investments	$ 2,623	$ 5,387

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Equity Method Investments and Other Investments - Summary of financial data for investments (Detail) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Shedule Of Equity Method Investment Summarized Balance Sheet [Line Items]
Current assets	$ 242,770	$ 287,145
Total assets	253,595	305,441
Current liabilities	17,926	19,897
Total liabilities	37,958	39,675
GABA Therapeutics Inc [Member]
Shedule Of Equity Method Investment Summarized Balance Sheet [Line Items]
Current assets	1,773	3,933
Non-current assets	0	0
Total assets	1,773	3,933
Current liabilities	1,751	1,542
Non-current liabilities	0	0
Total liabilities	1,751	1,542
COMPASS Pathways Plc Two [Member]
Shedule Of Equity Method Investment Summarized Balance Sheet [Line Items]
Current assets	193,601	191,651
Non-current assets	16,233	5,643
Total assets	209,834	197,294
Current liabilities	12,775	15,596
Non-current liabilities	30,663	418
Total liabilities	$ 43,438	$ 16,014

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Equity Method Investments and Other Investments - Summary of Statements of operations (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Shedule Of Equity Method Investment Summarized Statement Of Operations [Line Items]
Revenue	$ 172	$ 170	$ 209	$ 170
Net loss	(33,771)	(37,509)	(68,126)	(75,067)
COMPASS Pathways Plc Two [Member]
Shedule Of Equity Method Investment Summarized Statement Of Operations [Line Items]
Revenue	0	0	0	0
Loss from continuing operations	(32,664)	(27,256)	(64,452)	(52,676)
Net loss	(28,335)	(21,037)	(52,543)	(42,208)
GABA Therapeutics Inc [Member]
Shedule Of Equity Method Investment Summarized Statement Of Operations [Line Items]
Revenue	0	0	0	0
Loss from continuing operations	(1,928)	(1,964)	2,961	3,570
Net loss	$ (1,928)	$ (1,964)	$ 2,961	$ 3,570

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Equity Method Investments and Other Investments - Additional information (Detail) - USD ($) $ / shares in Units, $ in Thousands								1 Months Ended				3 Months Ended		6 Months Ended		12 Months Ended
		Sep. 30, 2022	May 31, 2021	May 15, 2021	May 14, 2021	Apr. 13, 2021	Nov. 30, 2020	Dec. 07, 2021	Feb. 28, 2021	Nov. 30, 2020	Aug. 31, 2019	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022	Dec. 31, 2019	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2021	Sep. 30, 2021	Feb. 16, 2021	Dec. 31, 2020
Cash and Cash Equivalents [Line Items]
Equity method investment, Investee shares sold														$ 9,600
Equity method investment, Shares transaction date														Dec. 31, 2026
Secured debt														$ 2,300		$ 2,400
Equity Method Investments												$ 0		0		$ 0
Losses from investments in equity method investees, net of tax												(1,928)	$ (6,652)	(2,961)	$ (12,248)
Fair value option gain loss														0
Warrant [Member]
Cash and Cash Equivalents [Line Items]
Shares, Outstanding																						44,000,000
Investment measured at fair value as per fair value option																				$ 1,200
IntelGenx SPA [Member]
Cash and Cash Equivalents [Line Items]
Business acquisition, Share price					$ 0.35
Fair value option gain loss												100		200
IntelGenx SPA [Member] | Strategic Development Agreement [Member]
Cash and Cash Equivalents [Line Items]
Percentage of the funds to be used for research and development purpose		20.00%
Compass Pathways Plc [Member]
Cash and Cash Equivalents [Line Items]
Equity method investment, Quoted market value												$ 79,200		$ 79,200
GABA Inc [Member]
Cash and Cash Equivalents [Line Items]
Percentage of voting interest acquired													50.00%		50.00%
IntelGenx Corp [Member]
Cash and Cash Equivalents [Line Items]
Percentage of voting interest acquired																					25.00%
Common Stock [Member]
Cash and Cash Equivalents [Line Items]
Shares, Outstanding												166,010,476	161,727,785	166,010,476	161,727,785	165,935,914		166,010,476	160,719,828	160,677,001
Common Stock [Member] | IntelGenx SPA [Member]
Cash and Cash Equivalents [Line Items]
Investment measured at fair value as per fair value option		$ 2,500																		$ 3,000
Unit [Member] | IntelGenx SPA [Member] | Warrant [Member]
Cash and Cash Equivalents [Line Items]
Investment measured at fair value as per fair value option																				$ 8,200
Unit [Member] | IntelGenx Corp [Member]
Cash and Cash Equivalents [Line Items]
Business acquisition, Share price					$ 0.331
IntelGenx [Member] | Warrant [Member]
Cash and Cash Equivalents [Line Items]
Investment measured at fair value as per fair value option					$ 1,200
IntelGenx [Member] | Unit [Member] | IntelGenx Corp [Member]
Cash and Cash Equivalents [Line Items]
Business acquisition, Share price					$ 0.75
Securities Purchase Agreement [Member]
Cash and Cash Equivalents [Line Items]
Number of years determining units purchase					3 years
Securities Purchase Agreement [Member] | IntelGenx SPA [Member]
Cash and Cash Equivalents [Line Items]
Payments to acquire investments					$ 12,300
Number of months determining unit price					12 months
Percentage Of Premium To Market Price					20.00%
Percentage of the volume weighted average price of the common share																					20.00%
Securities Purchase Agreement [Member] | IntelGenx Corp [Member]
Cash and Cash Equivalents [Line Items]
Business acquisition, Share price					$ 0.50
Securities Purchase Agreement [Member] | Common Stock [Member] | IntelGenx SPA [Member] | Minimum [Member]
Cash and Cash Equivalents [Line Items]
Investment owned number of shares					74,600,000
Securities Purchase Agreement [Member] | Additional Shares [Member] | IntelGenx SPA [Member] | Minimum [Member]
Cash and Cash Equivalents [Line Items]
Investment owned number of shares					74,600,000
Innoplexus AG [Member]
Cash and Cash Equivalents [Line Items]
Equity Method Investment, Ownership Percentage												35.00%		35.00%		35.00%							35.00%
Equity Method Investments												$ 0		$ 0		$ 0
Innoplexus AG [Member] | Innoplexus SPA [Member]
Cash and Cash Equivalents [Line Items]
Equity method investment, Investee shares sold									$ 2,400
Equity method investment, Proceeds														$ 22,300
COMPASS Pathways Plc Two [Member]
Cash and Cash Equivalents [Line Items]
Equity Method Investment, Ownership Percentage								22.80%				20.90%		20.90%		22.40%
Equity Method Investments												$ 0		$ 0		$ 0
Losses from investments in equity method investees, net of tax												$ 0	$ 4,700	$ 0	$ 9,500
Number of share purchased during period								1,490,111
Aggregate purchase price of additional shares purchased								$ 47,400
GABA Therapeutics Inc [Member]
Cash and Cash Equivalents [Line Items]
Equity Method Investment, Ownership Percentage	[1]											7.50%		7.50%		7.50%
Equity Method Investments												$ 0		$ 0		$ 0							$ 0
Losses from investments in equity method investees, net of tax												1,900	$ 1,900	2,900	$ 2,700
GABA Therapeutics Inc [Member] | Additional Shares [Member]
Cash and Cash Equivalents [Line Items]
Payments to acquire investments							$ 2,000
GABA Therapeutics Inc [Member] | Amended GABA PSPA | Preferred Stock [Member] | Series A Preferred Stock [Member]
Cash and Cash Equivalents [Line Items]
Equity Method Investment, Ownership Percentage											20.00%
Payments to acquire investments			$ 600								$ 5,500
GABA Therapeutics Inc [Member] | Amended GABA PSPA | Common Stock [Member] | Series A Preferred Stock [Member]
Cash and Cash Equivalents [Line Items]
Equity Method Investments												$ 900		900
Payments to acquire investments		$ 600		$ 5,000		$ 5,000								$ 10,000
GABA Therapeutics Inc [Member] | Amended GABA PSPA | Additional Shares [Member] | Series A Preferred Stock [Member]
Cash and Cash Equivalents [Line Items]
Equity Method Investments			$ 1,500
GABA Therapeutics Inc [Member] | Omnibus Amendment Agreement [Member]
Cash and Cash Equivalents [Line Items]
Payments to acquire investments										$ 1,800
GABA Options [Member]
Cash and Cash Equivalents [Line Items]
Equity Method Investment, Ownership Percentage												80.00%		80.00%		80.00%
DemeRx NB Options [Member] | Series A Preferred Stock [Member]
Cash and Cash Equivalents [Line Items]
Equity Method Investment, Ownership Percentage																	20.00%
Payments to acquire investments																	$ 1,000
Option to purchase additional shares value																					$ 19,000

[1] The Company is deemed to have significant influence over this entity through its total ownership interest in the entity’s equity, including the Company’s investment in the respective entity’s preferred stock, described below in Other Investments. The Company’s total ownership interest, considering both preferred and common stock is 54.7%.

XML

Notes Receivable - Additional Information (Detail) $ / shares in Units, $ in Millions					3 Months Ended		6 Months Ended		9 Months Ended	12 Months Ended
	Sep. 14, 2021 USD ($)	May 14, 2021 USD ($)	May 11, 2021 USD ($)	Jan. 03, 2020 USD ($) $ / shares	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Sep. 30, 2021	Dec. 31, 2021	Jun. 30, 2023 € / shares	Jun. 30, 2023 USD ($) $ / shares	Dec. 31, 2022 € / shares	Dec. 31, 2022 USD ($) $ / shares	Mar. 08, 2021 USD ($)
Notes Receivable [Line Items]
Proceeds from issuance of equity		$ 3.0
Loans and lease receivable, Outstanding												$ 8.5		$ 5.5
Interest income					$ 0.2	$ 0.1	$ 0.4	$ 0.2
Issuance of common stock shares par value | (per share)											€ 0.10	$ 0.12	€ 0.10	$ 0.12
Amended and Restated Loan Agreement [Member]
Notes Receivable [Line Items]
Loan agreement	$ 6.0
Term Loan Receivable [Member]
Notes Receivable [Line Items]
Allowance for credit losses							$ 0.4
Loans Receivable [Member]
Notes Receivable [Line Items]
Receivables, Maturity description							n May 2021, the Company amended the loan agreement under which the Maturity Date will be the first business day following the first closing of a subscription for additional units if the proceeds from such subscription amount to at least $3.0 million.
IntelGenx Corp [Member]
Notes Receivable [Line Items]
Loans receivable, Fixed interest rate										8.00%
IntelGenx Corp [Member] | Additional Term Loan And March Term Loan [Member]
Notes Receivable [Line Items]
Payments to acquire notes receivable			$ 0.5
IntelGenx Corp [Member] | March Term Loan Receivable [Member]
Notes Receivable [Line Items]
Receivable, Face amount															$ 2.0
IntelGenx Corp [Member] | Additional Term Loan Receivable [Member]
Notes Receivable [Line Items]
Receivable, Face amount															$ 0.5
IntelGenx Corp [Member] | Additional Term Loan Receivable [Member] | Amended and Restated Loan Agreement [Member]
Notes Receivable [Line Items]
Receivable, Face amount	6.0
IntelGenx Corp [Member] | Additional Term Loan Receivable [Member] | First Tranche [Member] | Amended and Restated Loan Agreement [Member]
Notes Receivable [Line Items]
Receivable, Face amount	3.0
IntelGenx Corp [Member] | Additional Term Loan Receivable [Member] | Second Tranche [Member] | Amended and Restated Loan Agreement [Member]
Notes Receivable [Line Items]
Receivable, Face amount	3.0
IntelGenx Corp [Member] | Term Loan Receivable [Member]
Notes Receivable [Line Items]
Receivable, Face amount	$ 8.5
Receivables, Maturity terms									120 days
IntelGenx Corp [Member] | Term Loan Receivable [Member] | Amended and Restated Loan Agreement [Member]
Notes Receivable [Line Items]
Term loan maturity date	Jan. 05, 2024
Promissory Note Agreement [Member] | DemeRx [Member]
Notes Receivable [Line Items]
Debt Instrument, face amount inclusive other payments				$ 1.0
DemeRx Note [Member]
Notes Receivable [Line Items]
Receivables, Maturity terms				5 years
Loans and lease receivable, Outstanding												$ 1.1		$ 1.1
Allowance for credit losses							$ 0.1
DemeRx Note [Member] | DemeRx IB, Inc. [Member]
Notes Receivable [Line Items]
Issuance of common stock shares par value | $ / shares				$ 0.0001
DemeRx Note [Member] | DemeRx [Member]
Notes Receivable [Line Items]
Debt Instrument, face amount inclusive other payments				$ 1.0

XML

Fair Value Measurement - Summary of Fair Value Measurement on Recurring Basis (Detail) - Fair Value, Recurring [Member] - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Cash equivalents:
Cash & Money market funds	$ 60,920	$ 72,334
Other investment at fair value	0	0
Assets fair value	147,322	154,830
Liabilities:
Contingent consideration liability—related parties	842	953
Liability fair value	842	953
U.S. Treasuries [Member]
Cash equivalents:
Fair value of debt securities	31,843	0
Commercial Paper [Member]
Cash equivalents:
Fair value of debt securities	0	5,958
Corporate Notes/Bonds [Member]
Cash equivalents:
Fair value of debt securities	4,900	17,719
U.S. Government Agencies [Member]
Cash equivalents:
Fair value of debt securities	49,659	58,819
Fair Value, Inputs, Level 1 [Member]
Cash equivalents:
Cash & Money market funds	60,920	72,334
Other investment at fair value	0	0
Assets fair value	60,920	72,334
Liabilities:
Contingent consideration liability—related parties	0	0
Liability fair value	0	0
Fair Value, Inputs, Level 1 [Member] | U.S. Treasuries [Member]
Cash equivalents:
Fair value of debt securities	0	0
Fair Value, Inputs, Level 1 [Member] | Commercial Paper [Member]
Cash equivalents:
Fair value of debt securities	0	0
Fair Value, Inputs, Level 1 [Member] | Corporate Notes/Bonds [Member]
Cash equivalents:
Fair value of debt securities	0	0
Fair Value, Inputs, Level 1 [Member] | U.S. Government Agencies [Member]
Cash equivalents:
Fair value of debt securities	0	0
Fair Value, Inputs, Level 2 [Member]
Cash equivalents:
Cash & Money market funds	0	0
Other investment at fair value	0	0
Assets fair value	86,402	82,496
Liabilities:
Contingent consideration liability—related parties	0	0
Liability fair value	0	0
Fair Value, Inputs, Level 2 [Member] | U.S. Treasuries [Member]
Cash equivalents:
Fair value of debt securities	31,843	0
Fair Value, Inputs, Level 2 [Member] | Commercial Paper [Member]
Cash equivalents:
Fair value of debt securities	0	5,958
Fair Value, Inputs, Level 2 [Member] | Corporate Notes/Bonds [Member]
Cash equivalents:
Fair value of debt securities	4,900	17,719
Fair Value, Inputs, Level 2 [Member] | U.S. Government Agencies [Member]
Cash equivalents:
Fair value of debt securities	49,659	58,819
Fair Value, Inputs, Level 3 [Member]
Cash equivalents:
Cash & Money market funds	0	0
Other investment at fair value	0	0
Assets fair value	0	0
Liabilities:
Contingent consideration liability—related parties	842	953
Liability fair value	842	953
Fair Value, Inputs, Level 3 [Member] | U.S. Treasuries [Member]
Cash equivalents:
Fair value of debt securities	0	0
Fair Value, Inputs, Level 3 [Member] | Commercial Paper [Member]
Cash equivalents:
Fair value of debt securities	0	0
Fair Value, Inputs, Level 3 [Member] | Corporate Notes/Bonds [Member]
Cash equivalents:
Fair value of debt securities	0	0
Fair Value, Inputs, Level 3 [Member] | U.S. Government Agencies [Member]
Cash equivalents:
Fair value of debt securities	$ 0	$ 0

XML

Fair Value Measurement - Summary of Fair Value Measurement Inputs and Valuation Techniques (Detail)	Jun. 30, 2023	Dec. 31, 2022
Measurement Input, Price Volatility [Member] | Fair Value, Inputs, Level 3 [Member] | Additional Warrants [Member] | IntelGenx [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Warrant Liability, Measurement Input	1.05	1
Measurement Input, Price Volatility [Member] | Neuronasal Inc [Member] | Fair Value, Inputs, Level 3 [Member] | Initial Warrants [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Warrant Liability, Measurement Input	1	1
Measurement Input, Share Price [Member] | Fair Value, Inputs, Level 3 [Member] | Additional Warrants [Member] | IntelGenx [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Alternative Investment, Measurement Input	0.18	0.19
Value Of Underlying [Member] | Neuronasal Inc [Member] | Fair Value, Inputs, Level 3 [Member] | Initial Warrants [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Warrant Liability, Measurement Input	0.18	0.19
Contingent Consideration Liability Related Parties [Member] | Measurement Input, Discount Rate [Member] | Valuation Technique, Discounted Cash Flow [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input	0.140	0.131
Contingent Consideration Liability Related Parties [Member] | Measurement Input Probability of the Milestone [Member] | Valuation Technique, Discounted Cash Flow [Member] | Minimum [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input	0.280	0.100
Contingent Consideration Liability Related Parties [Member] | Measurement Input Probability of the Milestone [Member] | Valuation Technique, Discounted Cash Flow [Member] | Maximum [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input		0.210
Contingent Consideration Liability Related Parties [Member] | Measurement Input Discount Rate for Royalties [Member] | Discounted Cash Flow with SBM [Member] | Minimum [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input	0.129	0.200
Contingent Consideration Liability Related Parties [Member] | Measurement Input Discount Rate for Royalties [Member] | Discounted Cash Flow with SBM [Member] | Maximum [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input	0.147	0.211
Contingent Consideration Liability Related Parties [Member] | Measurement Input Discount Rate for Royalties on Milestones [Member] | Discounted Cash Flow with SBM [Member] | Minimum [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input	0.129	0.123
Contingent Consideration Liability Related Parties [Member] | Measurement Input Discount Rate for Royalties on Milestones [Member] | Discounted Cash Flow with SBM [Member] | Maximum [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input	0.147	0.134
Contingent Consideration Liability Related Parties [Member] | Probability of Success Rate [Member] | Discounted Cash Flow with SBM [Member] | Minimum [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input	0.134	0.101
Contingent Consideration Liability Related Parties [Member] | Probability of Success Rate [Member] | Discounted Cash Flow with SBM [Member] | Maximum [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Business Combination, Contingent Consideration, Liability, Measurement Input	0.280	0.210

XML

Fair Value Measurement - Summary of Fair Value Measurement on Recurring Basis, Unobservable Input Reconciliation (Detail) - Contingent Consideration Liability Related Parties [Member] - USD ($) $ in Thousands	3 Months Ended
	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Mar. 31, 2022
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Beginning Balance		$ 953		$ 2,483
Beginning Balance	$ 918		$ 2,433
Initial fair value of instrument	0	0	0	0
Change in fair value	(76)	(35)	(95)	0
Extinguishment of liability	0	0	0	(50)
Ending Balance	$ 842	$ 918	$ 2,338	$ 2,433

XML

Fair Value Measurement - Additional Information (Detail) - USD ($) $ in Millions	Jun. 30, 2023	Dec. 31, 2022	Dec. 31, 2021	May 14, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of the contingent milestone and royalty liabilities	$ 0.1	$ 0.1
Fair value of common stock by applying discount for lack of marketability	5.00%	5.00%
TryptageniX Inc. [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of the contingent milestone and royalty liabilities	$ 0.2	$ 0.2
Common Stock [Member] | IntelGenx [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investment measured at fair value as per fair value option				$ 3.0
Warrant [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investment measured at fair value as per fair value option			$ 1.2
Warrant [Member] | IntelGenx [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investment measured at fair value as per fair value option				1.2
Additional Warrants [Member] | IntelGenx [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investment measured at fair value as per fair value option				$ 8.2
Royalty Liabilities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of the contingent milestone and royalty liabilities	$ 0.6	$ 0.6

XML

Prepaid Expenses and Other Current Assets - Summary of Prepaid Expenses and Other Current Assets (Detail) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Prepaid Expense and Other Assets, Current [Abstract]
Prepaid insurance	$ 41	$ 2,034
Prepaid Research And Development Related Expenses	3,019	4,626
Tax receivables	1,762	5,631
Other	1,435	1,745
Total	$ 6,257	$ 14,036

XML

Accrued Liabilities - Summary of Accrued Liabilities (Detail) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Accrued Liabilities, Current [Abstract]
Accrued accounting, legal, and other professional fees	$ 3,023	$ 3,566
Accrued external research and development expenses	4,886	5,550
Accrued restructuring costs	91	0
Accrued payroll	3,137	5,260
Taxes payable	808	2,224
Other liabilities	910	706
Total	$ 12,855	$ 17,306

XML

Leases (Additional Information) (Details)	Jun. 30, 2023
Leases [Abstract]
Operating Lease, Weighted Average Discount Rate, Percent	12.50%
Operating Lease, Weighted Average Remaining Lease Term	4 years 6 months

XML

Leases - Schedule of operating leases assets and liabilities lessee (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022	Jan. 01, 2022
Leases [Abstract]
Operating lease right-of-use asset, net	$ 1,367	$ 226	$ 200
Current portion of lease liability	322	180	100
Non-current portion of lease liability	$ 1,095	$ 44	$ 100

XML

Leases - Components of expenses related to leases is recorded on a straight-line basis over the lease term (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Operating lease cost		$ 77	$ 280	$ 124
General and Administrative Expense [Member]
Short-term lease cost	$ 88	122	180	221
Operating lease cost	145
Total lease cost	$ 233	$ 199	$ 460	$ 345

XML

Leases - Schedule of future minimum commitments maturity operating leases (Details) $ in Thousands	Jun. 30, 2023 USD ($)
Leases [Abstract]
2023 (excluding six months ended June 30, 2023)	$ 249
2024	410
2025	366
2026	366
2027	366
2028	122
Total lease payments	1,879
Less: Imputed interest	(462)
Operating Lease, Liability, Total	$ 1,417

XML

Leases - Schedule of supplemental cash flow information related to operating leases (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash paid for amounts included in the measurement of lease liabilities:
Operating cash flows from operating leases	$ 187	$ 120
Right of Use Asset Obtained in Exchange for Operating Lease Liabilities	$ 1,356	$ 487

XML

Debt - Summary of Convertible Promissory Notes (Detail) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Debt Instrument [Line Items]
Total	$ 420	$ 415
Convertible Notes Issued in October 2020 [Member]
Debt Instrument [Line Items]
Long-term Debt	$ 420	$ 415

XML

Debt - Additional Information (Detail) € / shares in Units, $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended		12 Months Ended
	Aug. 31, 2022 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 shares	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2022 EUR (€)	Dec. 31, 2021 USD ($)	Dec. 31, 2021 EUR (€) € / shares	May 26, 2023 USD ($)	Oct. 31, 2020 EUR (€)	Oct. 31, 2020 $ / shares	Nov. 30, 2018 USD ($)	Nov. 30, 2018 EUR (€)	Oct. 31, 2018 USD ($)	Oct. 31, 2018 EUR (€)
Debt Instrument [Line Items]
Convertible promissory notes issued		$ 15,000		$ 15,000		$ 15,000
Fair value of the outstanding debt obligation		$ 14,868		$ 14,868		14,702
Maturity date		Aug. 01, 2026		Aug. 01, 2026
Prime rate percent		4.55%		4.55%
Cash proceeds from certain permitted sources				$ 175,000
Accrued interest payable, percent		8.55%		8.55%
Amortization of debt discount				$ 173	$ 0
Borrowing amount percentage	33.00%
Common Stock [Member]
Debt Instrument [Line Items]
Stock issued during period, convertible share | shares			960,000
ATAI LIFE SCIENCES N.V. [Member]
Debt Instrument [Line Items]
Debt conversion price | $ / shares												$ 17.00
Face value of convertible notes | €											€ 1
2018 Convertible Note Agreement [Member]
Debt Instrument [Line Items]
Convertible promissory notes issued													$ 200	€ 200,000
Debt conversion price | € / shares									€ 17.00
Fair value of ordinary shares						4,600	€ 4,600,000	$ 6,900	€ 5,800,000
2018 Convertible Note Agreement [Member] | Maximum [Member]
Debt Instrument [Line Items]
Convertible promissory notes issued													1,200	1,000,000.0	$ 1,000	€ 800,000
2018 Convertible Note Agreement [Member] | Apeiron [Member]
Debt Instrument [Line Items]
Convertible promissory notes issued													600	500,000
2018 Convertible Note Agreement [Member] | Other Shareholder [Member]
Debt Instrument [Line Items]
Convertible promissory notes issued													$ 400	€ 300,000
Hercules Loan Agreement [Member]
Debt Instrument [Line Items]
Fair value of the outstanding debt obligation		$ 15,900		15,900		$ 14,900
Interest expense		$ 100		$ 200
Line of credit	$ 40,000									$ 30,000
Market capitalization daily basis	$ 550,000									550,000
Loan agreement description				In addition, the financial covenant under the Loan Agreement requires that beginning on the later of (i) July 1, 2023 and (ii) the date on which the aggregate outstanding amount borrowed under the 2022 Term Loan Facility is equal to or greater than $40.0 million, the Company shall maintain Qualified Cash in an amount no less than the sum of (1) 33% of the outstanding amount under the 2022 Term Loan Facility, and (2) the amount of the Borrowers’ and Subsidiary Guarantors’ accounts payable that have not been paid within 180 days from the invoice date of the relevant account payable, subject to certain exceptions; provided, that the financial covenant shall not apply on any day that the Company's market capitalization is at least $550.0 million measured on a consecutive 10-business day period immediately prior to such date of measurement and tested on a daily basis.
Term charge percentage	6.95%
Principal amount	$ 175,000
Hercules Loan Agreement [Member] | Line of Credit Agreements [Member]
Debt Instrument [Line Items]
Line of credit										40,000
Hercules Loan Agreement [Member] | Tranche 1B | Line of Credit Agreements [Member]
Debt Instrument [Line Items]
Term loan advance										10,000
Hercules Loan Agreement [Member] | Tranche 1C | Line of Credit Agreements [Member]
Debt Instrument [Line Items]
Term loan advance										15,000
Hercules Loan Agreement [Member] | Tranche 1D | Line of Credit Agreements [Member]
Debt Instrument [Line Items]
Term loan advance										20,000
Hercules Loan Agreement [Member] | Tranche 2 | Line of Credit Agreements [Member]
Debt Instrument [Line Items]
Term loan advance										$ 15,000
Prepayment occurs on or prior to the first anniversary[Member] | Hercules Loan Agreement [Member]
Debt Instrument [Line Items]
Prepayment principal amount percentage	2.00%
Prepayment occurs after the first anniversary and on or prior to the second anniversary [Member] | Hercules Loan Agreement [Member]
Debt Instrument [Line Items]
Prepayment principal amount percentage	1.00%
Prepayment occurs after the second anniversary [Member] | Hercules Loan Agreement [Member]
Debt Instrument [Line Items]
Prepayment principal amount percentage	0.50%

XML

Debt - Schedule of Outstanding debt obligations (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Debt and Lease Obligation [Abstract]
Principal amount	$ 15,000	$ 15,000
End of the term charge	1,042	1,042
Less: unamortized issuance discount	(240)	(274)
Less: unamortized issuance costs	(99)	(113)
Less: unamortized end of term charge	(835)	(952)
Net carrying amount	14,868	14,702
Less: current maturities	0	0
Long-term debt, net of current maturities and unamortized debt discount and issuance costs	$ 14,868	$ 14,702

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Stock-Based Compensation - Summary of share based Payment Arrangement Option Activity (Detail) - Service And Performance Based Options [Member] - Two Thousand And Twenty Incentive Plan [Member] - USD ($) $ / shares in Units, $ in Thousands		6 Months Ended		12 Months Ended
		Jun. 30, 2023		Dec. 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number Of Options Outstanding as of December 31, 2022		34,880,604
Number of Options, Granted	[1]	9,862,628
Number of Options, Exercised		(74,562)
Number of options, Cancelled or forfeited		(2,775,481)
Number of options Outstanding as of June 30, 2023		41,893,189	[2]	34,880,604
Number of Options exercisable as of June 30, 2023		21,049,667
Weighted-Average Exercise Price as of December 31, 2022		$ 5.98
Weighted-Average Exercise Price, Granted		1.29
Weighted-Average Exercise Price, Exercised		2.44
Weighted-Average Exercise Price, Cancelled or forfeited		7.47
Weighted-Average Exercise Price as of June 30, 2023		4.78		$ 5.98
Weighted-Average Exercise Price Options exercisable as of June 30, 2023		$ 5.31
Weighted-Average Remaining Contractual Term (Years)		6 years 1 month 17 days		5 years 8 months 15 days
Weighted-Average Remaining Contractual Term (Years), Options exercisable as of June 30, 2023		4 years 3 days
Aggregate Intrinsic Value, Outstanding		$ 10,203		$ 10,647
Aggregate Intrinsic Value, Options exercisable as of June 30, 2023		$ 5,723

[1] Includes (a) 9,862,628 stock options that will vest over a four-year service period.

[2] The 20,843,522 outstanding unvested stock options includes (a) 19,301,248 that will continue to vest over a one to four-year service period, (b) 1,269,708 that will continue to vest over a three to four-year service period and upon the satisfaction of specified performance-based vesting conditions, (c) 100,000 stock options that will continue to vest over a two-year service period and upon the satisfaction of specified market-based conditions tied to price of the Company's publicly traded shares, and (d) 172,566 stock options that will continue to vest over a three-year service period and upon the satisfaction of specified performance-based vesting conditions, which were achieved in the fourth quarter of 2022.

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Stock-Based Compensation - Summery of Vested and Non vested Option Outstanding (Parenthetical) (Details)	6 Months Ended
	Jun. 30, 2023 shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of options outstanding, including both vested and non-vested options.	20,843,522
Specified Performance Based Vesting [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share based payment arrangement, Options expected to vest outstanding	172,566
One to four year service period [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of options outstanding, including both vested and non-vested options.	19,301,248
Three To Four Year Service Period [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of options outstanding, including both vested and non-vested options.	1,269,708
Two Year Service Period [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share based payment arrangement, Options expected to vest outstanding	100,000
Two Thousand And Twenty Incentive Plan [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of Options, Granted	9,862,628

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Stock-Based Compensation - Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions (Detail) - Service And Performance Based Options [Member] - Two Thousand And Twenty Incentive Plan [Member]	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Weighted average expected term in years	6 years 25 days	5 days 22 hours
Weighted average expected stock price volatility	86.40%	70.50%
Risk-free interest rate, Minimum	3.50%	1.46%
Risk-free interest rate, Maximum	3.92%	3.03%
Expected dividend yield	0.00%	0.00%

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Stock-Based Compensation - Summary of Employee Stock Ownership Plan (ESOP) Disclosures (Detail) - HSOP Shares [Member] - HSOP Plan[Member] - $ / shares	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of optionsOutstanding as of January 1, 2023	6,921,829
Number of options Outstanding as of June 30, 2023	6,921,829	6,921,829
Number of Options,Options exercisable as of June 30, 2023	6,432,646
Weighted- Average Exercise Price Beginning as of December 31, 2022	$ 6.64
Weighted- Average Exercise Price as of June 30, 2023	6.64
Weighted- Average Exercise Price,Options exercisable as of June 30, 2023	$ 6.64
Weighted- Average Remaining Contractual Term (Years)	12 years 6 months 3 days	13 years 3 days
Weighted- Average Remaining Contractual Term (Years),Options exercisable as of June 30, 2023	12 years 6 months 3 days

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Stock-Based Compensation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Unrecognized stock based compensation compensation	$ 6.5		$ 6.5
Number of options outstanding, including both vested and non-vested options.	20,843,522		20,843,522
Other Subsidiaries Equity Plan
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Unrecognized stock based compensation compensation	$ 0.4		$ 0.4
Expected weighted average period			10 months 24 days
Share based compensation expenses	0.1	$ 0.2	$ 0.2	$ 0.4
Restricted Stock [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Unrecognized stock based compensation compensation	3.2		$ 3.2
Expected weighted average period			1 year 8 months 15 days
Fair Value Of Restricted Stock			$ 0.0
Share based compensation expenses	$ 0.5	0.0	$ 0.6	0.0
Specified Performance Based Vesting [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share based payment arrangement, Options expected to vest outstanding	172,566		172,566
HSOP Plan[Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Shares reserved for future issuance	257,419		257,419
Unrecognized stock based compensation compensation	$ 1.4		$ 1.4
Expected weighted average period			2 months 12 days
Share based compensation expenses	0.9	1.2	$ 1.8	2.5
Two Thousand And Twenty Incentive Plan [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Unrecognized stock based compensation compensation	52.8		$ 52.8
Expected weighted average period			1 year 10 months 28 days
Share based compensation expenses	$ 7.3	$ 8.1	$ 14.7	$ 16.7
Number of options outstanding	0		0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross			9,862,628
Two Thousand And Twenty Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Weighted average grant-date fair value of options granted			$ 0.96
Two Thousand And Twenty One Incentive Award Plan [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Shares reserved for future issuance	30,929,033		30,929,033

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Stock-Based Compensation - Summary of restricted stock awards (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	$ 8,762	$ 9,511	$ 17,424	$ 19,720
Atai ESOP [Member] | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	7,748	8,112	15,418	16,746
Atai HSOP [Member] | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	894	1,176	1,768	2,526
Other Subsidiaries Equity Plan
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	100	200	200	400
Other Subsidiaries Equity Plan | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	120	223	238	448
Research and Development Expense [Member] | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	3,275	3,866	6,741	7,640
Research and Development Expense [Member] | Atai ESOP [Member] | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	3,168	3,717	6,528	7,344
Research and Development Expense [Member] | Other Subsidiaries Equity Plan | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	107	149	213	296
General and Administrative Expense [Member] | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	5,487	5,645	10,683	12,080
General and Administrative Expense [Member] | Atai ESOP [Member] | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	4,580	4,395	8,890	9,402
General and Administrative Expense [Member] | Atai HSOP [Member] | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	894	1,176	1,768	2,526
General and Administrative Expense [Member] | Other Subsidiaries Equity Plan | Options and Restricted Stock Awards [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense	$ 13	$ 74	$ 25	$ 152

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Stock-Based Compensation - Summary of restricted common stock awards activity (Detail) - Restricted Stock Units (RSUs) [Member]	6 Months Ended
	Jun. 30, 2023 $ / shares shares
Share Based Arrangements To Obtain Goods And Services [Line Items]
Number of optionsOutstanding as of January 1, 2023 | shares	0
Number of Options, Granted | shares	3,251,815
Number of options,Vested | shares	0
Number of options,Forfeited | shares	80,680
Number of options Outstanding as of June 30, 2023 | shares	3,171,135
Weighted Average Grant Date Fair Valueat January 1, 2023 | $ / shares	$ 0
Weighted Average Grant Date Fair Value, Granted | $ / shares	1.18
Weighted Average Grant Date Fair Value, Vested | $ / shares	0
Weighted Average Grant Date Fair Value, Forfeited | $ / shares	1.18
Weighted Average Grant Date Fair Value at June 30, 2023 | $ / shares	$ 1.18

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Income Taxes - Additional Information (Detail) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Operating Loss Carryforwards [Line Items]
Provision for income taxes	$ 185,000	$ 51,000	$ 351,000	$ 92,000

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Net Loss Per Share - Summary of Basic and Diluted Net Loss Per Share (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Numerator:
Net loss	$ (33,771)	$ (37,509)	$ (68,126)	$ (75,067)
Net loss attributable to noncontrolling interests	(729)	(891)	(1,948)	(1,580)
Net loss attributable to ATAI Life Sciences N.V. shareholders - basic	(33,042)	(36,618)	(66,178)	(73,487)
Net loss attributable to ATAI Life Sciences N.V. shareholders - diluted	$ (33,042)	$ (36,618)	$ (66,178)	$ (73,487)
Denominator:
Weighted average common shares outstanding attributable to ATAI Life Sciences N.V. Stockholders - basic	155,792,490	153,971,202	155,793,323	153,751,456
Weighted average common shares outstanding attributable to ATAI Life Sciences N.V. stockholders - diluted	155,792,490	153,971,202	155,793,323	153,751,456
Net loss per share attributable to ATAI Life Sciences N.V. stockholders - basic	$ (0.21)	$ (0.24)	$ (0.42)	$ (0.48)
Net loss per share attributable to ATAI Life Sciences N.V. stockholders - diluted	$ (0.21)	$ (0.24)	$ (0.42)	$ (0.48)

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Net Loss Per Share - Schedule of Computation of Diluted net Income (Loss) Per Share Attributable to Common Shareholders (Detail) - shares	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	58,187,977	51,019,091
Options to purchase Common Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	41,893,189	34,410,771
HSOP options to purchase common stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	6,921,829	7,046,496
2018 Convertible Promissory Notes - Related Parties
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	6,201,824	9,561,824
Unvested restricted stock units
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	3,171,135	0

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Net Loss Per Share - Additional Information (Detail) - Common Stock [Member] - shares	3 Months Ended	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2023
Net Income (Loss) Per Share [Line Items]
Stock issued during period, convertible share	960,000
2018 Convertible Promissory Notes - Related Parties
Net Income (Loss) Per Share [Line Items]
Stock issued during period, convertible share		387,614
Common stock, conversion basis		one-for-sixteen

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License Agreements - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended			6 Months Ended		12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2021	Jan. 31, 2022	Jun. 30, 2020
License Agreements [Line Items]
Common Stock, Value, Issued	$ 18,571	$ 18,562	$ 300	$ 18,571	$ 300
Research and development expenses				0	357
ATAI Kures Inc. [Member] | License Agreement Terms [Member]
License Agreements [Line Items]
Percentage of the common stock shares outstanding								5.00%
Research And Development Services [Member] | License Agreement Terms [Member]
License Agreements [Line Items]
Research and development expenses			400		400
Otsuka Agreement [Member]
License Agreements [Line Items]
Revenue Related To Certain Research And Development	200		200	200	200
Accelerate License Agreement [Member]
License Agreements [Line Items]
Material Payment	0		0	0	0
CHIBA License [Member]
License Agreements [Line Items]
Material Payment	0		0	0	0
Allergan License Agreement [Member]
License Agreements [Line Items]
Material Payment	0		0	0	0
Dalriada License Agreement [Member]
License Agreements [Line Items]
Service fees			0		0	$ 12,800
Dalriada License Agreement [Member] | Research And Development Services [Member]
License Agreements [Line Items]
Research and development expenses	600	600	$ 1,400	1,100	$ 1,800
Invyxis ESLA [Member]
License Agreements [Line Items]
Upfront deposit							$ 1,100
Invyxis ESLA [Member] | Minimum [Member]
License Agreements [Line Items]
Upfront deposit		500
Invyxis ESLA [Member] | Maximum [Member]
License Agreements [Line Items]
Upfront deposit		$ 1,100
Otsuka [Member] | Otsuka Agreement [Member]
License Agreements [Line Items]
Performance obligation						$ 20,000
Otsuka [Member] | Commercial Milestones [Member] | Otsuka Agreement [Member]
License Agreements [Line Items]
Milestone payments, receivable	66,000			66,000
Otsuka [Member] | Development And Regulatory Milestones [Member] | Otsuka Agreement [Member]
License Agreements [Line Items]
Milestone payments, receivable	$ 35,000			$ 35,000

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Related Party Transactions - Additional Information (Detail) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended
	Mar. 31, 2021 shares	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 € / shares	Jun. 30, 2023 USD ($) $ / shares	Dec. 31, 2022 € / shares	Dec. 31, 2022 USD ($) $ / shares
Related Party Transaction [Line Items]
Principal amount							$ 15,000		$ 15,000
Issuance of common stock shares par value | (per share)						€ 0.10	$ 0.12	€ 0.10	$ 0.12
Percentage of common stock reserved				27.00%
General and administrative expense		$ 16,558	$ 17,221	$ 30,529	$ 35,203
General and Administrative Expense [Member]
Related Party Transaction [Line Items]
stock-based compensation		200	200	400	400
Apeiron [Member] | Common Stock [Member]
Related Party Transaction [Line Items]
Issuance of common shares, net of issuance costs				10,500
Stock issued during period, Value				10,500
Mr Angermayer [Member] | Consulting Agreement [Member]
Related Party Transaction [Line Items]
General and administrative expense		$ 100	$ 200	$ 300	$ 300
Mr Angermayer [Member] | Consulting Agreement [Member] | Two Thousand And Twenty Incentive Plan [Member]
Related Party Transaction [Line Items]
Stock issued during period, share based payments | shares	624,000
Atai Formation [Member] | Founder [Member]
Related Party Transaction [Line Items]
Equity method investment, ownership percentage							20.40%		19.70%
Atai Formation [Member] | Galaxy NYC Based Multi Strategy Investment Firm [Member]
Related Party Transaction [Line Items]
Equity method investment, ownership percentage							6.50%		6.50%

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Defined Contribution Plan (Additional Information) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Retirement Benefits [Abstract]
Labor and Related Expense	$ 0.1	$ 0.1	$ 0.3	$ 0.2

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Corporate Restructuring - Schedule Of Reconciliation Of The Cash Restructuring Charges And Related Payments (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2023 USD ($)
Restructuring and Related Activities [Abstract]
Restructuring liability, Beginning Balance	$ 0
Restructuring costs expensed during the period	3,194
Non-cash impact of stock-based compensation	(195)
Cash payments of restructuring liabilities, net	(2,908)
Restructuring liability , Ending Balance	$ 91

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Corporate Restructuring (Additional Information) (Details) - USD ($) $ in Thousands		3 Months Ended	6 Months Ended
	Feb. 28, 2023	Jun. 30, 2023	Jun. 30, 2023	Dec. 31, 2022
Restructuring Cost and Reserve [Line Items]
Percentage Of Restructed Workforce	30.00%
Restructuring expense			$ 3,194
Restructuring Reserve		$ 91	91	$ 0
General and Administrative Expense [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring expense		$ 1,800	1,400
Deferred Compensation, Share-Based Payments [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring expense			200
Employee Severance [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring expense			$ 3,000

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Subsequent Events - Additional Information (Detail) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Deposit paid	$ 3,019	$ 4,626