For the Year Ended December 31,

(in thousands)

2021

2020

2019

VUmc license expenses

$

14,357

$

203

$

—

Pre-clinical and clinical trial expenses

14,188

11,325

5,118

Personnel-related expenses

4,955

2,276

1,360

Research and development activities expenses

1,843

1,022

1,624

Share-based compensation expense

1,036

232

181

Facilities and other research and development expenses

814

643

64

$

37,193

$

15,701

$

8,347