<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002009280</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001840706</issuerCik>
            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MANUELA VALENTE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>7186</noOfUnitsSold>
            <aggregateMarketValue>21701.72</aggregateMarketValue>
            <noOfUnitsOutstanding>66687085</noOfUnitsOutstanding>
            <approxSaleDate>03/24/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/22/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7186</amountOfSecuritiesAcquired>
            <paymentDate>03/22/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/19/2025</saleDate>
            <amountOfSecuritiesSold>380</amountOfSecuritiesSold>
            <grossProceeds>1160.56</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/24/2025</saleDate>
            <amountOfSecuritiesSold>65</amountOfSecuritiesSold>
            <grossProceeds>266.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/19/2025</saleDate>
            <amountOfSecuritiesSold>381</amountOfSecuritiesSold>
            <grossProceeds>1714.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/23/2025</saleDate>
            <amountOfSecuritiesSold>66</amountOfSecuritiesSold>
            <grossProceeds>238.26</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/21/2025</saleDate>
            <amountOfSecuritiesSold>381</amountOfSecuritiesSold>
            <grossProceeds>1211.12</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/06/2025</saleDate>
            <amountOfSecuritiesSold>1703</amountOfSecuritiesSold>
            <grossProceeds>5293.61</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 03/22/2025 through 06/22/2025.
</remarks>
        <noticeSignature>
            <noticeDate>03/24/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/09/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Manuela Valente</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
