<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: AKRE CAPITAL MANAGEMENT LLC -->
          <cik>0001112520</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Ordinary Shares, par value CHF 0.05 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/20/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001840706</issuerCik>
        <issuerName>SOPHiA GENETICS SA</issuerName>
        <issuerCusip>H82027105</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>401 Park Drive Suite 505</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02215</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>AKRE CAPITAL MANAGEMENT, LLC</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>3719140.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>3719140.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3719140.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.6</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Braddock Partners Offshore, LP</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>E9</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>3719140.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>3719140.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3719140.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.6</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Braddock Capital Offshore, LLC</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>3719140.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>3719140.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3719140.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.6</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>SOPHiA GENETICS SA</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>401 Park Drive Suite 505, Boston, Massachusetts 02215, United States of America</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Akre Capital Management, LLC
Braddock Partners Offshore, LP
Braddock Capital Offshore, LLC</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>Akre Capital Management, LLC
2 West Marshall Street
P.O. Box 998
Middleburg, Virginia 20118-0998
United States of America

Braddock Partners Offshore, LP
c/o Akre Capital Management, LLC
2 West Marshall Street
P.O. Box 998
Middleburg, Virginia 20118-0998
United States of America

Braddock Capital Offshore, LLC
c/o Akre Capital Management, LLC
2 West Marshall Street
P.O. Box 998
Middleburg, Virginia 20118-0998
United States of America</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Akre Capital Management, LLC - Delaware
Braddock Partners Offshore, LP - Cayman Islands
Braddock Capital Offshore, LLC - Delaware</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>Akre Capital Management, LLC - 3,719,140
Braddock Partners Offshore, LP - 3,719,140
Braddock Capital Offshore, LLC - 3,719,140</amountBeneficiallyOwned>
        <classPercent>Akre Capital Management, LLC - 5.6%
Braddock Partners Offshore, LP - 5.6%
Braddock Capital Offshore, LLC - 5.6%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>Akre Capital Management, LLC - 0
Braddock Partners Offshore, LP - 0
Braddock Capital Offshore, LLC - 0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>Akre Capital Management, LLC - 3,719,140
Braddock Partners Offshore, LP - 3,719,140
Braddock Capital Offshore, LLC - 3,719,140</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>Akre Capital Management, LLC - 0
Braddock Partners Offshore, LP - 0
Braddock Capital Offshore, LLC - 0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>Akre Capital Management, LLC - 3,719,140
Braddock Partners Offshore, LP - 3,719,140
Braddock Capital Offshore, LLC - 3,719,140</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>Exhibit A - Joint Filing Agreement</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>AKRE CAPITAL MANAGEMENT, LLC</reportingPersonName>
      <signatureDetails>
        <signature>By: /s/ Charles T. Akre, Jr.*</signature>
        <title>Charles T. Akre, Jr./Managing Member</title>
        <date>06/27/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Braddock Partners Offshore, LP</reportingPersonName>
      <signatureDetails>
        <signature>By: Braddock Capital Offshore, LLC, its general partner, By: /s/ Charles T. Akre, Jr.*</signature>
        <title>Charles T. Akre, Jr./Managing Member</title>
        <date>06/27/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Braddock Capital Offshore, LLC</reportingPersonName>
      <signatureDetails>
        <signature>By: /s/ Charles T. Akre, Jr.*</signature>
        <title>Charles T. Akre, Jr./Managing Member</title>
        <date>06/27/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureComments>* Each Reporting Person disclaims beneficial ownership of the reported securities except to the extent of his, her or its pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.</signatureComments>
  </formData>

</edgarSubmission>
