X0306 4 2023-02-14 0 0001840574 Verve Therapeutics, Inc. VERV 0001383731 MacLean Michael F C/O VERVE THERAPEUTICS, INC. 201 BROOKLINE AVENUE, SUITE 601 BOSTON MA 02215 1 0 0 0 Stock Option (right to buy) 21.76 2023-02-14 4 A 0 7000 0.00 A 2033-02-13 Common Stock 7000 7000 D This stock option was issued pursuant to the 2021 Stock Incentive Plan of Verve Therapeutics, Inc. The shares of common stock underlying the option are scheduled to vest in full upon the one-year anniversary of the grant date, subject to the Reporting Person's continued service. /s/ Andrew Ashe, as Attorney-in-Fact for Michael MacLean 2023-02-16