X0306 4 2022-08-25 0 0001840574 Verve Therapeutics, Inc. VERV 0001573163 Ashe Andrew D. C/O VERVE THERAPEUTICS, INC. 500 TECHNOLOGY SQUARE, SUITE 901 CAMBRIDGE MA 02139 0 1 0 0 See Remarks Common Stock 2022-08-25 4 M 0 51203 1.39 A 221925 D Common Stock 2022-08-25 4 M 0 33749 1.48 A 255674 D Common Stock 2022-08-25 4 M 0 10835 2.87 A 266509 D Stock Option (right to buy) 1.39 2022-08-25 4 M 0 51203 0.00 D 2028-11-07 Common Stock 51203 0 D Stock Option (right to buy) 1.48 2022-08-25 4 M 0 33749 0.00 D 2029-09-16 Common Stock 33749 26999 D Stock Option (right to buy) 2.87 2022-08-25 4 M 0 10835 0.00 D 2030-09-15 Common Stock 10835 153278 D The remaining shares underlying this option, which was granted on November 8, 2018, were fully vested as of August 20, 2022. The remaining shares underlying this option, which was granted on September 17, 2019, vest in equal monthly installments until July 26, 2023. The remaining shares underlying this option, which was granted on September 16, 2020, vest in equal monthly installments until September 16, 2024. President, Chief Operating Officer and General Counsel /s/ Andrew Ashe 2022-08-29