X0306 4 2022-08-08 0 0001840574 Verve Therapeutics, Inc. VERV 0001612528 COATS LONNEL C/O VERVE THERAPEUTICS, INC. 500 TECHNOLOGY SQUARE, SUITE 901 CAMBRIDGE MA 02139 1 0 0 0 Stock Option (right to buy) 27.17 2022-08-08 4 A 0 31000 0.00 A 2032-08-07 Common Stock 31000 31000 D This stock option was issued pursuant to the 2021 Stock Incentive Plan of Verve Therapeutics, Inc. in accordance with its director compensation program. The vesting commencement date of the option is the grant date. The shares of common stock underlying the option are scheduled to vest in equal monthly installments through August 8, 2025, subject to the Reporting Person's continued service. /s Andrew Ashe, Attorney-in-Fact for Lonnel Coats 2022-08-09