Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2025	Mar. 31, 2024
Cash flows from operating activities:
Net loss	$ (31,033)	$ (48,736)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	1,716	1,632
Non-cash lease expense	1,865	1,768
Net accretion of discount on marketable securities	(1,893)	(3,967)
Stock-based compensation	11,174	10,341
Change in fair value of success payments liabilities	(223)	(78)
Changes in operating assets and liabilities:
Collaboration receivable	1,856	168
Prepaid expenses and other assets	2,117	(672)
Accounts payable	729	(3,306)
Accrued expenses and other liabilities	(7,515)	(3,649)
Operating lease liabilities	(1,348)	(1,234)
Deferred revenue	(5,290)	4,651
Net cash used in operating activities	(27,845)	(43,082)
Cash flows from investing activities:
Purchases of property and equipment	(1,224)	(433)
Purchases of marketable securities	(144,817)	(164,190)
Maturities of marketable securities	97,873	122,991
Net cash used in investing activities	(48,168)	(41,632)
Cash flows from financing activities:
Proceeds from issuance of common stock, net of issuance costs	0	22,484
Proceeds from exercise of stock options	7	301
Payment of equity offering costs	0	(51)
Net cash provided by financing activities	7	22,734
Decrease in cash, cash equivalents and restricted cash	(76,006)	(61,980)
Cash, cash equivalents and restricted cash—beginning of period	177,334	210,954
Cash, cash equivalents and restricted cash—end of period	101,328	148,974
Supplemental disclosure of noncash investing and financing activities:
Property and equipment additions included in accounts payable and accrued expenses	$ 396	$ 545