Preferred and Common Stock - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended	12 Months Ended
	Jul. 31, 2022	Jun. 30, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Subsidiary Sale Of Stock [Line Items]
Preferred stock, shares issued			0	0
Preferred stock, value per share			$ 0.001	$ 0.001
Proceeds from issuance of Preferred Stock, net			$ 0	$ 93,759	$ 92,616
Preferred stock, shares authorized			5,000,000	5,000,000
Common stock, shares authorized			200,000,000	200,000,000
Common Stock, Shares Issued		878,098	61,730,816	48,511,735
Common stock, par value			$ 0.001	$ 0.001
Sales Agreement [Member]
Subsidiary Sale Of Stock [Line Items]
Sale of Stock, Number of Shares Issued in Transaction			1,280,168
Commission On Aggregate Gross Sale Proceeds	3.00%
Sale of Stock, Consideration Received on Transaction			$ 42,900
IPO
Subsidiary Sale Of Stock [Line Items]
Proceeds from issuance of Preferred Stock, net			$ 281,600
Additional shares of common stock		2,105,368
Public Offering Price		$ 19.00
Proceeds from common stock, gross		$ 306,700
Shares issued upon conversion of preferred stock			27,720,923
Stock Purchase Agreement [Member] | Vertex Pharmaceuticals [Member]
Subsidiary Sale Of Stock [Line Items]
Common Stock, Shares Issued	1,519,756
Common stock, par value	$ 23.03
Agreegate Purchase Price	$ 35,000
Public offering [Member]
Subsidiary Sale Of Stock [Line Items]
Common Stock, Shares Issued	1,250,000
Sale of Stock, Number of Shares Issued in Transaction	9,583,334
Underwriting discounts and offering expenses	$ 15,800
Common Stock Offering Price Per Share	$ 27.00
Sale of Stock, Consideration Received on Transaction	$ 242,900
Harvard And Board [Member]
Subsidiary Sale Of Stock [Line Items]
Common Stock, Shares Issued		878,098
Preferred Stock
Subsidiary Sale Of Stock [Line Items]
Preferred stock, shares authorized		5,000,000
Preferred Stock | Series A Preferred Stock
Subsidiary Sale Of Stock [Line Items]
Preferred stock, shares issued			101,170,571
Preferred Stock | Series A-2 Preferred Stock
Subsidiary Sale Of Stock [Line Items]
Preferred stock, shares issued			7,838,461
Preferred Stock | Series B Preferred Stock
Subsidiary Sale Of Stock [Line Items]
Preferred stock, shares issued			77,163,022
Common Stock
Subsidiary Sale Of Stock [Line Items]
Common stock, shares authorized		200,000,000
Common stock, par value		$ 0.001
Stock Issued During Period, Shares, New Issues			9,583,334	16,141,157
Common Stock | IPO
Subsidiary Sale Of Stock [Line Items]
Common Stock, Shares Issued		16,141,157
Common Stock | Series B Preferred Stock
Subsidiary Sale Of Stock [Line Items]
Preferred stock, shares issued			77,163,022