License Agreements - Additional Information (Details) - USD ($)		1 Months Ended	10 Months Ended	12 Months Ended
	Jul. 05, 2022	Apr. 30, 2019	Oct. 31, 2020	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Mar. 31, 2022	Sep. 30, 2021	Jun. 30, 2021
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares issued				61,730,816	48,511,735					878,098
Issuance of common stock				$ 242,826,000	$ 281,584,000
Issuance of common stock, value				$ 62,000	49,000
Derivative Liability, Statement of Financial Position [Extensible Enumeration]				Nonoperating Income (Expense)
Research and development expense				$ 130,095,000	$ 68,202,000	$ 35,371,000
Preferred stock, shares issued				0	0
Non-US
Research And Development Arrangement Contract To Perform For Others [Line Items]
Payment of sales based milestone		$ 7,500,000
Broad License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares issued				276,075
Issuance of common stock				$ 300,000
Preferred stock financing partially satisfied							$ 100,000
Preferred stock financing were fully satisfied						$ 500,000
Common stock issued for partly satisfying preferred stock financing							$ 121,411
Common stock issued for fully satisfying preferred stock financing						187,867
Payment of milestone development				46,200,000
Payment of sales based milestone				108,000,000
Harvard and Board
Research And Development Arrangement Contract To Perform For Others [Line Items]
Success payment liability					$ 6,300,000			$ 300	$ 6,300,000
Beam License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares issued		276,075
Issuance of common stock		$ 300,000
Payment of milestone development		11,300,000
Payment of sales based milestone		$ 15,000,000.0
Commercializing Profits And Expenses	35.00%
Percentage Shares of Development Expense	35.00%	33.00%
Milestone related expenses					0
Beam License Agreement | Delivery Technology Product
Research And Development Arrangement Contract To Perform For Others [Line Items]
Payment of milestone development		$ 6,000,000.0
Beam License Agreement | Non-US
Research And Development Arrangement Contract To Perform For Others [Line Items]
Payment of milestone development		$ 5,600,000
Beam License Agreement | Sales Member
Research And Development Arrangement Contract To Perform For Others [Line Items]
Payment of sales based milestone				200,000
Beam License Agreement | Sales Member | N Z
Research And Development Arrangement Contract To Perform For Others [Line Items]
Payment of sales based milestone				300,000
Novartis License Agreement Member
Research And Development Arrangement Contract To Perform For Others [Line Items]
Non-refundable upfront license fees paid					800,000
Payment of sales based milestone				35,000,000.0
Milestone related expenses				0
Non Refundable Upfront License Fee				2,800,000
Clinical And Regulatory Milestone				10,000,000.0
Acuitas Agreements
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development expense				100,000	$ 1,000,000.0
License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Non Refundable Upfront License Fee			$ 2,000,000.0
Clinical And Regulatory Milestone				9,800,000
Sales Based Milestone				9,500,000
License Agreement | Broad License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Non-refundable upfront license fees paid				300,000
License Agreement | Acuitas Agreements | Sales Member
Research And Development Arrangement Contract To Perform For Others [Line Items]
Payment of sales based milestone				$ 800,000
Antidilution Rights | Broad License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares issued				878,098
Issuance of common stock, value				$ 32,500,000